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J. Ramírez · SciRah

Researcher profile · Semantic Scholar

J. Ramírez

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J. Ramírez — researcher profile on SciRah

h-index: 37
Works: 104
Citations: 6,389

Most-cited papers

Genetic variants in the UDP-glucuronosyltransferase 1A1 gene predict the risk of severe neutropenia of irinotecan.
F. Innocenti, S. Undevia, L. Iyer, Pei-Xian Chen +8 more
2004Journal of Clinical Oncology997 citations Open access
Semantic Scholar
UGT1A1*28 polymorphism as a determinant of irinotecan disposition and toxicity
L. Iyer, Soma Das, L. Janisch, Ming Wen +6 more
2002The Pharmacogenomics Journal726 citations Open access
Semantic Scholar
Phenotype‐genotype correlation of in vitro SN‐38 (active metabolite of irinotecan) and bilirubin glucuronidation in human liver tissue with UGT1A1 promoter polymorphism
L. Iyer, D. Hall, Soma Das, Melissa A. Mortell +4 more
1999Clinical pharmacology and therapy377 citations
Semantic Scholar
Comprehensive pharmacogenetic analysis of irinotecan neutropenia and pharmacokinetics.
F. Innocenti, D. Kroetz, E. Schuetz, M. Dolan +6 more
2009Journal of Clinical Oncology258 citations Open access
Semantic Scholar
Identification, Replication, and Functional Fine-Mapping of Expression Quantitative Trait Loci in Primary Human Liver Tissue
F. Innocenti, Gregory M. Cooper, I. Stanaway, E. Gamazon +16 more
2011PLoS Genetics257 citations Open access
Semantic Scholar
Pharmacogenomic and pharmacokinetic determinants of erlotinib toxicity.
C. Rudin, Wan-Qing Liu, A. Desai, T. Karrison +14 more
2008Journal of Clinical Oncology231 citations Open access
Semantic Scholar
A pharmacogenetic study of uridine diphosphate–glucuronosyltransferase 2B7 in patients receiving morphine
M. Sawyer, F. Innocenti, Soma Das, Cheng Cheng +8 more
2003Clinical pharmacology and therapy175 citations
Semantic Scholar
Haplotype structure of the UDP-glucuronosyltransferase 1A1 promoter in different ethnic groups.
F. Innocenti, C. Grimsley, Soma Das, J. Ramírez +4 more
2002Pharmacogenetics (London)164 citations
Semantic Scholar
Epirubicin glucuronidation is catalyzed by human UDP-glucuronosyltransferase 2B7.
F. Innocenti, L. Iyer, J. Ramírez, Mitchell D. Green +1 more
2001Drug Metabolism And Disposition152 citations
Semantic Scholar
Dose-finding and pharmacokinetic study to optimize the dosing of irinotecan according to the UGT1A1 genotype of patients with cancer.
F. Innocenti, R. Schilsky, J. Ramírez, L. Janisch +10 more
2014Journal of Clinical Oncology143 citations Open access
Semantic Scholar
Comparison of the Drug-Drug Interactions Potential of Erlotinib and Gefitinib via Inhibition of UDP-Glucuronosyltransferases
Yong Liu, J. Ramírez, L. House, M. Ratain
2010Drug Metabolism And Disposition108 citations Open access
Semantic Scholar
A phase I and pharmacokinetic study of irinotecan in patients with hepatic or renal dysfunction or with prior pelvic radiation: CALGB 9863.
A. Venook, C. Klein, G. Fleming, D. Hollis +10 more
2003Annals of Oncology87 citations Open access
Semantic Scholar
SNP discovery and functional assessment of variation in the UDP-glucuronosyltransferase 2B7 (UGT2B7) gene
F. Innocenti, Wan-Qing Liu, D. Fackenthal, J. Ramírez +8 more
2008Pharmacogenetics & Genomics86 citations Open access
Semantic Scholar
Flavopiridol metabolism in cancer patients is associated with the occurrence of diarrhea.
Federico Innocenti, Walter M. Stadler, L. Iyer, J. Ramírez +2 more
2000Clinical Cancer Research82 citations
Semantic Scholar
Biliary transport of irinotecan and metabolites in normal and P-glycoprotein-deficient mice
L. Iyer, J. Ramírez, D. Shepard, C. Bingham +3 more
2002Cancer Chemotherapy and Pharmacology80 citations
Semantic Scholar
In vitro and in vivo oxidative metabolism and glucuronidation of anastrozole.
L. Kamdem, Yong Liu, V. Stearns, Susan Kadlubar +8 more
2010British Journal of Clinical Pharmacology79 citations Open access
Semantic Scholar
CYP2B6, CYP3A4, and CYP2C19 are responsible for the in vitro N-demethylation of meperidine in human liver microsomes.
J. Ramírez, F. Innocenti, E. Schuetz, D. Flockhart +3 more
2004Drug Metabolism And Disposition74 citations
Semantic Scholar
Effects of Ketoconazole on Glucuronidation by UDP-Glucuronosyltransferase Enzymes
Wei-Peng Yong, J. Ramírez, F. Innocenti, M. Ratain
2005Clinical Cancer Research71 citations Open access
Semantic Scholar
Phase 1 Studies of Sirolimus Alone or in Combination with Pharmacokinetic Modulators in Advanced Cancer Patients
E. Cohen, Ke-Hua Wu, C. Hartford, M. Kocherginsky +12 more
2012Clinical Cancer Research68 citations Open access
Semantic Scholar
Genetic factors affecting gene transcription and catalytic activity of UDP-glucuronosyltransferases in human liver.
Wan-Qing Liu, J. Ramírez, E. Gamazon, S. Mirkov +7 more
2014Human Molecular Genetics66 citations Open access
Semantic Scholar
Glucuronidation by UGT1A1 Is the Dominant Pathway of the Metabolic Disposition of Belinostat in Liver Cancer Patients
Ling-Zhi Wang, J. Ramírez, W. Yeo, M. Chan +13 more
2013PLoS ONE65 citations Open access
Semantic Scholar
Inhibition of paracetamol glucuronidation by tyrosine kinase inhibitors.
Yong Liu, J. Ramírez, M. Ratain
2011British Journal of Clinical Pharmacology60 citations Open access
Semantic Scholar
A phase I and pharmacokinetic study of the quinoxaline antitumour Agent R(+)XK469 in patients with advanced solid tumours
S. Undevia, F. Innocenti, J. Ramírez, L. House +6 more
2008European Journal of Cancer58 citations Open access
Semantic Scholar
Age-Dependent Hepatic UDP-Glucuronosyltransferase Gene Expression and Activity in Children
E. Neumann, Huma Mehboob, J. Ramírez, S. Mirkov +2 more
2016Frontiers in Pharmacology57 citations Open access
Semantic Scholar
A phase I trial of pharmacologic modulation of irinotecan with cyclosporine and phenobarbital
F. Innocenti, S. Undevia, J. Ramírez, S. Mani +4 more
2004Clinical pharmacology and therapy55 citations
Semantic Scholar
A genome-wide integrative study of microRNAs in human liver
E. Gamazon, F. Innocenti, Rong-Rong Wei, Libo Wang +7 more
2013BMC Genomics49 citations Open access
Semantic Scholar
In Vitro Characterization of Hepatic Flavopiridol Metabolism Using Human Liver Microsomes and Recombinant UGT Enzymes
J. Ramírez, L. Iyer, Kim Journault, P. Bélanger +3 more
2002Pharmaceutical Research49 citations
Semantic Scholar
ABC Transporter Polymorphisms are Associated with Irinotecan Pharmacokinetics and Neutropenia
Megan Li, E. Seiser, R. M. Baldwin, J. Ramírez +3 more
2016The Pharmacogenomics Journal47 citations Open access
Semantic Scholar
Two Drug Interaction Studies of Sirolimus in Combination with Sorafenib or Sunitinib in Patients with Advanced Malignancies
T. Gangadhar, E. Cohen, Ke-Hua Wu, L. Janisch +8 more
2011Clinical Cancer Research46 citations Open access
Semantic Scholar
Functional EGFR germline polymorphisms may confer risk for EGFR somatic mutations in non-small cell lung cancer, with a predominant effect on exon 19 microdeletions
Wan-Qing Liu, Li-Jun He, J. Ramírez, Soundararajan Krishnaswamy +4 more
2011Cancer Research45 citations Open access
Semantic Scholar
Effects of Green Tea Compounds on Irinotecan Metabolism
S. Mirkov, B. Komoroski, J. Ramírez, A. Graber +3 more
2007Drug Metabolism And Disposition44 citations
Semantic Scholar
Hepatocyte nuclear factor-1 alpha is associated with UGT1A1, UGT1A9 and UGT2B7 mRNA expression in human liver
J. Ramírez, S. Mirkov, Wei Zhang, Pei-Xian Chen +4 more
2008The Pharmacogenomics Journal43 citations Open access
Semantic Scholar
A pharmacogenetic study of vorinostat glucuronidation
Soonmo Peter Kang, J. Ramírez, L. House, Wei Zhang +4 more
2010Pharmacogenetics & Genomics40 citations Open access
Semantic Scholar
Hepatocyte Nuclear Factor 1 Regulates the Expression of the Organic Cation Transporter 1 via Binding to an Evolutionary Conserved Region in Intron 1 of the OCT1 Gene
V. P. O'Brien, K. Bokelmann, J. Ramírez, K. Jobst +3 more
2013Journal of Pharmacology and Experimental Therapeutics37 citations Open access
Semantic Scholar
Lack of Association between Common Polymorphisms in UGT1A9 and Gene Expression and Activity
J. Ramírez, Wan-Qing Liu, S. Mirkov, A. Desai +4 more
2007Drug Metabolism And Disposition33 citations
Semantic Scholar
Establishment of CYP2D6 Reference Samples by Multiple Validated Genotyping Platforms
H. Fang, Xiao Liu, J. Ramírez, N. Choudhury +7 more
2014The Pharmacogenomics Journal32 citations Open access
Semantic Scholar
SNPs affecting serum metabolomic traits may regulate gene transcription and lipid accumulation in the liver
S. Mirkov, J. Myers, J. Ramírez, Wan-Qing Liu
2012Metabolism: Clinical and Experimental31 citations Open access
Semantic Scholar
UGT1A1*28 genotype affects the in-vitro glucuronidation of thyroxine in human livers
Andrea L. Yoder Graber, J. Ramírez, F. Innocenti, M. Ratain
2007Pharmacogenetics & Genomics31 citations
Semantic Scholar
A Phase I study of Sirolimus and Bevacizumab in Patients with Advanced Malignancies
E. W. Cohen, Manish Sharma, L. Janisch, M. Llobrera +6 more
2011European Journal of Cancer29 citations Open access
Semantic Scholar
Nonlinear Population Pharmacokinetics of Sirolimus in Patients With Advanced Cancer
Ke-Hua Wu, E. W. Cohen, L. House, J. Ramírez +3 more
2012CPT: Pharmacometrics & Systems Pharmacology27 citations Open access
Semantic Scholar
Vascular endothelial growth factor pathway
M. Maitland, X. Lou, J. Ramírez, A. Desai +6 more
2010Pharmacogenetics & Genomics26 citations Open access
Semantic Scholar
Clinical validity of new genetic biomarkers of irinotecan neutropenia: an independent replication study
D. Crona, J. Ramírez, W. Qiao, A. D. de Graan +5 more
2015The Pharmacogenomics Journal25 citations Open access
Semantic Scholar
The UGT1A1*28 Polymorphism Correlates with Erlotinib's Effect on SN-38 Glucuronidation
Yong Liu, J. Ramírez, L. House, M. Ratain
2010European Journal of Cancer23 citations Open access
Semantic Scholar
Pharmacogenetic analysis of interindividual irinotecan (CPT-11) pharmacokinetic (PK) variability: Evidence for a functional variant of ABCC2
F. Innocenti, S. Undevia, Pei-Xian Chen, Soma Das +5 more
200423 citations
Semantic Scholar
Pharmacokinetic modulation of oral etoposide by ketoconazole in patients with advanced cancer
Wei-Peng Yong, A. Desai, F. Innocenti, J. Ramírez +7 more
2007Cancer Chemotherapy and Pharmacology22 citations
Semantic Scholar
Study of the genetic determinants of UGT1A1 inducibility by phenobarbital in cultured human hepatocytes
J. Ramírez, B. Komoroski, S. Mirkov, A. Graber +6 more
2006Pharmacogenetics & Genomics22 citations
Semantic Scholar
Simultaneous determination of 5-fluorouracil and uracil by high-performance liquid chromatography using four serial columns.
LawrenceK House, J. Ramírez, M. Ratain
1998Journal of Chromatography B: Biomedical Sciences and Applications19 citations
Semantic Scholar
Glucuronidation of OTS167 in Humans Is Catalyzed by UDP-Glucuronosyltransferases UGT1A1, UGT1A3, UGT1A8, and UGT1A10
J. Ramírez, S. Mirkov, L. House, M. Ratain
2015Drug Metabolism And Disposition18 citations Open access
Semantic Scholar
Uridine 5′-diphosphoglucuronosyltransferase genetic polymorphisms and response to cancer chemotherapy
J. Ramírez, M. Ratain, F. Innocenti
2010Future Oncology17 citations Open access
Semantic Scholar
Interactions between MDM2 and TP53 genetic alterations, and their impact on response to MDM2 inhibitors and other chemotherapeutic drugs in cancer cells
Wan-Qing Liu, Li-Jun He, J. Ramírez, M. Ratain
2009Clinical Cancer Research17 citations Open access
Semantic Scholar

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