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Roger S. Lo · SciRah

Researcher profile · Semantic Scholar

Roger S. Lo

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Roger S. Lo — researcher profile on SciRah

h-index: 58
Works: 128
Citations: 24K

Most-cited papers

Genomic and Transcriptomic Features of Response to Anti-PD-1 Therapy in Metastatic Melanoma
W. Hugo, J. Zaretsky, Lu Sun, Chunying Song +14 more
2016Cell3,107 citations Open access
Semantic Scholar
Interferon Receptor Signaling Pathways Regulating PD-L1 and PD-L2 Expression
A. García-Díaz, D. Shin, B. H. Moreno, Justin D. Saco +15 more
2017Cell Reports1,773 citations Open access
Semantic Scholar
Tumor microenvironment induces innate RAF-inhibitor resistance through HGF secretion
R. Straussman, T. Morikawa, K. Shee, Michal Barzily-Rokni +15 more
2012Nature1,474 citations Open access
Semantic Scholar
Exome sequencing identifies recurrent somatic RAC1 mutations in melanoma
M. Krauthammer, Y. Kong, B. Ha, Perry Evans +26 more
2012Nature Genetics1,158 citations Open access
Semantic Scholar
Acquired resistance and clonal evolution in melanoma during BRAF inhibitor therapy
Hu-Bing Shi, W. Hugo, X. Kong, Aayoung Hong +15 more
2013Cancer Discovery935 citations Open access
Semantic Scholar
Melanoma whole exome sequencing identifies V600EB-RAF amplification-mediated acquired B-RAF inhibitor resistance
Hu-Bing Shi, G. Moriceau, X. Kong, Mi-Kyung Lee +12 more
2012Nature Communications647 citations Open access
Semantic Scholar
Low MITF/AXL ratio predicts early resistance to multiple targeted drugs in melanoma
J. Müller, O. Krijgsman, J. Tsoi, L. Robert +15 more
2014Nature Communications602 citations Open access
Semantic Scholar
Non-genomic and Immune Evolution of Melanoma Acquiring MAPKi Resistance
W. Hugo, Hu-Bing Shi, Lu Sun, M. Piva +9 more
2015Cell581 citations Open access
Semantic Scholar
RAS Mutations in Cutaneous Squamous-Cell Carcinomas in Patients Treated with BRAF Inhibitors
F. Su, A. Virós, C. Milagre, K. Trunzer +49 more
2012New England Journal of Medicine550 citations Open access
Semantic Scholar
Therapy-induced tumour secretomes promote resistance and tumour progression
A. Obenauf, Yi-Long Zou, A. Ji, S. Vanharanta +8 more
2015Nature451 citations Open access
Semantic Scholar
Pharmacodynamic effects and mechanisms of resistance to vemurafenib in patients with metastatic melanoma.
K. Trunzer, A. Pavlick, L. Schuchter, R. Gonzalez +25 more
2013Journal of Clinical Oncology363 citations Open access
Semantic Scholar
sFRP2 in the aged microenvironment drives melanoma metastasis and therapy resistance
Amanpreet Kaur, Marie R. Webster, K. Marchbank, Reeti Behera +42 more
2016Nature357 citations Open access
Semantic Scholar
Regional Glutamine Deficiency in Tumours Promotes De-differentiation through Inhibition of Histone Demethylation
Min Pan, Michael A. Reid, X. Lowman, Rajan P. Kulkarni +15 more
2016Nature Cell Biology343 citations Open access
Semantic Scholar
MDM4 is a key therapeutic target in cutaneous melanoma
Agnieszka Gembarska, F. Luciani, C. Fedele, Elisabeth A. Russell +18 more
2012Nature Medicine314 citations Open access
Semantic Scholar
Tunable-combinatorial Mechanisms of Acquired Resistance Limit the Efficacy of BRAF/MEK Co-targeting but Result in Melanoma Drug Addiction
G. Moriceau, W. Hugo, Aayoung Hong, Hu-Bing Shi +15 more
2015Cancer Cell312 citations Open access
Semantic Scholar
Acquired BRAF inhibitor resistance: a multicenter meta-analysis of the spectrum and frequencies, clinical behavior, and phenotypic associations of resistance mechanisms
Douglas B. Johnson, A. Menzies, L. Zimmer, Z. Eroglu +23 more
2015European Journal of Cancer305 citations Open access
Semantic Scholar
Response of BRAF mutant melanoma to BRAF inhibition is mediated by a network of transcriptional regulators of glycolysis
T. Parmenter, Margarete Kleinschmidt, K. Kinross, S. Bond +18 more
2014Cancer Discovery277 citations Open access
Semantic Scholar
Polymer Nanofiber-Embedded Microchips for Detection, Isolation, and Molecular Analysis of Single Circulating Melanoma Cells
S. Hou, Libo Zhao, Qing-Lin Shen, Jue-Hua Yu +15 more
2013Angewandte Chemie214 citations Open access
Semantic Scholar
Glucose deprivation activates a metabolic and signaling amplification loop leading to cell death
N. Graham, M. Tahmasian, B. Kohli, Evangelia Komisopoulou +9 more
2012Molecular Systems Biology207 citations Open access
Semantic Scholar
A novel AKT1 mutant amplifies an adaptive melanoma response to BRAF inhibition
Hu-Bing Shi, Aayoung Hong, X. Kong, R. Koya +11 more
2013Cancer Discovery174 citations Open access
Semantic Scholar
Phylogenetic analyses of melanoma reveal complex patterns of metastatic dissemination
J. Sanborn, Jongsuk Chung, E. Purdom, Nicholas Wang +19 more
2015Proceedings of the National Academy of Sciences of the United States of America169 citations Open access
Semantic Scholar
The heat shock protein-90 inhibitor XL888 overcomes BRAF inhibitor resistance mediated through diverse mechanisms
Kim H. T. Paraiso, H. E. Haarberg, Elizabeth R. Wood, Vito W. Rebecca +10 more
2012Clinical Cancer Research164 citations Open access
Semantic Scholar
Recurrent tumor cell-intrinsic and -extrinsic alterations during MAPKi-induced melanoma regression and early adaptation
Chunying Song, M. Piva, Lu Sun, Aayoung Hong +15 more
2017Cancer Discovery145 citations Open access
Semantic Scholar
Targeted profiling of human extrachromosomal DNA by CRISPR-CATCH
King L. Hung, J. Luebeck, S. R. Dehkordi, Caterina I. Colón +22 more
2021bioRxiv121 citations Open access
Semantic Scholar
Anti-PD-1/L1 lead-In before MAPK inhibitor combination maximizes antitumor immunity and efficacy
Yu-Jue Wang, Si-Xue Liu, Zhen-Tao Yang, A. Algazi +17 more
2021Cancer Cell116 citations Open access
Semantic Scholar
Vemurafenib resistance reprograms melanoma cells towards glutamine dependence
Jenny E. Hernandez-Davies, Thai Q. Tran, Michael A. Reid, K. Rosales +7 more
2015Journal of Translational Medicine110 citations Open access
Semantic Scholar
Preexisting MEK1 Exon 3 Mutations in V600E/KBRAF Melanomas Do Not Confer Resistance to BRAF Inhibitors
Hu-Bing Shi, G. Moriceau, X. Kong, R. Koya +11 more
2012Cancer Discovery108 citations Open access
Semantic Scholar
Antitumor activity of the ERK inhibitor SCH722984 against BRAF mutant, NRAS mutant and wild-type melanoma
D. Wong, L. Robert, M. Atefi, Amanda Lassen +10 more
2014Molecular Cancer104 citations Open access
Semantic Scholar
Neoadjuvant presurgical PD-1 inhibition in oral cavity squamous cell carcinoma
H. Knochelmann, J. Horton, Si-Xue Liu, K. Armeson +22 more
2019Cell Reports Medicine100 citations Open access
Semantic Scholar
Continuous versus intermittent BRAF and MEK inhibition in patients with BRAF mutated melanoma: a randomized phase 2 trial
A. Algazi, M. Othus, A. Daud, Roger S. Lo +16 more
2020Nature Medicine98 citations Open access
Semantic Scholar
The State of Melanoma: Challenges and Opportunities
G. Merlino, M. Herlyn, D. Fisher, B. Bastian +38 more
2016Pigment Cell & Melanoma Research98 citations Open access
Semantic Scholar
Multimodel preclinical platform predicts clinical response of melanoma to immunotherapy
Eva Pérez-Guijarro, H. Yang, R. Araya, R. El Meskini +21 more
2020Nature Medicine94 citations Open access
Semantic Scholar
The RNA-binding Protein MEX3B Mediates Resistance to Cancer Immunotherapy by Downregulating HLA-A Expression
Lu Huang, Shruti Malu, Jodi A. McKenzie, M. Andrews +22 more
2018Clinical Cancer Research88 citations Open access
Semantic Scholar
Exploiting drug addiction mechanisms to select against MAPKi-resistant melanoma
Aayoung Hong, G. Moriceau, Lu Sun, Shirley H. Lomeli +6 more
2017Cancer Discovery88 citations Open access
Semantic Scholar
Mixed Lineage Kinases Activate MEK Independently of RAF to Mediate Resistance to RAF Inhibitors
A. Marusiak, Zoe C. Edwards, W. Hugo, Eleanor W. Trotter +11 more
2014Nature Communications83 citations Open access
Semantic Scholar
Intratumoral Molecular Heterogeneity in a BRAF-Mutant, BRAF Inhibitor-Resistant Melanoma: A Case Illustrating the Challenges for Personalized Medicine
J. Wilmott, V. Tembe, J. Howle, Raghwa N. Sharma +6 more
2012Molecular Cancer Therapeutics80 citations
Semantic Scholar
Blocking Genomic Instability Prevents Acquired Resistance to MAPK Inhibitor Therapy in Melanoma
Prashanthi Dharanipragada, Xiao Zhang, Si-Xue Liu, Shirley H. Lomeli +9 more
2023Cancer Discovery74 citations Open access
Semantic Scholar
Plasticity of extrachromosomal and intrachromosomal BRAF amplifications in overcoming targeted therapy dosage challenges
Kai Song, Jenna K. Minami, Arthur Huang, S. R. Dehkordi +27 more
2021Cancer Discovery73 citations Open access
Semantic Scholar
JUN dependency in distinct early and late BRAF inhibition adaptation states of melanoma
B. Titz, A. Lomova, A. Le, W. Hugo +13 more
2016Cell Discovery67 citations Open access
Semantic Scholar
Cutaneous wound healing through paradoxical MAPK activation by BRAF inhibitors
Helena Escuin-Ordinas, Shuoran Li, Michael W. Xie, Lu Sun +18 more
2016Nature Communications66 citations Open access
Semantic Scholar
Future perspectives in melanoma research. Meeting report from the “Melanoma Bridge. Napoli, December 2nd-4th 2012”
P. Ascierto, A. Grimaldi, Nicolas Acquavella, L. Borgognoni +34 more
2013Journal of Translational Medicine64 citations Open access
Semantic Scholar
Durable Suppression of Acquired MEK Inhibitor Resistance in Cancer by Sequestering MEK from ERK and Promoting Anti-Tumor T-cell Immunity
Aayoung Hong, M. Piva, Si-Xue Liu, W. Hugo +21 more
2020Cancer Discovery62 citations Open access
Semantic Scholar
Rho-mediated signaling promotes BRAF inhibitor resistance in de-differentiated melanoma cells
Sean A. Misek, K. Appleton, T. Dexheimer, Erika M. Lisabeth +4 more
2019Oncogene53 citations Open access
Semantic Scholar
Future perspectives in melanoma research: meeting report from the “Melanoma Bridge”: Napoli, December 3rd–6th 2014
P. Ascierto, M. Atkins, C. Bifulco, G. Botti +33 more
2013Journal of Translational Medicine51 citations Open access
Semantic Scholar
Response and recurrence correlates in individuals treated with neoadjuvant anti-PD-1 therapy for resectable oral cavity squamous cell carcinoma
Si-Xue Liu, H. Knochelmann, Shirley H. Lomeli, Aayoung Hong +15 more
2021Cell Reports Medicine50 citations Open access
Semantic Scholar
High-Speed Live-Cell Interferometry: A New Method for Quantifying Tumor Drug Resistance and Heterogeneity.
Dian Huang, K. Leslie, Daniel Guest, Olga Yeshcheulova +7 more
2018Analytical Chemistry40 citations
Semantic Scholar
Enhancing PD-L1 Degradation by ITCH during MAPK Inhibitor Therapy Suppresses Acquired Resistance
Zhen-Tao Yang, Yan Wang, Si-Xue Liu, Weixian Deng +5 more
2022Cancer Discovery35 citations Open access
Semantic Scholar
Receptor tyrosine kinases in cancer escape from BRAF inhibitors
Roger S. Lo
2012Cell Research33 citations Open access
Semantic Scholar
Multi-organ landscape of therapy-resistant melanoma
Si-Xue Liu, Prashanthi Dharanipragada, Shirley H. Lomeli, Yan Wang +10 more
2023Nature Medicine29 citations Open access
Semantic Scholar
SPRED1 deletion confers resistance to MAPK inhibition in melanoma
Julien Ablain, Si-Xue Liu, G. Moriceau, Roger S. Lo +1 more
2020Journal of Experimental Medicine26 citations Open access
Semantic Scholar

Frequent co-authors

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A. Ribas×27
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A. Ribas — researcher profile on SciRah
G. Moriceau×20
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G. Moriceau — researcher profile on SciRah
W. Hugo×17
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W. Hugo — researcher profile on SciRah
X. Kong×15
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X. Kong — researcher profile on SciRah

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J. Sosman — researcher profile on SciRah

Shirley H. Lomeli×12

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Shirley H. Lomeli — researcher profile on SciRah

Aayoung Hong×11

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Aayoung Hong — researcher profile on SciRah

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G. Long — researcher profile on SciRah

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Hu-Bing Shi — researcher profile on SciRah

Douglas B. Johnson×8

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Douglas B. Johnson — researcher profile on SciRah

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Si-Xue Liu — researcher profile on SciRah

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Lu Sun — researcher profile on SciRah