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E. Meredith · SciRah

Researcher profile · Semantic Scholar

E. Meredith

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E. Meredith — researcher profile on SciRah

h-index: 19
Works: 43
Citations: 1,002

Most-cited papers

Design and Synthesis of Potent Sensitizers of Gram-Negative Bacteria Based on a Cholic Acid Scaffolding
Chunhong Li, A. S. Peters, E. Meredith, Glenn W. Allman +1 more
1998108 citations
Semantic Scholar
Reliability of the mouse model of choroidal neovascularization induced by laser photocoagulation.
Stephen H Poor, Yubin Qiu, Elizabeth Fassbender, Si-Yuan Shen +9 more
2014Investigative Ophthalmology and Visual Science75 citations
Semantic Scholar
Synthesis of resveratrol using a direct decarbonylative Heck approach from resorcylic acid
M. Andrus, Jing Liu, E. Meredith, E. Nartey
200374 citations
Semantic Scholar
Total synthesis of (+)-geldanamycin and (-)-o-quinogeldanamycin with use of asymmetric anti- and syn-glycolate aldol reactions.
M. Andrus, E. Meredith, B. Simmons, B. V. S. Soma Sekhar +1 more
2002Organic Letters62 citations
Semantic Scholar
A novel kinase inhibitor establishes a predominant role for protein kinase D as a cardiac class IIa histone deacetylase kinase
L. Monovich, Richard B. Vega, E. Meredith, K. Miranda +8 more
2010FEBS Letters59 citations
Semantic Scholar
Total synthesis of (+)-geldanamycin and (-)-o-quinogeldanamycin: asymmetric glycolate aldol reactions and biological evaluation.
M. Andrus, E. Meredith, E. Hicken, B. Simmons +2 more
2003Journal of Organic Chemistry55 citations
Semantic Scholar
Identification of orally available naphthyridine protein kinase D inhibitors.
E. Meredith, Ophelia Ardayfio, K. Beattie, M. Dobler +30 more
2010Journal of Medicinal Chemistry52 citations Open access
Semantic Scholar
Anti-selective glycolate aldol additions with an oxapyrone boron enolate.
M. Andrus, B. V. S. Soma Sekhar, E. Meredith, N. Dalley
2000Organic Letters52 citations
Semantic Scholar
Discovery and in Vivo Evaluation of Potent Dual CYP11B2 (Aldosterone Synthase) and CYP11B1 Inhibitors.
E. Meredith, G. Ksander, L. Monovich, J. Papillon +14 more
2013ACS Medicinal Chemistry Letters42 citations Open access
Semantic Scholar
Identification of potent and selective amidobipyridyl inhibitors of protein kinase D.
E. Meredith, K. Beattie, Robin Burgis, M. Capparelli +24 more
2010Journal of Medicinal Chemistry40 citations Open access
Semantic Scholar
The Discovery of N-(1-Methyl-5-(trifluoromethyl)-1H-pyrazol-3-yl)-5-((6- ((methylamino)methyl)pyrimidin-4-yl)oxy)-1H-indole-1-carboxamide (Acrizanib), a VEGFR-2 Inhibitor Specifically Designed for Topical Ocular Delivery, as a Therapy for Neovascular Age-Related Macular Degeneration.
C. Adams, K. Anderson, G. Artman, J. Bizec +31 more
2018Journal of Medicinal Chemistry35 citations Open access
Semantic Scholar
Nicotinamide Phosphoribosyltransferase Inhibitor as a Novel Payload for Antibody–Drug Conjugates
A. Karpov, T. Abrams, Suzanna Clark, Ankita Raikar +15 more
2018ACS Medicinal Chemistry Letters33 citations Open access
Semantic Scholar
3,5-diarylazoles as novel and selective inhibitors of protein kinase D.
Gabriel G. Gamber, E. Meredith, Qing-Ming Zhu, Wanlin Yan +14 more
2011Bioorganic & Medicinal Chemistry Letters31 citations Open access
Semantic Scholar
Selective synthesis of the para-quinone region of geldanamycin.
M. Andrus, E. Hicken, E. Meredith, B. Simmons +1 more
2003Organic Letters31 citations
Semantic Scholar
Discovery of Oral VEGFR-2 Inhibitors with Prolonged Ocular Retention That Are Efficacious in Models of Wet Age-Related Macular Degeneration.
E. Meredith, N. Mainolfi, Stephen H Poor, Yubin Qiu +25 more
2015Journal of Medicinal Chemistry28 citations Open access
Semantic Scholar
ChemInform Abstract: Highly Selective syn Glycolate Aldol Reactions with Boron Enolates of Masamune Norephedrine Esters.
M. Andrus, B. V. S. Soma Sekhar, Timothy M. Turner, E. Meredith
200125 citations
Semantic Scholar
Synthesis of the left-hand portion of geldanamycin using an anti glycolate aldol reaction.
M. Andrus, E. Meredith, B. V. S. Soma Sekhar
2001Organic Letters25 citations
Semantic Scholar
A small-molecule inhibitor of C5 complement protein
Keith Jendza, Mitsunori Kato, M. Salcius, H. Srinivas +23 more
2019Nature Chemical Biology24 citations
Semantic Scholar
Glycolate aldol reactions with boron enolates of bis-4-methoxyphenyl dioxanone
M. Andrus, K. Mendenhall, E. Meredith, B. V. S. Soma Sekhar
200221 citations
Semantic Scholar
A Reliable Synthesis of 3-Amino-5-Alkyl and 5-Amino-3-Alkyl Isoxazoles
Leland Johnson, J. PowersJames, Fupeng Ma, Keith Jendza +3 more
201217 citations
Semantic Scholar
Structure based design of nicotinamide phosphoribosyltransferase (NAMPT) inhibitors from a phenotypic screen.
Daniel S. Palacios, E. Meredith, T. Kawanami, C. Adams +17 more
2017Bioorganic & Medicinal Chemistry Letters16 citations
Semantic Scholar
Paradoxical Increase of Permeability and Lipophilicity with the Increasing Topological Polar Surface Area within a Series of PRMT5 Inhibitors.
U. Argikar, M. Blatter, D. Bednarczyk, Zhuoliang Chen +16 more
2022Journal of Medicinal Chemistry14 citations Open access
Semantic Scholar
Scaffold Morphing Identifies 3-Pyridyl Azetidine Ureas as Inhibitors of Nicotinamide Phosphoribosyltransferase (NAMPT).
Daniel S. Palacios, E. Meredith, T. Kawanami, C. Adams +11 more
2019ACS Medicinal Chemistry Letters13 citations Open access
Semantic Scholar
Binding of a glaucoma-associated myocilin variant to the αB-crystallin chaperone impedes protein clearance in trabecular meshwork cells
J. Lynch, Bing Li, Parvaneh Katoli, Chuan-Xi Xiang +10 more
2018Journal of Biological Chemistry13 citations Open access
Semantic Scholar
The discovery of potent inhibitors of aldosterone synthase that exhibit selectivity over 11-beta-hydroxylase.
C. Adams, Chii-Whei Hu, Arco Y. Jeng, R. Karki +12 more
2010Bioorganic & Medicinal Chemistry Letters13 citations Open access
Semantic Scholar
The Discovery of ( S)-1-(6-(3-((4-(1-(Cyclopropanecarbonyl)piperidin-4-yl)-2-methylphenyl)amino)-2,3-dihydro-1 H-inden-4-yl)pyridin-2-yl)-5-methyl-1 H-pyrazole-4-carboxylic Acid, a Soluble Guanylate Cyclase Activator Specifically Designed for Topical Ocular Delivery as a Therapy for Glaucoma.
T. Ehara, C. Adams, Douglas E Bevan, N. Ji +17 more
2018Journal of Medicinal Chemistry12 citations
Semantic Scholar
Core Replacements in a Potent Series of VEGFR-2 Inhibitors and Their Impact on Potency, Solubility, and hERG.
N. Mainolfi, James J. Powers, E. Meredith, J. Elliott +4 more
2016ACS Medicinal Chemistry Letters8 citations Open access
Semantic Scholar
Syntheses of 1-Substituted-3-aminopyrazoles.
Nan Ji, E. Meredith, Donglei Liu, C. Adams +6 more
20117 citations
Semantic Scholar
Lack of Involvement of CEP Adducts in TLR Activation and in Angiogenesis
J. Gounarides, Jennifer S. Cobb, Jing Zhou, Frank Cook +23 more
2014PLoS ONE6 citations Open access
Semantic Scholar
A Reliable Synthesis of 3‐Amino‐5‐alkyl and 5‐Amino‐3‐alkyl Isoxazoles.
Leland Johnson, J. PowersJames, Fupeng Ma, Keith Jendza +3 more
20135 citations
Semantic Scholar
Full-length myocilin protein is purified from mammalian cells as a dimer.
Parvaneh Katoli, Adarsh Godbole, M. Romanowski, K. Clark +6 more
2018Protein Expression and Purification4 citations
Semantic Scholar
A small-molecule inhibitor of C 5 complement protein
Keith Jendza, M. Salcius, H. Srinivas, A. D. de Erkenez +20 more
20192 citations
Semantic Scholar
Synthesis of the Left‐Hand Portion of Geldanamycin Using an anti Glycolate Aldol Reaction.
M. Andrus, E. Meredith, B. V. S. Soma Sekhar
20011 citations
Semantic Scholar
Abstract P4-07-11: Investigating the activity of ESR1 allosteric compounds in ER+ breast cancer
A. Uwimana, CL Tiong Yip, R. Das, Q. Cheng +2 more
2019Poster Session Abstracts0 citations
Semantic Scholar
Weekly oral delivery of a vascular endothelial growth factor receptor (VEGFR) inhibitor compound optimized for ocular exposure improves safety and maintains efficacy compared to daily dosing
Yubin Qiu, Si-Yuan Shen, Elizabeth Fassbender, Amber Woolfenden +5 more
20150 citations
Semantic Scholar
Fused imidazoloderivater to inhibition of aldosterone synthase and aromatase
G. Ksander, E. Meredith, L. Monovich, J. Papillon +2 more
20060 citations
Semantic Scholar
Chapter 2 Synthesis of geldanamycin using glycolate aldol reactions
M. Andrus, E. Hicken, E. Meredith
20050 citations
Semantic Scholar
Total Synthesis of (+)-Geldanamycin (I) and (-)-o-Quinogeldanamycin (II): Asymmetric Glycolate Aldol Reactions and Biological Evaluation.
M. Andrus, E. Meredith, E. Hicken, B. Simmons +2 more
20040 citations
Semantic Scholar
Synthesis of Resveratrol Using a Direct Decarbonylative Heck Approach from Resorcylic Acid.
M. Andrus, Jing Liu, E. Meredith, E. Nartey
20030 citations
Semantic Scholar
Highly Selective syn Glycolate Aldol Reactions with Boron Enolates of Masamune Norephedrine Esters.
M. Andrus, B. V. S. Soma Sekhar, Timothy M. Turner, E. Meredith
20020 citations
Semantic Scholar
Glycolate Aldol Reactions with Boron Enolates of Bis-4-methoxyphenyl Dioxanone.
M. Andrus, K. Mendenhall, E. Meredith, B. V. S. Soma Sekhar
20020 citations
Semantic Scholar
Synthese de resveratrol
M. Andrus, E. Meredith
20010 citations
Semantic Scholar
Anti‐Selective Glycolate Aldol Additions with an Oxapyrone Boron Enolate.
M. Andrus, B. V. S. Soma Sekhar, E. Meredith, N. Dalley
20010 citations
Semantic Scholar

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