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Wei-Rong Wang · SciRah

Researcher profile · Semantic Scholar

Wei-Rong Wang

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Wei-Rong Wang — researcher profile on SciRah

h-index: 23
Works: 70
Citations: 2,211

Most-cited papers

Impact of methionine oxidation in human IgG1 Fc on serum half-life of monoclonal antibodies.
Wei-Rong Wang, J. Vlasák, Yun-Song Li, Pavlo Pristatsky +6 more
2011Molecular Immunology250 citations
Semantic Scholar
Impact of methionine oxidation on the binding of human IgG1 to Fc Rn and Fc gamma receptors.
Andrea Bertolotti-Ciarlet, Wei-Rong Wang, R. Lownes, Pavlo Pristatsky +7 more
2009Molecular Immunology228 citations
Semantic Scholar
Monoclonal Antibodies with Identical Fc Sequences Can Bind to FcRn Differentially with Pharmacokinetic Consequences
Wei-Rong Wang, P. Lu, Yu-Lin Fang, Lora Hamuro +4 more
2011Drug Metabolism And Disposition167 citations
Semantic Scholar
A PCSK9-binding antibody that structurally mimics the EGF(A) domain of LDL-receptor reduces LDL cholesterol in vivo1[S]
Y. Ni, S. Di Marco, J. Condra, L. Peterson +26 more
2011Journal of Lipid Research139 citations Open access
Semantic Scholar
Development of a quantitative relationship between CAR-affinity, antigen abundance, tumor cell depletion and CAR-T cell expansion using a multiscale systems PK-PD model
Aman P. Singh, Xirong Zheng, Xiefan Lin-Schmidt, Wenbo Chen +4 more
2019mAbs110 citations Open access
Semantic Scholar
An Anti-PCSK9 Antibody Reduces LDL-Cholesterol On Top Of A Statin And Suppresses Hepatocyte SREBP-Regulated Genes
Liwen Zhang, T. Mccabe, J. Condra, Y. Ni +36 more
2012International Journal on Biological Sciences108 citations Open access
Semantic Scholar
Prediction of human clearance of therapeutic proteins: simple allometric scaling method revisited
Wei-Rong Wang, T. Prueksaritanont
2010Biopharmaceutics & drug disposition101 citations
Semantic Scholar
Model-based Cellular Kinetic Analysis of Chimeric Antigen Receptor-T Cells in Humans
Can Liu, Vivaswath S. Ayyar, Xirong Zheng, Wenbo Chen +6 more
2020medRxiv97 citations Open access
Semantic Scholar
Lymphatic Transport and Catabolism of Therapeutic Proteins after Subcutaneous Administration to Rats and Dogs
Wei-Rong Wang, N. Chen, Xiao-Lan Shen, P. Cunningham +13 more
2012Drug Metabolism And Disposition92 citations
Semantic Scholar
Current Approaches for Absorption, Distribution, Metabolism, and Excretion Characterization of Antibody-Drug Conjugates: An Industry White Paper
E. Kraynov, Amrita V. Kamath, M. Walles, E. Tarcsa +13 more
2016Drug Metabolism And Disposition81 citations Open access
Semantic Scholar
The Impact of Glycosylation on the Pharmacokinetics of a TNFR2:Fc Fusion Protein Expressed in Glycoengineered Pichia Pastoris
Li-Ming Liu, S. Gomathinayagam, Lora Hamuro, T. Prueksaritanont +3 more
2013Pharmaceutical Research66 citations
Semantic Scholar
Increased muscle force production and bone mineral density in ActRIIB-Fc-treated mature rodents.
Chi-Sung Chiu, N. Peekhaus, H. Weber, S. Adamski +18 more
2013The journals of gerontology. Series A, Biological sciences and medical sciences65 citations Open access
Semantic Scholar
First-in-Human Study in Healthy Subjects with FR104, a Pegylated Monoclonal Antibody Fragment Antagonist of CD28
N. Poirier, G. Blancho, Maryvonne Hiance, C. Mary +13 more
2016Journal of Immunology63 citations
Semantic Scholar
Pharmacokinetics of IgG1 monoclonal antibodies produced in humanized Pichia pastoris with specific glycoforms: a comparative study with CHO produced materials.
Li-Ming Liu, A. Stadheim, Lora Hamuro, Tamara Pittman +4 more
2011Biologicals (Print)61 citations
Semantic Scholar
The effect of the neonatal Fc receptor on human IgG biodistribution in mice
N. Chen, Wei-Rong Wang, Scott E. Fauty, Yu-Lin Fang +3 more
2014mAbs53 citations Open access
Semantic Scholar
Development of a Target cell-Biologics-Effector cell (TBE) complex-based cell killing model to characterize target cell depletion by T cell redirecting bispecific agents
Xi-Ling Jiang, Xi Chen, Thomas J. Carpenter, Jun Wang +4 more
2018mAbs52 citations Open access
Semantic Scholar
Mechanistic Pharmacokinetic/Target Engagement/Pharmacodynamic (PK/TE/PD) Modeling in Deciphering Interplay Between a Monoclonal Antibody and Its Soluble Target in Cynomolgus Monkeys
Wei-Rong Wang, Xiao-Feng Wang, Rajitha Doddareddy, D. Fink +3 more
2013AAPS Journal48 citations Open access
Semantic Scholar
Cross-arm binding efficiency of an EGFR x c-Met bispecific antibody
Song-Mao Zheng, Sheri L. Moores, Stephen Jarantow, J. Pardinas +3 more
2016mAbs44 citations Open access
Semantic Scholar
Utility of free and total target measurements as target engagement and efficacy biomarkers in biotherapeutic development—Opportunities and challenges
Song-Mao Zheng, Thomas J. McIntosh, Wei-Rong Wang
2015Journal of clinical pharmacology40 citations
Semantic Scholar
Development of a Physiologically Based Pharmacokinetic Model to Predict Disease-Mediated Therapeutic Protein–Drug Interactions: Modulation of Multiple Cytochrome P450 Enzymes by Interleukin-6
Xi-Ling Jiang, Y. Zhuang, Zhen-Hua Xu, Wei-Rong Wang +1 more
2016AAPS Journal38 citations Open access
Semantic Scholar
A novel C2 domain binding CD33xCD3 bispecific antibody with potent T-cell redirection activity against acute myeloid leukemia.
Priyanka Nair-Gupta, M. Diem, Dara A. Reeves, Wei-Rong Wang +16 more
2020Blood Advances36 citations Open access
Semantic Scholar
Minimal physiologically-based pharmacokinetic (mPBPK) model for a monoclonal antibody against interleukin-6 in mice with collagen-induced arthritis
Xi Chen, Xi-Ling Jiang, W. Jusko, Hong-Hui Zhou +1 more
2016Journal of Pharmacokinetics and Pharmacodynamics35 citations Open access
Semantic Scholar
Development and Translational Application of a Minimal Physiologically Based Pharmacokinetic Model for a Monoclonal Antibody against Interleukin 23 (IL-23) in IL-23-Induced Psoriasis-Like Mice
Xi Chen, Xi-Ling Jiang, Rajitha Doddareddy, Brian J. Geist +4 more
2018Journal of Pharmacology and Experimental Therapeutics26 citations Open access
Semantic Scholar
Current practices for QSP model assessment: an IQ consortium survey
Jason R. Chan, Richard J. Allen, B. Boras, Antonio Cabal +13 more
2022Journal of Pharmacokinetics and Pharmacodynamics22 citations Open access
Semantic Scholar
Development of a Minimal Physiologically-Based Pharmacokinetic/ Pharmacodynamic Model to Characterize Target Cell Depletion and Cytokine Release for T Cell-Redirecting Bispecific Agents in Humans.
Xi-Ling Jiang, Xi Chen, Pharavee Jaiprasart, Thomas J. Carpenter +2 more
2020European Journal of Pharmaceutical Sciences22 citations
Semantic Scholar
Characterization of concurrent target suppression by JNJ-61178104, a bispecific antibody against human tumor necrosis factor and interleukin-17A
Song-Mao Zheng, F. Shen, B. Jones, D. Fink +7 more
2020mAbs19 citations Open access
Semantic Scholar
Investigation of the Mechanism of Therapeutic Protein-Drug Interaction Between Methotrexate and Golimumab, an Anti-TNFα Monoclonal Antibody
Wei-Rong Wang, J. Leu, R. Watson, Zhen-Hua Xu +1 more
2018AAPS Journal19 citations
Semantic Scholar
Passive Immunotherapies Targeting Amyloid-β in Alzheimer’s Disease: A Quantitative Systems Pharmacology Perspective
M. Markovic, Jelica Milošević, Wei-Rong Wang, Yanguang Cao
2023Molecular Pharmacology15 citations
Semantic Scholar
Challenges of Antibody Drug Conjugates in Cancer Therapy: Current Understanding of Mechanisms and Future Strategies
J. Lin, Yue Guo, Wei-Rong Wang
2018Current Pharmacology Reports15 citations
Semantic Scholar
Discovery and pharmacological characterization of cetrelimab (JNJ-63723283), an anti–programmed cell death protein-1 (PD-1) antibody, in human cancer models
Nikki A. Deangelis, Catherine Ferrante, G. Powers, J. Sendecki +12 more
2022Cancer Chemotherapy and Pharmacology13 citations Open access
Semantic Scholar
Teclistamab Dosing in Responders: Modeling and Simulation Results from the MajesTEC-1 Study in Relapsed/Refractory Multiple Myeloma
Yue Guo, Jin Niu, N. Q. Quijano Cardé, L. Wu +9 more
2025Targeted oncology9 citations Open access
Semantic Scholar
Mechanism-based pharmacokinetic and pharmacodynamic modeling for bispecific antibodies: challenges and opportunities
Jingcheng Niu, Wei-Rong Wang, D. Ouellet
2023Expert Review of Clinical Pharmacology8 citations
Semantic Scholar
Pharmacological considerations for predicting PK/PD at the site of action for therapeutic proteins.
Wei-Rong Wang, Hong-Hui Zhou
2016Drug Discovery Today : Technologies8 citations
Semantic Scholar
No Recipe for Quantitative Systems Pharmacology Model Validation, but a Balancing Act Between Risk and Cost
V. Lemaire, Chuanpu Hu, P. H. van der Graaf, Steven C. Chang +1 more
2023Clinical pharmacology and therapy7 citations Open access
Semantic Scholar
Minimal Physiologically-Based Pharmacokinetic (mPBPK) Metamodeling of Target Engagement in Skin Informs Anti-IL17A Drug Development in Psoriasis
Vivaswath S. Ayyar, Jong-Bong Lee, Wei-Rong Wang, M. Pryor +3 more
2022Frontiers in Pharmacology7 citations Open access
Semantic Scholar
A minimal physiologically based pharmacokinetic model to characterize colon TNF suppression and treatment effects of an anti-TNF monoclonal antibody in a mouse inflammatory bowel disease model
Song-Mao Zheng, Jin Niu, Brian J. Geist, D. Fink +3 more
2020mAbs7 citations Open access
Semantic Scholar
Deciphering the In Vivo Performance of a Monoclonal Antibody to Neutralize Its Soluble Target at the Site of Action in a Mouse Collagen-Induced Arthritis Model
Wei-Rong Wang, T. McIntosh, Xi-Ling Jiang, Rajitha Doddareddy +2 more
2016Pharmaceutical Research6 citations
Semantic Scholar
Model-Based Exploration of the Impact of Prophylactic Tocilizumab on IL-6 Dynamics in Multiple Myeloma Patients Receiving Teclistamab Treatment
Jia Zhou, D. Vishwamitra, Yue Guo, R. Verona +7 more
2023Blood4 citations Open access
Semantic Scholar
Translational PK/PD and model‐informed development of JNJ‐67842125, a Fab reversal agent for JNJ‐64179375, a long‐acting thrombin inhibitor
Vivaswath S. Ayyar, Pharavee Jaiprasart, Brian J. Geist, Zheng Huang Devine +5 more
2021British Journal of Pharmacology4 citations Open access
Semantic Scholar
Less Frequent Teclistamab Dosing in Responders: Modeling and Simulation Data from the Majestec-1 Study in Relapsed/Refractory Multiple Myeloma
Yue Guo, Jin Niu, N. Q. Quijano Cardé, L. Wu +9 more
2024Blood3 citations
Semantic Scholar
The quest for balance between capturing data and model complexity: A quantitative clinical pharmacology approach applied to monoclonal antibodies
Michelle A Pressly, L. Peletier, Song-Mao Zheng, V. D. Sharma +4 more
2023CPT: Pharmacometrics & Systems Pharmacology3 citations Open access
Semantic Scholar
Current Approaches for ADME Characterization of Antibody-Drug Conjugates: An Industry White Paper
Eugenia Kraynov, Amrita V. Kamath, M. Walles, E. Tarcsa +14 more
20153 citations
Semantic Scholar
Lymphatic Transport and Catabolism of Therapeutic Proteins Following Subcutaneous Administration to Rats and Dogs
Wei-Rong Wang, N. Chen, Xiao-Lan Shen, P. Cunningham +14 more
20123 citations
Semantic Scholar
Revised Recommendations for Restarting Teclistamab Following Dose Delays: Insights from the MajesTEC-1 Study on Clinical Safety, and from Simulated Pharmacokinetics and Cytokine Dynamics
N. Q. Quijano Cardé, Jin Niu, Yue Guo, Jia Zhou +15 more
2026Targeted oncology2 citations Open access
Semantic Scholar
Impact of Diseases, Comorbidity, and Target Physiology on ADME, PK, and PK/PD of Therapeutic Biologics
Song-Mao Zheng, Wei-Rong Wang, Hong-Hui Zhou
20152 citations
Semantic Scholar
The Impact of Glycosylation on the Pharmacokinetics of a TNFR2:Fc Fusion Protein Expressed in Glycoengineered Pichia Pastoris
Li-Ming Liu, S. Gomathinayagam, Lora Hamuro, T. Prueksaritanont +3 more
2012Pharmaceutical Research2 citations
Semantic Scholar
Abstract 1317: A Proprotein Convertase Subtilisin-like/Kexin Type 9 (PCSK9)-binding Antibody, That Structurally Mimics the Egf-a Domain of the LDL-receptor, Lowers LDL-cholesterol in a Transgenic Mouse Model and in Rhesus Monkeys
J. Condra, A. Carfi, S. Dimarco, Y. Ni +21 more
20092 citations
Semantic Scholar
Best Practices on QSP Model Reporting for Regulatory Use: perspectives from ISoP QSP SIG Working Group
S. Zaph, Blerta Shtylla, Steven C. Chang, You-Gan Cheng +11 more
20261 citations
Semantic Scholar
Abstract 5662: JNJ-67571244: A novel anti-CD33 C2 domain binding bispecific antibody with potent T cell redirection activity
Priyanka Nair-Gupta, M. Diem, Dara A. Reeves, Wei-Rong Wang +15 more
2020Immunology1 citations
Semantic Scholar
Abstract 2085: Development of a mechanism-based pharmacokinetic/pharmacodynamic model to characterize tumor killing effect of an anti-VISTA monoclonal antibody in tumor bearing mice
Xi-Ling Jiang, J. Leu, I. Singh, L. Snyder +1 more
20161 citations
Semantic Scholar

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