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M. Hayden · SciRah

Researcher profile · Semantic Scholar

M. Hayden

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M. Hayden — researcher profile on SciRah

h-index: 133
Works: 693
Citations: 61K

Most-cited papers

Length of Uninterrupted CAG, Independent of Polyglutamine Size, Results in Increased Somatic Instability, Hastening Onset of Huntington Disease.
Galen E. B. Wright, J. Collins, C. Kay, Cassandra L. McDonald +15 more
2019American Journal of Human Genetics179 citations Open access
Semantic Scholar
Modeling Doxorubicin-Induced Cardiotoxicity in Human Pluripotent Stem Cell Derived-Cardiomyocytes
A. Maillet, K. Tan, Xiaoran Chai, Singh N. Sadananda +7 more
2016Scientific Reports172 citations Open access
Semantic Scholar
Design, Characterization, and Lead Selection of Therapeutic miRNAs Targeting Huntingtin for Development of Gene Therapy for Huntington's Disease
J. Miniarikova, Ilaria Zanella, A. Huseinovic, Tom van der Zon +8 more
2016Molecular Therapy: Nucleic Acids117 citations Open access
Semantic Scholar
Huntingtin suppression restores cognitive function in a mouse model of Huntington’s disease
Amber L. Southwell, Holly B. Kordasiewicz, D. Langbehn, N. H. Skotte +15 more
2018Science Translational Medicine112 citations Open access
Semantic Scholar
An enhanced Q175 knock-in mouse model of Huntington disease with higher mutant huntingtin levels and accelerated disease phenotypes.
Amber L. Southwell, Amy I. Smith-Dijak, C. Kay, Marja D. Sepers +13 more
2016Human Molecular Genetics107 citations Open access
Semantic Scholar
Intrinsic mutant HTT-mediated defects in oligodendroglia cause myelination deficits and behavioral abnormalities in Huntington disease
Costanza Ferrari Bardile, M. Garcia-Miralles, N. Caron, N. Rayan +13 more
2019Proceedings of the National Academy of Sciences of the United States of America100 citations Open access
Semantic Scholar
Targeting the Sigma-1 Receptor via Pridopidine Ameliorates Central Features of ALS Pathology in a SOD1G93A Model
A. Ionescu, T. Gradus, Topaz Altman, R. Maimon +4 more
2019Cell Death and Disease90 citations Open access
Semantic Scholar
Preventing mutant huntingtin proteolysis and intermittent fasting promote autophagy in models of Huntington disease
Dagmar E. Ehrnhoefer, Dale D. O. Martin, Mandi E. Schmidt, X. Qiu +9 more
2018Acta Neuropathologica Communications76 citations Open access
Semantic Scholar
Interrupting sequence variants and age of onset in Huntington's disease: clinical implications and emerging therapies.
Galen E. B. Wright, Hailey Findlay Black, J. Collins, Terence Gall-Duncan +3 more
2020Lancet Neurology75 citations
Semantic Scholar
Potent and sustained huntingtin lowering via AAV5 encoding miRNA preserves striatal volume and cognitive function in a humanized mouse model of Huntington disease
N. Caron, Amber L. Southwell, C. Brouwers, Louisa Dal Cengio +9 more
2019Nucleic Acids Research73 citations Open access
Semantic Scholar
Pharmacogenomics of Vincristine‐Induced Peripheral Neuropathy Implicates Pharmacokinetic and Inherited Neuropathy Genes
Galen E. B. Wright, U. Amstutz, B. Drögemöller, Joanne Shih +30 more
2018Clinical pharmacology and therapy69 citations Open access
Semantic Scholar
Laquinimod rescues striatal, cortical and white matter pathology and results in modest behavioural improvements in the YAC128 model of Huntington disease
M. Garcia-Miralles, X. Hong, L. Tan, N. Caron +9 more
2016Scientific Reports68 citations Open access
Semantic Scholar
The molecular epidemiology of Huntington disease is related to intermediate allele frequency and haplotype in the general population
C. Kay, J. Collins, Galen E. B. Wright, F. Baine +14 more
2018American Journal of Medical Genetics Part B: Neuropsychiatric Genetics66 citations Open access
Semantic Scholar
Pridopidine protects neurons from mutant-huntingtin toxicity via the sigma-1 receptor
Chelsy R. Eddings, N. Arbez, S. Akimov, M. Geva +2 more
2019Neurobiology of Disease65 citations Open access
Semantic Scholar
The Sigma-1 Receptor Mediates Pridopidine Rescue of Mitochondrial Function in Huntington Disease Models
Luana Naia, P. Ly, S. Mota, Carla Lopes +7 more
2021Neurotherapeutics64 citations Open access
Semantic Scholar
ABCA8 Regulates Cholesterol Efflux and High-Density Lipoprotein Cholesterol Levels
L. Trigueros-Motos, J. V. van Capelleveen, Federico T. Torta, D. Castaño +23 more
2017Arteriosclerosis, Thrombosis and Vascular Biology55 citations Open access
Semantic Scholar
Mutant Huntingtin Is Cleared from the Brain via Active Mechanisms in Huntington Disease
N. Caron, Raúl Baños, Christopher Yanick, A. Aly +15 more
2020Journal of Neuroscience54 citations Open access
Semantic Scholar
Therapeutic modulation of the bile acid pool by Cyp8b1 knockdown protects against nonalcoholic fatty liver disease in mice
R. Chèvre, L. Trigueros-Motos, D. Castaño, Tricia Chua +12 more
2018The FASEB Journal54 citations Open access
Semantic Scholar
Association Between SLC16A5 Genetic Variation and Cisplatin-Induced Ototoxic Effects in Adult Patients With Testicular Cancer
B. Drögemöller, J. Monzon, A. Bhavsar, A. Borrie +17 more
2017JAMA Oncology52 citations Open access
Semantic Scholar
eEF2K inhibition blocks Aβ42 neurotoxicity by promoting an NRF2 antioxidant response
A. Jan, Brandon Jansonius, A. Delaidelli, S. Somasekharan +9 more
2016Acta Neuropathologica52 citations
Semantic Scholar
Frequency of the loss of CAA interruption in the HTT CAG tract and implications for Huntington disease in the reduced penetrance range
Hailey Findlay Black, Galen E. B. Wright, J. Collins, N. Caron +7 more
2020Genetics in Medicine50 citations Open access
Semantic Scholar
Impairment and Restoration of Homeostatic Plasticity in Cultured Cortical Neurons From a Mouse Model of Huntington Disease
Amy I. Smith-Dijak, Wissam B. Nassrallah, Lily Y. J. Zhang, M. Geva +2 more
2019Frontiers in Cellular Neuroscience50 citations Open access
Semantic Scholar
Sigma-1 and dopamine D2/D3 receptor occupancy of pridopidine in healthy volunteers and patients with Huntington disease: a [18F] fluspidine and [18F] fallypride PET study
I. Grachev, P. Meyer, G. Becker, M. Bronzel +20 more
2020European Journal of Nuclear Medicine and Molecular Imaging49 citations Open access
Semantic Scholar
Sigma-1 Receptor (S1R) Interaction with Cholesterol: Mechanisms of S1R Activation and Its Role in Neurodegenerative Diseases
V. Zhemkov, M. Geva, M. Hayden, I. Bezprozvanny
2021International Journal of Molecular Sciences47 citations Open access
Semantic Scholar
Early pridopidine treatment improves behavioral and transcriptional deficits in YAC128 Huntington disease mice.
M. Garcia-Miralles, M. Geva, Jing-Ying Tan, N. Yusof +8 more
2017JCI Insight44 citations Open access
Semantic Scholar
Epidemiology of Huntington disease.
C. Kay, M. Hayden, B. Leavitt
2017Handbook of Clinical Neurology43 citations
Semantic Scholar
Altered Regulation of Striatal Neuronal N-Methyl-D-Aspartate Receptor Trafficking by Palmitoylation in Huntington Disease Mouse Model
Rujun Kang, Liang Wang, S. Sanders, Kurt Zuo +2 more
2019Frontiers in Synaptic Neuroscience39 citations Open access
Semantic Scholar
Further Investigation of the Role of ACYP2 and WFS1 Pharmacogenomic Variants in the Development of Cisplatin-Induced Ototoxicity in Testicular Cancer Patients
B. Drögemöller, B. Brooks, Carol Critchley, J. Monzon +9 more
2018Clinical Cancer Research39 citations
Semantic Scholar
Quantification of Motor Function in Huntington Disease Patients Using Wearable Sensor Devices
M. Gordon, I. Grachev, Itzik Mazeh, Yonatan Dolan +8 more
2019Digital Biomarkers37 citations Open access
Semantic Scholar
Laquinimod Treatment Improves Myelination Deficits at the Transcriptional and Ultrastructural Levels in the YAC128 Mouse Model of Huntington Disease
M. Garcia-Miralles, N. Yusof, J. Tan, Carola I. Radulescu +6 more
2018Molecular Neurobiology37 citations
Semantic Scholar
A novel humanized mouse model of Huntington disease for preclinical development of therapeutics targeting mutant huntingtin alleles
Amber L. Southwell, N. Skotte, Erika B. Villanueva, Michael E. Østergaard +18 more
2017Human Molecular Genetics37 citations Open access
Semantic Scholar
A human huntingtin SNP alters post-translational modification and pathogenic proteolysis of the protein causing Huntington disease
Dale D. O. Martin, C. Kay, J. Collins, Y. Nguyen +2 more
2017Scientific Reports36 citations Open access
Semantic Scholar
Rescue of aberrant huntingtin palmitoylation ameliorates mutant huntingtin-induced toxicity
Fanny L. Lemarié, N. Caron, S. Sanders, Mandi E. Schmidt +6 more
2021bioRxiv35 citations Open access
Semantic Scholar
Large-scale transcriptomic analysis reveals that pridopidine reverses aberrant gene expression and activates neuroprotective pathways in the YAC128 HD mouse
Rebecca Kusko, Jennifer Dreymann, Jermaine Ross, Yoonjeong Cha +10 more
2018Molecular Neurodegeneration35 citations Open access
Semantic Scholar
Mitochondrial and redox modifications in early stages of Huntington's disease
Carla Lopes, I. L. Ferreira, Carina Maranga, M. Beatriz +11 more
2022bioRxiv34 citations Open access
Semantic Scholar
Haploinsufficiency of CYP8B1 associates with increased insulin sensitivity in humans
Shi-Qi Zhong, R. Chèvre, David Castaño Mayan, M. Corlianò +22 more
2022Journal of Clinical Investigation34 citations Open access
Semantic Scholar
Coupled Control of Distal Axon Integrity and Somal Responses to Axonal Damage by the Palmitoyl Acyltransferase ZDHHC17
Jingwen Niu, S. Sanders, H. Jeong, Sabrina M. Holland +9 more
2020bioRxiv34 citations Open access
Semantic Scholar
HACE1 is essential for astrocyte mitochondrial function and influences Huntington disease phenotypes in vivo
Dagmar E. Ehrnhoefer, Amber L. Southwell, M. Sivasubramanian, X. Qiu +9 more
2018Human Molecular Genetics33 citations Open access
Semantic Scholar
Cerebrospinal fluid biomarkers for assessing Huntington disease onset and severity
N. Caron, A. Haqqani, A. Sandhu, A. Aly +7 more
2022Brain Communications32 citations Open access
Semantic Scholar
Pridopidine reduces mutant huntingtin‐induced endoplasmic reticulum stress by modulation of the Sigma‐1 receptor
M. Shenkman, M. Geva, Noga Gershoni-Emek, M. Hayden +1 more
2021Journal of Neurochemistry31 citations
Semantic Scholar
Pharmacogenomics strategies to optimize treatments for multiple sclerosis: Insights from clinical research
I. Grossman, V. Knappertz, D. Laifenfeld, C. Ross +7 more
2017Progress in neurobiology31 citations
Semantic Scholar
A Comprehensive Haplotype Targeting Strategy for Allele-Specific HTT Suppression in Huntington Disease.
C. Kay, J. Collins, N. Caron, Luciana de Andrade Agostinho +11 more
2019American Journal of Human Genetics28 citations Open access
Semantic Scholar
Genetic ablation of Cyp8b1 preserves host metabolic function by repressing steatohepatitis and altering gut microbiota composition.
J. Patankar, C. Wong, V. Morampudi, W. Gibson +3 more
2018American Journal of Physiology. Endocrinology and Metabolism28 citations Open access
Semantic Scholar
Sudden death due to paralysis and synaptic and behavioral deficits when Hip14/Zdhhc17 is deleted in adult mice
S. Sanders, Matthew P. Parsons, Katherine K. N. Mui, Amber L. Southwell +5 more
2016BMC Biology28 citations Open access
Semantic Scholar
Super-resolution imaging reveals extrastriatal synaptic dysfunction in presymptomatic Huntington disease mice.
A. Ravalia, James H Lau, J. Barron, Stephanie L.M. Purchase +4 more
2021Neurobiology of Disease27 citations Open access
Semantic Scholar
Juvenile amyotrophic lateral sclerosis
P. Orban, R. S. Devon, M. Hayden, B. Leavitt
2020Definitions27 citations Open access
Semantic Scholar
Gene expression profiles complement the analysis of genomic modifiers of the clinical onset of Huntington disease
Galen E. B. Wright, N. Caron, B. Ng, Lorenzo L Casal +7 more
2019bioRxiv27 citations Open access
Semantic Scholar
Effects of Pridopidine on Functional Capacity in Early-Stage Participants from the PRIDE-HD Study
A. McGarry, M. Leinonen, K. Kieburtz, M. Geva +2 more
2020Journal of Huntington's Disease26 citations Open access
Semantic Scholar
A pharmacogenetic signature of high response to Copaxone in late-phase clinical-trial cohorts of multiple sclerosis
C. Ross, F. Towfic, Jyoti Shankar, D. Laifenfeld +8 more
2017Genome Medicine26 citations Open access
Semantic Scholar
Full-length huntingtin is palmitoylated at multiple sites and post-translationally myristoylated following caspase-cleavage
Fanny L. Lemarié, S. Sanders, Y. Nguyen, Dale D. O. Martin +1 more
2023Frontiers in Physiology25 citations Open access
Semantic Scholar

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