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Joshua J. Ziarek · SciRah

Researcher profile · Semantic Scholar

Joshua J. Ziarek

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Joshua J. Ziarek — researcher profile on SciRah

h-index: 21
Works: 69
Citations: 1,502

Most-cited papers

Monomeric and dimeric CXCL12 inhibit metastasis through distinct CXCR4 interactions and signaling pathways
Luke J. Drury, Joshua J. Ziarek, S. Gravel, C. T. Veldkamp +5 more
2011Proceedings of the National Academy of Sciences of the United States of America217 citations Open access
Semantic Scholar
Structure-based ligand discovery for the protein–protein interface of chemokine receptor CXCR4
Michael M. Mysinger, Dahlia R. Weiss, Joshua J. Ziarek, S. Gravel +5 more
2012Proceedings of the National Academy of Sciences of the United States of America141 citations Open access
Semantic Scholar
New paradigms in chemokine receptor signal transduction: moving beyond the two-site model
A. Kleist, Anthony E. Getschman, Joshua J. Ziarek, Amanda M. Nevins +4 more
2016Biochemical Pharmacology120 citations Open access
Semantic Scholar
The CXC Chemokine Receptor 4 Ligands Ubiquitin and Stromal Cell-derived Factor-1α Function through Distinct Receptor Interactions*
Vikas Saini, Daniel M Staren, Joshua J. Ziarek, Zayd N Nashaat +4 more
2011Journal of Biological Chemistry95 citations Open access
Semantic Scholar
Structural basis for chemokine recognition by a G protein-coupled receptor and implications for receptor activation
Joshua J. Ziarek, A. Kleist, N. London, Barak Raveh +16 more
2017Science Signaling88 citations Open access
Semantic Scholar
Heparin Oligosaccharides Inhibit Chemokine (CXC Motif) Ligand 12 (CXCL12) Cardioprotection by Binding Orthogonal to the Dimerization Interface, Promoting Oligomerization, and Competing with the Chemokine (CXC Motif) Receptor 4 (CXCR4) N Terminus*
Joshua J. Ziarek, C. T. Veldkamp, Fu-Ming Zhang, N. J. Murray +6 more
2012Journal of Biological Chemistry87 citations Open access
Semantic Scholar
Targeting SDF-1/CXCL12 with a ligand that prevents activation of CXCR4 through structure based drug design
C. T. Veldkamp, Joshua J. Ziarek, F. Peterson, Yu Chen +1 more
2010Journal of the American Chemical Society68 citations Open access
Semantic Scholar
Binding site identification and structure determination of protein-ligand complexes by NMR
Joshua J. Ziarek, F. Peterson, Betsy L. Lytle, B. Volkman
2011Methods in Enzymology56 citations Open access
Semantic Scholar
Discovery and Characterization of a Disulfide-Locked C2-Symmetric Defensin Peptide
A. Wommack, Joshua J. Ziarek, J. Tomaras, H. Chileveru +3 more
2014Journal of the American Chemical Society55 citations Open access
Semantic Scholar
A locked, dimeric CXCL12 variant effectively inhibits pulmonary metastasis of CXCR4-expressing melanoma cells due to enhanced serum stability
T. Takekoshi, Joshua J. Ziarek, B. Volkman, Samuel T. Hwang
2012Molecular Cancer Therapeutics53 citations Open access
Semantic Scholar
Sulfopeptide probes of the CXCR4/CXCL12 interface reveal oligomer-specific contacts and chemokine allostery
Joshua J. Ziarek, Anthony E. Getschman, Stephen J. Butler, Deni Taleski +5 more
2013ACS Chemical Biology50 citations Open access
Semantic Scholar
Solution structure of CCL21 and identification of a putative CCR7 binding site
M. Love, Jamie L Sandberg, Joshua J. Ziarek, Kyle P. Gerarden +5 more
2012Biochemistry48 citations Open access
Semantic Scholar
Biased antagonism of CXCR4 avoids antagonist tolerance
B. Hitchinson, Jonathan M. Eby, Xian-Long Gao, François Guité-Vinet +10 more
2018Science Signaling39 citations Open access
Semantic Scholar
Recent developments in solution nuclear magnetic resonance (NMR)-based molecular biology
Joshua J. Ziarek, Diego Baptista, G. Wagner
2017Journal of molecular medicine37 citations Open access
Semantic Scholar
15N detection harnesses the slow relaxation property of nitrogen: Delivering enhanced resolution for intrinsically disordered proteins
S. Chhabra, P. Fischer, K. Takeuchi, A. Dubey +7 more
2018Proceedings of the National Academy of Sciences of the United States of America36 citations Open access
Semantic Scholar
Chemokine cooperativity is caused by competitive glycosaminoglycan binding
Folkert Verkaar, Jody van Offenbeek, Miranda M. C. Van der Lee, Lambertus H. C. J. van Lith +11 more
2014Journal of Immunology36 citations Open access
Semantic Scholar
Expanding the genotype and phenotype spectrum of SYT1-associated neurodevelopmental disorder
Holly Melland, Fabian Bumbak, A. Kolesnik-Taylor, E. Ng-Cordell +22 more
2021medRxiv35 citations Open access
Semantic Scholar
Visibility as a factor in the copepod-planktivorous fish relationship
J. Strickler, A. Udvadia, J. Marino, Nicholas B. Radabaugh +2 more
200530 citations Open access
Semantic Scholar
A multi-iron enzyme installs copper-binding oxazolone/thioamide pairs on a nontypeable Haemophilus influenzae virulence factor
Olivia M. Manley, Tucker J. Shriver, Tian Xu, Isaac A Melendrez +6 more
2024Proceedings of the National Academy of Sciences of the United States of America23 citations Open access
Semantic Scholar
Ligands selectively tune the local and global motions of neurotensin receptor 1 (NTS1)
Fabian Bumbak, M. Pons, A. Inoue, J. Paniagua +7 more
2023Cell Reports23 citations Open access
Semantic Scholar
Structural Analysis of a Novel Small Molecule Ligand Bound to the CXCL12 Chemokine
Emmanuel W. Smith, Yan Liu, Anthony E. Getschman, F. Peterson +4 more
2014Journal of Medicinal Chemistry23 citations Open access
Semantic Scholar
Fragment-Based Optimization of Small Molecule CXCL12 Inhibitors for Antagonizing the CXCL12/CXCR4 Interaction
Joshua J. Ziarek, Yan Liu, Emmanuel W. Smith, Guo-Lin Zhang +6 more
2013Current Topics in Medicinal Chemistry22 citations Open access
Semantic Scholar
Stabilization of pre-existing neurotensin receptor conformational states by β-arrestin-1 and the biased allosteric modulator ML314
Fabian Bumbak, James B Bower, Skylar C Zemmer, A. Inoue +10 more
2023Nature Communications20 citations Open access
Semantic Scholar
Effect of Ligands and Transducers on the Neurotensin Receptor 1 Conformational Ensemble
A. D. Dixon, A. Inoue, S. Robson, Kelly J. Culhane +4 more
2022Journal of the American Chemical Society18 citations Open access
Semantic Scholar
TRACT revisited: an algebraic solution for determining overall rotational correlation times from cross-correlated relaxation rates
S. Robson, Ç. Daǧ, Hongwei Wu, Joshua J. Ziarek
2021Journal of Biomolecular NMR16 citations Open access
Semantic Scholar
Sulfotyrosine Recognition as Marker for Druggable Sites in the Extracellular Space
Joshua J. Ziarek, Maxime S. Heroux, C. T. Veldkamp, F. Peterson +1 more
2011International Journal of Molecular Sciences16 citations Open access
Semantic Scholar
Molecular basis for the evolved instability of a human G-protein coupled receptor
Laura M. Chamness, Nathan B. Zelt, Haley R. Harrington, Charles P. Kuntz +5 more
2019bioRxiv13 citations Open access
Semantic Scholar
Chemically induced partial unfolding of the multifunctional apurinic/apyrimidinic endonuclease 1
R. Rai, Olabode Dawodu, Jing-Wei Meng, Steven M. Johnson +4 more
2023bioRxiv10 citations Open access
Semantic Scholar
Examining weak protein-protein interactions in start codon recognition via nuclear magnetic resonance spectroscopy
R. Luna, Sabine R. Akabayov, Joshua J. Ziarek, G. Wagner
2014The FEBS Journal8 citations Open access
Semantic Scholar
Behavioural interseasonal adaptations in Daphnia pulicaria (Crustacea: Cladocera) as induced by predation infochemicals
Ai Nihongi, Joshua J. Ziarek, M. Uttieri, R. Sandulli +2 more
2016Aquatic Ecology6 citations
Semantic Scholar
NMR in the Analysis of Functional Chemokine Interactions and Drug Discovery
Joshua J. Ziarek, B. Volkman
2012Drug Discovery Today : Technologies6 citations Open access
Semantic Scholar
Insights on the G protein‐coupled receptor helix 8 solution structure and orientation using a neurotensin receptor 1 peptide
James B. Bower, Scott A. Robson, Joshua J. Ziarek
2024Protein Science4 citations Open access
Semantic Scholar
Bis-hydroxylation of Homocitrulline Catalyzed by a Multinuclear Nonheme Iron-Dependent Oxidative Enzyme during RiPP Biosynthesis
Dayna P. Hebron, Tucker J. Shriver, Joshua J. Ziarek, Amy C. Rosenzweig
2026bioRxiv2 citations Open access
Semantic Scholar
A method for selective 19F‐labeling absent of probe sequestration (SLAPS)
A. D. Dixon, S. Robson, J. Trinidad, Joshua J. Ziarek
2022bioRxiv2 citations Open access
Semantic Scholar
Differentiating 5-thiooxazoles from oxazolone-coupled thioamides in RiPP natural products
Olivia M. Manley, Tucker J. Shriver, José M. Ayala, Benjamin C. Owen +2 more
2026bioRxiv1 citations
Semantic Scholar
Stabilization versus flexibility: detergent-dependent trade-offs in neurotensin receptor 1 GPCR ensembles
James B. Bower, W. V. D. van der Velden, Karen P Gomez, Mingzhe Pan +3 more
2025bioRxiv1 citations Open access
Semantic Scholar
Intrinsic conformational equilibria position arrestin-2 for activation
Tucker J. Shriver, K. Kahraman, Mingzhe Pan, Ç. Daǧ +3 more
2025bioRxiv1 citations Open access
Semantic Scholar
Characterizing the Monomer–Dimer Equilibrium of UbcH8/Ube2L6: A Combined SAXS and NMR Study
K. Kahraman, Scott A. Robson, O. Gocenler, Cansu M. Yenici +7 more
2024ACS Omega1 citations Open access
Semantic Scholar
Characterizing the monomer-dimer equilibrium of UbcH8/Ube2L6: A combined SAXS and NMR study
K. Kahraman, S. Robson, O. Gocenler, Cansu M. Yenici +7 more
2023bioRxiv1 citations Open access
Semantic Scholar
The dynamic nature of neurotensin receptor 1 (NTS1) allostery and signaling bias
Fabian Bumbak, A. Inoue, M. Pons, J. Paniagua +7 more
2022bioRxiv1 citations Open access
Semantic Scholar
Ligands tune the local and global motions of neurotensin receptor 1 (NTS1): a DFT-guided solution NMR analysis
Fabian Bumbak, M. Pons, A. Inoue, J. Paniagua +7 more
2022bioRxiv1 citations Open access
Semantic Scholar
Dimeric CXCL 12 inhibits lung metastasis of melanoma 1 A locked , dimeric CXCL 12 variant effectively inhibits pulmonary metastasis of CXCR 4-expressing melanoma cells due to enhanced serum stability
T. Takekoshi, Joshua J. Ziarek, B. Volkman, Samuel T. Hwang
20121 citations
Semantic Scholar
Stabilization versus flexibility: Detergent‐dependent trade‐offs in neurotensin receptor 1 GPCR ensembles
James B. Bower, W. V. D. van der Velden, Karen P Gomez, Mingzhe Pan +3 more
2026Protein Science0 citations Open access
Semantic Scholar
MW073 Treatment Attenuates Synaptic Dysfunction, Cognition-Related Behavior Deficits, and Aggression in Alzheimer's Disease Models (Abstract ID: 273213)
S. Roy, E. Acquarone, Joshua J. Ziarek, A. Ottavio +1 more
2026Journal of Pharmacology and Experimental Therapeutics0 citations
Semantic Scholar
Bis-hydroxylation of Homocitrulline Catalyzed by a Multinuclear Nonheme Iron Oxidative Enzyme during RiPP Biosynthesis
Dayna P. Hebron, Tucker J. Shriver, Joshua J. Ziarek, Amy C. Rosenzweig
2026Journal of the American Chemical Society0 citations Open access
Semantic Scholar
Mapping the Ligand-dependent Remodeling of the Conformational Entropy Landscape in Neurotensin Receptor 1 by NMR-guided Molecular Simulations
Scott A. Robson, Fabian Bumbak, Supriyo Bhattacharya, W. V. D. van der Velden +2 more
2026bioRxiv0 citations
Semantic Scholar
Chemical control of CSA geometry enables relaxation-optimized 19F-13C NMR probes
J. Shim, Nikol Georgieva, Scott A. Robson, N. Burdzhiev +6 more
2026bioRxiv0 citations Open access
Semantic Scholar
In Silico Characterization of Two Human Pegivirus Proteins Highlights Similarities with Hepatitis C Virus and Possible Therapeutic Repurposing
Kaleigh M. Copenhaver, Barbara A. Hanson, Joshua J. Ziarek, I. Koralnik
2026Viruses0 citations Open access
Semantic Scholar
The isolated Stachel peptide of the adhesion G protein-coupled receptor GPR126 is intrinsically disordered
Tucker J. Shriver, Sandra Berndt, Scott A. Robson, A. D. Dixon +2 more
2026bioRxiv0 citations Open access
Semantic Scholar
A bivalent lysine-acetylated small-molecule binding site in MYC
D. G. Gupta, M. Truica, J. Shim, J. Parker +18 more
2026bioRxiv0 citations
Semantic Scholar

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