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A. D. de Graan · SciRah

Researcher profile · Semantic Scholar

A. D. de Graan

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A. D. de Graan — researcher profile on SciRah

h-index: 17
Works: 33
Citations: 787

Most-cited papers

CYP3A4*22 genotype and systemic exposure affect paclitaxel-induced neurotoxicity
A. D. de Graan, L. Elens, J. Sprowl, A. Sparreboom +10 more
2013Clinical Cancer Research103 citations Open access
Semantic Scholar
Influence of Polymorphic OATP1B-Type Carriers on the Disposition of Docetaxel
A. D. de Graan, Cynthia S. Lancaster, A. Obaidat, B. Hagenbuch +15 more
2012Clinical Cancer Research101 citations Open access
Semantic Scholar
Genome-wide association study of paclitaxel and carboplatin disposition in women with epithelial ovarian cancer
B. Gao, Yi Lu, A. Nieuweboer, Hongmei Xu +18 more
2018Scientific Reports94 citations Open access
Semantic Scholar
CYP3A4 intron 6 C>T SNP (CYP3A4*22) encodes lower CYP3A4 activity in cancer patients, as measured with probes midazolam and erythromycin.
L. Elens, A. Nieuweboer, S. Clarke, Kellie A. Charles +4 more
2013Pharmacogenomics (London)64 citations
Semantic Scholar
Dextromethorphan as a phenotyping test to predict endoxifen exposure in patients on tamoxifen treatment.
A. D. de Graan, S. F. Teunissen, F. D. de Vos, W. Loos +9 more
2011Journal of Clinical Oncology59 citations Open access
Semantic Scholar
Inter-patient variability in docetaxel pharmacokinetics: A review.
A. Nieuweboer, E. D. de Morrée, A. D. de Graan, A. Sparreboom +2 more
2015Cancer Treatment Reviews44 citations
Semantic Scholar
Impact of POR*28 on the clinical pharmacokinetics of CYP3A phenotyping probes midazolam and erythromycin
L. Elens, A. Nieuweboer, S. Clarke, Kellie A. Charles +5 more
2013Pharmacogenetics & Genomics42 citations
Semantic Scholar
Quantification of cabazitaxel in human plasma by liquid chromatography/triple-quadrupole mass spectrometry: a practical solution for non-specific binding.
P. de Bruijn, A. D. de Graan, A. Nieuweboer, R. Mathijssen +4 more
2012Journal of Pharmaceutical and Biomedical Analysis41 citations
Semantic Scholar
Influence of Smoking on the Pharmacokinetics and Toxicity Profiles of Taxane Therapy
A. D. de Graan, W. Loos, L. Friberg, S. Baker +6 more
2012Clinical Cancer Research36 citations Open access
Semantic Scholar
Population pharmacokinetic modelling to assess the impact of CYP2D6 and CYP3A metabolic phenotypes on the pharmacokinetics of tamoxifen and endoxifen.
R. ter Heine, Lisette Binkhorst, A. D. de Graan, P. de Bruijn +3 more
2014British Journal of Clinical Pharmacology28 citations Open access
Semantic Scholar
Clinical validity of new genetic biomarkers of irinotecan neutropenia: an independent replication study
D. Crona, J. Ramírez, W. Qiao, A. D. de Graan +5 more
2015The Pharmacogenomics Journal25 citations Open access
Semantic Scholar
Pharmacokinetically based dosing of weekly paclitaxel to reduce drug-related neurotoxicity based on a single sample strategy
S. Kraff, A. Nieuweboer, R. Mathijssen, F. Baty +4 more
2015Cancer Chemotherapy and Pharmacology24 citations
Semantic Scholar
A Pharmacogenetic Predictive Model for Paclitaxel Clearance Based on the DMET Platform
A. D. de Graan, L. Elens, M. Smid, J. Martens +9 more
2013Clinical Cancer Research22 citations
Semantic Scholar
4β-hydroxycholesterol as an endogenous CYP3A marker in cancer patients treated with taxanes.
A. D. de Graan, A. Sparreboom, P. de Bruijn, E. de Jonge +5 more
2015British Journal of Clinical Pharmacology20 citations Open access
Semantic Scholar
Influence of pharmacogenetic variability on the pharmacokinetics and toxicity of the aurora kinase inhibitor danusertib
N. Steeghs, R. Mathijssen, J. Wessels, A. D. de Graan +7 more
2010Investigational new drugs19 citations Open access
Semantic Scholar
Predicting paclitaxel-induced neutropenia using the DMET platform.
A. Nieuweboer, M. Smid, A. D. de Graan, Samira Elbouazzaoui +4 more
2015Pharmacogenomics (London)18 citations
Semantic Scholar
Role of genetic variation in docetaxel-induced neutropenia and pharmacokinetics
A. Nieuweboer, M. Smid, A. D. de Graan, Samira Elbouazzaoui +8 more
2015The Pharmacogenomics Journal17 citations Open access
Semantic Scholar
Simultaneous quantification of dextromethorphan and its metabolites dextrorphan, 3-methoxymorphinan and 3-hydroxymorphinan in human plasma by ultra performance liquid chromatography/tandem triple-quadrupole mass spectrometry.
W. Loos, A. D. de Graan, P. de Bruijn, R. V. van Schaik +4 more
2011Journal of Pharmaceutical and Biomedical Analysis15 citations
Semantic Scholar
Effects of Budesonide on Cabazitaxel Pharmacokinetics and Cabazitaxel-Induced Diarrhea: A Randomized, Open-Label Multicenter Phase II Study
A. Nieuweboer, A. D. de Graan, P. Hamberg, S. Bins +11 more
2016Clinical Cancer Research11 citations Open access
Semantic Scholar
Predictive Biomarkers and Personalized Medicine In fl uence of Polymorphic OATP 1 B-Type Carriers on the Disposition of Docetaxel
A. D. de Graan, Cynthia S. Lancaster, A. Obaidat, B. Hagenbuch +15 more
20123 citations
Semantic Scholar
A randomized phase II multicenter trial on the effects of budesonide on cabazitaxel-induced diarrhea: CABARESC.
S. Bins, A. Nieuweboer, A. D. de Graan, R. V. van Soest +12 more
20161 citations
Semantic Scholar
An independent, external validation study of proposed genetic biomarkers of irinotecan toxicity and pharmacokinetics.
Federico Innocenti, Gary L. Rosner, W. Qiao, A. D. de Graan +4 more
2011Journal of Clinical Oncology1 citations
Semantic Scholar
Abstract 5493: Genome-wide study of carboplatin and paclitaxel disposition in ovarian cancer patients
B. Gao, Yi Lu, A. Nieuweboer, Hongmei Xu +18 more
20150 citations
Semantic Scholar
Genome-wide association study for identification of candidate SNPs associated with carboplatin and paclitaxel clearance in ovarian cancer patients.
B. Gao, Yi Lu, A. Nieuweboer, Hongmei Xu +13 more
20140 citations
Semantic Scholar
Predictive Biomarkers and Personalized Medicine CYP 3 A 4 22 Genotype and Systemic Exposure Affect Paclitaxel-Induced Neurotoxicity
A. D. de Graan, L. Elens, J. Sprowl, A. Sparreboom +10 more
20130 citations
Semantic Scholar
A Pharmacological Approach to Personalize the Use of Anti-Cancer Drugs
A. D. de Graan
20130 citations
Semantic Scholar
Abstract A55: Influence of ABCB1 polymorphisms on paclitaxel pharmacokinetics in ovarian cancer patients
B. Gao, A. Nieuweboer, Hongmei Xu, J. Beesley +10 more
20130 citations
Semantic Scholar
Influence of drug exposure and genetic variation on paclitaxel-induced neurotoxicity
A. D. de Graan, L. Elens, A. Sparreboom, L. Friberg +6 more
20120 citations Open access
Semantic Scholar
Reply to F.L. Opdam et al
A. D. de Graan, Lisette Binkhorst, W. Loos, R. V. van Schaik +2 more
20120 citations Open access
Semantic Scholar
Oral Session II‐B (OII‐B)
J. Schwartz, S. Hall, J. Gorski, L. Li +13 more
20120 citations
Semantic Scholar
Abstract A189: Influence of smoking on the pharmacology of taxane therapy.
A. D. de Graan, W. Loos, L. Friberg, S. Baker +5 more
20110 citations
Semantic Scholar
Abstract C118: Influence of CYP2D6 phenotype on tamoxifen‐treatment outcome in women with metastatic breast cancer
L. Lammers, R. Mathijssen, T. van Gelder, Monique J. Bijl +6 more
20090 citations
Semantic Scholar
Targeted therapy in oncology: mechanisms and toxicity
N. Steeghs, R. Mathijssen, J. Wessels, A. D. de Graan +7 more
0 citations
Semantic Scholar

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