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N. Kerkvliet · SciRah

Researcher profile · Semantic Scholar

N. Kerkvliet

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N. Kerkvliet — researcher profile on SciRah

h-index: 41
Works: 122
Citations: 6,925

Most-cited papers

TOXICITY TESTING IN THE 21ST CENTURY: A VISION AND A STRATEGY
Daniel Krewski, Daniel Acosta, Melvin E. Andersen, H. Anderson +18 more
2010Journal of Toxicology and Environmental Health. Part B, Critical Reviews2,045 citations Open access
Semantic Scholar
Cutting Edge: Activation of the Aryl Hydrocarbon Receptor by 2,3,7,8-Tetrachlorodibenzo-p-dioxin Generates a Population of CD4+CD25+ Cells with Characteristics of Regulatory T Cells1
Castle J. Funatake, Nikki B. Marshall, L. B. Steppan, D. Mourich +1 more
2005Journal of Immunology235 citations Open access
Semantic Scholar
Recent advances in understanding the mechanisms of TCDD immunotoxicity.
N. Kerkvliet
2002International Immunopharmacology218 citations
Semantic Scholar
AHR-Mediated Immunomodulation: The Role of Altered Gene Transcription
N. Kerkvliet
2008Biochemical Pharmacology190 citations Open access
Semantic Scholar
Aryl hydrocarbon receptor-deficient mice generate normal immune responses to model antigens and are resistant to TCDD-induced immune suppression.
B. Vorderstrasse, L. B. Steppan, A. Silverstone, N. Kerkvliet
2001Toxicology and Applied Pharmacology174 citations
Semantic Scholar
Immunological effects of chlorinated dibenzo-p-dioxins.
N. Kerkvliet
1995Environmental Health Perspectives172 citations Open access
Semantic Scholar
Activation of aryl hydrocarbon receptor by TCDD prevents diabetes in NOD mice and increases Foxp3+ T cells in pancreatic lymph nodes
N. Kerkvliet, L. B. Steppan, W. Vorachek, S. Oda +4 more
2009Immunotherapy170 citations Open access
Semantic Scholar
Modeling of the Aryl Hydrocarbon Receptor (AhR) ligand binding domain and its utility in virtual ligand screening to predict new AhR ligands
W. Bisson, D. Koch, E. O'Donnell, S. Khalil +4 more
2009Journal of Medicinal Chemistry150 citations Open access
Semantic Scholar
Dioxin and immune regulation
N. B. Marshall, N. Kerkvliet
2010Annals of the New York Academy of Sciences146 citations Open access
Semantic Scholar
TCDD, FICZ, and Other High Affinity AhR Ligands Dose-Dependently Determine the Fate of CD4+ T Cell Differentiation
Allison K. Ehrlich, Jamie M. Pennington, W. Bisson, S. Kolluri +1 more
2018Toxicological Sciences142 citations Open access
Semantic Scholar
T lymphocytes are direct, aryl hydrocarbon receptor (AhR)-dependent targets of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD): AhR expression in both CD4+ and CD8+ T cells is necessary for full suppression of a cytotoxic T lymphocyte response by TCDD.
N. Kerkvliet, D. Shepherd, L. Baecher-Steppan
2002Toxicology and Applied Pharmacology126 citations
Semantic Scholar
Role of the Ah locus in suppression of cytotoxic T lymphocyte activity by halogenated aromatic hydrocarbons (PCBs and TCDD): structure-activity relationships and effects in C57Bl/6 mice congenic at the Ah locus.
N. Kerkvliet, L. Baecher-Steppan, B. Smith, J. Youngberg +2 more
1990Fundamental and Applied Toxicology121 citations
Semantic Scholar
The Anti-Inflammatory Drug Leflunomide Is an Agonist of the Aryl Hydrocarbon Receptor
E. O'Donnell, Katerine S. Saili, D. Koch, P. R. Kopparapu +7 more
2010PLoS ONE119 citations Open access
Semantic Scholar
Inhibition of TC-1 cytokine production, effector cytotoxic T lymphocyte development and alloantibody production by 2,3,7,8-tetrachlorodibenzo-p-dioxin.
N. Kerkvliet, L. Baecher-Steppan, D. Shepherd, J. A. Oughton +2 more
1996Journal of Immunology116 citations
Semantic Scholar
Functional Characterization and Gene Expression Analysis of CD4+CD25+ Regulatory T Cells Generated in Mice Treated with 2,3,7,8-Tetrachlorodibenzo-p-Dioxin
Nikki B. Marshall, W. Vorachek, L. B. Steppan, D. Mourich +1 more
2008Journal of Immunology107 citations Open access
Semantic Scholar
2,3,7,8-Tetrachlorodibenzo-p-dioxin affects the number and function of murine splenic dendritic cells and their expression of accessory molecules.
B. Vorderstrasse, N. Kerkvliet
2001Toxicology and Applied Pharmacology95 citations
Semantic Scholar
2,3,7,8-Tetrachlorodibenzo-p-dioxin suppresses tumor necrosis factor-alpha and anti-CD40-induced activation of NF-kappaB/Rel in dendritic cells: p50 homodimer activation is not affected.
Carl E. Ruby, M. Leid, N. Kerkvliet
2002Molecular Pharmacology82 citations
Semantic Scholar
The Aryl Hydrocarbon Receptor Mediates Leflunomide-Induced Growth Inhibition of Melanoma Cells
E. O'Donnell, P. R. Kopparapu, D. Koch, H. Jang +4 more
2012PLoS ONE80 citations Open access
Semantic Scholar
Flow cytometric analysis of lymphocyte subpopulations in the spleen and thymus of mice exposed to an acute immunosuppressive dose of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD).
N. Kerkvliet, J. Brauner
1990Environmental Research79 citations
Semantic Scholar
Toxicology of protein allergenicity: prediction and characterization.
I. Kimber, N. Kerkvliet, Steve L. Taylor, J. Astwood +2 more
1999Toxicological Sciences72 citations
Semantic Scholar
The role of polycyclic aromatic hydrocarbon metabolism in dimethylbenz[a]anthracene-induced pre-B lymphocyte apoptosis.
Koren K. Mann, Raymond A. Matulka, M. Hahn, A. Trombino +3 more
1999Toxicology and Applied Pharmacology68 citations Open access
Semantic Scholar
In utero exposure of mice to dibenzo[a,l]pyrene produces lymphoma in the offspring: role of the aryl hydrocarbon receptor.
Zhen Yu, Christiane Loehr, Kay A. Fischer, Mandy A Louderback +9 more
2006Cancer Research65 citations
Semantic Scholar
The effects of TCDD on the activation of ovalbumin (OVA)-specific DO11.10 transgenic CD4(+) T cells in adoptively transferred mice.
David M. Shepherd, E. Dearstyne, N. Kerkvliet
2000Toxicological Sciences60 citations
Semantic Scholar
A Structural Switch between Agonist and Antagonist Bound Conformations for a Ligand-Optimized Model of the Human Aryl Hydrocarbon Receptor Ligand Binding Domain
A. Perkins, J. L. Phillips, N. Kerkvliet, Robert L. Tanguay +3 more
2014Biology53 citations Open access
Semantic Scholar
Effect of 2,3,7,8-tetrachlorodibenzo-p-dioxin on anti-CD3-induced changes in T-cell subsets and cytokine production.
R. Prell, J. A. Oughton, N. Kerkvliet
1995International Journal of Immunopharmacology50 citations
Semantic Scholar
Influence of 2,3,7,8-tetrachlorodibenzo-p-dioxin on the antigen-presenting activity of dendritic cells.
B. Vorderstrasse, E. Dearstyne, N. Kerkvliet
2003Toxicological Sciences49 citations
Semantic Scholar
Disruption of CD154:CD40 blocks generation of allograft immunity without affecting APC activation.
David M. Shepherd, N. Kerkvliet
1999Journal of Immunology48 citations Open access
Semantic Scholar
Benzimidazoisoquinolines: A New Class of Rapidly Metabolized Aryl Hydrocarbon Receptor (AhR) Ligands that Induce AhR-Dependent Tregs and Prevent Murine Graft-Versus-Host Disease
S. Punj, P. R. Kopparapu, H. Jang, J. L. Phillips +6 more
2014PLoS ONE47 citations Open access
Semantic Scholar
Dibenzo[a,l]pyrene induced DNA adduct formation in lung tissue in vivo.
B. Mahadevan, A. Luch, C. F. Bravo, Jennifer Atkin +4 more
2005Cancer Letters45 citations
Semantic Scholar
2,3,7,8-Tetrachlorodibenzo-p-dioxin Alters the Differentiation of Alloreactive CD8+ T Cells Toward a Regulatory T Cell Phenotype by a Mechanism that is Dependent on Aryl Hydrocarbon Receptor in CD4+ T Cells
Castle J. Funatake, Nikki B. Marshall, N. Kerkvliet
2008Journal of Immunotoxicology44 citations Open access
Semantic Scholar
Acute inflammatory response to sheep red blood cells in mice treated with 2,3,7,8-tetrachlorodibenzo-p-dioxin: the role of proinflammatory cytokines, IL-1 and TNF.
A. Moos, L. Baecher-Steppan, N. Kerkvliet
1994Toxicology and Applied Pharmacology44 citations
Semantic Scholar
Dietary Indole-3-Carbinol Activates AhR in the Gut, Alters Th17-Microbe Interactions, and Exacerbates Insulitis in NOD Mice
Heather M. Kahalehili, N. Newman, Jamie M. Pennington, S. Kolluri +4 more
2021Frontiers in Immunology43 citations Open access
Semantic Scholar
Activation of the aryl hydrocarbon receptor by 10-Cl-BBQ prevents insulitis and effector T cell development independently of Foxp3+ regulatory T cells in NOD mice
Allison K. Ehrlich, Jamie M. Pennington, Xi-Sheng Wang, D. Rohlman +5 more
2015Journal of Immunology43 citations Open access
Semantic Scholar
Reduced T-helper cell function in mice exposed to 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD).
Rajpal S. Tomar, N. Kerkvliet
1991Toxicology Letters42 citations
Semantic Scholar
Early consequences of 2,3,7,8-tetrachlorodibenzo-p-dioxin exposure on the activation and survival of antigen-specific T cells.
Castle J. Funatake, E. Dearstyne, L. B. Steppan, D. Shepherd +3 more
2004Toxicological Sciences41 citations
Semantic Scholar
Effects of Aroclor 1254 on the thyroid gland, immune function, and hepatic cytochrome P450 activity in mallards.
J. Fowles, A. Fairbrother, Kimberly A. Trust, N. Kerkvliet
1997Environmental Research40 citations
Semantic Scholar
Involvement of altered B7 expression in dioxin immunotoxicity: B7 transfection restores the CTL but not the autoantibody response to the P815 mastocytoma.
R. Prell, N. Kerkvliet
1997Journal of Immunology39 citations
Semantic Scholar
Immunotoxicology of Dioxins and Related Chemicals
N. Kerkvliet
199439 citations
Semantic Scholar
DNA Heterogeneity in prostatic adenocarcinoma. A DNA flow cytometric mapping study with whole organ sections of prostate
F. O'Malley, D. Grignon, M. Keeney, N. Kerkvliet +1 more
1993Cancer39 citations Open access
Semantic Scholar
TCDD: An Environmental Immunotoxicant Reveals a Novel Pathway of Immunoregulation—A 30-Year Odyssey
N. Kerkvliet
2012Toxicologic pathology (Print)38 citations
Semantic Scholar
Suppression of cytotoxic T lymphocyte activity by 2,3,7,8-tetrachlorodibenzo-p-dioxin occurs in vivo, but not in vitro, and is independent of corticosterone elevation.
G. K. De Krey, N. Kerkvliet
1995Toxicology38 citations
Semantic Scholar
Functional alterations in CD11b(+)Gr-1(+) cells in mice injected with allogeneic tumor cells and treated with 2,3,7,8-tetrachlorodibenzo-p-dioxin.
Jin-Young Choi, J. A. Oughton, N. Kerkvliet
2003International Immunopharmacology36 citations
Semantic Scholar
Immune Modulation by TCDD and Related Polyhalogenated Aromatic Hydrocarbons
B. Lawrence, N. Kerkvliet
200634 citations
Semantic Scholar
Immunologic effects of pesticides
P. Thomas, W. Busse, N. Kerkvliet, M. Luster +7 more
199033 citations
Semantic Scholar
The effects of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) on tumor necrosis factor (TNF) production by peritoneal cells.
A. Moos, J. A. Oughton, N. Kerkvliet
1997Toxicology Letters32 citations
Semantic Scholar
Is chronic AhR activation by rapidly metabolized ligands safe for the treatment of immune-mediated diseases?
Allison K. Ehrlich, N. Kerkvliet
2017Current Opinion in Toxicology31 citations Open access
Semantic Scholar
AhR activation increases IL-2 production by alloresponding CD4+ T cells initiating the differentiation of mucosal-homing Tim3+Lag3+ Tr1 cells
Allison K. Ehrlich, Jamie M. Pennington, S. Tilton, Xi-Sheng Wang +8 more
2017European Journal of Immunology30 citations Open access
Semantic Scholar
2,3,7,8 Tetrachlorodibenzo-p-Dioxin (TCDD) Directly Enhances the Maturation and Apoptosis of Dendritic Cells In Vitro
Carl E. Ruby, Castle J. Funatake, N. Kerkvliet
2005Journal of Immunotoxicology30 citations Open access
Semantic Scholar
Aryl Hydrocarbon Receptor-Mediated Perturbations in Gene Expression during Early Stages of CD4+ T-cell Differentiation
D. Rohlman, Duy Pham, Yu Zhen, L. B. Steppan +1 more
2012Front. Immun.29 citations Open access
Semantic Scholar
Role of altered arachidonic acid metabolism in 2,3,7, 8-tetrachlorodibenzo-p-dioxin-induced immune suppression in C57Bl/6 mice.
B. Lawrence, N. Kerkvliet
1998Toxicological Sciences27 citations
Semantic Scholar

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L. B. Steppan×7
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Castle J. Funatake×5
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E. O'Donnell×5
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