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R. V. van Schaik · SciRah

Researcher profile · Semantic Scholar

R. V. van Schaik

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R. V. van Schaik — researcher profile on SciRah

h-index: 80
Works: 598
Citations: 23K

Most-cited papers

Dutch Pharmacogenetics Working Group (DPWG) guideline for the gene-drug interaction between CYP2D6, CYP3A4 and CYP1A2 and antipsychotics
L. Beunk, M. Nijenhuis, Bianca Soree, Nienke J. de Boer-Veger +11 more
2023European Journal of Human Genetics159 citations Open access
Semantic Scholar
Characterizing prostate cancer risk through multi-ancestry genome-wide discovery of 187 novel risk variants
Anqi Wang, Jiayi Shen, Alex A. Rodriguez, E. Saunders +309 more
2023Nature Genetics136 citations Open access
Semantic Scholar
Clinical Pharmacogenetics Implementation Consortium Guideline (CPIC) for CYP2D6, ADRB1, ADRB2, ADRA2C, GRK4, and GRK5 Genotypes and Beta-Blocker Therapy
J. Duarte, Cameron D. Thomas, Craig R. Lee, R. Huddart +14 more
2024Clinical pharmacology and therapy72 citations Open access
Semantic Scholar
Implementation of dihydropyrimidine dehydrogenase deficiency testing in Europe
M. de With, A. Sadlon, E. Cecchin, V. Haufroid +5 more
2023ESMO Open72 citations Open access
Semantic Scholar
A vision to the future: value-based laboratory medicine
M. Plebani, J. Cadamuro, P. Vermeersch, S. Jovičić +18 more
2024Clinical Chemistry and Laboratory Medicine55 citations Open access
Semantic Scholar
PharmVar GeneFocus: CYP3A5
C. Rodríguez-Antona, Jessica Savieo, V. Lauschke, K. Sangkuhl +11 more
2022Clinical pharmacology and therapy41 citations Open access
Semantic Scholar
Determination of cortisone and cortisol in human scalp hair using an improved LC-MS/MS-based method
M. Mirzaian, Sofie K. M. van Zundert, Wim F. Schilleman, Mostafa Mohseni +4 more
2023Clinical Chemistry and Laboratory Medicine33 citations Open access
Semantic Scholar
Dutch Pharmacogenetics Working Group (DPWG) guideline for the gene-drug interaction between CYP2D6, CYP2C19 and non-SSRI/non-TCA antidepressants
L. Beunk, M. Nijenhuis, Bianca Soree, Nienke J. de Boer-Veger +10 more
2024European Journal of Human Genetics27 citations Open access
Semantic Scholar
Irinotecan-Induced Toxicity: A Pharmacogenetic Study Beyond UGT1A1
M. de With, L. van Doorn, E. Kloet, Anne van Veggel +7 more
2023Clinical Pharmacokinetics23 citations Open access
Semantic Scholar
Dutch Pharmacogenetics Working Group (DPWG) guideline for the gene-drug interaction of CYP2C9, HLA-A and HLA-B with anti-epileptic drugs
Lisanne E. N. Manson, M. Nijenhuis, Bianca Soree, Nienke J. de Boer-Veger +10 more
2024European Journal of Human Genetics22 citations Open access
Semantic Scholar
Cardiac Toxicity of Alectinib in Patients With ALK+ Lung Cancer
M. Pruis, G. D. Marijn Veerman, H. Hassing, D. A. C. Lanser +5 more
2023JACC CardioOncology22 citations Open access
Semantic Scholar
Clinical utility of circulating tumor DNA in patients with advanced KRASG12C-mutated non-small cell lung cancer treated with sotorasib.
S. M. Ernst, R. van Marion, P. Atmodimedjo, E. de Jonge +9 more
2024Journal of Thoracic Oncology19 citations Open access
Semantic Scholar
Capecitabine-induced hand-foot syndrome: A pharmacogenetic study beyond DPYD.
M. de With, L. van Doorn, D. Maasland, Tessa A. Mulder +7 more
2023Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie19 citations Open access
Semantic Scholar
The Pharmacogenomics Global Research Network Implementation Working Group: global collaboration to advance pharmacogenetic implementation
Larisa H. Cavallari, J. K. Hicks, Jai N. Patel, A. Elchynski +44 more
2024Pharmacogenetics & Genomics17 citations Open access
Semantic Scholar
First trimester maternal tryptophan metabolism and embryonic and fetal growth: the Rotterdam Periconceptional Cohort (Predict Study)
Sofie K. M. van Zundert, Nina C. M. van Egmond, L. van Rossem, S. Willemsen +4 more
2024Human Reproduction16 citations Open access
Semantic Scholar
Everolimus Personalized Therapy: Second Consensus Report by the International Association of Therapeutic Drug Monitoring and Clinical Toxicology
Satohiro Masuda, F. Lemaitre, M. J. Barten, S. Bergan +28 more
2024Therapeutic Drug Monitoring15 citations Open access
Semantic Scholar
Dose-individualisation of fluoropyrimidines based on pre-treatment serum uracil levels: the Alpe2U study.
J. Knikman, M. de With, N. Heersche, M. Lopez-Yurda +24 more
2025European Journal of Cancer14 citations Open access
Semantic Scholar
Real-World Implementation of a Genotype-Guided P2Y12 Inhibitor De-Escalation Strategy in Acute Coronary Syndrome Patients.
J. Azzahhafi, W. V. D. van den Broek, D. R. Chan Pin Yin, N. V. D. van der Sangen +17 more
2024JACC: Cardiovascular Interventions13 citations Open access
Semantic Scholar
Dutch Pharmacogenetics Working Group (DPWG) guideline for the gene-drug interaction between SLCO1B1 and statins and CYP2C9 and sulfonylureas
D. Wolthuis, M. Nijenhuis, Bianca Soree, Nienke J. de Boer-Veger +10 more
2024European Journal of Human Genetics13 citations Open access
Semantic Scholar
Dutch Pharmacogenetics Working Group (DPWG) guideline for the gene-drug interaction between TPMT/NUDT15 and thiopurines
Marieke J. H. Coenen, M. Nijenhuis, Bianca Soree, Nienke J. de Boer-Veger +10 more
2025European Journal of Human Genetics12 citations Open access
Semantic Scholar
Discovering novel germline genetic variants linked to severe fluoropyrimidine-related toxicity in- and outside DPYD
J. Knikman, Qinglian Zhai, Carin A. T. C. Lunenburg, L. Henricks +25 more
2024Genome Medicine12 citations Open access
Semantic Scholar
Characterization of Reference Materials for CYP3A4 and CYP3A5: A GeT-RM Collaborative Project
A. Gaedigk, Erin C. Boone, A. Turner, R. V. van Schaik +11 more
2023Journal of Molecular Diagnostics12 citations Open access
Semantic Scholar
A Population Pharmacokinetic Model and Dosing Algorithm to Guide the Tacrolimus Starting and Follow-Up Dose in Living and Deceased Donor Kidney Transplant Recipients
M. Francke, S. Sassen, Nuria Lloberas, H. Colom +7 more
2025Clinical Pharmacokinetics11 citations Open access
Semantic Scholar
External Quality Assessment on Molecular Tumor Profiling with Circulating Tumor DNA-Based Methodologies Routinely Used in Clinical Pathology within the COIN Consortium.
P. van der Leest, Pim Rozendal, John W. J. Hinrichs, C. V. van Noesel +16 more
2024Clinical Chemistry11 citations Open access
Semantic Scholar
Implementation of Pharmacogenetics in First-Line Care: Evaluation of Its Use by General Practitioners
Denise van der Drift, M. Simoons, B. Koch, G. Brufau +3 more
2023Genes11 citations Open access
Semantic Scholar
The Clinical Implementation of CYP2C19 Genotyping in Patients with an Acute Coronary Syndrome: Insights From the FORCE-ACS Registry
J. Azzahhafi, W. V. D. van den Broek, D. R. Chan Pin Yin, A. Harmsze +2 more
2023Journal of Cardiovascular Pharmacology and Therapeutics11 citations Open access
Semantic Scholar
CYP3A4*22 Genotype-Guided Dosing of Kinase Inhibitors in Cancer Patients
R. A. G. van Eerden, N. Ijzerman, Milan van Meekeren, Esther Oomen-de Hoop +12 more
2023Clinical Pharmacokinetics10 citations Open access
Semantic Scholar
Cost-effectiveness of implementing a genotype-guided de-escalation strategy in patients with acute coronary syndrome
W. V. D. van den Broek, J. Azzahhafi, D. R. Chan Pin Yin, N. V. D. van der Sangen +13 more
2024European Heart Journal - Cardiovascular Pharmacotherapy9 citations Open access
Semantic Scholar
Genotype‐Guided Asthma Treatment Reduces Exacerbations in Children: Meta‐Analysis of Two Randomized Control Trials
E. Slob, S. Vijverberg, T. Ruffles, L. Noij +34 more
2024Allergy. European Journal of Allergy and Clinical Immunology9 citations Open access
Semantic Scholar
Towards precision dosing of aripiprazole in children and adolescents with autism spectrum disorder: Linking blood levels to weight gain and effectiveness
R. A. Hermans, S. Sassen, S. M. Kloosterboer, C. Reichart +10 more
2023British Journal of Clinical Pharmacology9 citations Open access
Semantic Scholar
Modelling changes in the pharmacokinetics of tacrolimus during pregnancy after kidney transplantation: A retrospective cohort study
M. Schagen, A. Ulu, M. Francke, J. van de Wetering +6 more
2023British Journal of Clinical Pharmacology9 citations Open access
Semantic Scholar
Influence of germline variations in drug transporters ABCB1 and ABCG2 on intracerebral osimertinib efficacy in patients with non-small cell lung cancer
G. D. Marijn Veerman, R. Boosman, M. Jebbink, Esther Oomen-de Hoop +13 more
2023EClinicalMedicine8 citations Open access
Semantic Scholar
Dutch Pharmacogenetics Working Group (DPWG) guideline for the gene-drug interaction between CYP2D6 and CYP2C19 and tricyclic antidepressants.
Kristian Kleine Schaars, M. Nijenhuis, Bianca Soree, Nienke J. de Boer-Veger +10 more
2026European Journal of Human Genetics7 citations Open access
Semantic Scholar
The impact of maternal vulnerability on stress biomarkers and first-trimester growth: the Rotterdam Periconceptional Cohort (Predict Study)
Sofie K. M. van Zundert, L. van Rossem, Mina Mirzaian, S. Willemsen +10 more
2024Human Reproduction7 citations Open access
Semantic Scholar
Review - The impact of pharmacogenetics on the outcome of immune checkpoint inhibitors.
K. de Joode, N. Heersche, E. A. Basak, S. Bins +3 more
2023Cancer Treatment Reviews7 citations Open access
Semantic Scholar
Pharmacokinetics of betamethasone in pre‐eclampsia: An in vivo and ex vivo study
S. Schoenmakers, Le-Tao Li, A. Kluivers, M. Broekhuizen +12 more
2025British Journal of Clinical Pharmacology6 citations Open access
Semantic Scholar
Global Investigation of Clinical Implementation Strategies for DPYD Testing to Guide Fluoropyrimidine Therapy
Nihal El Rouby, Christina L. Aquilante, Salma A. Bargal, L. Cavallari +12 more
2025Clinical and Translational Science6 citations Open access
Semantic Scholar
First-trimester maternal tryptophan metabolites, utero-placental (vascular)development and hypertensive disorders of pregnancy: The Rotterdam periconceptional cohort.
Sofie K. M. van Zundert, M. Broekhuizen, Mina Mirzaian, L. van Rossem +7 more
2024Placenta6 citations Open access
Semantic Scholar
Correction: Dutch Pharmacogenetics Working Group (DPWG) guideline for the gene–drug interaction between UGT1A1 and irinotecan
E. Hulshof, M. Deenen, M. Nijenhuis, Bianca Soree +12 more
2023European Journal of Human Genetics6 citations Open access
Semantic Scholar
Serially measured high-sensitivity cardiac troponin T, N-terminal-pro-B-type natriuretic peptide, high-sensitivity C-reactive protein, and growth differentiation factor 15 for risk assessment after acute coronary syndrome: the BIOMArCS cohort
Muhammed T. Gürgöze, K. Akkerhuis, R. Oemrawsingh, V. Umans +19 more
2023European heart journal. Acute cardiovascular care6 citations Open access
Semantic Scholar
Real-World Impact of UGT1A1 Genotype-Guided Irinotecan Dosing on Severe Toxicity and Hospitalization: A Multicenter Study.
N. Heersche, Sofía L. J. Peeters, Doortje Böhm, S. Bohringer +18 more
2026The Journal of the National Comprehensive Cancer Network5 citations
Semantic Scholar
Implementation of model-informed precision dosing for tamoxifen therapy in patients with breast cancer: A prospective intervention study
Ruben Y. M. van Nijnatten, S. Buijs, B. Agema, Raphaël M J Fischer +12 more
2025Breast5 citations Open access
Semantic Scholar
Nonlinear Mixed‐Effects Model of Z‐Endoxifen Concentrations in Tamoxifen‐Treated Patients from the CEPAM Cohort
Anna M. Mc Laughlin, T. Helland, Fenja Klima, S. Koolen +18 more
2024Clinical pharmacology and therapy5 citations Open access
Semantic Scholar
Toward model-informed precision dosing for tamoxifen: A population-pharmacokinetic model with a continuous CYP2D6 activity scale.
B. Agema, S. Buijs, S. Sassen, T. Mürdter +6 more
2023Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie5 citations Open access
Semantic Scholar
Effects of CTLA-4 Single Nucleotide Polymorphisms on Toxicity of Ipilimumab-Containing Regimens in Patients With Advanced Stage Melanoma
K. de Joode, A. R. Mora, R. V. van Schaik, A. Zippelius +15 more
2024Journal of immunotherapy4 citations Open access
Semantic Scholar
TGF-β mRNA levels in circulating extracellular vesicles are associated with response to anti-PD1 treatment in metastatic melanoma
S. Crucitta, F. Cucchiara, R. Marconcini, A. Bulleri +11 more
2024Frontiers in Molecular Biosciences4 citations Open access
Semantic Scholar
Efficacy and Tolerability of Osimertinib and Sotorasib Combination Treatment for Osimertinib Resistance Caused by KRAS G12C Mutation: A Report of Two Cases.
S. M. Ernst, Sevim Uzun, M. Paats, R. van Marion +7 more
2023JCO Precision Oncology4 citations Open access
Semantic Scholar
Survival of patients with colorectal or pancreatic cancer who received UGT1A1 genotype-guided dosing of irinotecan in the Netherlands (2017–2024): a retrospective, multicentre cohort study
Sofía L. J. Peeters, N. Heersche, Doortje Böhm, Stefan Böhringer +19 more
2026The Lancet Regional Health - Europe3 citations Open access
Semantic Scholar
Sex and common germline variants impact the toxicity profile and pharmacokinetics of alectinib: a nation-wide cohort study in patients with ALK-positive non-small cell lung cancer.
N. Heersche, D. A. C. Lanser, M. B. Muntinghe-Wagenaar, M. I. Mohmaed Ali +14 more
2024Journal of Thoracic Oncology3 citations Open access
Semantic Scholar
1280P Effects of semaglutide on the exposure of alectinib in patients with NSCLC
D. Lanser, N. Heersche, E. O. Hoop, A. Içli +8 more
2024Annals of Oncology3 citations Open access
Semantic Scholar

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