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Carl E. Ruby · SciRah

Researcher profile · Semantic Scholar

Carl E. Ruby

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Carl E. Ruby — researcher profile on SciRah

h-index: 24
Works: 47
Citations: 2,125

Most-cited papers

Current status of granulocyte–macrophage colony-stimulating factor in the immunotherapy of melanoma
H. Kaufman, Carl E. Ruby, T. Hughes, Craig L. Jr Slingluff
2014Journal of Immunotherapy for Cancer211 citations Open access
Semantic Scholar
The role of OX40-mediated co-stimulation in T cell activation and survival
William L. Redmond, Carl E. Ruby, A. Weinberg
2009Critical Reviews in Immunology210 citations Open access
Semantic Scholar
OX40 agonist therapy enhances CD8 infiltration and decreases immune suppression in the tumor.
M. Gough, Carl E. Ruby, William L. Redmond, B. Dhungel +2 more
2008Cancer Research173 citations Open access
Semantic Scholar
Cutting Edge: OX40 Agonists Can Drive Regulatory T Cell Expansion if the Cytokine Milieu Is Right
Carl E. Ruby, M. Yates, D. Hirschhorn-Cymerman, P. Chlebeck +4 more
2009Journal of Immunology167 citations Open access
Semantic Scholar
Signaling through OX40 Enhances Anti-tumor Immunity
S. Jensen, L. Maston, M. Gough, Carl E. Ruby +15 more
2010Seminars in Oncology150 citations Open access
Semantic Scholar
Optimal Management of Metastatic Melanoma: Current Strategies and Future Directions
M. Batus, Salman Waheed, Carl E. Ruby, Lindsay Petersen +2 more
2013American Journal of Clinical Dermatology113 citations Open access
Semantic Scholar
HIV-1 Nef assembles a Src family kinase-ZAP-70/Syk-PI3K cascade to downregulate cell-surface MHC-I.
Chien-Hui Hung, L. Thomas, Carl E. Ruby, K. Atkins +7 more
2007Cell Host and Microbe109 citations Open access
Semantic Scholar
Anti‐OX40 stimulation in vivo enhances CD8+ memory T cell survival and significantly increases recall responses
Carl E. Ruby, William L. Redmond, D. Haley, A. Weinberg
2007European Journal of Immunology94 citations Open access
Semantic Scholar
IL-18 Bridges Innate and Adaptive Immunity through IFN-γ and the CD134 Pathway1
J. Maxwell, Rajwardhan Yadav, Robert J. Rossi, Carl E. Ruby +3 more
2006Journal of Immunology83 citations Open access
Semantic Scholar
2,3,7,8-Tetrachlorodibenzo-p-dioxin suppresses tumor necrosis factor-alpha and anti-CD40-induced activation of NF-kappaB/Rel in dendritic cells: p50 homodimer activation is not affected.
Carl E. Ruby, M. Leid, N. Kerkvliet
2002Molecular Pharmacology82 citations
Semantic Scholar
IL-12 Is Required for Anti-OX40-Mediated CD4 T Cell Survival
Carl E. Ruby, R. Montler, Rongxui Zheng, S. Shu +1 more
2008Journal of Immunology75 citations Open access
Semantic Scholar
Exosomes from Osteosarcoma and normal osteoblast differ in proteomic cargo and immunomodulatory effects on T cells
R. Troyer, Carl E. Ruby, C. Goodall, Liping Yang +7 more
2017Experimental Cell Research74 citations
Semantic Scholar
NK cells and CD8+ T cells cooperate to improve therapeutic responses in melanoma treated with interleukin-2 (IL-2) and CTLA-4 blockade
F. Kohlhapp, Joseph R. Broucek, T. Hughes, E. Huelsmann +15 more
2015Journal of Immunotherapy for Cancer64 citations Open access
Semantic Scholar
Oncolytic virus therapy for cancer.
Joe Goldufsky, Shanthi Sivendran, Sara Harcharik, Michael Pan +6 more
2013Oncolytic Virotherapy62 citations Open access
Semantic Scholar
A Preliminary Proteomic Investigation of Circulating Exosomes and Discovery of Biomarkers Associated with the Progression of Osteosarcoma in a Clinical Model of Spontaneous Disease1
J. Brady, R. Troyer, S. Ramsey, H. Leeper +7 more
2018Translational Oncology47 citations Open access
Semantic Scholar
IL-18 bridges innate and adaptive immunity through IFN-gamma and the CD134 pathway.
J. Maxwell, Rajwardhan Yadav, Robert J. Rossi, Carl E. Ruby +3 more
2006Journal of Immunology46 citations
Semantic Scholar
Pseudomonas aeruginosa exotoxin T induces potent cytotoxicity against a variety of murine and human cancer cell lines.
Joe Goldufsky, Stephen J Wood, Behnam Hajihossainlou, T. Rehman +4 more
2015Journal of Medical Microbiology41 citations Open access
Semantic Scholar
OX40-enhanced tumor rejection and effector T cell differentiation decreases with age
Carl E. Ruby, A. Weinberg
2009Journal of Immunology40 citations Open access
Semantic Scholar
Inhibition of p70 S6 Kinase (S6K1) Activity by A77 1726 and Its Effect on Cell Proliferation and Cell Cycle Progress
Michelle E. Doscas, Ashley J. Williamson, L. Usha, Y. Bogachkov +9 more
2014Neoplasia35 citations Open access
Semantic Scholar
Caloric restriction maintains OX40 agonist-mediated tumor immunity and CD4 T cell priming during aging
M. Farazi, Justine Nguyen, Josef W. Goldufsky, S. Linnane +3 more
2014Cancer Immunology and Immunotherapy33 citations Open access
Semantic Scholar
2,3,7,8 Tetrachlorodibenzo-p-Dioxin (TCDD) Directly Enhances the Maturation and Apoptosis of Dendritic Cells In Vitro
Carl E. Ruby, Castle J. Funatake, N. Kerkvliet
2005Journal of Immunotoxicology30 citations Open access
Semantic Scholar
Exosomal proteomic signatures correlate with drug resistance and carboplatin treatment outcome in a spontaneous model of canine osteosarcoma
Marcus A Weinman, S. Ramsey, H. Leeper, J. Brady +6 more
2021Cancer Cell International25 citations Open access
Semantic Scholar
Interleukin-2 alters distribution of CD144 (VE-cadherin) in endothelial cells
D. Kim, A. Zloza, Joseph R. Broucek, J. Schenkel +3 more
2014Journal of Translational Medicine25 citations Open access
Semantic Scholar
OX40 engagement stabilizes Mxd4 and Mnt protein levels in antigen-stimulated T cells leading to an increase in survival
N. Vasilevsky, Carl E. Ruby, P. Hurlin, Andrew D. Weinberg
2011European Journal of Immunology24 citations Open access
Semantic Scholar
Impact of aging on cancer immunity and immunotherapy
G. Pawelec, J. Lustgarten, Carl E. Ruby, C. Gravekamp
2009Cancer Immunology and Immunotherapy24 citations Open access
Semantic Scholar
Mutations in PIK3CA sensitize breast cancer cells to physiologic levels of aspirin
Sanja B. Turturro, Matthew S. Najor, Carl E. Ruby, M. Cobleigh +1 more
2016Breast Cancer Research and Treatment21 citations Open access
Semantic Scholar
TroVax(®) vaccine therapy for renal cell carcinoma.
Rui-Tao Zhang, S. Bines, Carl E. Ruby, H. Kaufman
2012Immunotherapy16 citations
Semantic Scholar
The effect of aging on OX40 agonist-mediated cancer immunotherapy
Carl E. Ruby, A. Weinberg
2009Cancer Immunology and Immunotherapy16 citations Open access
Semantic Scholar
Fasting reduces the incidence of vincristine‐associated adverse events in dogs
M. Duckett, K. Curran, H. Leeper, Carl E. Ruby +1 more
2020Veterinary and Comparative Oncology11 citations Open access
Semantic Scholar
Modulating the Tumor Microenvironment
Carl E. Ruby, H. Kaufman
20128 citations
Semantic Scholar
Potential Promises and Perils of Human Biological Treatments for Immunotherapy in Veterinary Oncology
Jeilene N. Hambly, Carl E. Ruby, D. Mourich, Shay Bracha +1 more
2023Veterinary Sciences5 citations Open access
Semantic Scholar
Early‐onset age‐related changes in dendritic cell subsets can impair antigen‐specific T helper 1 (Th1) CD4 T cell priming
M. Farazi, Zachary Cohn, Justine Nguyen, Andrew D. Weinberg +1 more
2014Journal of Leukocyte Biology4 citations Open access
Semantic Scholar
Creating a Selective Nanobody Against 3-Nitrotyrosine Containing Proteins
Elise M. Van Fossen, Sonia Grutzius, Carl E. Ruby, D. Mourich +5 more
2022Frontiers in Chemistry3 citations Open access
Semantic Scholar
Combination immunotherapy with anti-CTLA-4 and interleukin-2 redirects regulatory T cells into tumor-draining lymph nodes and expands anti-tumor CD8+ T cells in the tumor microenvironment
Joseph R. Broucek, T. Hughes, E. Huelsmann, Eugene Lusciks +7 more
2014Journal of Immunotherapy for Cancer1 citations Open access
Semantic Scholar
Oncolytic virus therapy for cancer
Joe Goldufsky, Shanthi Sivendran, Sara Harcharik, Michael Pan +6 more
20131 citations
Semantic Scholar
CD 4 T Cell Survival IL-12 Is Required for Anti-OX 40-Mediated
Carl E. Ruby, R. Montler, Rongxui Zheng, S. Shu +1 more
20081 citations
Semantic Scholar
Characterization of a Potential Therapeutic Anti-Canine PD-1 Single Domain Antibody Produced in Yeast
Kartikeya Vijayasimha, Andrew J. Annalora, D. Mourich, Carl E. Ruby +6 more
2025Veterinary Sciences0 citations Open access
Semantic Scholar
The impact of age on a mitoxantrone-based tumor vaccine
Keven Stonewall, C. Quintero, A. Zloza, H. Kaufman +1 more
2013Journal of Immunotherapy for Cancer0 citations Open access
Semantic Scholar
Combination immunotherapy with Interleukin-2 and CTLA-4 blockade decreases tumor growth and improves overall survival
Joseph R. Broucek, T. Hughes, E. Huelsmann, Joseph L Poshepny +3 more
2013Journal of Immunotherapy for Cancer0 citations Open access
Semantic Scholar
Caloric-restriction maintains tumor immunity and CD4 T cells priming during aging: role of an inflammatory DC population (P2175)
Carl E. Ruby, M. Farazi, Josef W. Goldufsky, Zachary Cohn +4 more
2013Journal of Immunology0 citations
Semantic Scholar
Caloric restriction responses can maintain immune responses during aging (47.14)
Carl E. Ruby, Hugo Jimenez, Josef W. Goldufsky, Lana Chisholm +3 more
2012Journal of Immunology0 citations
Semantic Scholar
OX40 Agonists can drive Treg expansion if the cytokine milieu is right
Carl E. Ruby, M. Yates, D. Hirschhorn-Cymerman, P. Chlebeck +4 more
2009Journal of Immunology0 citations Open access
Semantic Scholar
Milieu Is Right Regulatory T Cell Expansion if the Cytokine Cutting Edge: OX40 Agonists Can Drive
Carl E. Ruby, M. Yates, Daniel Hirschhorn-Cymerman, P. Chlebeck +4 more
20090 citations
Semantic Scholar
Age withEffector T Cell Differentiation Decreases OX 40-Enhanced Tumor Rejection and
Carl E. Ruby, A. Weinberg
20090 citations
Semantic Scholar
Manipulating TNF Receptors to Enhance Tumor Immunity for the Treatment of Cancer
Carl E. Ruby, A. Weinberg
20090 citations
Semantic Scholar
OX40‐mediated tumor protection is decreased in aging mice: the role of CD4+CD25+FoxP3+ T cells and IL‐12
Carl E. Ruby, Andrew D. Weinberg
20080 citations
Semantic Scholar
Direct effects of 2,3,7,8 tetrachlorodibenzo-p-dioxin on antigen-presenting cells and molecular signaling pathways in dendritic cells
Carl E. Ruby
20010 citations
Semantic Scholar

Frequent co-authors

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A. Weinberg×18
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A. Weinberg — researcher profile on SciRah
H. Kaufman×14
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Shay Bracha×7
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A. Zloza×5
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T. Hughes — researcher profile on SciRah

William L. Redmond×4

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William L. Redmond — researcher profile on SciRah

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Joseph R. Broucek×4

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Joseph R. Broucek — researcher profile on SciRah

Andrew D. Weinberg×4

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