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B. Lake · SciRah

Researcher profile · Semantic Scholar

B. Lake

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B. Lake — researcher profile on SciRah

h-index: 41
Works: 169
Citations: 6,361

Most-cited papers

Scaling factors for the extrapolation of in vivo metabolic drug clearance from in vitro data: reaching a consensus on values of human microsomal protein and hepatocellularity per gram of liver.
Z. Barter, M. Bayliss, P. Beaune, A. Boobis +8 more
2007Current drug metabolism466 citations
Semantic Scholar
Mode of action and human relevance analysis for nuclear receptor-mediated liver toxicity: A case study with phenobarbital as a model constitutive androstane receptor (CAR) activator
C. Elcombe, R. Peffer, D. Wolf, Jason P Bailey +13 more
2013Critical Reviews in Toxicology265 citations Open access
Semantic Scholar
Identification of cytochrome P-450 isoforms responsible for cis-tramadol metabolism in human liver microsomes.
V. Subrahmanyam, A. B. Renwick, D. G. Walters, P. Young +3 more
2001Drug Metabolism And Disposition200 citations
Semantic Scholar
Induction of drug metabolism: species differences and toxicological relevance.
M. Graham, B. Lake
2008Toxicology144 citations
Semantic Scholar
Identification of human urinary biomarkers of cruciferous vegetable consumption by metabonomic profiling.
W. Edmands, O. Beckonert, C. Stella, A. Campbell +4 more
2011Journal of Proteome Research110 citations Open access
Semantic Scholar
Differential maintenance of cytochrome P450 enzymes in cultured precision-cut human liver slices.
A. B. Renwick, Patricia S. Watts, R. Edwards, Paula T. Barton +6 more
2000Drug Metabolism And Disposition110 citations
Semantic Scholar
Cruciferous vegetable consumption alters the metabolism of the dietary carcinogen 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) in humans.
D. G. Walters, P. Young, C. Agus, M. Knize +3 more
2004Carcinogenesis101 citations Open access
Semantic Scholar
Species differences in the hepatic effects of inducers of CYP2B and CYP4A subfamily forms: relationship to rodent liver tumour formation
B. Lake
2009Xenobiotica; the fate of foreign compounds in biological systems89 citations
Semantic Scholar
Eletriptan metabolism by human hepatic CYP450 enzymes and transport by human P-glycoprotein.
David C. Evans, D. O'Connor, B. Lake, R. Evers +2 more
2003Drug Metabolism And Disposition83 citations
Semantic Scholar
Determination of a Human Hepatic Microsomal Scaling Factor for Predicting in Vivo Drug Clearance
N. Hakooz, Kiyomi Ito, H. Rawden, H. Gill +6 more
2006Pharmaceutical Research82 citations
Semantic Scholar
Studies on the induction of rat hepatic CYP1A, CYP2B, CYP3A and CYP4A subfamily form mRNAs in vivo and in vitro using precision-cut rat liver slices
C. Meredith, M. P. Scott, A. B. Renwick, R. J. Price +1 more
2003Xenobiotica; the fate of foreign compounds in biological systems79 citations
Semantic Scholar
Human hepatocytes support the hypertrophic but not the hyperplastic response to the murine nongenotoxic hepatocarcinogen sodium phenobarbital in an in vivo study using a chimeric mouse with humanized liver.
T. Yamada, Y. Okuda, Masahiko Kushida, K. Sumida +6 more
2014Toxicological Sciences75 citations Open access
Semantic Scholar
Inhibition of zaleplon metabolism by cimetidine in the human liver: in vitro studies with subcellular fractions and precision-cut liver slices
A. B. Renwick, S. Ball, J. Tredger, R. Price +4 more
2002Xenobiotica; the fate of foreign compounds in biological systems70 citations
Semantic Scholar
Comparative studies on the cytochrome p450-associated metabolism and interaction potential of selegiline between human liver-derived in vitro systems.
J. S. Salonen, L. Nyman, A. Boobis, R. Edwards +14 more
2003Drug Metabolism And Disposition67 citations
Semantic Scholar
Carbamazepine: a 'blind' assessment of CYP-associated metabolism and interactions in human liver-derived in vitro systems
O. Pelkonen, P. Myllynen, P. Taavitsainen, A. Boobis +12 more
2001Xenobiotica; the fate of foreign compounds in biological systems63 citations
Semantic Scholar
Human relevance of rodent liver tumour formation by constitutive androstane receptor (CAR) activators.
B. Lake
2018Toxicological Research62 citations Open access
Semantic Scholar
Comparison of the effects of the synthetic pyrethroid Metofluthrin and phenobarbital on CYP2B form induction and replicative DNA synthesis in cultured rat and human hepatocytes.
Yukihiro Hirose, H. Nagahori, T. Yamada, Y. Deguchi +7 more
2009Toxicology58 citations
Semantic Scholar
Metabolism of 7-benzyloxy-4-trifluoromethylcoumarin by human hepatic cytochrome P450 isoforms
A. B. Renwick, D. Surry, R. J. Price, B. Lake +1 more
2000Xenobiotica; the fate of foreign compounds in biological systems58 citations
Semantic Scholar
Metabolism of coumarin by human P450s: a molecular modelling study.
D. Lewis, Yuko Ito, B. Lake
2006Toxicology in Vitro46 citations
Semantic Scholar
Rapid biomonitoring of heterocyclic aromatic amines in human urine by tandem solvent solid phase extraction liquid chromatography electrospray ionization mass spectrometry.
Ricky D. Holland, Jason R. Taylor, Laura K. Schoenbachler, R. C. Jones +5 more
2004Chemical Research in Toxicology46 citations
Semantic Scholar
Development and Application of a Life-Stage Physiologically Based Pharmacokinetic (PBPK) Model to the Assessment of Internal Dose of Pyrethroids in Humans
Pankajini Mallick, Marjory Moreau, Gina Song, A. Efremenko +8 more
2019Toxicological Sciences45 citations Open access
Semantic Scholar
Species differences in coumarin metabolism: a molecular modelling evaluation of CYP2A interactions
D. Lewis, B. Lake
2002Xenobiotica; the fate of foreign compounds in biological systems39 citations
Semantic Scholar
Studies on the effects of orally administered dicyclohexyl phthalate in the rat.
B. Lake, J. Foster, M. A. Collins, C. R. Stubberfield +2 more
2009Acta Pharmacologica et Toxicologica38 citations
Semantic Scholar
Mode-of-action analysis for induction of rat liver tumors by pyrethrins: relevance to human cancer risk
T. Osimitz, B. Lake
2009Critical Reviews in Toxicology38 citations
Semantic Scholar
Effect of Pyrethrins on cytochrome P450 forms in cultured rat and human hepatocytes.
R. J. Price, A. Giddings, M. Scott, D. G. Walters +3 more
2008Toxicology37 citations
Semantic Scholar
A mode of action for induction of liver tumors by Pyrethrins in the rat.
R. J. Price, D. G. Walters, J. Finch, K. L. Gabriel +3 more
2007Toxicology and Applied Pharmacology36 citations
Semantic Scholar
Critical evaluation of the human relevance of the mode of action for rodent liver tumor formation by activators of the constitutive androstane receptor (CAR)
T. Yamada, S. Cohen, B. Lake
2021Critical Reviews in Toxicology35 citations Open access
Semantic Scholar
A mode of action for induction of thyroid gland tumors by Pyrethrins in the rat.
J. Finch, T. Osimitz, K. L. Gabriel, T. Martin +4 more
2006Toxicology and Applied Pharmacology33 citations
Semantic Scholar
Quantitative structure-activity relationships (QSARs) in inhibitors of various cytochromes P450: The importance of compound lipophilicity
D. Lewis, B. Lake, M. Dickins
2007Journal of Enzyme Inhibition and Medicinal Chemistry32 citations Open access
Semantic Scholar
Use of a quantitative real-time reverse transcription-polymerase chain reaction method to study the induction of CYP1A, CYP2B and CYP4A forms in precision-cut rat liver slices
Jin-Mei Pan, Q. Xiang, A. B. Renwick, R. J. Price +4 more
2002Xenobiotica; the fate of foreign compounds in biological systems32 citations
Semantic Scholar
Metabolism of 2,5-bis(trifluoromethyl)-7-benzyloxy-4-trifluoromethylcoumarin by human hepatic CYP isoforms: evidence for selectivity towards CYP3A4
A. B. Renwick, D. Lewis, S. Fulford, D. Surry +7 more
2001Xenobiotica; the fate of foreign compounds in biological systems32 citations
Semantic Scholar
Evaluation of the human relevance of the constitutive androstane receptor-mediated mode of action for rat hepatocellular tumor formation by the synthetic pyrethroid momfluorothrin.
Y. Okuda, Masahiko Kushida, Hiroko Kikumoto, Yoshimasa Nakamura +5 more
2017Journal of Toxicological Sciences31 citations Open access
Semantic Scholar
Quantitative structure–activity relationships (QSARs) in CYP3A4 inhibitors: The importance of lipophilic character and hydrogen bonding
D. Lewis, B. Lake, M. Dickins
2006Journal of Enzyme Inhibition and Medicinal Chemistry31 citations Open access
Semantic Scholar
Metabolism of nicotine and induction of CYP1A forms in precision-cut rat liver and lung slices.
R. J. Price, A. B. Renwick, D. G. Walters, P. Young +1 more
2004Toxicology in Vitro31 citations
Semantic Scholar
CYP isoform induction screening in 96-well plates: use of 7-benzyloxy-4-trifluoromethylcoumarin as a substrate for studies with rat hepatocytes
R. J. Price, D. Surry, A. B. Renwick, G. Meneses-Lorente +2 more
2000Xenobiotica; the fate of foreign compounds in biological systems31 citations
Semantic Scholar
Evaluation of the utility of the lifetime mouse bioassay in the identification of cancer hazards for humans.
T. Osimitz, W. Droege, A. Boobis, B. Lake
2013Food and Chemical Toxicology29 citations
Semantic Scholar
A Comprehensive Approach to the Profiling of the Cooked Meat Carcinogens 2-Amino-3,8-dimethylimidazo[4,5-f]quinoxaline, 2-Amino-1-methyl-6-phenylimidazo[4,5-b]pyridine and their Metabolites in Human Urine
Dan Gu, Lynn McNaughton, D. LeMaster, B. Lake +3 more
2010Chemical Research in Toxicology29 citations Open access
Semantic Scholar
Lack of effect of metofluthrin and sodium phenobarbital on replicative DNA synthesis and Ki-67 mRNA expression in cultured human hepatocytes
T. Yamada, Hiroko Kikumoto, B. Lake, S. Kawamura
201528 citations Open access
Semantic Scholar
Metabolism of deltamethrin and cis- and trans-permethrin by human expressed cytochrome P450 and carboxylesterase enzymes
Laura Hedges, Susan Brown, A. MacLeod, A. Vardy +6 more
2018Xenobiotica; the fate of foreign compounds in biological systems27 citations
Semantic Scholar
Comparison of the effects of sodium phenobarbital in wild type and humanized constitutive androstane receptor (CAR)/pregnane X receptor (PXR) mice and in cultured mouse, rat and human hepatocytes.
Corinne N. Haines, B. Elcombe, L. Chatham, A. Vardy +3 more
2018Toxicology26 citations
Semantic Scholar
Evaluation of the metabolism and hepatotoxicity of xenobiotics utilizing precision-cut slices
B. Lake, R. J. Price
2013Xenobiotica; the fate of foreign compounds in biological systems26 citations
Semantic Scholar
Effect of chronic phenobarbitone administration on liver tumour formation in the C57BL/10J mouse.
H. Jones, T. Orton, B. Lake
2009Food and Chemical Toxicology26 citations
Semantic Scholar
Mode of action analysis for pesticide-induced rodent liver tumours involving activation of the constitutive androstane receptor: relevance to human cancer risk.
B. Lake, R. J. Price, T. Osimitz
2015Pest Management Science25 citations
Semantic Scholar
Effect of thiabendazole on some rat hepatic xenobiotic metabolising enzymes.
R. J. Price, M. Scott, D. G. Walters, R. Stierum +3 more
2004Food and Chemical Toxicology25 citations
Semantic Scholar
In vitro assays for induction of drug metabolism.
B. Lake, R. J. Price, A. Giddings, D. G. Walters
2009Methods in molecular biology24 citations
Semantic Scholar
Evaluation of 7-benzyloxy-4-trifluoromethylcoumarin, some other 7-hydroxy-4-trifluoromethylcoumarin derivatives and 7-benzyloxyquinoline as fluorescent substrates for rat hepatic cytochrome P450 enzymes
A. B. Renwick, G. Lavignette, P. Worboys, B. Williams +5 more
2001Xenobiotica; the fate of foreign compounds in biological systems24 citations
Semantic Scholar
Transcriptome analysis provides new insights into liver changes induced in the rat upon dietary administration of the food additives butylated hydroxytoluene, curcumin, propyl gallate and thiabendazole.
R. Stierum, A. Conesa, W. Heijne, B. van Ommen +6 more
2008Food and Chemical Toxicology23 citations
Semantic Scholar
Quantitative structure-activity relationships within a homologous series of 7-alkoxyresorufins exhibiting activity towards CYP1A and CYP2B enzymes: molecular modelling studies on key members of the resorufin series with CYP2C5-derived models of human CYP1A1, CYP1A2, CYP2B6 and CYP3A4
D. Lewis, B. Lake, M. Dickins
2004Xenobiotica; the fate of foreign compounds in biological systems23 citations
Semantic Scholar
Evaluation of Age-Related Pyrethroid Pharmacokinetic Differences in Rats: Physiologically-Based Pharmacokinetic Model Development Using In Vitro Data and In Vitro to In Vivo Extrapolation.
Gina Song, Marjory Moreau, A. Efremenko, B. Lake +8 more
2019Toxicological Sciences22 citations Open access
Semantic Scholar
Comparison of the hepatic and thyroid gland effects of sodium phenobarbital and pregnenolone-16α-carbonitrile in wild-type and constitutive androstane receptor (CAR)/pregnane X receptor (PXR) knockout rats
Corinne N. Haines, L. Chatham, A. Vardy, C. Elcombe +2 more
2019Xenobiotica; the fate of foreign compounds in biological systems22 citations
Semantic Scholar

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R. J. Price×16
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R. J. Price — researcher profile on SciRah
A. B. Renwick×12
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A. B. Renwick — researcher profile on SciRah
D. Lewis×9
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D. Lewis — researcher profile on SciRah
T. Osimitz×9
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D. G. Walters — researcher profile on SciRah

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T. Yamada — researcher profile on SciRah

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D. C. Evans — researcher profile on SciRah