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I. Achour · SciRah

Researcher profile · Semantic Scholar

I. Achour

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I. Achour — researcher profile on SciRah

h-index: 20
Works: 56
Citations: 1,247

Most-cited papers

Clinical and molecular features of acquired resistance to immunotherapy in non-small cell lung cancer
Danish Memon, A. Schoenfeld, D. Ye, G. Fromm +29 more
2021bioRxiv203 citations Open access
Semantic Scholar
Design and efficacy of a monovalent bispecific PD-1/CTLA-4 antibody that enhances CTLA-4 blockade on PD-1+ activated T cells.
S. Dovedi, Matthew J. Elder, Chun-Ning Yang, S. Sitnikova +31 more
2021Cancer Discovery146 citations Open access
Semantic Scholar
Single-domain antibodies recognize selectively small oligomeric forms of amyloid beta, prevent Abeta-induced neurotoxicity and inhibit fibril formation.
P. Lafaye, I. Achour, P. England, C. Duyckaerts +1 more
2009Molecular Immunology111 citations
Semantic Scholar
Camelid Ig V genes reveal significant human homology not seen in therapeutic target genes, providing for a powerful therapeutic antibody platform
A. Klarenbeek, Khalil El Mazouari, A. Desmyter, C. Blanchetot +9 more
2015mAbs91 citations Open access
Semantic Scholar
Tetrameric and Homodimeric Camelid IgGs Originate from the Same IgH Locus
I. Achour, P. Cavelier, M. Tichit, C. Bouchier +2 more
2008Journal of Immunology74 citations Open access
Semantic Scholar
Flexible ordering of antibody class switch and V(D)J joining during B-cell ontogeny
Satyendra Kumar, R. Wuerffel, I. Achour, B. Lajoie +4 more
2013Genes & Development50 citations Open access
Semantic Scholar
Analysis of PD1, LAG3, TIGIT, and TIM3 expression in human lung adenocarcinoma reveals a 25-gene signature predicting immunotherapy response
J. Guégan, F. Peyraud, B. Dadone-Montaudié, D. Teyssonneau +19 more
2024Cell Reports Medicine49 citations Open access
Semantic Scholar
Research and applications: Network models of genome-wide association studies uncover the topological centrality of protein interactions in complex diseases
Younghee Lee, Hai-Quan Li, Jianrong Li, Ellen Rebman +7 more
2013J. Am. Medical Informatics Assoc.42 citations
Semantic Scholar
‘N-of-1-pathways’ unveils personal deregulated mechanisms from a single pair of RNA-Seq samples: towards precision medicine
V. Gardeux, I. Achour, Jianrong Li, M. Maienschein-Cline +8 more
2014J. Am. Medical Informatics Assoc.39 citations Open access
Semantic Scholar
Research and applications: The discriminatory cost of ICD-10-CM transition between clinical specialties: metrics, case study, and mitigating tools
A. Boyd, Jianrong Li, Mike D. Burton, Michael Jonen +8 more
2013J. Am. Medical Informatics Assoc.37 citations
Semantic Scholar
53BP1 contributes to Igh locus chromatin topology during class switch recombination
S. Feldman, R. Wuerffel, I. Achour, Li-Li Wang +2 more
2017Journal of Immunology27 citations Open access
Semantic Scholar
N-of-1-pathways MixEnrich: advancing precision medicine via single-subject analysis in discovering dynamic changes of transcriptomes
Qi-Ke Li, A. Grant Schissler, V. Gardeux, I. Achour +5 more
2017BMC Medical Genomics27 citations Open access
Semantic Scholar
Dynamic changes of RNA-sequencing expression for precision medicine: N-of-1-pathways Mahalanobis distance within pathways of single subjects predicts breast cancer survival
A. G. Schissler, V. Gardeux, Qi-Ke Li, I. Achour +3 more
2015Bioinform.27 citations Open access
Semantic Scholar
Three dimensional architecture of the Igh locus facilitates class switch recombination
A. Kenter, S. Feldman, R. Wuerffel, I. Achour +2 more
2012Annals of the New York Academy of Sciences27 citations Open access
Semantic Scholar
LBA56 MEDI5752 or pembrolizumab (P) plus carboplatin/pemetrexed (CP) in treatment-naïve (1L) non-small cell lung cancer (NSCLC): A phase Ib/II trial
M.-J. Ahn, S.-W. Kim, E. C. Costa, L. Rodríguez +16 more
2022Annals of Oncology26 citations Open access
Semantic Scholar
Anti-PD-1 monoclonal antibody MEDI0680 in a phase I study of patients with advanced solid malignancies
A. Naing, J. Infante, S. Goel, H. Burris +17 more
2019Journal of Immunotherapy for Cancer26 citations Open access
Semantic Scholar
Constraints contributed by chromatin looping limit recombination targeting during immunoglobulin class switch recombination
S. Feldman, I. Achour, R. Wuerffel, Satyendra Kumar +3 more
2015Journal of Immunology26 citations Open access
Semantic Scholar
hMSH2 expression is driven by AP1-dependent regulation through phorbol-ester exposure.
O. Humbert, I. Achour, D. Lautier, G. Laurent +1 more
2003Nucleic Acids Research22 citations Open access
Semantic Scholar
A genome-by-environment interaction classifier for precision medicine: personal transcriptome response to rhinovirus identifies children prone to asthma exacerbations
V. Gardeux, J. Berghout, I. Achour, A. Grant Schissler +11 more
2017J. Am. Medical Informatics Assoc.21 citations Open access
Semantic Scholar
The discriminatory cost of ICD-10-CM transition between clinical specialties: metrics, case study, and mitigating tools
A. D. Boyd, Jianrong Li, Mike D. Burton, Michael Jonen +8 more
2013JAMIA Journal of the American Medical Informatics Association21 citations Open access
Semantic Scholar
Integrative genomics analyses unveil downstream biological effectors of disease-specific polymorphisms buried in intergenic regions
Hai-Quan Li, I. Achour, L. Bastarache, J. Berghout +10 more
2016npj Genomic Medicine20 citations Open access
Semantic Scholar
Concordance of deregulated mechanisms unveiled in underpowered experiments: PTBP1 knockdown case study
V. Gardeux, A. Arslan, I. Achour, T. Ho +2 more
2014BMC Medical Genomics19 citations Open access
Semantic Scholar
Safety, pharmacokinetics (PK), pharmacodynamics (PD) and preliminary efficacy of AZD2936, a bispecific antibody targeting PD-1 and TIGIT, in checkpoint inhibitor (CPI)-experienced advanced/metastatic non-small-cell lung cancer (NSCLC): First report of ARTEMIDE-01.
K. Rohrberg, M. Brandão, Eduardo Castañón Álvarez, E. Felip +16 more
2023Journal of Clinical Oncology17 citations
Semantic Scholar
kMEn: analyzing noisy and bidirectional transcriptional pathway responses in single subjects
Qi-Ke Li, A. Grant Schissler, V. Gardeux, J. Berghout +5 more
2016Journal of Biomedical Informatics16 citations Open access
Semantic Scholar
Correction to: 33rd Annual Meeting & Pre-Conference Programs of the Society for Immunotherapy of Cancer (SITC 2018)
S. Berry, Nicolas A. Giraldo, Peter Nguyen, B. Green +87 more
2019Journal of Immunotherapy for Cancer14 citations Open access
Semantic Scholar
Analysis of aggregated cell–cell statistical distances within pathways unveils therapeutic-resistance mechanisms in circulating tumor cells
A. Grant Schissler, Qi-Ke Li, James L. Chen, C. Kenost +5 more
2016Bioinform.14 citations Open access
Semantic Scholar
A Randomized Phase 2 Study of MEDI0680 in Combination With Durvalumab Versus Nivolumab Monotherapy in Patients With Advanced or Metastatic Clear Cell Renal Cell Carcinoma
M. Voss, A. Azad, A. Hansen, J. Gray +9 more
2022Clinical Cancer Research10 citations Open access
Semantic Scholar
Abstract 2776: MEDI5752: A novel bispecific antibody that preferentially targets CTLA-4 on PD-1 expressing T-cells
S. Dovedi, Y. Mazor, Matthew J. Elder, Sumati Hasani +18 more
2018Immunology10 citations
Semantic Scholar
eQTL networks unveil enriched mRNA master integrators downstream of complex disease-associated SNPs
Hai-Quan Li, N. Pouladi, I. Achour, V. Gardeux +6 more
2015Journal of Biomedical Informatics10 citations Open access
Semantic Scholar
Somatic mutations in BRCA2, NFE2L2, ARID1A and NOTCH1 sensitize to anti-PDL1 therapy in multiple tumor types
Michael Kuziora, H. Si, B. Higgs, Philip Z. Brohawn +16 more
2018Annals of Oncology4 citations Open access
Semantic Scholar
Abstract CT016: MEDI5752, a novel PD-1/CTLA-4 bispecific checkpoint inhibitor for advanced solid tumors: First-in-human study
B. Tran, M. Voskoboynik, Sang-We Kim, C. Lemech +16 more
2022Cancer Research3 citations
Semantic Scholar
Constraints Contributed by Chromatin Looping Limit Recombination Targeting during Immunoglobulin Class Switch Recombination
S. Feldman, I. Achour, R. Wuerffel, Satyendra Kumar +3 more
20153 citations
Semantic Scholar
Mucocle aprs radiothrapie chez deux patients traits pour cancer du nasopharynx
M. Mnejja, B. Hammami, I. Achour, A. Chakroun +4 more
20113 citations
Semantic Scholar
Safety, Pharmacokinetics, Pharmacodynamics, and Preliminary Efficacy from a First-in-Human Study of Volrustomig, a Novel PD-1/CTLA-4 Bispecific Antibody
B. Tran, M. Voskoboynik, Sang-We Kim, C. Lemech +25 more
2026Clinical Cancer Research2 citations Open access
Semantic Scholar
Abstract 3627: Volrustomig a novel PD-1/CTLA-4 bispecific antibody leads to robust increase in peripheral and intra-tumoral pharmacodynamic biomarkers in solid tumors from FTiH study
I. Achour, Michael Kuziora, Florian Song, Steven Eck +18 more
2024Cancer Research2 citations
Semantic Scholar
Abstract 1235: Presence of TLS and combined high densities of PD-L1+ macrophages & CD8+ T cells predict long-term overall survival for patients with advanced NSCLC treated with durvalumab
Lina Meinecke, J. Blando, Thomas A. Herz, M. Surace +12 more
2022Cancer Research2 citations
Semantic Scholar
Results from a randomised phase I/II trial evaluating the safety and antitumour activity of anti-PD-1 (MEDI0680)/anti-PD-L1 (durvalumab) vs anti-PD-1 (nivolumab) alone in metastatic clear cell renal cell carcinoma (ccRCC)
M. Voss, A. Azad, A. Hansen, J. Gray +6 more
2019Annals of Oncology2 citations Open access
Semantic Scholar
In Silico cancer cell versus stroma cellularity index computed from species-specific human and mouse transcriptome of xenograft models: towards accurate stroma targeting therapy assessment
X. Yang, Yong Huang, Younghee Lee, V. Gardeux +5 more
2014BMC Medical Genomics2 citations Open access
Semantic Scholar
Network models of genome-wide association studies uncover the topological centrality of protein interactions in complex diseases
Younghee Lee, Hai-Quan Li, Jianrong Li, Ellen Rebman +7 more
2013JAMIA Journal of the American Medical Informatics Association2 citations Open access
Semantic Scholar
Abstract 4212: Baseline peripheral blood scRNA-seq AI estimator framework predicts solid-tumor response and adverse events via molecular foundation models and cell-to-patient learning
Pablo Moreno, Marta Milo, Ricardo J. Miragaia, A. Proutski +2 more
2026Cancer Research1 citations
Semantic Scholar
Rilvegostomig for Metastatic Non–Small Cell Lung Cancer: A First-In-Human Phase I/II Clinical Study
K. Rohrberg, M. Brandão, Eduardo Castañón Álvarez, E. Felip +21 more
2026Clinical Cancer Research1 citations Open access
Semantic Scholar
Abstract 3245: Durvalumab induces an NK cell response associated with clinical benefit of patients with advanced NSCLC
M. Ascierto, Y. Shrestha, Qu Zhang, Ji-Xin Wang +9 more
2019Immunology1 citations
Semantic Scholar
Convergent downstream candidate mechanisms of independent intergenic polymorphisms between co-classified diseases implicate epistasis among noncoding elements
Jia-Li Han, Jianrong Li, I. Achour, L. Pesce +3 more
2018Pacific Symposium on Biocomputing1 citations Open access
Semantic Scholar
Clinical Validation of Mathematically Derived Early Tumor Dynamics for Solid Tumors in Response to Durvalumab
Qin Li, V. Cristini, A. Gupta, I. Achour +2 more
2024JCO Clinical Cancer Informatics0 citations
Semantic Scholar
Abstract 5466: Functional status of tumor-associated macrophages impacts clinical outcome of durvalumab in patients with advanced NSCLC as revealed by proteomics mass spectrometry
A. M. Hansen, V.-Y. Wang, Andrew Chambers, David C. Chain +8 more
2023Cancer Research0 citations
Semantic Scholar
NOVEL DIGITAL IMAGE APPROACH OF MULTIPLEX IMMUNOFLUORESCENCE BASED PD-L1 EXPRESSION ENABLES THE STRATIFICATION OF ADVANCED NSCLC PATIENTS TREATED WITH DURVALUMAB
H. Hessel, A. Gupta, I. Achour
20220 citations
Semantic Scholar
73 Delta-radiomics predicts response and overall survival in advanced non-small cell lung cancer patients treated with durvalumab
Mohammadhadi Khorrami, V. Viswanathan, Amit Gupta, Qin Li +5 more
2022Regular and Young Investigator Award Abstracts0 citations Open access
Semantic Scholar
IMAGE APPROACH OF MULTIPLEX IMMUNOFLUORESCENCE BASED PD-L1 EXPRESSION ENABLES THE STRATIFICATION OF ADVANCED NSCLC PATIENTS TREATED WITH DURVALUMAB
N. Brieu, H. Hessel, A. Gupta, I. Achour
20220 citations
Semantic Scholar
Abstract 5667: Biomarkers associated with tertiary lymphoid structures are elevated in lung and bladder cancer patients who respond to durvalumab treatment
S. Sridhar, C. Morehouse, Yashaswi Shreshta, M. Rebelatto +4 more
2020Tumor Biology0 citations
Semantic Scholar
Structure of a Llama Glama Fab 48A2 against human cMet
A. Klarenbeek, K. El Mazouari, A. Desmyter, C. Blanchetot +8 more
20150 citations
Semantic Scholar

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