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T. Handel · SciRah

Researcher profile · Semantic Scholar

T. Handel

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T. Handel — researcher profile on SciRah

h-index: 60
Works: 199
Citations: 14K

Most-cited papers

Crystal structure of the chemokine receptor CXCR4 in complex with a viral chemokine
L. Qin, I. Kufareva, L. Holden, Chong Wang +9 more
2015Science366 citations Open access
Semantic Scholar
Structure of CC Chemokine Receptor 2 with Orthosteric and Allosteric Antagonists
Yi Zheng, L. Qin, N. V. Ortiz Zacarías, H. D. de Vries +15 more
2016Nature274 citations Open access
Semantic Scholar
TSG-6 inhibits neutrophil migration via direct interaction with the chemokine CXCL8
D. Dyer, J. Thomson, Aurélie Hermant, T. Jowitt +4 more
2014Journal of Immunology184 citations Open access
Semantic Scholar
Structure of CC Chemokine Receptor 5 with a Potent Chemokine Antagonist Reveals Mechanisms of Chemokine Recognition and Molecular Mimicry by HIV
Yi Zheng, G. Han, R. Abagyan, Beili Wu +4 more
2017Immunity148 citations Open access
Semantic Scholar
Glycosaminoglycan Interactions with Chemokines Add Complexity to a Complex System
A. Proudfoot, Z. Johnson, Pauline Bonvin, T. Handel
2017Pharmaceuticals126 citations Open access
Semantic Scholar
Signal transmission through the CXC chemokine receptor 4 (CXCR4) transmembrane helices
Melanie P. Wescott, I. Kufareva, Cheryl Paes, Jason R. Goodman +6 more
2016Proceedings of the National Academy of Sciences of the United States of America115 citations Open access
Semantic Scholar
Structures of the CXCR4 Chemokine GPCR with Small-Molecule and Cyclic Peptide Antagonists
Beili Wu, E. Chien, C. Mol, G. Fenalti +11 more
2011107 citations
Semantic Scholar
MCP-1 binds to oxidized LDL and is carried by lipoprotein(a) in human plasma
Philipp Wiesner, M. Tafelmeier, Dominik Chittka, Soo-Ho Choi +11 more
2013Journal of Lipid Research106 citations Open access
Semantic Scholar
The dependence of chemokine-glycosaminoglycan interactions on chemokine oligomerization.
D. Dyer, Catherina L. Salanga, B. Volkman, T. Kawamura +1 more
2015Glycobiology104 citations Open access
Semantic Scholar
The Anti-inflammatory Protein TSG-6 Regulates Chemokine Function by Inhibiting Chemokine/Glycosaminoglycan Interactions
D. Dyer, Catherina L. Salanga, Scott C. Johns, Elena Valdambrini +4 more
2016Journal of Biological Chemistry100 citations Open access
Semantic Scholar
Inactivation of heparan sulfate 2-O-sulfotransferase accentuates neutrophil infiltration during acute inflammation in mice.
Jakob Axelsson, Ding Xu, B. Kang, Julia K. Nussbacher +4 more
2012Blood98 citations Open access
Semantic Scholar
Leukocyte Adhesion: Reconceptualizing Chemokine Presentation by Glycosaminoglycans.
G. Graham, T. Handel, A. Proudfoot
2019Trends in immunology97 citations Open access
Semantic Scholar
Structural basis of ligand interaction with atypical chemokine receptor 3
M. Gustavsson, Liwen Wang, Noortje van Gils, Bryan S. Stephens +7 more
2017Nature Communications97 citations Open access
Semantic Scholar
Heparan Sulfate Microarray Reveals That Heparan Sulfate–Protein Binding Exhibits Different Ligand Requirements
Chengli Zong, A. Venot, Xiuru Li, Wei-Gang Lu +7 more
2017Journal of the American Chemical Society95 citations Open access
Semantic Scholar
What do structures tell us about chemokine receptor function and antagonism?
I. Kufareva, M. Gustavsson, Yi Zheng, Bryan S. Stephens +1 more
2017Annual Review of Biophysics90 citations Open access
Semantic Scholar
Oligomeric Structure of the Chemokine CCL5/RANTES from NMR, MS, and SAXS Data
Xu Wang, Caroline M. Watson, J. Sharp, T. Handel +1 more
2011Structure85 citations Open access
Semantic Scholar
Regulation of Chemerin Chemoattractant and Anti-bacterial Activity by Human Cysteine Cathepsins
P. Kulig, T. Kantyka, Brian A. Zabel, Magdalena Banaś +9 more
2011Journal of Immunology84 citations Open access
Semantic Scholar
Structures of atypical chemokine receptor 3 reveal the basis for its promiscuity and signaling bias
Y. Yen, Christopher T. Schafer, M. Gustavsson, S. A. Eberle +7 more
2022Science Advances75 citations Open access
Semantic Scholar
The Chemokine Receptor CCR1 Is Constitutively Active, Which Leads to G Protein-independent, β-Arrestin-mediated Internalization*
C. T. Gilliland, Catherina L. Salanga, T. Kawamura, JoAnn Trejo +1 more
2013Journal of Biological Chemistry75 citations Open access
Semantic Scholar
DISTINCT CHEMOKINE RECEPTOR AXES REGULATE T HELPER 9 CELL TRAFFICKING TO ALLERGIC AND AUTOIMMUNE INFLAMMATORY SITES
Ervin E. Kara, I. Comerford, Cameron R. Bastow, Kevin A. Fenix +3 more
2013Journal of Immunology71 citations Open access
Semantic Scholar
Chronic lymphocytic leukemia cells receive RAF-dependent survival signals in response to CXCL12 that are sensitive to inhibition by sorafenib.
D. Messmer, J. Fecteau, M. O’Hayre, I. Bharati +2 more
2011Blood70 citations Open access
Semantic Scholar
Cytokines and growth factors cross-link heparan sulfate
E. Migliorini, D. Thakar, J. Kühnle, R. Sadir +9 more
2015Open Biology63 citations Open access
Semantic Scholar
Structure of the Minimal Interface Between ApoE and LRP
M. Guttman, J. H. Prieto, T. Handel, P. Domaille +1 more
2010Journal of Molecular Biology59 citations Open access
Semantic Scholar
NMR Analysis of the Structure, Dynamics, and Unique Oligomerization Properties of the Chemokine CCL27*
Ariane L. Jansma, J. Kirkpatrick, Andro R. Hsu, T. Handel +1 more
2010Journal of Biological Chemistry58 citations Open access
Semantic Scholar
Chemokine CXCL4 interactions with extracellular matrix proteoglycans mediate wide-spread immune cell recruitment independent of chemokine receptors
Anna L Gray, Richard Karlsson, Abigail R. E. Roberts, A. J. Ridley +20 more
2023Cell Reports57 citations Open access
Semantic Scholar
Chemokine Receptor Oligomerization and Allostery
Bryan S. Stephens, T. Handel
2013Progress in Molecular Biology and Translational Science56 citations Open access
Semantic Scholar
CXCR4‐targeting nanobodies differentially inhibit CXCR4 function and HIV entry
Anneleen Van Hout, A. Klarenbeek, V. Bobkov, Jordi Doijen +14 more
2018Biochemical Pharmacology53 citations Open access
Semantic Scholar
Chemokine Oligomerization in Cell Signaling and Migration
Xu Wang, J. Sharp, T. Handel, J. Prestegard
2013Progress in Molecular Biology and Translational Science53 citations Open access
Semantic Scholar
A Tyrosine Switch on NEDD4-2 E3 Ligase Transmits GPCR Inflammatory Signaling
Neil J. Grimsey, Rachan Narala, C. Rada, Sohum Mehta +7 more
2018Cell Reports50 citations Open access
Semantic Scholar
Intracellular receptor modulation: Novel approach to target GPCRs
N. V. Ortiz Zacarías, E. B. Lenselink, A. IJzerman, T. Handel +1 more
2018TIPS - Trends in Pharmacological Sciences50 citations Open access
Semantic Scholar
Multiple Glycosaminoglycan-binding Epitopes of Monocyte Chemoattractant Protein-3/CCL7 Enable It to Function as a Non-oligomerizing Chemokine*
Catherina L. Salanga, D. Dyer, J. Kiselar, Sayan Gupta +2 more
2014Journal of Biological Chemistry50 citations Open access
Semantic Scholar
Sulfopeptide probes of the CXCR4/CXCL12 interface reveal oligomer-specific contacts and chemokine allostery
Joshua J. Ziarek, Anthony E. Getschman, Stephen J. Butler, Deni Taleski +5 more
2013ACS Chemical Biology50 citations Open access
Semantic Scholar
Opportunities for Functional Selectivity in GPCR Antibodies
D. Webb, T. Handel, A. Kretz-Rommel, R. Stevens
2012Biochemical Pharmacology47 citations Open access
Semantic Scholar
Kinetics of CXCL12 binding to atypical chemokine receptor 3 reveal a role for the receptor N-terminus in chemokine binding
M. Gustavsson, D. Dyer, Chun-Xia Zhao, T. Handel
2019Science Signaling46 citations Open access
Semantic Scholar
Sorafenib-Induced Apoptosis of Chronic Lymphocytic Leukemia Cells Is Associated with Downregulation of RAF and Myeloid Cell Leukemia Sequence 1 (Mcl-1)
J. Fecteau, I. Bharati, M. O’Hayre, T. Handel +2 more
2012Molecular Medicine46 citations Open access
Semantic Scholar
Interactions of the Chemokine CCL5/RANTES with Medium Sized Chondroitin Sulfate Ligands
Courtney Deshauer, A. Morgan, Eathen O Ryan, T. Handel +2 more
2015Structure41 citations Open access
Semantic Scholar
Differential structural remodelling of heparan sulfate by chemokines: the role of chemokine oligomerization
D. Dyer, E. Migliorini, Catherina L. Salanga, D. Thakar +2 more
2017Open Biology40 citations Open access
Semantic Scholar
Dual Targeting of the Chemokine Receptors CXCR4 and ACKR3 with Novel Engineered Chemokines*
M. Hanes, Catherina L. Salanga, A. Chowdry, I. Comerford +3 more
2015Journal of Biological Chemistry38 citations Open access
Semantic Scholar
Functional anatomy of the full-length CXCR4-CXCL12 complex systematically dissected by quantitative model-guided mutagenesis
Bryan S. Stephens, T. Ngo, I. Kufareva, T. Handel
2020Science Signaling37 citations Open access
Semantic Scholar
The dual function chemokine receptor CCR2 drives migration and chemokine scavenging through distinct pathways
Thomas Shroka, I. Kufareva, Catherina L. Salanga, T. Handel
2023Science Signaling36 citations Open access
Semantic Scholar
Chemokine cooperativity is caused by competitive glycosaminoglycan binding
Folkert Verkaar, Jody van Offenbeek, Miranda M. C. Van der Lee, Lambertus H. C. J. van Lith +11 more
2014Journal of Immunology36 citations Open access
Semantic Scholar
Crosslinking-guided geometry of a complete CXC receptor-chemokine complex and the basis of chemokine subfamily selectivity
T. Ngo, Bryan S. Stephens, M. Gustavsson, L. Holden +3 more
2020bioRxiv35 citations Open access
Semantic Scholar
A General Method for Site Specific Fluorescent Labeling of Recombinant Chemokines
T. Kawamura, Bryan S. Stephens, L. Qin, Xin Yin +9 more
2014PLoS ONE30 citations Open access
Semantic Scholar
Heparin-induced Leukocytosis Requires 6-O-Sulfation and Is Caused by Blockade of Selectin- and CXCL12 Protein-mediated Leukocyte Trafficking in Mice*
Si-Yuan Zhang, E. Condac, Hong-tao Qiu, Jun-Lin Jiang +4 more
2011Journal of Biological Chemistry30 citations Open access
Semantic Scholar
Anticancer opportunities at every stage of chemokine function.
N. V. Ortiz Zacarías, Martijn P Bemelmans, T. Handel, K. D. de Visser +1 more
2021TIPS - Trends in Pharmacological Sciences27 citations Open access
Semantic Scholar
Perspectives on the Biological Role of Chemokine:Glycosaminoglycan Interactions
T. Handel, D. Dyer
2020Journal of Histochemistry and Cytochemistry26 citations Open access
Semantic Scholar
Design and Characterization of an Intracellular Covalent Ligand for CC Chemokine Receptor 2
N. V. Ortiz Zacarías, K. Chahal, Tereza Šimková, Cas van der Horst +10 more
2021Journal of Medicinal Chemistry25 citations Open access
Semantic Scholar
CCR2-Mediated Uptake of Constitutively Produced CCL2: A Mechanism for Regulating Chemokine Levels in the Blood
Bin N. Zhao, J. Campbell, Catherina L. Salanga, L. Ertl +12 more
2019Journal of Immunology25 citations Open access
Semantic Scholar
Identification of the Pharmacophore of the CC Chemokine-binding Proteins Evasin-1 and -4 Using Phage Display*
Pauline Bonvin, S. Dunn, F. Rousseau, D. Dyer +4 more
2014Journal of Biological Chemistry25 citations Open access
Semantic Scholar
A RAPID AND EFFICIENT WAY TO OBTAIN MODIFIED CHEMOKINES FOR FUNCTIONAL AND BIOPHYSICAL STUDIES
Samantha J. Allen, D. Hamel, T. Handel
2011Cytokine25 citations Open access
Semantic Scholar

Frequent co-authors

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I. Kufareva×15
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I. Kufareva — researcher profile on SciRah
Catherina L. Salanga×11
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Catherina L. Salanga — researcher profile on SciRah
D. Dyer×10
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D. Dyer — researcher profile on SciRah
Bryan S. Stephens×8
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Bryan S. Stephens — researcher profile on SciRah

×7

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R. Abagyan — researcher profile on SciRah

M. Gustavsson×6

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M. Gustavsson — researcher profile on SciRah

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Yi Zheng — researcher profile on SciRah

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R. Stevens — researcher profile on SciRah

A. Proudfoot×5

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A. Proudfoot — researcher profile on SciRah

Chun-Xia Zhao×4

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Chun-Xia Zhao — researcher profile on SciRah

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V. Cherezov — researcher profile on SciRah

N. V. Ortiz Zacarías×4

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N. V. Ortiz Zacarías — researcher profile on SciRah