A. Wyllie

Most-cited papers

1. Defying death after DNA damage

   T. Rich, R. Allen, A. Wyllie

   2000Nature804 citations

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2. Cancer risk associated with germline DNA mismatch repair gene mutations.

   Malcolm G. Dunlop, S. Farrington, A. Carothers, A. Wyllie +5 more

   1997Human Molecular Genetics726 citations

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3. Apoptosis: an overview.

   A. Wyllie

   1997British Medical Bulletin359 citations

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4. APC mutations in colorectal tumors with mismatch repair deficiency.

   J. Huang, N. Papadopoulos, A. J. McKinley, S. Farrington +9 more

   1996Proceedings of the National Academy of Sciences of the United States of America351 citations Open access

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5. PARK2 deletions occur frequently in sporadic colorectal cancer and accelerate adenoma development in Apc mutant mice

   George Poulogiannis, R. McIntyre, Maria Dimitriadi, J. Apps +7 more

   2010Proceedings of the National Academy of Sciences of the United States of America243 citations Open access

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6. Microsatellite instability and the role of hMSH2 in sporadic colorectalcancer.

   V. Bubb, L. Curtis, C. Cunningham, M. Dunlop +5 more

   1996Oncogene241 citations

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7. Accuracy of reporting of family history of colorectal cancer

   R. Mitchell, D. Brewster, H. Campbell, M. Porteous +3 more

   2004Gut191 citations Open access

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8. “Where, O Death, Is Thy Sting?” A Brief Review of Apoptosis Biology

   A. Wyllie

   2010Molecular Neurobiology186 citations Open access

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9. Spectral karyotyping suggests additional subsets of colorectal cancers characterized by pattern of chromosome rearrangement

   W. M. Abdel-Rahman, Kanade Katsura, W. Rens, P. Gorman +6 more

   2001Proceedings of the National Academy of Sciences of the United States of America184 citations Open access

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10. Msh2 status modulates both apoptosis and mutation frequency in the murine small intestine.

    N. Toft, D. Winton, J. Kelly, L. Howard +6 more

    1999Proceedings of the National Academy of Sciences of the United States of America172 citations Open access

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11. Expression of the human mismatch repair gene hMSH2 in normal and neoplastic tissues.

    F. Leach, K. Polyak, M. Burrell, Karen A. Johnson +8 more

    1996Cancer Research168 citations Open access

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12. Sequential DNA methylation changes are associated with DNMT3B overexpression in colorectal neoplastic progression

    A. Ibrahim, M. Arends, Ana-Luisa Silva, A. Wyllie +7 more

    2010Gut146 citations

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13. Somatic frameshift mutations in the MBD4 gene of sporadic colon cancers with mismatch repair deficiency

    S. Bader, M. Walker, B. Hendrich, A. Bird +3 more

    1999Oncogene144 citations Open access

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14. More than one way to go.

    A. Wyllie, P. Golstein

    2001Proceedings of the National Academy of Sciences of the United States of America127 citations Open access

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15. Apoptosis: an overview of the process and its relevance in disease.

    S. J. Webb, D. J. Harrison, A. Wyllie

    1997Advances in Pharmacology126 citations

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16. New insights into the role of PML in tumour suppression

    P. Salomoni, B. Ferguson, A. Wyllie, T. Rich

    2008Cell Research120 citations Open access

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17. DNA chip technolgy

    K. Kurian, C. Watson, A. Wyllie

    1999Journal of Pathology116 citations Open access

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18. Apoptosis: the germs of death

    T. Rich, C. Watson, A. Wyllie

    1999Nature Cell Biology113 citations

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19. APC EXPRESSION IN NORMAL HUMAN TISSUES

    C. Midgley, Susan White, R. Howitt, V. Save +5 more

    1997Journal of Pathology113 citations

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20. NF-κB Inhibits Apoptosis in Murine Mammary Epithelia*

    R. Clarkson, J. Heeley, R. Chapman, F. Aillet +3 more

    2000Journal of Biological Chemistry110 citations Open access

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21. THE PATTERN OF K‐rasMUTATION IN PULMONARY ADENOCARCINOMA DEFINES A NEW PATHWAY OF TUMOUR DEVELOPMENT IN THE HUMAN LUNG

    Cindy A. Cooper, Francis A. Carey, V. Bubb, D. Lamb +2 more

    1997Journal of Pathology95 citations

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22. Absence of p53 permits propagation of mutant cells following genotoxic damage

    S. D. Griffiths, A. R. Clarke, L. Healy, G. Ross +4 more

    1997Oncogene94 citations

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23. Germline, somatic and epigenetic events underlying mismatch repair deficiency in colorectal and HNPCC-related cancers

    Siu T. Yuen, T. Chan, J. Ho, An-Nie S. Y. Chan +5 more

    2002Oncogene90 citations Open access

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24. p53 deficiency in liver reduces local control of survival and proliferation, but does not affect apoptosis after DNA damage

    Christopher Bellamy, A. Clarke, A. Wyllie, D. J. Harrison

    1997The FASEB Journal85 citations

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25. P53-dependent and -independent links between DNA-damage, apoptosis and mutation frequency in ES cells

    S. Corbet, A. R. Clarke, S. Gledhill, A. Wyllie

    1999Oncogene83 citations

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26. Early-onset colorectal cancer with stable microsatellite DNA and near-diploid chromosomes

    T. Chan, Lucy C Curtis, S. Leung, S. Farrington +7 more

    2001Oncogene81 citations Open access

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27. N-acetyltransferase 2 genotype in colorectal cancer and selective gene retention in cancers with chromosome 8p deletions

    A. Hubbard, D. J. Harrison, C. Moyes, A. Wyllie +3 more

    1997Gut71 citations Open access

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28. Dysregulated expression of β-catenin marks early neoplastic change in Apc mutant mice, but not all lesions arising in Msh2 deficient mice

    Rungtiva Kongkanuntn, V. Bubb, O. Sansom, A. Wyllie +2 more

    1999Oncogene68 citations Open access

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29. Apoptosis: Clues in the p53 murder mystery

    A. Wyllie

    1997Nature67 citations Open access

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30. Apoptosis: An endonuclease at last

    A. Wyllie

    1998Nature64 citations

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31. Prognostic relevance of DNA copy number changes in colorectal cancer

    George Poulogiannis, K. Ichimura, R. Hamoudi, Fei-Jun Luo +5 more

    2010Journal of Pathology63 citations

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32. Frequent microsatellite instability and mismatch repair gene mutations in young Chinese patients with colorectal cancer.

    T. Chan, Siu T. Yuen, L. Chung, J. Ho +5 more

    1999Journal of the National Cancer Institute55 citations

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33. MMASS: an optimized array-based method for assessing CpG island methylation

    A. Ibrahim, N. P. Thorne, K. Baird, N. Barbosa-Morais +5 more

    2006Nucleic Acids Research53 citations Open access

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34. Evidence for an age‐related influence of microsatellite instability on colorectal cancer survival

    S. Farrington, A. Mckinley, A. Carothers, C. Cunningham +4 more

    2002International Journal of Cancer52 citations

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35. Chromosomal instability and p53 inactivation are required for genesis of glioblastoma but not for colorectal cancer in patients with germline mismatch repair gene mutation

    S. Leung, Siu T. Yuen, T. Chan, An-Nie S. Y. Chan +6 more

    2000Oncogene52 citations Open access

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36. LOSS OF HETEROZYGOSITY AT 5q21 IN NON‐SMALL CELL LUNG CANCER: A FREQUENT EVENT BUT WITHOUT EVIDENCE OF APC MUTATION

    Cindy A. Cooper, V. Bubb, Nicola Smithson, Robert L. Carter +4 more

    1996Journal of Pathology51 citations

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37. p53‐independent DNA repair and cell cycle arrest in embryonic stem cells

    S. Prost, Christopher Bellamy, A. Clarke, A. Wyllie +1 more

    1998FEBS Letters50 citations

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38. Detailed physical and deletion mapping of 8p with isolation of YAC clones from tumour suppressor loci involved in colorectal cancer.

    S. Farrington, C. Cunningham, S. Boyle, A. Wyllie +1 more

    1996Oncogene45 citations

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39. NF-kappaB inhibits apoptosis in murine mammary epithelia.

    R. Clarkson, J. Heeley, R. Chapman, F. Aillet +3 more

    2000Journal of Biological Chemistry41 citations

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40. Role of BAX mutations in mismatch repair-deficient colorectal carcinogenesis

    W. M. Abdel-Rahman, I. Georgiades, L. Curtis, M. Arends +1 more

    1999Oncogene41 citations

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41. Ki‐ras MUTATIONS IN ADENOMAS: A CHARACTERISTIC OF CANCER‐BEARING COLORECTAL MUCOSA

    Robert G. Morris, L. Curtis, P. Romanowski, J. Hardcastle +4 more

    1996Journal of Pathology40 citations

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42. Germline APC mutation (Gln1317) in a cancer‐prone family that does not result in familial adenomatous polyposis

    Susan White, V. Bubb, A. Wyllie

    1996Genes, Chromosomes and Cancer38 citations

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43. Evidence for the receipt of DNA damage stimuli by PML nuclear domains

    Archana Varadaraj, Claire L. Dovey, L. Laredj, B. Ferguson +4 more

    2007Journal of Pathology35 citations

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44. Specific patterns of chromosomal abnormalities are associated with RER status in sporadic colorectal cancer

    L. Curtis, Izabela B. Georgiades, Susan White, C. Bird +2 more

    2000Journal of Pathology34 citations

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45. Identification of a region of frequent loss of heterozygosity at 11q24 in colorectal cancer.

    K. Connolly, H. Gabra, Christopher J. Millwater, K. Taylor +5 more

    1999Cancer Research34 citations

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46. Apoptosis and carcinogenesis.

    A. Wyllie, C. Bellamy, V. Bubb, A. Clarke +7 more

    1999British Journal of Cancer32 citations

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47. Heterozygosity for p53 promotes microsatellite instability and tumorigenesis on a Msh2 deficient background

    N. Toft, L. Curtis, O. Sansom, A. Leitch +4 more

    2002Oncogene30 citations

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48. Caspase‐mediated cleavage of APC results in an amino‐terminal fragment with an intact armadillo repeat domain

    S. J. Webb, D. Nicholson, V. Bubb, A. Wyllie

    1999The FASEB Journal29 citations

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49. UV but not γ‐irradiation induces specific transcriptional activity of p53 in primary hepatocytes

    Christopher Bellamy, S. Prost, A. Wyllie, D. J. Harrison

    199728 citations

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50. p53 is not required for regulation of apoptosis or radioprotection by interleukin-3.

    Augusto Silva, A. Wyllie, M. Collins

    1997Blood28 citations Open access

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