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F. Da Settimo · SciRah

Researcher profile · Semantic Scholar

F. Da Settimo

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F. Da Settimo — researcher profile on SciRah

h-index: 42
Works: 263
Citations: 5,780

Most-cited papers

11C-ER176, a Radioligand for 18-kDa Translocator Protein, Has Adequate Sensitivity to Robustly Image All Three Affinity Genotypes in Human Brain
Masamichi Ikawa, Talakad G. Lohith, S. Shrestha, S. Telu +7 more
2017Journal of Nuclear Medicine179 citations Open access
Semantic Scholar
The Alpha Keto Amide Moiety as a Privileged Motif in Medicinal Chemistry: Current Insights and Emerging Opportunities
Marco Robello, E. Barresi, Emma Baglini, Silvia Salerno +2 more
2021Journal of Medicinal Chemistry106 citations Open access
Semantic Scholar
Synthesis and Evaluation of Translocator 18 kDa Protein (TSPO) Positron Emission Tomography (PET) Radioligands with Low Binding Sensitivity to Human Single Nucleotide Polymorphism rs6971
P. Zanotti-Fregonara, Yi Zhang, Kimberly J. Jenko, Robert L. Gladding +9 more
2014ACS Chemical Neuroscience96 citations Open access
Semantic Scholar
Microglial Pro-Inflammatory and Anti-Inflammatory Phenotypes Are Modulated by Translocator Protein Activation
E. Da Pozzo, Chiara Tremolanti, B. Costa, C. Giacomelli +7 more
2019International Journal of Molecular Sciences73 citations Open access
Semantic Scholar
Genetic Analysis of dTSPO, an Outer Mitochondrial Membrane Protein, Reveals Its Functions in Apoptosis, Longevity, and Aβ42-induced Neurodegeneration
R. Lin, A. Angelin, F. Da Settimo, C. Martini +3 more
2014Aging Cell67 citations Open access
Semantic Scholar
Apoptosis Therapy in Cancer: The First Single-molecule Co-activating p53 and the Translocator Protein in Glioblastoma
S. Daniele, Sabrina Taliani, E. Da Pozzo, C. Giacomelli +12 more
2014Scientific Reports65 citations Open access
Semantic Scholar
Iminothioethers as Hydrogen Sulfide Donors: From the Gasotransmitter Release to the Vascular Effects.
E. Barresi, Giulia Nesi, V. Citi, E. Piragine +9 more
2017Journal of Medicinal Chemistry55 citations Open access
Semantic Scholar
Indole-Based Compounds in the Development of Anti-Neurodegenerative Agents
E. Barresi, Emma Baglini, Valeria Poggetti, Jacopo Castagnoli +4 more
2024Molecules54 citations Open access
Semantic Scholar
TSPO ligand residence time: a new parameter to predict compound neurosteroidogenic efficacy
B. Costa, E. Da Pozzo, C. Giacomelli, E. Barresi +3 more
2016Scientific Reports53 citations Open access
Semantic Scholar
CLM3, a multitarget tyrosine kinase inhibitor with antiangiogenic properties, is active against primary anaplastic thyroid cancer in vitro and in vivo.
A. Antonelli, G. Bocci, P. Fallahi, C. La Motta +13 more
2014Journal of Clinical Endocrinology and Metabolism53 citations Open access
Semantic Scholar
An update into the medicinal chemistry of translocator protein (TSPO) ligands.
E. Barresi, Marco Robello, B. Costa, E. Da Pozzo +5 more
2020European journal of medicinal chemistry47 citations Open access
Semantic Scholar
Structure-activity relationship refinement and further assessment of 4-phenylquinazoline-2-carboxamide translocator protein ligands as antiproliferative agents in human glioblastoma tumors.
S. Castellano, Sabrina Taliani, M. Viviano, Ciro Milite +11 more
2014Journal of Medicinal Chemistry45 citations Open access
Semantic Scholar
TSPO-ligands prevent oxidative damage and inflammatory response in C6 glioma cells by neurosteroid synthesis.
A. Santoro, G. Mattace Raso, Sabrina Taliani, E. Da Pozzo +9 more
2016European Journal of Pharmaceutical Sciences44 citations Open access
Semantic Scholar
The Anxiolytic Etifoxine Binds to TSPO Ro5-4864 Binding Site with Long Residence Time Showing a High Neurosteroidogenic Activity.
B. Costa, C. Cavallini, E. Da Pozzo, Sabrina Taliani +2 more
2017ACS Chemical Neuroscience43 citations Open access
Semantic Scholar
TSPO PIGA Ligands Promote Neurosteroidogenesis and Human Astrocyte Well-Being
E. Da Pozzo, C. Giacomelli, B. Costa, C. Cavallini +4 more
2016International Journal of Molecular Sciences41 citations Open access
Semantic Scholar
Multiple Topoisomerase I (TopoI), Topoisomerase II (TopoII) and Tyrosyl-DNA Phosphodiesterase (TDP) inhibitors in the development of anticancer drugs.
Emma Baglini, Silvia Salerno, E. Barresi, Marco Robello +3 more
2020European Journal of Pharmaceutical Sciences40 citations Open access
Semantic Scholar
Osteoblast differentiation and survival: A role for A2B adenosine receptor allosteric modulators.
M. Trincavelli, S. Daniele, C. Giacomelli, Sabrina Taliani +5 more
2014Biochimica et Biophysica Acta40 citations Open access
Semantic Scholar
Carbonic Anhydrase Activators for Neurodegeneration: An Overview
Valeria Poggetti, Silvia Salerno, Emma Baglini, E. Barresi +2 more
2022Molecules36 citations Open access
Semantic Scholar
Deepening the Topology of the Translocator Protein Binding Site by Novel N,N-Dialkyl-2-arylindol-3-ylglyoxylamides.
E. Barresi, Agostino Bruno, Sabrina Taliani, S. Cosconati +13 more
2015Journal of Medicinal Chemistry36 citations Open access
Semantic Scholar
TSPO Radioligands for Neuroinflammation: An Overview
Silvia Salerno, M. Viviano, Emma Baglini, Valeria Poggetti +6 more
2024Molecules32 citations Open access
Semantic Scholar
Bax Activation Blocks Self-Renewal and Induces Apoptosis of Human Glioblastoma Stem Cells.
S. Daniele, D. Pietrobono, B. Costa, Mariateresa Giustiniano +10 more
2017ACS Chemical Neuroscience32 citations Open access
Semantic Scholar
p53 functional inhibitors behaving like pifithrin-β counteract the Alzheimer peptide non-β-amyloid component effects in human SH-SY5Y cells.
E. Da Pozzo, V. La Pietra, B. Cosimelli, F. Da Settimo +6 more
2014ACS Chemical Neuroscience32 citations Open access
Semantic Scholar
Target-Based Anticancer Indole Derivatives for the Development of Anti-Glioblastoma Agents
Silvia Salerno, E. Barresi, Emma Baglini, Valeria Poggetti +2 more
2023Molecules30 citations Open access
Semantic Scholar
Essential Principles and Recent Progress in the Development of TSPO PET Ligands for Neuroinflammation Imaging
M. Viviano, E. Barresi, F. Siméon, B. Costa +4 more
2022Current Medicinal Chemistry30 citations Open access
Semantic Scholar
Novel 2-substituted-benzimidazole-6-sulfonamides as carbonic anhydrase inhibitors: synthesis, biological evaluation against isoforms I, II, IX and XII and molecular docking studies
Ciro Milite, Giorgio Amendola, A. Nocentini, Silvia Bua +9 more
2019Journal of Enzyme Inhibition and Medicinal Chemistry30 citations Open access
Semantic Scholar
G-Protein-Coupled Receptor Kinase 2 (GRK2) Inhibitors: Current Trends and Future Perspectives.
Manuela Guccione, R. Ettari, Sabrina Taliani, F. Da Settimo +2 more
2016Journal of Medicinal Chemistry28 citations Open access
Semantic Scholar
Unbinding of Translocator Protein 18 kDa (TSPO) Ligands: From in Vitro Residence Time to in Vivo Efficacy via in Silico Simulations.
Agostino Bruno, E. Barresi, N. Simola, E. Da Pozzo +6 more
2019ACS Chemical Neuroscience27 citations Open access
Semantic Scholar
Allosteric modulators of human A2B adenosine receptor.
M. Trincavelli, C. Giacomelli, S. Daniele, Sabrina Taliani +9 more
2014Biochimica et Biophysica Acta27 citations
Semantic Scholar
Targeting the KRAS Oncogene: Synthesis, Physicochemical and Biological Evaluation of Novel G-Quadruplex DNA Binders.
Federica D'Aria, Vincenzo Maria D'amore, F. S. Di Leva, J. Amato +16 more
2020European Journal of Pharmaceutical Sciences26 citations
Semantic Scholar
Lead Optimization of 2-Phenylindolylglyoxylyldipeptide Murine Double Minute (MDM)2/Translocator Protein (TSPO) Dual Inhibitors for the Treatment of Gliomas.
S. Daniele, V. La Pietra, E. Barresi, S. Di Maro +9 more
2016Journal of Medicinal Chemistry26 citations Open access
Semantic Scholar
De novo Neurosteroidogenesis in Human Microglia: Involvement of the 18 kDa Translocator Protein
Lorenzo Germelli, E. Da Pozzo, C. Giacomelli, Chiara Tremolanti +7 more
2021International Journal of Molecular Sciences25 citations Open access
Semantic Scholar
1,2-Benzisothiazole Derivatives Bearing 4-, 5-, or 6-Alkyl/arylcarboxamide Moieties Inhibit Carbonic Anhydrase Isoform IX (CAIX) and Cell Proliferation under Hypoxic Conditions.
Vito Coviello, B. Marchi, S. Sartini, Luca Quattrini +12 more
2016Journal of Medicinal Chemistry24 citations Open access
Semantic Scholar
4-Substituted Benzenesulfonamides Incorporating Bi/Tricyclic Moieties Act as Potent and Isoform-Selective Carbonic Anhydrase II/IX Inhibitors.
Silvia Salerno, E. Barresi, Giorgio Amendola, E. Berrino +7 more
2018Journal of Medicinal Chemistry22 citations Open access
Semantic Scholar
CLM29, a multi-target pyrazolopyrimidine derivative, has anti-neoplastic activity in medullary thyroid cancer in vitro and in vivo.
A. Antonelli, G. Bocci, C. La Motta, S. Ferrari +14 more
2014Molecular and Cellular Endocrinology22 citations
Semantic Scholar
Exploiting the Indole Scaffold to Design Compounds Binding to Different Pharmacological Targets
Sabrina Taliani, F. Da Settimo, C. Martini, S. Laneri +2 more
2020Molecules21 citations Open access
Semantic Scholar
Sulfonamides incorporating heteropolycyclic scaffolds show potent inhibitory action against carbonic anhydrase isoforms I, II, IX and XII.
E. Barresi, Silvia Salerno, A. Marini, Sabrina Taliani +5 more
2016Bioorganic & Medicinal Chemistry21 citations Open access
Semantic Scholar
Simultaneous Targeting of RGD-Integrins and Dual Murine Double Minute Proteins in Glioblastoma Multiforme.
F. Merlino, S. Daniele, V. La Pietra, S. Di Maro +17 more
2018Journal of Medicinal Chemistry20 citations Open access
Semantic Scholar
Novel positive allosteric modulators of A2B adenosine receptor acting as bone mineralisation promoters
E. Barresi, C. Giacomelli, L. Marchetti, Emma Baglini +6 more
2020Journal of Enzyme Inhibition and Medicinal Chemistry19 citations Open access
Semantic Scholar
Acid Derivatives of Pyrazolo[1,5-a]pyrimidine as Aldose Reductase Differential Inhibitors.
F. Balestri, Luca Quattrini, Vito Coviello, S. Sartini +6 more
2018Cell Chemical Biology19 citations Open access
Semantic Scholar
Computer-Aided Identification and Lead Optimization of Dual Murine Double Minute 2 and 4 Binders: Structure-Activity Relationship Studies and Pharmacological Activity.
Mariateresa Giustiniano, S. Daniele, Sveva Pelliccia, V. La Pietra +15 more
2017Journal of Medicinal Chemistry19 citations Open access
Semantic Scholar
Investigation of new 2-aryl substituted Benzothiopyrano[4,3-d]pyrimidines as kinase inhibitors targeting vascular endothelial growth factor receptor 2.
Silvia Salerno, A. Marini, G. Fornaciari, F. Simorini +13 more
2015European journal of medicinal chemistry19 citations Open access
Semantic Scholar
Synthesis and Screening in Mice of Fluorine-Containing PET Radioligands for TSPO: Discovery of a Promising 18F-Labeled Ligand
F. Siméon, Jae-Hoon Lee, C. Morse, Ian Stukes +13 more
2021Journal of Medicinal Chemistry17 citations Open access
Semantic Scholar
Two mixed valence diruthenium(II,III) isomeric complexes show different anticancer properties.
E. Barresi, Iogann Tolbatov, T. Marzo, E. Zappelli +7 more
2021Dalton Transactions17 citations Open access
Semantic Scholar
A mixed-valence diruthenium(II,III) complex endowed with high stability: from experimental evidence to theoretical interpretation.
E. Barresi, Iogann Tolbatov, A. Pratesi, V. Notarstefano +9 more
2020Dalton Transactions17 citations Open access
Semantic Scholar
Long lasting inhibition of Mdm2-p53 interaction potentiates mesenchymal stem cell differentiation into osteoblasts.
S. Daniele, C. Giacomelli, D. Pietrobono, E. Barresi +8 more
2019Biochimica et biophysica acta. Molecular cell research17 citations Open access
Semantic Scholar
Long lasting MDM2/Translocator protein modulator: a new strategy for irreversible apoptosis of human glioblastoma cells
S. Daniele, E. Barresi, E. Zappelli, L. Marinelli +5 more
2016OncoTarget17 citations Open access
Semantic Scholar
Antineoplastic activity of the multitarget tyrosine kinase inhibitors CLM3 and CLM94 in medullary thyroid cancer in vitro.
S. Ferrari, P. Fallahi, C. La Motta, G. Bocci +8 more
2014Surgery17 citations
Semantic Scholar
Structure-based optimization of tyrosine kinase inhibitor CLM3. Design, synthesis, functional evaluation, and molecular modeling studies.
S. Sartini, Vito Coviello, Agostino Bruno, V. La Pietra +12 more
2014Journal of Medicinal Chemistry17 citations Open access
Semantic Scholar
Challenging clinically unresponsive medullary thyroid cancer: Discovery and pharmacological activity of novel RET inhibitors.
V. La Pietra, S. Sartini, L. Botta, A. Antonelli +11 more
2018European journal of medicinal chemistry16 citations Open access
Semantic Scholar
Soyasaponins from Zolfino bean as aldose reductase differential inhibitors
F. Balestri, M. De Leo, C. Sorce, M. Cappiello +8 more
2018Journal of Enzyme Inhibition and Medicinal Chemistry16 citations Open access
Semantic Scholar

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Sabrina Taliani×44
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E. Barresi×27
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E. Barresi — researcher profile on SciRah
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Silvia Salerno — researcher profile on SciRah

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