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Aloysius T. Nchinda · SciRah

Researcher profile · Semantic Scholar

Aloysius T. Nchinda

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Aloysius T. Nchinda — researcher profile on SciRah

h-index: 18
Works: 39
Citations: 898

Most-cited papers

3,5-Diaryl-2-aminopyridines as a novel class of orally active antimalarials demonstrating single dose cure in mice and clinical candidate potential.
Yassir Younis, Frédèric Douelle, Tzu-Shean Feng, Diego González Cabrera +19 more
2012Journal of Medicinal Chemistry131 citations Open access
Semantic Scholar
UCT943, a Next-Generation Plasmodium falciparum PI4K Inhibitor Preclinical Candidate for the Treatment of Malaria
Christel Brunschwig, N. Lawrence, D. Taylor, E. Abay +44 more
2018Antimicrobial Agents and Chemotherapy97 citations Open access
Semantic Scholar
Novel orally active antimalarial thiazoles.
Diego González Cabrera, Frédèric Douelle, Tzu-Shean Feng, Aloysius T. Nchinda +10 more
2011Journal of Medicinal Chemistry78 citations Open access
Semantic Scholar
Identification of a Potential Antimalarial Drug Candidate from a Series of 2-Aminopyrazines by Optimization of Aqueous Solubility and Potency across the Parasite Life Cycle.
Claire Le Manach, Aloysius T. Nchinda, Tanya Paquet, Diego González Cabrera +24 more
2016Journal of Medicinal Chemistry49 citations Open access
Semantic Scholar
Structure-activity-relationship studies around the 2-amino group and pyridine core of antimalarial 3,5-diarylaminopyridines lead to a novel series of pyrazine analogues with oral in vivo activity.
Yassir Younis, Frédèric Douelle, Diego González Cabrera, Claire Le Manach +12 more
2013Journal of Medicinal Chemistry47 citations Open access
Semantic Scholar
Medicinal chemistry optimization of antiplasmodial imidazopyridazine hits from high throughput screening of a SoftFocus kinase library: part 1.
Claire Le Manach, Diego González Cabrera, Frédèric Douelle, Aloysius T. Nchinda +14 more
2014Journal of Medicinal Chemistry45 citations
Semantic Scholar
Structure-activity relationship studies of orally active antimalarial 3,5-substituted 2-aminopyridines.
Diego González Cabrera, Frédèric Douelle, Yassir Younis, Tzu-Shean Feng +17 more
2012Journal of Medicinal Chemistry42 citations Open access
Semantic Scholar
Synthesis of novel keto-ACE analogues as domain-selective angiotensin I-converting enzyme inhibitors.
Aloysius T. Nchinda, K. Chibale, Pierre Redelinghuys, E. Sturrock
2006Bioorganic & Medicinal Chemistry Letters40 citations Open access
Semantic Scholar
Novel Heterocyclic Analogues of the HIV‐1 Protease Inhibitor, Ritonavir
P. T. Kaye, Musiliyu A. Musa, Aloysius T. Nchinda, X. Nocanda
200440 citations
Semantic Scholar
Positional-scanning combinatorial libraries of fluorescence resonance energy transfer peptides for defining substrate specificity of the angiotensin I-converting enzyme and development of selective C-domain substrates.
P. A. Bersanetti, M. C. Andrade, D. Casarini, M. Juliano +4 more
2004Biochemistry39 citations
Semantic Scholar
Synthesis and molecular modeling of a lisinopril-tryptophan analogue inhibitor of angiotensin I-converting enzyme.
Aloysius T. Nchinda, K. Chibale, Pierre Redelinghuys, E. Sturrock
2006Bioorganic & Medicinal Chemistry Letters38 citations Open access
Semantic Scholar
2,4-Diaminothienopyrimidines as orally active antimalarial agents.
Diego A. González-Cabrera, Claire Le Manach, Frédèric Douelle, Yassir Younis +18 more
2014Journal of Medicinal Chemistry32 citations Open access
Semantic Scholar
1,3-Diarylpyrazolyl-acylsulfonamides as potent anti-tuberculosis agents targeting cell wall biosynthesis in Mycobacterium tuberculosis
L. Khonde, Rudolf Müller, G. A. Boyle, V. Reddy +20 more
2021Journal of Medicinal Chemistry23 citations Open access
Semantic Scholar
Synthesis, Structure–Activity Relationship, and Mechanistic Studies of Aminoquinazolinones Displaying Antimycobacterial Activity
J. Akester, Paul M. Njaria, Aloysius T. Nchinda, Claire Le Manach +13 more
2020ACS Infectious Diseases22 citations Open access
Semantic Scholar
Novel Antitubercular 6-Dialkylaminopyrimidine Carboxamides from Phenotypic Whole-Cell High Throughput Screening of a SoftFocus Library: Structure–Activity Relationship and Target Identification Studies
Colin R. Wilson, R. Gessner, Atica Moosa, R. Seldon +33 more
2017Journal of Medicinal Chemistry22 citations Open access
Semantic Scholar
Lerisetron Analogues with Antimalarial Properties: Synthesis, Structure–Activity Relationship Studies, and Biological Assessment
R. Mueller, V. Reddy, Aloysius T. Nchinda, Fanuel M. Mebrahtu +11 more
2020ACS Omega20 citations Open access
Semantic Scholar
Chromone studies. Part 13. Synthesis and electron-impact mass spectrometric studies of 5-hydroxy-2-isopropyl-7-methoxychromone, a constituent of the medicinal plant Baeckea frutescens, and side-chain analogues.
Christopher A. Gray, P. T. Kaye, Aloysius T. Nchinda
2003Journal of Natural Products19 citations
Semantic Scholar
Residue L143 of the Foot-and-Mouth Disease Virus Leader Proteinase Is a Determinant of Cleavage Specificity
C. Mayer, D. Neubauer, Aloysius T. Nchinda, R. Cencic +2 more
2008Journal of Virology18 citations Open access
Semantic Scholar
Identification of Fast-Acting 2,6-Disubstituted Imidazopyridines That Are Efficacious in the in Vivo Humanized Plasmodium falciparum NODscidIL2Rγ null Mouse Model of Malaria.
Aloysius T. Nchinda, Claire Le Manach, Tanya Paquet, Diego González Cabrera +16 more
2018Journal of Medicinal Chemistry17 citations
Semantic Scholar
Antimalarial Lead-Optimization Studies on a 2,6-Imidazopyridine Series within a Constrained Chemical Space To Circumvent Atypical Dose-Response Curves against Multidrug Resistant Parasite Strains.
Claire Le Manach, Tanya Paquet, K. Wicht, Aloysius T. Nchinda +12 more
2018Journal of Medicinal Chemistry16 citations Open access
Semantic Scholar
Identification of 2,4-disubstituted imidazopyridines as hemozoin formation inhibitors with fast killing kinetics and in vivo efficacy in the Plasmodium falciparum NSG mouse model
A. Horatscheck, A. Andrijević, Aloysius T. Nchinda, Claire Le Manach +23 more
2020Journal of Medicinal Chemistry11 citations Open access
Semantic Scholar
Novel ketomethylene inhibitors of angiotensin I-converting enzyme (ACE): inhibition and molecular modelling
Pierre Redelinghuys, Aloysius T. Nchinda, K. Chibale, E. Sturrock
2006Biological chemistry10 citations
Semantic Scholar
Novel Heterocyclic Analogues of the HIV-1 Protease Inhibitor, Ritonavir.
P. T. Kaye, Musiliyu A. Musa, Aloysius T. Nchinda, X. Nocanda
20047 citations
Semantic Scholar
Chromone studies. Part 15. Formation and condensation of Baylis–Hillman adducts in DABCO-catalysed reactions of chromone-3-carbaldehydes with acrylonitrile
P. T. Kaye, D. Molefe, Aloysius T. Nchinda, Liezel V. Sabbagh
20045 citations
Semantic Scholar
Catalytic properties of recombinant dipeptidyl carboxypeptidase from Escherichia coli: a comparative study with angiotensin I-converting enzyme
Carlos E Cunha, Helena de Fátima Magliarelli, Thaysa Paschoalin, Aloysius T. Nchinda +6 more
2009Biological chemistry4 citations
Semantic Scholar
Chromone Studies. Part 14.1 Unprecedented Dimerisation of Chromone-3-Carbaldehyde-Derived Baylis–Hillman Adducts
P. T. Kaye, Aloysius T. Nchinda, Liezel V. Sabbagh, J. Bacsa
20034 citations Open access
Semantic Scholar
Chromone Studies. Part 11.1 Synthesis and Electron-Impact Mass Spectrometric Study of Granulosin and Side-Chain Analogues †
P. T. Kaye, Aloysius T. Nchinda, Christopher A. Gray
20024 citations Open access
Semantic Scholar
Chromone studies. Part 10.1 Substituent effects on the basicity of 2-(N,N-dimethylamino)chromones†
P. T. Kaye, Aloysius T. Nchinda, Liezel V. Sabbagh, C. Mccleland
20004 citations
Semantic Scholar
Characterization of angiotensin I-converting enzyme N-domain selectivity using positional-scanning combinatorial libraries of fluorescence resonance energy transfer peptides
P. A. Bersanetti, R. A. Sabatini, Beatriz Matos, Ross G. Douglas +5 more
2012Biological chemistry3 citations
Semantic Scholar
Erratum for Brunschwig et al., “UCT943, a Next-Generation Plasmodium falciparum PI4K Inhibitor Preclinical Candidate for the Treatment of Malaria”
Christel Brunschwig, N. Lawrence, D. Taylor, E. Abay +44 more
2018Antimicrobial Agents and Chemotherapy2 citations Open access
Semantic Scholar
Development of Domain-Selective Angiotensin I-Converting Enzyme Inhibitors
Pierre Redelinghuys, Aloysius T. Nchinda, E. Sturrock
20072 citations
Semantic Scholar
Inhibitors of the angiotensin I-converting enzyme (ACE)
E. Sturrock, Aloysius T. Nchinda, K. Chibale
20062 citations
Semantic Scholar
Chromone Studies. Part 14. Unprecedented Dimerization of Chromone-3-carbaldehyde-Derived Baylis—Hillman Adducts.
P. T. Kaye, Aloysius T. Nchinda, Liezel V. Sabbagh, J. Bacsa
20032 citations
Semantic Scholar
Optimizing Drug Discovery in Resource-Limited Settings: Multi-Parameter Optimization and Data-Driven Workflows.
Aloysius T. Nchinda, Karsten Menzel
2026ACS Medicinal Chemistry Letters1 citations
Semantic Scholar
Chromone Studies. Part 15. Formation and Condensation of Baylis—Hillman Adducts in DABCO-Catalyzed Reactions of Chromone-3-carbaldehydes with Acrylonitrile.
P. T. Kaye, D. Molefe, Aloysius T. Nchinda, Liezel V. Sabbagh
20041 citations
Semantic Scholar
Chromone Studies. Part 11. Synthesis and Electron‐Impact Mass Spectrometric Study of Granulosin and Side‐Chain Analogues.
P. T. Kaye, Aloysius T. Nchinda, Christopher A. Gray
20031 citations
Semantic Scholar
Chemical studies of selected chromone derivatives
Aloysius T. Nchinda
20021 citations
Semantic Scholar
Correction to "Identification of 2,4-Disubstituted Imidazopyridines as Hemozoin Formation Inhibitors with Fast-Killing Kinetics and In Vivo Efficacy in the Plasmodium falciparum NSG Mouse Model".
A. Horatscheck, A. Andrijević, Aloysius T. Nchinda, Claire Le Manach +23 more
2021Journal of Medicinal Chemistry0 citations Open access
Semantic Scholar
Chromones Studies. Part 10. Substituent Effects on the Basicity of 2-(N,N-Dimethylamino)chromones.
P. T. Kaye, Aloysius T. Nchinda, Liezel V. Sabbagh, C. Mccleland
20000 citations
Semantic Scholar

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