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L. Chatham · SciRah

Researcher profile · Semantic Scholar

L. Chatham

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L. Chatham — researcher profile on SciRah

h-index: 8
Works: 19
Citations: 199

Most-cited papers

Generation and Characterization of Novel Cytochrome P450 Cyp2c Gene Cluster Knockout and CYP2C9 Humanized Mouse Lines
N. Scheer, Y. Kapelyukh, L. Chatham, A. Rode +2 more
2012Molecular Pharmacology66 citations
Semantic Scholar
Comparison of the effects of sodium phenobarbital in wild type and humanized constitutive androstane receptor (CAR)/pregnane X receptor (PXR) mice and in cultured mouse, rat and human hepatocytes.
Corinne N. Haines, B. Elcombe, L. Chatham, A. Vardy +3 more
2018Toxicology26 citations
Semantic Scholar
Comparison of the hepatic and thyroid gland effects of sodium phenobarbital and pregnenolone-16α-carbonitrile in wild-type and constitutive androstane receptor (CAR)/pregnane X receptor (PXR) knockout rats
Corinne N. Haines, L. Chatham, A. Vardy, C. Elcombe +2 more
2019Xenobiotica; the fate of foreign compounds in biological systems22 citations
Semantic Scholar
Comparison of the hepatic and thyroid gland effects of sodium phenobarbital in wild type and constitutive androstane receptor (CAR) knockout rats and pregnenolone-16α-carbonitrile in wild type and pregnane X receptor (PXR) knockout rats.
Corinne N. Haines, L. Chatham, A. Vardy, C. Elcombe +2 more
2018Toxicology13 citations
Semantic Scholar
A functional SUMO-motif in the active site of PIM1 promotes its degradation via RNF4, and stimulates protein kinase activity
R. S. Iyer, L. Chatham, R. Sleigh, D. Meek
2017Scientific Reports13 citations Open access
Semantic Scholar
Piperonyl butoxide: mode of action analysis for mouse liver tumour formation and human relevance.
B. Lake, R. J. Price, M. Scott, L. Chatham +2 more
2020Toxicology12 citations
Semantic Scholar
Metazachlor: mode of action analysis for rat liver tumour formation and human relevance.
C. Wiemann, Manuela Goettel, A. Vardy, B. Elcombe +10 more
2019Toxicology12 citations
Semantic Scholar
An assay for screening xenobiotics for inhibition of rat thyroid gland peroxidase activity
R. J. Price, R. Burch, L. Chatham, Larry G. Higgins +2 more
2020Xenobiotica; the fate of foreign compounds in biological systems11 citations
Semantic Scholar
Evidence That the Capacity of Nongenotoxic Carcinogens to Induce Oxidative Stress Is Subject to Marked Variability
C. Henderson, Amy R. Cameron, L. Chatham, L. Stanley +1 more
2015Toxicological Sciences8 citations Open access
Semantic Scholar
Comparative studies on the effects of sodium phenobarbital and two other constitutive androstane receptor (CAR) activators on induction of cytochrome P450 enzymes and replicative DNA synthesis in cultured hepatocytes from wild type and CAR knockout rats.
Manuela Goettel, I. Fegert, N. Honarvar, A. Vardy +3 more
2020Toxicology6 citations
Semantic Scholar
Mode of action analysis for fluxapyroxad-induced rat liver tumour formation: evidence for activation of the constitutive androstane receptor and assessment of human relevance.
Manuela Goettel, C. Werner, N. Honarvar, S. Gröters +5 more
2024Toxicology4 citations
Semantic Scholar
Differential lymphatic versus portal vein uptake of the synthetic pyrethroids deltamethrin and cis-permethrin in rats.
Larry G. Higgins, L. Chatham, Sara L Tomczynski, A. MacLeod +6 more
2020Toxicology3 citations
Semantic Scholar
The potent human CAR activator CITCO is a non-genotoxic hepatic tumour-promoting agent in humanised constitutive androstane receptor mice but not in wild-type animals
C. Henderson, A. McLaren, A. MacLeod, D. Lin +9 more
2025Archives of Toxicology1 citations Open access
Semantic Scholar
In vitro approaches to risk assess chemical mediated changes in thyroid function
Larry G. Higgins, Corinne N. Haines, A. MacLeod, L. Chatham +2 more
2018Toxicology Letters1 citations
Semantic Scholar
cluster knockout and CYP2C9 humanized mouse lines
N. Scheer, Y. Kapelyukh, L. Chatham, A. Rode +3 more
20121 citations
Semantic Scholar
Correction: The potent human CAR activator CITCO is a non-genotoxic hepatic tumour-promoting agent in humanised constitutive androstane receptor mice but not in wild-type animals
C. Henderson, A. McLaren, A. K. MacLeod, D. Lin +9 more
2026Archives of Toxicology0 citations Open access
Semantic Scholar
A functional SUMO-motif in the active site of PIM1 promotes its degradation via RNF4, and stimulates protein kinase activity
R. S. Iyer, L. Chatham, R. Sleigh, D. Meek
2017Scientific Reports0 citations Open access
Semantic Scholar
Distinct Chromosomal Alterations Segregate with SEPT6 Expression Levels in Leukaemia
L. Chatham, C. Todd, K. Hillan, K. Mills +2 more
20120 citations
Semantic Scholar
Abstract 244: Effects of upregulation of Sept6 v4** splice variant in AML
Ekaterina Minskaia, L. Chatham, C. Todd, K. Mills +2 more
20100 citations
Semantic Scholar

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B. Lake×8
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B. Lake — researcher profile on SciRah
A. Vardy×7
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Corinne N. Haines×5
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Larry G. Higgins×4
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Manuela Goettel×3

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