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G. Doss · SciRah

Researcher profile · Semantic Scholar

G. Doss

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G. Doss — researcher profile on SciRah

h-index: 30
Works: 112
Citations: 3,088

Most-cited papers

Studies on the metabolism of troglitazone to reactive intermediates in vitro and in vivo. Evidence for novel biotransformation pathways involving quinone methide formation and thiazolidinedione ring scission.
K. Kassahun, P. Pearson, Wei Tang, Ian Mcintosh +6 more
2001Chemical Research in Toxicology273 citations
Semantic Scholar
Metabolic activation of diclofenac by human cytochrome P450 3A4: role of 5-hydroxydiclofenac.
S. Shen, M. Marchick, M. Davis, G. Doss +1 more
1999Chemical Research in Toxicology188 citations
Semantic Scholar
Studies on cytochrome P-450-mediated bioactivation of diclofenac in rats and in human hepatocytes: identification of glutathione conjugated metabolites.
Wei Tang, R. Stearns, S. Bandiera, Yong Zhang +11 more
1999Drug Metabolism And Disposition186 citations
Semantic Scholar
Omarigliptin (MK-3102): a novel long-acting DPP-4 inhibitor for once-weekly treatment of type 2 diabetes.
T. Biftu, Ranabir Sinha-Roy, Ping Chen, Xiaoxia Qian +25 more
2014Journal of Medicinal Chemistry150 citations Open access
Semantic Scholar
Cytochrome P450 3A4-mediated bioactivation of raloxifene: irreversible enzyme inhibition and thiol adduct formation.
Qing Chen, J. Ngui, G. Doss, R. Wang +8 more
2002Chemical Research in Toxicology143 citations
Semantic Scholar
Bioactivation of diclofenac via benzoquinone imine intermediates-identification of urinary mercapturic acid derivatives in rats and humans.
G. Poon, Qing Chen, Y. Teffera, J. Ngui +8 more
2001Drug Metabolism And Disposition96 citations
Semantic Scholar
Rational design of a novel, potent, and orally bioavailable cyclohexylamine DPP-4 inhibitor by application of molecular modeling and X-ray crystallography of sitagliptin.
T. Biftu, G. Scapin, Suresh B. Singh, D. Feng +13 more
2007Bioorganic & Medicinal Chemistry Letters72 citations Open access
Semantic Scholar
Zafirlukast Metabolism by Cytochrome P450 3A4 Produces an Electrophilic α,β-Unsaturated Iminium Species That Results in the Selective Mechanism-Based Inactivation of the Enzyme
K. Kassahun, K. Skordos, Ian Mcintosh, Donald E. Slaughter +3 more
200565 citations
Semantic Scholar
Asymmetric Synthesis of Chiral, Nonracemic Trifluoromethyl-Substituted Piperidines and Decahydroquinolines
Jin-Long Jiang, R. DeVita, G. Doss, Mark T. Goulet +1 more
199963 citations
Semantic Scholar
Characterization of 1′-Hydroxymidazolam Glucuronidation in Human Liver Microsomess⃞
Bing Zhu, D. Bush, G. Doss, S. Vincent +2 more
2008Drug Metabolism And Disposition58 citations
Semantic Scholar
Dipeptidyl peptidase IV inhibitors derived from beta-aminoacylpiperidines bearing a fused thiazole, oxazole, isoxazole, or pyrazole.
W. Ashton, Rosemary M Sisco, Hong-Ru Dong, K. Lyons +8 more
2005Bioorganic & Medicinal Chemistry Letters58 citations Open access
Semantic Scholar
EVIDENCE FOR THE BIOACTIVATION OF ZOMEPIRAC AND TOLMETIN BY AN OXIDATIVE PATHWAY: IDENTIFICATION OF GLUTATHIONE ADDUCTS IN VITRO IN HUMAN LIVER MICROSOMES AND IN VIVO IN RATS
Qing Chen, G. Doss, Elaine C. Tung, Wensheng Liu +9 more
2006Drug Metabolism And Disposition56 citations
Semantic Scholar
Addressing Metabolic Activation as an Integral Component of Drug Design
G. Doss, T. Baillie
2006Drug metabolism reviews (Softcover ed.)53 citations
Semantic Scholar
In Vitro Metabolic Activation of Lumiracoxib in Rat and Human Liver Preparations
Ying Li, J. G. Slatter, Zhou-Peng Zhang, Yan Li +6 more
2008Drug Metabolism And Disposition50 citations
Semantic Scholar
In vitro bioactivation of dihydrobenzoxathiin selective estrogen receptor modulators by cytochrome P450 3A4 in human liver microsomes: formation of reactive iminium and quinone type metabolites.
Zhou-Peng Zhang, Qing Chen, Ying Li, G. Doss +11 more
2005Chemical Research in Toxicology50 citations
Semantic Scholar
Synthesis of apicidin-derived quinolone derivatives: parasite-selective histone deacetylase inhibitors and antiproliferative agents.
P. Meinke, S. Colletti, G. Doss, R. W. Myers +8 more
2000Journal of Medicinal Chemistry50 citations Open access
Semantic Scholar
Synthesis and activity of 4,5-diarylimidazoles as human CB1 receptor inverse agonists.
C. Plummer, P. Finke, S. Mills, Jun-Ying Wang +11 more
2005Bioorganic & Medicinal Chemistry Letters48 citations Open access
Semantic Scholar
Determination of efavirenz, a selective non-nucleoside reverse transcriptase inhibitor, in human plasma using HPLC with post-column photochemical derivatization and fluorescence detection.
C. Z. Matthews, Eric Woolf, Ralph S. Mazenko, H. Haddix-Wiener +4 more
2002Journal of Pharmaceutical and Biomedical Analysis47 citations
Semantic Scholar
The disposition and metabolism of rofecoxib, a potent and selective cyclooxygenase-2 inhibitor, in human subjects.
R. A. Halpin, A. Porras, L. Geer, M. Davis +10 more
2002Drug Metabolism And Disposition46 citations
Semantic Scholar
Disposition and metabolism of the hypoglycemic agent pioglitazone in rats.
P. Krieter, A. Colletti, G. Doss, Randy R. Miller
1994Drug Metabolism And Disposition46 citations
Semantic Scholar
Identification in rat bile of glutathione conjugates of fluoromethyl 2,2-difluoro-1-(trifluoromethyl)vinyl ether, a nephrotoxic degradate of the anesthetic agent sevoflurane.
Lixia Jin, Margaret R. Davis, E. Kharasch, G. Doss +1 more
1996Chemical Research in Toxicology45 citations
Semantic Scholar
Discovery of (2S)-N-[(1R)-2-[4-cyclohexyl-4-[[(1,1-dimethylethyl)amino]carbonyl]-1-piperidinyl]-1-[(4-fluorophenyl)methyl]-2-oxoethyl]-4-methyl-2-piperazinecarboxamide (MB243), a potent and selective melanocortin subtype-4 receptor agonist.
B. Palucki, M. Park, R. Nargund, Zhi-Xiong Ye +21 more
2005Bioorganic & Medicinal Chemistry Letters40 citations Open access
Semantic Scholar
Glucuronidation, oxidative metabolism, and bioactivation of enterolactone in rhesus monkeys.
B. Dean, Steve W Chang, G. Doss, C. King +1 more
2004Archives of Biochemistry and Biophysics40 citations
Semantic Scholar
Metabolic activation of a 1,3-disubstituted piperazine derivative: evidence for a novel ring contraction to an imidazoline.
G. Doss, Randall R. Miller, Zhou-Peng Zhang, Y. Teffera +7 more
2005Chemical Research in Toxicology38 citations
Semantic Scholar
Conformational analysis and receptor docking of N-[(1S,2S)-3-(4-chlorophenyl)-2-(3-cyanophenyl)-1-methylpropyl]-2-methyl-2-{[5-(trifluoromethyl)pyridin-2-yl]oxy}propanamide (taranabant, MK-0364), a novel, acyclic cannabinoid-1 receptor inverse agonist.
L. Lin, Sookhee N. Ha, R. Ball, N. Tsou +7 more
2008Journal of Medicinal Chemistry37 citations Open access
Semantic Scholar
The metabolic disposition of aprepitant, a substance P receptor antagonist, in rats and dogs.
S. Huskey, B. Dean, G. Doss, Zhen Wang +12 more
2004Drug Metabolism And Disposition34 citations
Semantic Scholar
Mechanistic studies on the reversible metabolism of rofecoxib to 5-hydroxyrofecoxib in the rat: evidence for transient ring opening of a substituted 2-furanone derivative using stable isotope-labeling techniques.
Thomas A. Baillie, R. A. Halpin, B. Matuszewski, L. Geer +8 more
2001Drug Metabolism And Disposition34 citations
Semantic Scholar
Zafirlukast metabolism by cytochrome P450 3A4 produces an electrophilic alpha,beta-unsaturated iminium species that results in the selective mechanism-based inactivation of the enzyme.
K. Kassahun, K. Skordos, Ian Mcintosh, Donald E. Slaughter +3 more
2005Chemical Research in Toxicology30 citations
Semantic Scholar
CCR5 antagonists: bicyclic isoxazolidines as conformationally constrained N-1-substituted pyrrolidines.
C. L. Lynch, Amy L Gentry, J. Hale, S. Mills +18 more
2002Bioorganic & Medicinal Chemistry Letters30 citations Open access
Semantic Scholar
The synthesis of novel 8a-aza-8a-homoerythromycin derivatives via the beckmann rearrangement of (9z)-erythromycin a oxime
R. Wilkening, R. W. Ratcliffe, G. Doss, F. BartizalKenneth +2 more
199330 citations
Semantic Scholar
METABOLIC ACTIVATION OF FLUOROPYRROLIDINE DIPEPTIDYL PEPTIDASE-IV INHIBITORS BY RAT LIVER MICROSOMES
S. Xu, Bing Zhu, Y. Teffera, Deborah E. Pan +5 more
2004Drug Metabolism And Disposition29 citations
Semantic Scholar
Synthesis of the liposidomycin diazepanone nucleoside.
S. Knapp, Gregori J. Morriello, G. Doss
2002Organic Letters29 citations
Semantic Scholar
Absorption, Metabolism, and Excretion of [14C]MK-0524, a Prostaglandin D2 Receptor Antagonist, in Humans
B. Karanam, Maria Madeira, S. Bradley, Larissa A. Wenning +10 more
2007Drug Metabolism And Disposition27 citations
Semantic Scholar
Fused bicyclic pyrrolizinones as new scaffolds for human NK1 antagonists.
Gregori J. Morriello, R. DeVita, S. Mills, Jonathan R. Young +13 more
2008Bioorganic & Medicinal Chemistry26 citations Open access
Semantic Scholar
Assignment of the liposidomycin diazepanone stereochemistry.
S. Knapp, Gregori J. Morriello, Santosh R. Nandan, T. Emge +3 more
2001Journal of Organic Chemistry26 citations
Semantic Scholar
Synthesis of functionalized 1,8-naphthyridinones and their evaluation as novel, orally active CB1 receptor inverse agonists.
John S. Debenham, Christina B. Madsen-Duggan, T. F. Walsh, Jun-Ying Wang +16 more
2006Bioorganic & Medicinal Chemistry Letters24 citations Open access
Semantic Scholar
Citrafungins A and B, two new fungal metabolite inhibitors of GGTase I with antifungal activity.
Sheo B. Singh, D. Zink, G. Doss, J. Polishook +6 more
2004Organic Letters22 citations Open access
Semantic Scholar
Diastereoselective synthesis and configuration-dependent activity of (3-substituted-cycloalkyl)glycine pyrrolidides and thiazolidides as dipeptidyl peptidase IV inhibitors.
W. Ashton, Hong-Ru Dong, Rosemary M Sisco, G. Doss +6 more
2004Bioorganic & Medicinal Chemistry Letters21 citations Open access
Semantic Scholar
Metabolism and Renal Elimination of Gaboxadol in Humans: Role of UDP-Glucuronosyltransferases and Transporters
X. Chu, Yuexia Liang, Xiaoxin Cai, Karla G. Cuevas-Licea +7 more
2009Pharmaceutical Research20 citations
Semantic Scholar
Short synthesis of octosyl nucleosides.
S. Knapp, V. Thakur, M. R. Madduru, Krishnan Malolanarasimhan +2 more
2006Organic Letters20 citations
Semantic Scholar
Identification of a hydroxylamine glucuronide metabolite of an oral hypoglycemic agent.
Randall R. Miller, G. Doss, R. Stearns
2004Drug Metabolism And Disposition20 citations
Semantic Scholar
Potent Kv1.3 inhibitors from correolide-modification of the C18 position.
Jian-Ming Bao, S. Miao, F. Kayser, Andrew Kotliar +15 more
2005Bioorganic & Medicinal Chemistry Letters19 citations Open access
Semantic Scholar
2-Piperazinecarboxamides as potent and selective melanocortin subtype-4 receptor agonists.
B. Palucki, M. Park, R. Nargund, R. Tang +11 more
2005Bioorganic & Medicinal Chemistry Letters19 citations Open access
Semantic Scholar
Identification of a new source of interference leached from polypropylene tubes in mass-selective analysis
Yuan-Qing Xia, Shefali R Patel, R. Bakhtiar, R. Franklin +1 more
2005Journal of the American Society for Mass Spectrometry18 citations Open access
Semantic Scholar
IN VITRO METABOLISM OF MK-0767 [(±)-5-[(2,4-DIOXOTHIAZOLIDIN-5-YL)METHYL]-2-METHOXY-N-[[(4-TRIFLUOROMETHYL)-PHENYL] METHYL]BENZAMIDE], A PEROXISOME PROLIFERATOR-ACTIVATED RECEPTOR α/γ AGONIST. II. IDENTIFICATION OF METABOLITES BY LIQUID CHROMATOGRAPHY-TANDEM MASS SPECTROMETRY
David Q. Liu, B. Karanam, G. Doss, Rick R. Sidler +2 more
2004Drug Metabolism And Disposition18 citations
Semantic Scholar
Highly constrained bicyclic VLA-4 antagonists.
Linda L. Chang, Quang T. Truong, G. Doss, M. Maccoss +7 more
2007Bioorganic & Medicinal Chemistry Letters17 citations Open access
Semantic Scholar
Structure-activity-relationship of amide and sulfonamide analogs of omarigliptin.
Ping Chen, D. Feng, Xiaoxia Qian, James M. Apgar +18 more
2015Bioorganic & Medicinal Chemistry Letters16 citations Open access
Semantic Scholar
Metabolism of a thiazole benzenesulfonamide derivative, a potent and elective agonist of the human beta3-adrenergic receptor, in rats: identification of a novel isethionic acid conjugate.
Wei Tang, R. Stearns, Randall R. Miller, J. Ngui +8 more
2002Drug Metabolism And Disposition16 citations
Semantic Scholar
The elusive 8-fluoroadenosine : a simple non-enzymatic synthesis and characterization
G. Butora, C. Schmitt, D. Levorse, E. Streckfuss +2 more
200715 citations
Semantic Scholar
Estrogen receptor ligands. 12. Synthesis of the major metabolites of an ERalpha-selective, dihydrobenzoxathiin antagonist for osteoporosis.
Seongkon Kim, Jane Y. Wu, Zhou-Peng Zhang, Wei Tang +4 more
2005Organic Letters15 citations
Semantic Scholar

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