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I. Enyedy · SciRah

Researcher profile · Semantic Scholar

I. Enyedy

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I. Enyedy — researcher profile on SciRah

h-index: 26
Works: 65
Citations: 2,193

Most-cited papers

Discovery of small-molecule inhibitors of Bcl-2 through structure-based computer screening.
I. Enyedy, Y. Ling, K. Nacro, Y. Tomita +10 more
2001Journal of Medicinal Chemistry319 citations Open access
Semantic Scholar
Small molecules inhibit the interaction of Nrf2 and the Keap1 Kelch domain through a non-covalent mechanism.
D. Marcotte, Weike Zeng, Jean-Christophe Hus, A. McKenzie +17 more
2013Bioorganic & Medicinal Chemistry240 citations Open access
Semantic Scholar
Can we use docking and scoring for hit-to-lead optimization?
I. Enyedy, W. Egan
2008J. Comput. Aided Mol. Des.91 citations
Semantic Scholar
Synthesis and evaluation of the sunflower derived trypsin inhibitor as a potent inhibitor of the type II transmembrane serine protease, matriptase.
Y. Long, She-Au-Ling Lee, Chen-Yong Lin, I. Enyedy +4 more
2001Bioorganic & Medicinal Chemistry Letters85 citations Open access
Semantic Scholar
Structure-based approach for the discovery of bis-benzamidines as novel inhibitors of matriptase.
I. Enyedy, Sheau‐Ling Lee, Angera H. Kuo, R. B. Dickson +2 more
2001Journal of Medicinal Chemistry80 citations Open access
Semantic Scholar
Pharmacophore-based discovery of substituted pyridines as novel dopamine transporter inhibitors.
I. Enyedy, Sukumar Sakamuri, Wahiduz A. Zaman, Kenneth M. Johnson +1 more
2003Bioorganic & Medicinal Chemistry Letters78 citations Open access
Semantic Scholar
Identification and Biochemical Characterization of Small-Molecule Inhibitors of Clostridium botulinum Neurotoxin Serotype A
Virginia I. Roxas-Duncan, I. Enyedy, V. Montgomery, Vanessa S Eccard +5 more
2009Antimicrobial Agents and Chemotherapy69 citations Open access
Semantic Scholar
EC144 is a potent inhibitor of the heat shock protein 90.
Jiandong Shi, R. W. Van de Water, Kevin Hong, Ryan Lamer +25 more
2012Journal of Medicinal Chemistry66 citations Open access
Semantic Scholar
Virtual screening for kinase targets.
I. Muegge, I. Enyedy
2004Current Medicinal Chemistry60 citations
Semantic Scholar
Docking and Scoring
I. Muegge, I. Enyedy
200357 citations
Semantic Scholar
In silico prediction of hERG inhibition.
Yan-Kang Jing, A. Easter, D. Peters, Norman Kim +1 more
2015Future Medicinal Chemistry56 citations
Semantic Scholar
Molecular modeling studies of the Akt PH domain and its interaction with phosphoinositides.
Suo-Bao Rong, Youhong Hu, I. Enyedy, G. Powis +5 more
2001Journal of Medicinal Chemistry56 citations
Semantic Scholar
Discovery of a novel dopamine transporter inhibitor, 4-hydroxy-1-methyl-4-(4-methylphenyl)-3-piperidyl 4-methylphenyl ketone, as a potential cocaine antagonist through 3D-database pharmacophore searching. Molecular modeling, structure-activity relationships, and behavioral pharmacological studies.
Shaomeng Wang, Sukumar Sakamuri, I. Enyedy, A. Kozikowski +5 more
2000Journal of Medicinal Chemistry55 citations Open access
Semantic Scholar
Identification of orally available naphthyridine protein kinase D inhibitors.
E. Meredith, Ophelia Ardayfio, K. Beattie, M. Dobler +30 more
2010Journal of Medicinal Chemistry52 citations Open access
Semantic Scholar
Design, synthesis and identification of novel, orally bioavailable non-covalent Nrf2 activators.
Bin Ma, B. Lucas, Andrew G. Capacci, Edward Y. S. Lin +7 more
2019Bioorganic & Medicinal Chemistry Letters42 citations Open access
Semantic Scholar
Identification of potent and selective amidobipyridyl inhibitors of protein kinase D.
E. Meredith, K. Beattie, Robin Burgis, M. Capparelli +24 more
2010Journal of Medicinal Chemistry40 citations Open access
Semantic Scholar
Structural basis of binding of high-affinity ligands to protein kinase C: prediction of the binding modes through a new molecular dynamics method and evaluation by site-directed mutagenesis.
Youngshang Pak, I. Enyedy, J. Varady, Justin W. Kung +3 more
2001Journal of Medicinal Chemistry40 citations Open access
Semantic Scholar
Iridals are a novel class of ligands for phorbol ester receptors with modest selectivity for the RasGRP receptor subfamily.
L. Shao, N. Lewin, Patricia S. Lorenzo, Zeng-Jian Hu +6 more
2001Journal of Medicinal Chemistry39 citations Open access
Semantic Scholar
Pharmacophore-based discovery of 3,4-disubstituted pyrrolidines as a novel class of monoamine transporter inhibitors.
I. Enyedy, Wahiduz A. Zaman, Sukumar Sakamuri, A. Kozikowski +2 more
2001Bioorganic & Medicinal Chemistry Letters39 citations Open access
Semantic Scholar
Discovery of biaryl carboxylamides as potent RORγ inverse agonists.
Jian-Hua Chao, I. Enyedy, Kurt van Vloten, D. Marcotte +14 more
2015Bioorganic & Medicinal Chemistry Letters35 citations Open access
Semantic Scholar
Discovery of novel pyrazole-containing benzamides as potent RORγ inverse agonists.
Tao Wang, D. Banerjee, T. Bohnert, Jian-Hua Chao +8 more
2015Bioorganic & Medicinal Chemistry Letters34 citations Open access
Semantic Scholar
Origins and diversity of the aging reaction in phosphonate adducts of serine hydrolase enzymes: what characteristics of the active site do they probe?
Á. Bencsura, I. Enyedy, I. Kovach
1995Biochemistry34 citations
Semantic Scholar
3,5-diarylazoles as novel and selective inhibitors of protein kinase D.
Gabriel G. Gamber, E. Meredith, Qing-Ming Zhu, Wanlin Yan +14 more
2011Bioorganic & Medicinal Chemistry Letters31 citations Open access
Semantic Scholar
Human PLD structures enable drug design and characterization of isoenzyme selectivity
Claire M. Metrick, Emily A. Peterson, Joseph C. Santoro, I. Enyedy +8 more
2020Nature Chemical Biology30 citations
Semantic Scholar
Structural basis of RasGRP binding to high-affinity PKC ligands.
S. Rong, I. Enyedy, Li-Xin Qiao, Lian-Yun Zhao +7 more
2002Journal of Medicinal Chemistry28 citations Open access
Semantic Scholar
Structure-based design of low-nanomolar PIM kinase inhibitors.
A. Ishchenko, Lin Zhang, Jean-Yves LeBrazidec, Jun-Hua Fan +10 more
2015Bioorganic & Medicinal Chemistry Letters27 citations Open access
Semantic Scholar
Probing the Active Site of Acetylcholinesterase by Molecular Dynamics of Its Phosphonate Ester Adducts
Á. Bencsura, I. Enyedy, I. Kovach
199626 citations
Semantic Scholar
Rational Design and Optimization of a Novel Class of Macrocyclic ASK1 Inhibitors.
Martin K. Himmelbauer, Z. Xin, John H. Jones, I. Enyedy +10 more
2019Journal of Medicinal Chemistry25 citations Open access
Semantic Scholar
Alternate Pathways for Acetic Acid and Acetate ion Release from Acetylcholinesterase: a Molecular Dynamics Study
I. Enyedy, I. Kovach, B. Brooks
199821 citations
Semantic Scholar
Potent PDZ-Domain PICK1 Inhibitors that Modulate Amyloid Beta-Mediated Synaptic Dysfunction
Edward Y. S. Lin, L. Silvian, D. Marcotte, Charles C. Banos +18 more
2018Scientific Reports20 citations Open access
Semantic Scholar
Inhibitors of protein-protein interactions: new methodologies to tackle this challenge.
L. Silvian, I. Enyedy, G. Kumaravel
2013Drug Discovery Today : Technologies20 citations
Semantic Scholar
Substituted aminobenzimidazole pyrimidines as cyclin-dependent kinase inhibitors.
S. Verma, D. Nagarathnam, Jian-Xing Shao, Lei Zhang +11 more
2005Bioorganic & Medicinal Chemistry Letters20 citations Open access
Semantic Scholar
Pharmacophore-based discovery, synthesis, and biological evaluation of 4-phenyl-1-arylalkyl piperidines as dopamine transporter inhibitors.
Sukumar Sakamuri, I. Enyedy, A. Kozikowski, Wahiduz A. Zaman +2 more
2001Bioorganic & Medicinal Chemistry Letters19 citations
Semantic Scholar
Discovery of CNS-Penetrant Apoptosis Signal-Regulating Kinase 1 (ASK1) Inhibitors.
Z. Xin, Martin K. Himmelbauer, J. Jones, I. Enyedy +7 more
2020ACS Medicinal Chemistry Letters18 citations Open access
Semantic Scholar
Elucidation of the GSK3α Structure Informs the Design of Novel, Paralog-Selective Inhibitors
Brenda Amaral, Andrew G. Capacci, T. Anderson, Ceren Tezer +19 more
2023ACS Chemical Neuroscience17 citations Open access
Semantic Scholar
Discovery of biaryls as RORγ inverse agonists by using structure-based design.
I. Enyedy, Noel A. Powell, Justin A. Caravella, Kurt van Vloten +7 more
2016Bioorganic & Medicinal Chemistry Letters17 citations Open access
Semantic Scholar
Computational solvent mapping in structure-based drug design.
D. Hall, I. Enyedy
2015Future Medicinal Chemistry17 citations
Semantic Scholar
Molecular modeling, structure--activity relationships and functional antagonism studies of 4-hydroxy-1-methyl-4-(4-methylphenyl)-3-piperidyl 4-methylphenyl ketones as a novel class of dopamine transporter inhibitors.
Shao-Meng Wang, Sukumar Sakamuri, I. Enyedy, A. Kozikowski +2 more
2001Bioorganic & Medicinal Chemistry17 citations
Semantic Scholar
The statistics of virtual screening and lead optimization
Mark R. McGann, A. Nicholls, I. Enyedy
2015Journal of Computer-Aided Molecular Design16 citations
Semantic Scholar
Discovery of Potent, Selective, and Brain-Penetrant Apoptosis Signal-Regulating Kinase 1 (ASK1) Inhibitors that Modulate Brain Inflammation In Vivo.
J. Jones, Z. Xin, Martin K. Himmelbauer, M. Dechantsreiter +17 more
2021Journal of Medicinal Chemistry15 citations Open access
Semantic Scholar
Antisense and small-molecule modulation of diacylglycerol acyltransferase
B. Hubbard, I. Enyedy, T. Gilmore, M. Serrano-Wu
200715 citations
Semantic Scholar
The influence of calculated physicochemical properties of compounds on their ADMET profiles.
Shifan Ma, Mark R. McGann, I. Enyedy
2021Bioorganic & Medicinal Chemistry Letters14 citations
Semantic Scholar
SAR of a novel 'Anthranilamide Like' series of VEGFR-2, multi protein kinase inhibitors for the treatment of cancer.
P. Wickens, H. Kluender, J. Dixon, Catherine Brennan +35 more
2007Bioorganic & Medicinal Chemistry Letters13 citations Open access
Semantic Scholar
Identification and experimental confirmation of novel cGMP efflux inhibitors by virtual ligand screening of vardenafil-analogues.
Farzane Kuresh Kashgari, A. Ravna, G. Sager, R. Lyså +2 more
2020Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie12 citations Open access
Semantic Scholar
Discovery of substituted 3,4-diphenyl-thiazoles as a novel class of monoamine transporter inhibitors through 3-D pharmacophore search using a new pharmacophore model derived from mazindol.
I. Enyedy, Jian-Suo Wang, Wahiduz A. Zaman, Kenneth M. Johnson +1 more
2002Bioorganic & Medicinal Chemistry Letters11 citations Open access
Semantic Scholar
A self-consistent mechanism for dealkylation in soman-inhibited acetylcholinesterase.
I. Kovach, R. Akhmetshin, I. Enyedy, Carol Viragh
1997Biochemical Journal11 citations Open access
Semantic Scholar
Discovery of Phospholipase D Inhibitors with Improved Drug-like Properties and Central Nervous System Penetrance.
Tricia L. May-Dracka, Fang Gao, Brian T. Hopkins, X. Hronowski +17 more
2022ACS Medicinal Chemistry Letters10 citations Open access
Semantic Scholar
Synthesis of 2-alkyl-3-aryl-substituted quinuclidines as novel dopamine transporter inhibitors
Sukumar Sakamuri, I. Enyedy, A. Kozikowski, Shaomeng Wang
200010 citations Open access
Semantic Scholar
Molecular dynamics study of active-site interactions with tetracoordinate transients in acetylcholinesterase and its mutants.
I. Enyedy, I. Kovach, Ákos Bencsura
2001Biochemical Journal9 citations Open access
Semantic Scholar
2,3-Disubstituted quinuclidines as a novel class of dopamine transporter inhibitors.
Sukumar Sakamuri, I. Enyedy, Wahiduz A. Zaman, S. Tella +5 more
2003Bioorganic & Medicinal Chemistry7 citations
Semantic Scholar

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A. Kozikowski×8
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Shaomeng Wang×7
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Sukumar Sakamuri×7
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