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Ola M. Saad · SciRah

Researcher profile · Semantic Scholar

Ola M. Saad

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Ola M. Saad — researcher profile on SciRah

h-index: 26
Works: 68
Citations: 3,687

Most-cited papers

Conjugation site modulates the in vivo stability and therapeutic activity of antibody-drug conjugates
Ben-Quan Shen, Keyang Xu, Luna Liu, H. Raab +29 more
2012Nature Biotechnology942 citations
Semantic Scholar
Clinical pharmacology of trastuzumab emtansine (T-DM1): an antibody–drug conjugate in development for the treatment of HER2-positive cancer
S. Girish, M. Gupta, Bei Wang, D. Lu +10 more
2012Cancer Chemotherapy and Pharmacology264 citations Open access
Semantic Scholar
Bioanalytical assay strategies for the development of antibody-drug conjugate biotherapeutics.
Surinder Kaur, Keyang Xu, Ola M. Saad, Randall Dere +1 more
2013Bioanalysis225 citations
Semantic Scholar
Impact of drug conjugation on pharmacokinetics and tissue distribution of anti-STEAP1 antibody-drug conjugates in rats.
C. Boswell, E. Mundo, Crystal Zhang, D. Bumbaca +15 more
2011Bioconjugate chemistry208 citations
Semantic Scholar
Characterization of intact antibody-drug conjugates from plasma/serum in vivo by affinity capture capillary liquid chromatography-mass spectrometry.
Keyang Xu, Luna Liu, Ola M. Saad, Jakub Baudys +7 more
2011Analytical Biochemistry185 citations
Semantic Scholar
Preclinical safety profile of trastuzumab emtansine (T-DM1): mechanism of action of its cytotoxic component retained with improved tolerability.
K. A. Poon, Kelly M. Flagella, J. Beyer, Jay Tibbitts +6 more
2013Toxicology and Applied Pharmacology184 citations Open access
Semantic Scholar
Potential Mechanisms for Thrombocytopenia Development with Trastuzumab Emtansine (T-DM1)
H. Uppal, Estelle Doudement, Kaushiki Mahapatra, W. Darbonne +12 more
2014Clinical Cancer Research179 citations Open access
Semantic Scholar
Catabolic fate and pharmacokinetic characterization of trastuzumab emtansine (T-DM1): an emphasis on preclinical and clinical catabolism.
Ben-Quan Shen, D. Bumbaca, Ola M. Saad, Q. Yue +8 more
2012Current drug metabolism133 citations
Semantic Scholar
Compositional analysis and quantification of heparin and heparan sulfate by electrospray ionization ion trap mass spectrometry.
Ola M. Saad, J. Leary
2003Analytical Chemistry120 citations
Semantic Scholar
Delineating mechanisms of dissociation for isomeric heparin disaccharides using isotope labeling and ion trap tandem mass spectrometry
Ola M. Saad, J. Leary
2004Journal of the American Society for Mass Spectrometry99 citations Open access
Semantic Scholar
Compositional profiling of heparin/heparan sulfate using mass spectrometry: assay for specificity of a novel extracellular human endosulfatase.
Ola M. Saad, H. Ebel, Kenji Uchimura, S. Rosen +2 more
2005Glycobiology98 citations Open access
Semantic Scholar
A Phase 1, Randomized, Single-Ascending-Dose Study To Investigate the Safety, Tolerability, and Pharmacokinetics of DSTA4637S, an Anti-Staphylococcus aureus Thiomab Antibody-Antibiotic Conjugate, in Healthy Volunteers
Melicent C. Peck, M. Rothenberg, R. Deng, N. Lewin-Koh +9 more
2019Antimicrobial Agents and Chemotherapy91 citations Open access
Semantic Scholar
Anti-CD22-MCC-DM1 and MC-MMAF conjugates: impact of assay format on pharmacokinetic parameters determination.
J. Stephan, Pamela Chan, Chien C Lee, Christopher Nelson +12 more
2008Bioconjugate chemistry84 citations
Semantic Scholar
Heparin sequencing using enzymatic digestion and ESI-MSn with HOST: a heparin/HS oligosaccharide sequencing tool.
Ola M. Saad, J. Leary
2005Analytical Chemistry74 citations
Semantic Scholar
PK assays for antibody-drug conjugates: case study with ado-trastuzumab emtansine.
Randall Dere, J. Yi, Corinna Lei, Ola M. Saad +4 more
2013Bioanalysis72 citations
Semantic Scholar
Pharmacokinetics and pharmacodynamics of DSTA4637A: A novel THIOMAB™ antibody antibiotic conjugate against Staphylococcus aureus in mice
Chenguang Zhou, Sophie M. Lehar, Johnny Gutierrez, Carrie M. Rosenberger +9 more
2016mAbs64 citations Open access
Semantic Scholar
The HER2-directed antibody-drug conjugate DHES0815A in advanced and/or metastatic breast cancer: preclinical characterization and phase 1 trial results
Gail D Lewis, Guangmin Li, Jun Guo, Shang-Fan Yu +27 more
2024Nature Communications52 citations Open access
Semantic Scholar
Chemokine-Glycosaminoglycan Binding
Yong-Hao Yu, Matthew D. Sweeney, Ola M. Saad, Susan E. Crown +2 more
2005Journal of Biological Chemistry51 citations Open access
Semantic Scholar
Immunogenicity of antibody-drug conjugates: observations across eight molecules in eleven clinical trials.
M. Carrasco-Triguero, Randall Dere, Marija Milojic-Blair, Ola M. Saad +3 more
2019Bioanalysis42 citations Open access
Semantic Scholar
Effects of Trastuzumab Emtansine (T‐DM1) on QT Interval and Safety of Pertuzumab Plus T‐DM1 in Patients With Previously Treated Human Epidermal Growth Factor Receptor 2–Positive Metastatic Breast Cancer
M. Gupta, Bei Wang, T. Carrothers, P. LoRusso +7 more
2013Clinical pharmacology in drug development38 citations
Semantic Scholar
Hypoxia Attenuates Trastuzumab Uptake and Trastuzumab-Emtansine (T-DM1) Cytotoxicity through Redistribution of Phosphorylated Caveolin-1
Vineesh Indira Chandran, A. Månsson, Magdalena Barbachowska, M. Cerezo-Magaña +11 more
2020Molecular Cancer Research33 citations Open access
Semantic Scholar
Preclinical and translational pharmacokinetics of a novel THIOMAB™ antibody-antibiotic conjugate against Staphylococcus aureus
R. Deng, Chenguang Zhou, Dong-Wei Li, Hao Cai +7 more
2019mAbs33 citations Open access
Semantic Scholar
Bioanalytical approaches for characterizing catabolism of antibody-drug conjugates.
Ola M. Saad, Ben-Quan Shen, Keyang Xu, S. C. Khojasteh +2 more
2015Bioanalysis33 citations
Semantic Scholar
Potential inhibitors of chemokine function: Analysis of noncovalent complexes of cc chemokine and small polyanionic molecules by ESI FT-ICR mass spectrometry
Yong-Hao Yu, Matthew D. Sweeney, Ola M. Saad, J. Leary
2006Journal of the American Society for Mass Spectrometry31 citations
Semantic Scholar
Preclinical Characterization of the Distribution, Catabolism, and Elimination of a Polatuzumab Vedotin-Piiq (POLIVY®) Antibody–Drug Conjugate in Sprague Dawley Rats
Victor Yip, M. V. Lee, Ola M. Saad, Shu-Guang Ma +2 more
2021Journal of Clinical Medicine29 citations Open access
Semantic Scholar
Analysis of hyaluronan content in chondroitin sulfate preparations by using selective enzymatic digestion and electrospray ionization mass spectrometry.
Ola M. Saad, Richard A. Myers, D. L. Castleton, J. Leary
2005Analytical Biochemistry28 citations
Semantic Scholar
Chemokine-glycosaminoglycan binding. SPECIFICITY FOR CCR2 LIGAND BINDING TO HIGHLY SULFATED OLIGOSACCHARIDES USING FTICR MASS SPECTROMETRY. VOLUME 280 (2005) PAGES 32200-32208
Yong-Hao Yu, Matthew D. Sweeney, Ola M. Saad, Susan E. Crown +3 more
200526 citations
Semantic Scholar
2017 White Paper: rise of hybrid LBA/LCMS immunogenicity assays (Part 2: hybrid LBA/LCMS biotherapeutics, biomarkers & immunogenicity assays and regulatory agencies' inputs).
H. Neubert, An Song, Anita Y. H. Lee, Cong Wei +45 more
2017Bioanalysis24 citations Open access
Semantic Scholar
Semi-mechanistic Multiple-Analyte Pharmacokinetic Model for an Antibody-Drug-Conjugate in Cynomolgus Monkeys
D. Lu, Jin Y. Jin, S. Girish, P. Agarwal +8 more
2014Pharmaceutical Research24 citations Open access
Semantic Scholar
Development and Translational Application of an Integrated, Mechanistic Model of Antibody-Drug Conjugate Pharmacokinetics
S. Sukumaran, Crystal Zhang, D. Leipold, Ola M. Saad +10 more
2016AAPS Journal22 citations
Semantic Scholar
2018 White Paper on Recent Issues in Bioanalysis: focus on immunogenicity assays by hybrid LBA/LCMS and regulatory feedback (Part 2 - PK, PD & ADA assays by hybrid LBA/LCMS & regulatory agencies' inputs on bioanalysis, biomarkers and immunogenicity).
H. Neubert, T. Olah, Anita Y. H. Lee, Stephanie Fraser +43 more
2018Bioanalysis21 citations Open access
Semantic Scholar
Non-Clinical Disposition and Metabolism of DM1, a Component of Trastuzumab Emtansine (T-DM1), in Sprague Dawley Rats.
Ben-Quan Shen, D. Bumbaca, Q. Yue, Ola M. Saad +3 more
2015Drug Metabolism Letters18 citations
Semantic Scholar
Antibody-Drug Conjugates Derived from Cytotoxic seco-CBI-Dimer Payloads Are Highly Efficacious in Xenograft Models and Form Protein Adducts In Vivo.
Dian Su, Jinhua Chen, Ely Cosino, Josefa Dela Cruz-Chuh +39 more
2019Bioconjugate chemistry17 citations
Semantic Scholar
Preclinical pharmacokinetics and pharmacodynamics of DCLL9718A: An antibody-drug conjugate for the treatment of acute myeloid leukemia
Doug Leipold, I. Figueroa, Shabkhaiz Masih, B. Latifi +17 more
2018mAbs15 citations Open access
Semantic Scholar
Method development of a novel PK assay for antibody-conjugated drug measurement of ADCs using peptide-linker drug analyte
Suk-Joon Hyung, Dong-Wei Li, Neelima Koppada, Surinder Kaur +1 more
2019Analytical and Bioanalytical Chemistry14 citations
Semantic Scholar
Monomethyl auristatin E (MMAE), a payload for multiple antibody drug conjugates (ADCs), demonstrates differential red blood cell partitioning across human and animal species
Victor Yip, Ola M. Saad, Doug Leipold, Chun-Ze Li +2 more
2024Xenobiotica; the fate of foreign compounds in biological systems13 citations Open access
Semantic Scholar
Minimal physiologically-based pharmacokinetic modeling of DSTA4637A, A novel THIOMAB™ antibody antibiotic conjugate against Staphylococcus aureus, in a mouse model
Shun Xin Wang-Lin, Chenguang Zhou, Amrita V. Kamath, Kyu Hong +5 more
2018mAbs13 citations Open access
Semantic Scholar
Development of a semi-automated MHC-associated peptide proteomics (MAPPs) method using streptavidin bead-based immunoaffinity capture and nano LC-MS/MS to support immunogenicity risk assessment in drug development
M. V. Lee, Ola M. Saad, S. Wong, Jason LaMar +6 more
2023Frontiers in Immunology11 citations Open access
Semantic Scholar
Abstract A136: Nonclinical disposition, metabolism, and in vitro drug-drug interaction assessment of DM1, a component of trastuzumab emtansine (T-DM1).
Susan D. Wong, D. Bumbaca, Q. Yue, Jason S. Halladay +7 more
201111 citations
Semantic Scholar
Characterization of Tissue Distribution, Catabolism, and Elimination of an Anti–Staphylococcus aureus THIOMAB Antibody-Antibiotic Conjugate in Rats
Hao Cai, Victor Yip, M. V. Lee, Sylvia C. Wong +6 more
2020Drug Metabolism And Disposition10 citations Open access
Semantic Scholar
Platform model describing pharmacokinetic properties of vc-MMAE antibody–drug conjugates
M. Kågedal, L. Gibiansky, Jian Xu, Xin Wang +11 more
2017Journal of Pharmacokinetics and Pharmacodynamics10 citations
Semantic Scholar
Conjugation Site Influences Antibody-Conjugated Drug PK Assays: Case Studies for Disulfide-Linked, Self-Immolating Next-Generation Antibody Drug Conjugates.
M. V. Lee, Surinder Kaur, Ola M. Saad
2020Analytical Chemistry8 citations
Semantic Scholar
Abstract P5-18-11: Pharmacokinetics and exposure-efficacy relationship of trastuzumab emtansine in EMILIA, a phase 3 study of trastuzumab emtansine vs capecitabine and lapatinib in HER2-positive locally advanced or metastatic breast cancer
Bu-Er Wang, J. Jin, R. Wada, L. Fang +6 more
20128 citations
Semantic Scholar
Proton hydrates as soft ion/ion proton transfer reagents for multiply deprotonated biomolecules
Jeremiah J. Bowers, B. Hodges, Ola M. Saad, J. Leary +1 more
20088 citations
Semantic Scholar
Multiplexed Quantitative Analysis of Antibody-Drug Conjugates with Labile CBI-Dimer Payloads In Vivo Using Immunoaffinity LC-MS/MS.
Suk-Joon Hyung, D. Leipold, Donna W. Lee, Surinder Kaur +1 more
2021Analytical Chemistry7 citations
Semantic Scholar
Mass Spectrometry of Antibody–Drug Conjugates in Plasma and Tissue in Drug Development
Surinder Kaur, Keyang Xu, Ola M. Saad, Luna Liu +2 more
20136 citations
Semantic Scholar
1305. Comparison of Pharmacokinetics of DSTA4637S, a novel THIOMABTM Antibody-Antibiotic Conjugate, in Patients with Staphylococcus aureus Bacteremia Receiving Standard-of-Care Antibiotics with Pharmacokinetics in Healthy Volunteers
Sharon M. Rymut, R. Deng, R. Owen, Ola M. Saad +5 more
2020Open Forum Infectious Diseases5 citations Open access
Semantic Scholar
Abstract P2-13-25: A phase I dose-escalation study of DHES0815A, a HER2-targeting antibody-drug conjugate with a DNA monoalkylator payload, in patients with HER2-positive breast cancer
I. Krop, E. Hamilton, K. Jung, S. Modi +11 more
2022Cancer Research4 citations
Semantic Scholar
Population Pharmacokinetics of Trastuzumab-DM1, a First-in-Class HER2 Antibody-Drug Conjugate Given Every 3 Weeks (q3w) and Weekly (qw) to Patients with HER2-Positive Metastatic Breast Cancer (MBC).
P. LoRusso, S. Girish, H. Burris, M. Beeram +6 more
20093 citations
Semantic Scholar
Abstract P2-13-33: Preclinical development of DHES0815A: A HER2-directed antibody-drug conjugate comprised of a reduced potency PBD dimer linked to a domain I binding HER2 antibody
G. Phillips, Guangmin Li, Jun Guo, Shang-Fan Yu +11 more
2022Cancer Research2 citations
Semantic Scholar

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