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R. Timpl · SciRah

Researcher profile · Semantic Scholar

R. Timpl

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R. Timpl — researcher profile on SciRah

h-index: 142
Works: 683
Citations: 64K

Most-cited papers

Fibulins: a versatile family of extracellular matrix proteins
R. Timpl, T. Sasaki, G. Kostka, Mon-Li H. Chu
2003Nature reviews. Molecular cell biology493 citations
Semantic Scholar
Local endostatin treatment of gliomas administered by microencapsulated producer cells
T. Read, D. R. Sørensen, R. Mahesparan, P. O. Enger +5 more
2001Nature Biotechnology309 citations
Semantic Scholar
Structural basis for Gas6–Axl signalling
T. Sasaki, P. Knyazev, N. J. Clout, Y. Cheburkin +4 more
2006EMBO Journal298 citations Open access
Semantic Scholar
Structure and function of laminin LG modules.
R. Timpl, D. Tisi, J. Talts, Z. Andac +2 more
2000Matrix Biology289 citations
Semantic Scholar
Endostatin-induced tyrosine kinase signaling through the Shb adaptor protein regulates endothelial cell apoptosis.
Johan Dixelius, Helena Larsson, T. Sasaki, K. Holmqvist +5 more
2000Blood282 citations
Semantic Scholar
A Comparative Analysis of the Fibulin Protein Family
Naoyuki Kobayashi, G. Kostka, Jörg H. O. Garbe, D. Keene +7 more
2007Journal of Biological Chemistry269 citations Open access
Semantic Scholar
Endostatins derived from collagens XV and XVIII differ in structural and binding properties, tissue distribution and anti-angiogenic activity.
T. Sasaki, Helena Larsson, D. Tisi, Lena Claesson-Welsh +2 more
2000Journal of Molecular Biology219 citations
Semantic Scholar
Specific ablation of the nidogen-binding site in the laminin gamma1 chain interferes with kidney and lung development.
M. Willem, N. Miosge, W. Halfter, N. Smyth +4 more
2002Development211 citations
Semantic Scholar
The Proteoglycans Aggrecan and Versican Form Networks with Fibulin-2 through Their Lectin Domain Binding*
A. Olin, M. Mörgelin, T. Sasaki, R. Timpl +2 more
2001Journal of Biological Chemistry210 citations Open access
Semantic Scholar
Role of the cell wall phenolic glycolipid-1 in the peripheral nerve predilection of Mycobacterium leprae.
V. Ng, G. Zanazzi, R. Timpl, J. Talts +3 more
2000Cell208 citations Open access
Semantic Scholar
Biglycan and Decorin Bind Close to the N-terminal Region of the Collagen VI Triple Helix*
C. Wiberg, E. Hedbom, A. Khairullina, S. Lamandé +4 more
2001Journal of Biological Chemistry204 citations Open access
Semantic Scholar
Biglycan Organizes Collagen VI into Hexagonal-like Networks Resembling Tissue Structures*
C. Wiberg, D. Heinegård, C. Wenglén, R. Timpl +1 more
2002Journal of Biological Chemistry195 citations Open access
Semantic Scholar
Compositional differences between infant and adult human corneal basement membranes.
Andrea Kabosova, D. Azar, Gregory A. Bannikov, Kevin P. Campbell +18 more
2007Investigative Ophthalmology and Visual Science193 citations Open access
Semantic Scholar
Perinatal Lethality and Endothelial Cell Abnormalities in Several Vessel Compartments of Fibulin-1-Deficient Mice
G. Kostka, R. Giltay, W. Bloch, K. Addicks +3 more
2001Molecular and Cellular Biology179 citations Open access
Semantic Scholar
Recombinant domain IV of perlecan binds to nidogens, laminin-nidogen complex, fibronectin, fibulin-2 and heparin.
M. Hopf, W. Göhring, E. Kohfeldt, Yoshihiko Yamada +1 more
2001European Journal of Biochemistry179 citations
Semantic Scholar
Structure of the C‐terminal laminin G‐like domain pair of the laminin α2 chain harbouring binding sites for α‐dystroglycan and heparin
D. Tisi, J. Talts, R. Timpl, E. Hohenester
2000178 citations Open access
Semantic Scholar
The angiogenesis inhibitor endostatin impairs blood vessel maturation during wound healing
W. Bloch, K. Huggel, T. Sasaki, R. Grose +4 more
2000The FASEB Journal174 citations
Semantic Scholar
The Leucine-rich Repeat Protein PRELP Binds Perlecan and Collagens and May Function as a Basement Membrane Anchor*
E. Bengtsson, M. Mörgelin, T. Sasaki, R. Timpl +2 more
2002Journal of Biological Chemistry168 citations Open access
Semantic Scholar
Genetic heterogeneity of cutis laxa: a heterozygous tandem duplication within the fibulin-5 (FBLN5) gene.
D. Markova, Ya-Qun Zou, F. Ringpfeil, T. Sasaki +4 more
2003American Journal of Human Genetics153 citations Open access
Semantic Scholar
Structural and Functional Analysis of the Recombinant G Domain of the Laminin α4 Chain and Its Proteolytic Processing in Tissues*
J. Talts, T. Sasaki, N. Miosge, W. Göhring +3 more
2000Journal of Biological Chemistry153 citations Open access
Semantic Scholar
Gene Structure and Functional Analysis of the Mouse Nidogen-2 Gene: Nidogen-2 Is Not Essential for Basement Membrane Formation in Mice
J. Schymeinsky, S. Nedbal, N. Miosge, E. Pöschl +5 more
2002Molecular and Cellular Biology147 citations Open access
Semantic Scholar
Endostatin regulates endothelial cell adhesion and cytoskeletal organization.
Johan Dixelius, Michael J. Cross, Taro Matsumoto, T. Sasaki +2 more
2002Cancer Research132 citations
Semantic Scholar
Alternative Splicing in the Aggrecan G3 Domain Influences Binding Interactions with Tenascin-C and Other Extracellular Matrix Proteins*
J. Day, A. Olin, A. Murdoch, A. Canfield +4 more
2004Journal of Biological Chemistry129 citations Open access
Semantic Scholar
Expression and distribution of laminin alpha1 and alpha2 chains in embryonic and adult mouse tissues: an immunochemical approach.
T. Sasaki, R. Giltay, U. Talts, R. Timpl +1 more
2002Experimental Cell Research128 citations
Semantic Scholar
The 1.9-Å crystal structure of the noncollagenous (NC1) domain of human placenta collagen IV shows stabilization via a novel type of covalent Met-Lys cross-link
M. Than, S. Henrich, R. Huber, A. Ries +6 more
2002Proceedings of the National Academy of Sciences of the United States of America128 citations Open access
Semantic Scholar
Recombinant human laminin-10 (alpha5beta1gamma1). Production, purification, and migration-promoting activity on vascular endothelial cells.
M. Doi, Jill Thyboll, J. Kortesmaa, K. Jansson +6 more
2002Journal of Biological Chemistry123 citations Open access
Semantic Scholar
Short arm region of laminin-5 gamma2 chain: structure, mechanism of processing and binding to heparin and proteins.
T. Sasaki, W. Göhring, Karlheinz Mann, C. Brakebusch +3 more
2001Journal of Molecular Biology116 citations
Semantic Scholar
Proteinases of the Bone Morphogenetic Protein-1 Family Convert Procollagen VII to Mature Anchoring Fibril Collagen*
A. Rattenholl, W. Pappano, M. Koch, D. Keene +6 more
2002Journal of Biological Chemistry113 citations Open access
Semantic Scholar
Microfibrils at Basement Membrane Zones Interact with Perlecan via Fibrillin-1*
K. Tiedemann, T. Sasaki, E. Gustafsson, W. Göhring +6 more
2005Journal of Biological Chemistry112 citations Open access
Semantic Scholar
Binding of mouse nidogen-2 to basement membrane components and cells and its expression in embryonic and adult tissues suggest complementary functions of the two nidogens.
K. Salmivirta, J. Talts, M. Olsson, T. Sasaki +2 more
2002Experimental Cell Research108 citations
Semantic Scholar
The Type XIII Collagen Ectodomain Is a 150-nm Rod and Capable of Binding to Fibronectin, Nidogen-2, Perlecan, and Heparin*
H. Tu, T. Sasaki, A. Snellman, W. Göhring +3 more
2002Journal of Biological Chemistry105 citations Open access
Semantic Scholar
Targeted inactivation of murine laminin gamma2-chain gene recapitulates human junctional epidermolysis bullosa.
Xian-Min Meng, J. F. Klement, D. Leperi, D. Birk +4 more
2003Journal of Investigative Dermatology101 citations Open access
Semantic Scholar
Mapping of SPARC/BM-40/Osteonectin-binding Sites on Fibrillar Collagens*
C. Giudici, N. Raynal, H. Wiedemann, Wayne A. Cabral +6 more
2008Journal of Biological Chemistry100 citations Open access
Semantic Scholar
Role of heparan sulfate domain organization in endostatin inhibition of endothelial cell function
J. Kreuger, Taro Matsumoto, Maarten Vanwildemeersch, T. Sasaki +4 more
2002EMBO Journal100 citations Open access
Semantic Scholar
Perlecan domain V of Drosophila melanogaster. Sequence, recombinant analysis and tissue expression.
Martin V. K. Friedrich, Martina Schneider, R. Timpl, S. Baumgartner
2000European Journal of Biochemistry100 citations
Semantic Scholar
Mapping of binding sites for nidogens, fibulin-2, fibronectin and heparin to different IG modules of perlecan.
M. Hopf, W. Göhring, K. Mann, R. Timpl
2001Journal of Molecular Biology99 citations
Semantic Scholar
Chondroitin Sulfate Perlecan Enhances Collagen Fibril Formation
A. Kvist, Anna Johnson, M. Mörgelin, E. Gustafsson +7 more
2006Journal of Biological Chemistry95 citations Open access
Semantic Scholar
Fibulin‐2 expression marks transformed mesenchymal cells in developing cardiac valves, aortic arch vessels, and coronary vessels
T. Tsuda, Hui Wang, R. Timpl, Mon-Li H. Chu
2001Developmental Dynamics86 citations
Semantic Scholar
Evidence of nidogen-2 compensation for nidogen-1 deficiency in transgenic mice.
N. Miosge, T. Sasaki, R. Timpl
2002Matrix Biology82 citations
Semantic Scholar
Domain IVa of laminin α5 chain is cell‐adhesive and binds β1 and αVβ3 integrins through Arg‐Gly‐Asp
T. Sasaki, R. Timpl
200182 citations
Semantic Scholar
Fibulin‐5 deposition in human skin: decrease with ageing and ultraviolet B exposure and increase in solar elastosis
Kuniko Kadoya, Takako Sasaki, G. Kostka, R. Timpl +5 more
2005British Journal of Dermatology79 citations
Semantic Scholar
Chondrogenic Activity of the Heparan Sulfate Proteoglycan Perlecan Maps to the N‐terminal Domain I
M. French, Ronald R. Gomes, R. Timpl, M. Höök +3 more
2002Journal of Bone and Mineral Research79 citations Open access
Semantic Scholar
Crystal structure and mutational analysis of a perlecan-binding fragment of nidogen-1
M. Hopf, W. Göhring, A. Ries, R. Timpl +1 more
2001Nature Structural Biology79 citations
Semantic Scholar
Opposing roles of integrin alpha6Abeta1 and dystroglycan in laminin-mediated extracellular signal-regulated kinase activation.
M. Ferletta, Y. Kikkawa, Hao Yu, J. Talts +6 more
2003Molecular Biology of the Cell73 citations Open access
Semantic Scholar
Laminin γ3 Chain Binds to Nidogen and Is Located in Murine Basement Membranes*
N. Gersdorff, E. Kohfeldt, T. Sasaki, R. Timpl +1 more
2005Journal of Biological Chemistry70 citations Open access
Semantic Scholar
Crystal Structure of a C-terminal Fragment of Growth Arrest-specific Protein Gas6
T. Sasaki, P. Knyazev, Y. Cheburkin, W. Göhring +4 more
2002Journal of Biological Chemistry70 citations Open access
Semantic Scholar
Distinct requirements for heparin and α-dystroglycan binding revealed by structure-based mutagenesis of the laminin α2 LG4-LG5 domain pair
H. Wizemann, Jörg H. O. Garbe, Martin V. K. Friedrich, R. Timpl +2 more
200368 citations
Semantic Scholar
Laminin alpha1 globular domains 4-5 induce fetal development but are not vital for embryonic basement membrane assembly.
Susanne Schéele, M. Falk, A. Franzén, F. Ellin +6 more
2005Proceedings of the National Academy of Sciences of the United States of America66 citations Open access
Semantic Scholar
Complete sequence, recombinant analysis and binding to laminins and sulphated ligands of the N-terminal domains of laminin α3B and α5 chains
Jörg H. O. Garbe, W. Göhring, K. Mann, R. Timpl +1 more
200266 citations Open access
Semantic Scholar
Domain IV of mouse laminin beta1 and beta2 chains.
T. Sasaki, K. Mann, J. Miner, N. Miosge +1 more
2002European Journal of Biochemistry64 citations Open access
Semantic Scholar

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