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J. Cain · SciRah

Researcher profile · Semantic Scholar

J. Cain

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J. Cain — researcher profile on SciRah

h-index: 34
Works: 108
Citations: 3,763

Most-cited papers

Genomic analysis of diffuse intrinsic pontine gliomas identifies three molecular subgroups and recurrent activating ACVR1 mutations
P. Buczkowicz, Christine M. Hoeman, P. Rakopoulos, S. Pajovic +48 more
2014Nature Genetics579 citations Open access
Semantic Scholar
Integrated Proteogenomic Characterization across Major Histological Types of Pediatric Brain Cancer
F. Petralia, N. Tignor, B. Reva, M. Koptyra +140 more
2020Cell275 citations Open access
Semantic Scholar
Hedgehog Signaling in the Maintenance of Cancer Stem Cells
Catherine R. Cochrane, A. Szczepny, D. Watkins, J. Cain
2015Cancers237 citations Open access
Semantic Scholar
Preclinical activity of nanoliposomal irinotecan is governed by tumor deposition and intratumor prodrug conversion.
A. Kalra, Jaeyeon Kim, S. Klinz, N. Paz +4 more
2014Cancer Research181 citations Open access
Semantic Scholar
Therapeutic Impact of Cytoreductive Surgery and Irradiation of Posterior Fossa Ependymoma in the Molecular Era: A Retrospective Multicohort Analysis.
V. Ramaswamy, T. Hielscher, S. Mack, Á. Lassaletta +111 more
2016Journal of Clinical Oncology173 citations Open access
Semantic Scholar
Correlation between Ferumoxytol Uptake in Tumor Lesions by MRI and Response to Nanoliposomal Irinotecan in Patients with Advanced Solid Tumors: A Pilot Study
R. Ramanathan, R. Korn, N. Raghunand, J. Sachdev +11 more
2017Clinical Cancer Research148 citations Open access
Semantic Scholar
Clinical efficacy of ONC201 in H3K27M-mutant diffuse midline gliomas is driven by disruption of integrated metabolic and epigenetic pathways
S. Venneti, A. Kawakibi, Sunjong Ji, Sebastian M. Waszak +80 more
2023Cancer Discovery115 citations Open access
Semantic Scholar
ADAM17 selectively activates the IL‐6 trans‐signaling/ERK MAPK axis in KRAS‐addicted lung cancer
Mohamed I. Saad, S. Alhayyani, L. McLeod, Liang Yu +20 more
2019EMBO Molecular Medicine100 citations Open access
Semantic Scholar
The children's brain tumor network (CBTN) - Accelerating research in pediatric central nervous system tumors through collaboration and open science
Jena V. Lilly, J. L. Rokita, Jennifer L. Mason, Tatiana S. Patton +96 more
2022bioRxiv78 citations Open access
Semantic Scholar
GLI3 repressor controls functional development of the mouse ureter.
J. Cain, Epshita Islam, Fiona Haxho, Joshua Blake +1 more
2011Journal of Clinical Investigation77 citations Open access
Semantic Scholar
Pharmaco-proteogenomic profiling of pediatric diffuse midline glioma to inform future treatment strategies
Izac J. Findlay, G. De Iuliis, Ryan J. Duchatel, Evangeline R. Jackson +4 more
2021Oncogene68 citations Open access
Semantic Scholar
The Role of Canonical and Non-Canonical Hedgehog Signaling in Tumor Progression in a Mouse Model of Small Cell Lung Cancer
A. Szczepny, Samuel Rogers, W. S. N. Jayasekara, Kwon-Sik Park +9 more
2017Oncogene59 citations Open access
Semantic Scholar
ONC201 in Combination with Paxalisib for the Treatment of H3K27-Altered Diffuse Midline Glioma
Evangeline R. Jackson, Ryan J. Duchatel, Dilana E. Staudt, Mika L Persson +44 more
2023Cancer Research57 citations Open access
Semantic Scholar
Generation and multi-dimensional profiling of a childhood cancer cell line atlas defines new therapeutic opportunities.
C. Sun, P. Daniel, G. Bradshaw, Hui Shi +52 more
2023Cancer Cell54 citations Open access
Semantic Scholar
Low-Dose Histone Deacetylase Inhibitor Treatment Leads to Tumor Growth Arrest and Multi-Lineage Differentiation of Malignant Rhabdoid Tumors
Andrea M. Muscat, Dean Popovski, W. S. N. Jayasekara, F. Rossello +8 more
2016Clinical Cancer Research53 citations Open access
Semantic Scholar
The degree of mitochondrial DNA methylation in tumor models of glioblastoma and osteosarcoma
Xin Sun, Vijesh Vaghjiani, W. S. N. Jayasekara, J. Cain +1 more
2018Clinical Epigenetics48 citations Open access
Semantic Scholar
Control of mammalian kidney development by the Hedgehog signaling pathway
J. Cain, N. Rosenblum
2011Pediatric nephrology (Berlin, West)47 citations
Semantic Scholar
Cre-dependent DNA recombination activates a STING-dependent innate immune response
G. Pépin, J. Ferrand, Klara Höning, W. S. Jayasekara +6 more
2016Nucleic Acids Research45 citations Open access
Semantic Scholar
Deletions in 16q24.2 are associated with autism spectrum disorder, intellectual disability and congenital renal malformation
G. Handrigan, D. Chitayat, A. C. Lionel, M. Pinsk +16 more
2013Journal of Medical Genetics44 citations
Semantic Scholar
Preclinical and clinical evaluation of German-sourced ONC201 for the treatment of H3K27M-mutant diffuse intrinsic pontine glioma
Ryan J. Duchatel, Abdul Mannan, A. Woldu, Tom J. Hawtrey +23 more
2021Neuro-Oncology Advances40 citations Open access
Semantic Scholar
β-catenin causes renal dysplasia via upregulation of Tgfβ2 and Dkk1.
D. Bridgewater, Valeria E. Di Giovanni, J. Cain, Brian Cox +3 more
2011Journal of the American Society of Nephrology40 citations Open access
Semantic Scholar
Prevailing importance of the hedgehog signaling pathway and the potential for treatment advancement in sarcoma.
F. Kelleher, J. Cain, Joan M. Healy, D. Watkins +1 more
2012Pharmacology and Therapeutics39 citations
Semantic Scholar
Circulating Tumor DNA is Prognostic and Potentially Predictive of Eryaspase Efficacy in Second-line in Patients with Advanced Pancreatic Adenocarcinoma
J. Bachet, H. Blons, P. Hammel, Iman El Hariry +8 more
2020Clinical Cancer Research38 citations
Semantic Scholar
Topoisomerase 1 Inhibition Promotes Cyclic GMP-AMP Synthase-Dependent Antiviral Responses
G. Pépin, Charlotte Nejad, J. Ferrand, B. Thomas +8 more
2017mBio38 citations Open access
Semantic Scholar
Phosphoproteomic Profiling Reveals ALK and MET as Novel Actionable Targets across Synovial Sarcoma Subtypes.
Emmy D. G. Fleuren, M. Vlenterie, W. V. D. van der Graaf, M. H. Hillebrandt-Roeffen +19 more
2017Cancer Research35 citations Open access
Semantic Scholar
Genomic Characterisation of Small Cell Lung Cancer Patient-Derived Xenografts Generated from Endobronchial Ultrasound-Guided Transbronchial Needle Aspiration Specimens
T. Leong, Kieren D. Marini, F. Rossello, Samantha Jayasekara +11 more
2014PLoS ONE35 citations Open access
Semantic Scholar
Sustained Low-Dose Treatment with the Histone Deacetylase Inhibitor LBH589 Induces Terminal Differentiation of Osteosarcoma Cells
J. Cain, Andrew McCaw, W. S. N. Jayasekara, F. Rossello +6 more
2013Sarcoma35 citations Open access
Semantic Scholar
Positive regulatory interactions between YAP and Hedgehog signalling in skin homeostasis and BCC development in mouse skin in vivo
Bassem Akladios, Veronica Mendoza Reinoso, J. Cain, Tao-Peng Wang +3 more
2017PLoS ONE34 citations Open access
Semantic Scholar
Deep multi-region whole-genome sequencing reveals heterogeneity and gene-by-environment interactions in treatment-naive, metastatic lung cancer
T. Leong, V. Gayevskiy, Daniel P Steinfort, M. R. de Massy +24 more
2018Oncogene32 citations Open access
Semantic Scholar
Pattern of Relapse and Treatment Response in WNT-Activated Medulloblastoma
L. Nobre, M. Zápotocký, Sara Khan, K. Fukuoka +57 more
2020Cell Reports Medicine31 citations Open access
Semantic Scholar
MYC drives platinum resistant SCLC that is overcome by the dual PI3K-HDAC inhibitor fimepinostat
Jasmine Chen, Aleks C Guanizo, W. S. N. Jakasekara, Chaitanya Inampudi +9 more
2023Journal of experimental & clinical cancer research : CR30 citations Open access
Semantic Scholar
The Tumor Suppressor Hic1 Maintains Chromosomal Stability Independent of Tp53
A. Szczepny, Kirstyn T. Carey, L. Mckenzie, W. S. N. Jayasekara +16 more
2018Oncogene30 citations Open access
Semantic Scholar
Distinctive molecular features of regenerative stem cells in the damaged male germline
Hue M. La, J. Liao, Julien M. D. Legrand, F. Rossello +6 more
2022Nature Communications29 citations Open access
Semantic Scholar
Abridged republication of FIGO's staging classification for cancer of the ovary, fallopian tube, and peritoneum.
J. Prat, H. Belhadj, J. Berek, A. Bermúdez +12 more
2015European Journal of Gynaecological Oncology29 citations
Semantic Scholar
Urogenital development in Pallister-Hall syndrome is disrupted in a cell-lineage-specific manner by constitutive expression of GLI3 repressor.
Joshua Blake, Di Hu, J. Cain, N. Rosenblum
2016Human Molecular Genetics27 citations Open access
Semantic Scholar
Lineage-restricted neoplasia driven by Myc defaults to small cell lung cancer when combined with loss of p53 and Rb in the airway epithelium
Jasmine Chen, Aleks C Guanizo, Q. Luong, W. S. N. Jayasekara +9 more
2021Oncogene26 citations
Semantic Scholar
The mouse endometrium contains epithelial, endothelial and leucocyte populations expressing the stem cell marker telomerase reverse transcriptase.
J. Deane, Y. Ong, J. Cain, W. S. N. Jayasekara +5 more
2016Molecular human reproduction26 citations Open access
Semantic Scholar
Activated Hedgehog-GLI Signaling Causes Congenital Ureteropelvic Junction Obstruction.
Sepideh Sheybani-Deloui, Lijun Chi, Marian V. Staite, J. Cain +7 more
2017Journal of the American Society of Nephrology23 citations Open access
Semantic Scholar
A STAT3–STING–IFN axis controls the metastatic spread of small cell lung cancer
Aleks C Guanizo, Q. Luong, W. S. N. Jayasekara, E. D. de Geus +14 more
2024Nature Immunology22 citations
Semantic Scholar
Implementation of DNA methylation array profiling in pediatric central nervous system tumors - the AIM BRAIN Project: an Australian and New Zealand Children's Haematology and Oncology (ANZCHOG) Group study.
Christine L. White, K. Kinross, Molly K. Buntine, Elnaz Rasouli +30 more
2023Journal of Molecular Diagnostics22 citations Open access
Semantic Scholar
Visualizing renal primary cilia
J. Deane, E. Verghese, L. Martelotto, J. Cain +4 more
2013Nephrology22 citations Open access
Semantic Scholar
Blockade of ROS production inhibits oncogenic signaling in acute myeloid leukemia and amplifies response to precision therapies
Zacary P. Germon, Jonathan R. Sillar, Abdul Mannan, Ryan J. Duchatel +28 more
2023Science Signaling21 citations Open access
Semantic Scholar
Trp53 and Rb1 regulate autophagy and ligand-dependent Hedgehog signaling.
Catherine R. Cochrane, Vijesh Vaghjiani, A. Szczepny, W. S. N. Jayasekara +7 more
2020Journal of Clinical Investigation19 citations Open access
Semantic Scholar
A Sexually Dimorphic Role for STAT3 in Sonic Hedgehog Medulloblastoma
Christine L. White, W. S. N. Jayasekara, D. Picard, Jasmine Chen +4 more
2019Cancers18 citations Open access
Semantic Scholar
A non-genetic, cell cycle-dependent mechanism of platinum resistance in lung adenocarcinoma
Alvaro Gonzalez Rajal, K. Marzec, R. Mccloy, Max Nobis +11 more
2021eLife17 citations Open access
Semantic Scholar
PI3K/mTOR is a therapeutically targetable genetic dependency in diffuse intrinsic pontine glioma
Ryan J. Duchatel, Evangeline R. Jackson, Sarah Parackal, C. Sun +35 more
2023bioRxiv16 citations Open access
Semantic Scholar
Abstract 5771: Targeting EphA2 in bladder cancer using a novel antibody-directed nanotherapeutic
W. Kamoun, E. Swindell, C. Pien, L. Luus +9 more
2018Experimental and Molecular Therapeutics15 citations
Semantic Scholar
Activating Transcription Factor 3 Expression as a Marker of Response to the Histone Deacetylase Inhibitor Pracinostat
Dhanya Sooraj, Da-Kang Xu, J. Cain, D. Gold +1 more
2016Molecular Cancer Therapeutics12 citations Open access
Semantic Scholar
Abstract 2065: Magnetic resonance imaging with an iron oxide nanoparticle demonstrates the preclinical feasibility of predicting intratumoral uptake and activity of MM-398, a nanoliposomal irinotecan (nal-IRI)
A. Kalra, Joseph A. Spernyak, Jaeyeon Kim, Arnold Sengooba +12 more
201412 citations
Semantic Scholar
Atypical Teratoid Rhabdoid Tumours Are Susceptible to Panobinostat-Mediated Differentiation Therapy
Wai C. Chong, W. S. N. Jayasekara, Vijesh Vaghjiani, Sarah Parackal +10 more
2021Cancers10 citations Open access
Semantic Scholar

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