M. Leo

Most-cited papers

Model of nonalcoholic steatohepatitis.
C. Lieber, M. Leo, Ki M. Mak, You-Qing Xu +4 more
2004American Journal of Clinical Nutrition433 citations Open access
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S‐Adenosyl‐L‐methionine attenuates alcohol‐induced liver injury in the baboon
C. S. Lieber, A. Casini, L. de Carli, Cho-il Kim +3 more
1990Hepatology316 citations Open access
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Alcoholic liver injury in baboons: transformation of lipocytes to transitional cells.
Ki M. Mak, M. Leo, C. Lieber
1984Gastroenterology311 citations Open access
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Phosphatidylcholine protects against fibrosis and cirrhosis in the baboon.
C. Lieber, S. Robins, J. Li, L. de Carli +3 more
1994Gastroenterology299 citations Open access
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Alcohol and the Liver
C. Lieber, M. Leo
1992290 citations
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Alcohol, vitamin A, and beta-carotene: adverse interactions, including hepatotoxicity and carcinogenicity.
M. Leo, C. Lieber
1999American Journal of Clinical Nutrition253 citations Open access
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Metabolism of retinol and retinoic acid by human liver cytochrome P450IIC8.
M. Leo, J. Lasker, J. Raucy, C. Kim +2 more
1989Archives of Biochemistry and Biophysics176 citations
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Hepatic Fibrosis After Long‐Term Administration of Ethanol and Moderate Vitamin A Supplementation in the Rat
M. Leo, C. S. Lieber
2007Hepatology172 citations
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Silymarin Retards the Progression of Alcohol-Induced Hepatic Fibrosis in Baboons
C. Lieber, M. Leo, Q. Cao, C. Ren +1 more
2003Journal of Clinical Gastroenterology159 citations
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New pathway for retinol metabolism in liver microsomes.
M. Leo, C. Lieber
1985Journal of Biological Chemistry153 citations Open access
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Retinoic acid metabolism by a system reconstituted with cytochrome P-450.
M. Leo, S. Iida, C. S. Lieber
1984Archives of Biochemistry and Biophysics153 citations
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Attenuation of alcohol‐induced hepatic fibrosis by polyunsaturated lecithin
C. S. Lieber, L. de Carli, Ki M. Mak, C. Kim +1 more
1990Hepatology151 citations Open access
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Differential depletion of carotenoids and tocopherol in liver disease
M. Leo, A. Rosman, C. S. Lieber
1993Hepatology146 citations
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Polyenylphosphatidylcholine prevents carbon tetrachloride-induced lipid peroxidation while it attenuates liver fibrosis.
S. Aleynik, M. Leo, Xiao-Li Ma, M. K. Aleynik +1 more
1997Journal of Hepatology128 citations
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Polyenylphosphatidylcholine decreases alcohol-induced oxidative stress in the baboon.
C. S. Lieber, M. Leo, S. Aleynik, M. K. Aleynik +1 more
1997Alcoholism: Clinical and Experimental Research128 citations
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Effect of chronic alcohol consumption on Hepatic SIRT1 and PGC-1alpha in rats.
C. Lieber, M. Leo, Xiaolei Wang, L. de Carli
2008Biochemical and Biophysical Research Communications - BBRC124 citations
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Polyunsaturated lecithin prevents acetaldehyde‐mediated hepatic collagen accumulation by stimulating collagenase activity in cultured lipocytes
Jian-Jun Li, Cho-il Kim, M. Leo, Ki M. Mak +2 more
1992Hepatology117 citations Open access
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Acetaldehyde and lactate stimulate collagen synthesis of cultured baboon liver myofibroblasts
E. Savolainen, M. Leo, R. Timpl, C. Lieber
1984114 citations Open access
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Interaction of ethanol with β‐carotene: Delayed blood clearance and enhanced hepatotoxicity
M. Leo, C. Kim, Nancy Lowe, C. S. Lieber
1992Hepatology111 citations
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Increased circulating products of lipid peroxidation in patients with alcoholic liver disease.
S. Aleynik, M. Leo, M. K. Aleynik, C. S. Lieber
1998Alcoholism: Clinical and Experimental Research110 citations
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Hepatic phosphatidylethanolamine methyltransferase activity is decreased by ethanol and increased by phosphatidylcholine.
C. S. Lieber, S. Robins, M. Leo
1994Alcoholism: Clinical and Experimental Research96 citations
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Hypervitaminosis a: A liver lover's lament
M. Leo, C. S. Lieber
1988Hepatology85 citations Open access
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Diagnostic value of serum procollagen peptide measurements in alcoholic liver disease.
Eeva-RiittaSavolainen, B. Goldberg, M. Leo, M. Velez +1 more
1984Alcoholism: Clinical and Experimental Research83 citations
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Interactions between alcohol and beta-carotene in patients with alcoholic liver disease.
Shameetn Ahmed, M. Leo, C. S. Lieber
1994American Journal of Clinical Nutrition82 citations Open access
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Gene expression profiling of alcoholic liver disease in the baboon (Papio hamadryas) and human liver.
D. Seth, M. Leo, P. H. McGuinness, C. Lieber +6 more
2003American Journal of Pathology79 citations Open access
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NAD+-dependent retinol dehydrogenase in liver microsomes.
M. Leo, C. Kim, C. S. Lieber
1987Archives of Biochemistry and Biophysics75 citations
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Alcohol alters hepatic FoxO1, p53, and mitochondrial SIRT5 deacetylation function.
C. Lieber, M. Leo, Xiaolei Wang, L. de Carli
2008Biochemical and Biophysical Research Communications - BBRC72 citations
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SMART amplification maintains representation of relative gene expression: quantitative validation by real time PCR and application to studies of alcoholic liver disease in primates.
D. Seth, M. Gorrell, P. H. McGuinness, M. Leo +3 more
2003Journal of Biochemical and Biophysical Methods71 citations
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Desmin distinguishes cultured fat-storing cells from myofibroblasts, smooth muscle cells and fibroblasts in the rat.
S. Takase, M. Leo, T. Nouchi, C. Lieber
1988Journal of Hepatology71 citations
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Inflammation and Repair in Viral Hepatitis C
M. Neuman, K. Sha, R. Esguerra, S. Zakhari +16 more
2008Digestive Diseases and Sciences66 citations
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Tissue inhibitor of metalloproteinase is increased in the serum of precirrhotic and cirrhotic alcoholic patients and can serve as a marker of fibrosis
J. Li, A. Rosman, M. Leo, Yasuo Nagai +1 more
1994Hepatology66 citations Open access
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Ethanol metabolism in vivo by the microsomal ethanol-oxidizing system in deermice lacking alcohol dehydrogenase (ADH).
Y. Shigeta, Fumio Nomura, Shinji Iida, M. Leo +2 more
1984Biochemical Pharmacology64 citations
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Retinol forms retinoic acid via retinal.
C. Kim, M. Leo, C. S. Lieber
1992Archives of Biochemistry and Biophysics63 citations
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Increased vitamin A in esophagus and other extrahepatic tissues after chronic ethanol consumption in the rat.
M. Leo, C. Kim, C. Lieber
1986Alcoholism: Clinical and Experimental Research62 citations
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Decreased hepatic vitamin A after drug administration in men and in rats.
M. Leo, N. Lowe, C. Lieber
1984American Journal of Clinical Nutrition62 citations Open access
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Polyenylphosphatidylcholine opposes the increase of cytochrome P-4502E1 by ethanol and corrects its iron-induced decrease.
M. K. Aleynik, M. Leo, S. Aleynik, C. S. Lieber
1999Alcoholism: Clinical and Experimental Research58 citations
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Interaction of acute ethanol administration with acetaminophen metabolism and toxicity in rats fed alcohol chronically.
E. Altomare, M. Leo, C. Lieber
1984Alcoholism: Clinical and Experimental Research56 citations
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International Commission for Protection against Environmental Mutagens and Carcinogens. ICPEMC Working Paper No. 15/2. Metabolism and metabolic effects of ethanol, including interaction with drugs, carcinogens and nutrition.
C. Lieber, E. Baraona, M. Leo, A. Garro
1987Mutation research55 citations
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Lycopene attenuates alcoholic apoptosis in HepG2 cells expressing CYP2E1.
You-Qing Xu, M. Leo, C. Lieber
2003Biochemical and Biophysical Research Communications - BBRC49 citations
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Role of medium-chain triglycerides in the alcohol-mediated cytochrome P450 2E1 induction of mitochondria.
C. Lieber, Q. Cao, L. de Carli, M. Leo +4 more
2007Alcoholism: Clinical and Experimental Research48 citations
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Acarbose attenuates experimental non-alcoholic steatohepatitis.
C. Lieber, M. Leo, Ki M. Mak, You-Qing Xu +4 more
2004Biochemical and Biophysical Research Communications - BBRC46 citations
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beta-Carotene beadlets potentiate hepatotoxicity of alcohol.
M. Leo, S. Aleynik, M. K. Aleynik, C. Lieber
1997American Journal of Clinical Nutrition44 citations Open access
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Interaction of ethanol with enflurane metabolism and toxicity: role of P450IIE1.
Rika Tsutsumi, M. Leo, C. Kim, M. Tsutsumi +3 more
1990Alcoholism: Clinical and Experimental Research44 citations
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Acetaldehyde and lactate stimulate collagen synthesis of cultured baboon liver myofibroblasts.
E. Savolainen, M. Leo, R. Timpl, C. Lieber
1984Gastroenterology44 citations
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Effects of alcohol consumption on eight circulating markers of liver fibrosis.
Y. Ponomarenko, M. Leo, W. Kroll, C. Lieber
2002Alcohol and Alcoholism42 citations Open access
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Potentiation of ethanol-induced hepatic vitamin A depletion by phenobarbital and butylated hydroxytoluene.
M. Leo, Nancy Lowe, C. S. Lieber
1987Journal of NutriLife42 citations Open access
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Interaction of drugs and retinol.
M. Leo, Nancy Lowe, C. S. Lieber
1986Biochemical Pharmacology42 citations
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Effect of ethanol and vitamin A deficiency on epithelial cell proliferation and structure in the rat esophagus.
Ki M. Mak, M. Leo, C. S. Lieber
1987Gastroenterology41 citations Open access
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Alcohol and retinoids.
D. Crabb, J. Pinairs, R. Hasanadka, M. Fang +17 more
2001Alcoholism: Clinical and Experimental Research38 citations
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Interaction of ethanol with acetaminophen metabolism in the baboon.
E. Altomare, M. Leo, C. Sato, G. Vendemiale +1 more
1984Biochemical Pharmacology37 citations
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