Skip to content

Home Search Authors Pakistan News Saved

SciRah

SciRah does not host or store research papers. Results come live from free, official scholarly APIs, and every paper links back to its original source.

Data sources

OpenAlex
Semantic Scholar
Crossref
CORE
arXiv
PubMed

Privacy policy Terms of service

X. Brazzolotto · SciRah

Researcher profile · Semantic Scholar

X. Brazzolotto

Share profile

X. Brazzolotto — researcher profile on SciRah

h-index: 26
Works: 123
Citations: 2,967

Most-cited papers

Comparison of the Binding of Reversible Inhibitors to Human Butyrylcholinesterase and Acetylcholinesterase: A Crystallographic, Kinetic and Calorimetric Study
T. Rosenberry, X. Brazzolotto, I. Macdonald, M. Wandhammer +3 more
2017Molecules263 citations Open access
Semantic Scholar
The Magic of Crystal Structure-Based Inhibitor Optimization: Development of a Butyrylcholinesterase Inhibitor with Picomolar Affinity and in Vivo Activity.
U. Košak, B. Brus, D. Knez, S. Žakelj +14 more
2018Journal of Medicinal Chemistry155 citations Open access
Semantic Scholar
Development of an in-vivo active reversible butyrylcholinesterase inhibitor
U. Košak, B. Brus, D. Knez, R. Sink +21 more
2016Scientific Reports146 citations Open access
Semantic Scholar
Discovery of a Potent Dual Inhibitor of Acetylcholinesterase and Butyrylcholinesterase with Antioxidant Activity that Alleviates Alzheimer-like Pathology in Old APP/PS1 Mice.
Elisabet Viayna, N. Coquelle, Monika Cieslikiewicz-Bouet, P. Cisternas +22 more
2020Journal of Medicinal Chemistry92 citations Open access
Semantic Scholar
Novel tacrine-tryptophan hybrids: Multi-target directed ligands as potential treatment for Alzheimer's disease.
K. Chalupova, J. Korábečný, M. Bartolini, Barbara Monti +31 more
2019European journal of medicinal chemistry90 citations Open access
Semantic Scholar
N-Propargylpiperidines with naphthalene-2-carboxamide or naphthalene-2-sulfonamide moieties: Potential multifunctional anti-Alzheimer's agents.
U. Košak, D. Knez, N. Coquelle, B. Brus +6 more
2017Bioorganic & Medicinal Chemistry67 citations Open access
Semantic Scholar
Tryptophan-derived butyrylcholinesterase inhibitors as promising leads against Alzheimer's disease.
A. Meden, D. Knez, M. Jukič, X. Brazzolotto +8 more
2019Chemical Communications57 citations
Semantic Scholar
N-alkylpiperidine carbamates as potential anti-Alzheimer's agents.
U. Košak, Nika Strašek, D. Knez, M. Jukič +7 more
2020European journal of medicinal chemistry42 citations Open access
Semantic Scholar
8-Hydroxyquinolylnitrones as multifunctional ligands for the therapy of neurodegenerative diseases
D. Knez, Daniel Diez-Iriepa, M. Chioua, Andrea Gottinger +19 more
2023Acta Pharmaceutica Sinica B36 citations Open access
Semantic Scholar
Rivastigmine and metabolite analogues with putative Alzheimer’s disease-modifying properties in a Caenorhabditis elegans model
Satish N. Dighe, E. de la Mora, S. Chan, Srinivas Kantham +12 more
2019Communications Chemistry35 citations Open access
Semantic Scholar
Bacterial Expression of Human Butyrylcholinesterase as a Tool for Nerve Agent Bioscavengers Development
X. Brazzolotto, A. Igert, V. Guillon, G. Santoni +1 more
2017Molecules32 citations Open access
Semantic Scholar
Multi-target-directed ligands for treating Alzheimer's disease: Butyrylcholinesterase inhibitors displaying antioxidant and neuroprotective activities.
D. Knez, N. Coquelle, A. Pišlar, S. Žakelj +8 more
2018European journal of medicinal chemistry28 citations Open access
Semantic Scholar
Diisopropylfluorophosphate-induced status epilepticus drives complex glial cell phenotypes in adult male mice.
Clémence Maupu, J. Enderlin, A. Igert, M. Oger +7 more
2021Neurobiology of Disease26 citations Open access
Semantic Scholar
Structure-activity relationship study of tryptophan-based butyrylcholinesterase inhibitors.
A. Meden, D. Knez, Natalia Malikowska-Racia, X. Brazzolotto +5 more
2020European journal of medicinal chemistry26 citations Open access
Semantic Scholar
From tryptophan-based amides to tertiary amines: Optimization of a butyrylcholinesterase inhibitor series.
A. Meden, D. Knez, X. Brazzolotto, F. Nachon +5 more
2022European journal of medicinal chemistry24 citations Open access
Semantic Scholar
Development and crystallography-aided SAR studies of multifunctional BuChE inhibitors and 5-HT6R antagonists with β-amyloid anti-aggregation properties.
T. Wichur, Justyna Godyń, Izabella Góral, G. Latacz +14 more
2021European journal of medicinal chemistry24 citations Open access
Semantic Scholar
Enantioseparation, in vitro testing, and structural characterization of triple-binding reactivators of organophosphate-inhibited cholinesterases.
N. Maraković, A. Knežević, Igor Rončević, X. Brazzolotto +2 more
2020Biochemical Journal22 citations Open access
Semantic Scholar
Discovery of 1-(phenylsulfonyl)-1H-indole-based multifunctional ligands targeting cholinesterases and 5-HT6 receptor with anti-aggregation properties against amyloid-beta and tau.
T. Wichur, Anna Pasieka, Justyna Godyń, Dawid Panek +13 more
2021European journal of medicinal chemistry21 citations Open access
Semantic Scholar
Development of potent reversible selective inhibitors of butyrylcholinesterase as fluorescent probes
S. Pajk, D. Knez, U. Košak, M. Zorović +7 more
2020Journal of Enzyme Inhibition and Medicinal Chemistry21 citations Open access
Semantic Scholar
Discovery of multifunctional anti-Alzheimer's agents with a unique mechanism of action including inhibition of the enzyme butyrylcholinesterase and γ-aminobutyric acid transporters.
Anna Pasieka, Dawid Panek, Jakub Jończyk, Justyna Godyń +16 more
2021European journal of medicinal chemistry18 citations Open access
Semantic Scholar
Pseudo-irreversible butyrylcholinesterase inhibitors: Structure-activity relationships, computational and crystallographic study of the N-dialkyl O-arylcarbamate warhead.
A. Meden, D. Knez, X. Brazzolotto, Fabrice Modeste +9 more
2022European journal of medicinal chemistry17 citations Open access
Semantic Scholar
Discovery of new, highly potent and selective inhibitors of BuChE - design, synthesis, in vitro and in vivo evaluation and crystallography studies.
Dawid Panek, Anna Pasieka, G. Latacz, Paula Zaręba +13 more
2023European journal of medicinal chemistry16 citations Open access
Semantic Scholar
Fine-Tuning the Biological Profile of Multitarget Mitochondriotropic Antioxidants for Neurodegenerative Diseases
D. Chavarria, O. Da Silva, S. Benfeito, S. Barreiro +9 more
2021Antioxidants16 citations Open access
Semantic Scholar
Efficacy Assessment of an Uncharged Reactivator of NOP-Inhibited Acetylcholinesterase Based on Tetrahydroacridine Pyridine-Aldoxime Hybrid in Mouse Compared to Pralidoxime
A. Calas, A. Hanak, N. Jaffré, A. Nervo +15 more
2020Biomolecules16 citations Open access
Semantic Scholar
Highly selective butyrylcholinesterase inhibitors related to Amaryllidaceae alkaloids - Design, synthesis, and biological evaluation.
Filip Pidaný, J. Křoustková, A. al Mamun, Daniela Suchánková +16 more
2023European journal of medicinal chemistry13 citations
Semantic Scholar
X-ray structures of human bile-salt activated lipase conjugated to nerve agents surrogates.
C. Touvrey, C. Courageux, V. Guillon, R. Terreux +2 more
2019Toxicology13 citations
Semantic Scholar
Lead Optimization of a Butyrylcholinesterase Inhibitor for the Treatment of Alzheimer’s Disease
U. Košak, Nika Strašek Benedik, D. Knez, S. Žakelj +21 more
2025Journal of Medicinal Chemistry11 citations Open access
Semantic Scholar
Purification of recombinant human butyrylcholinesterase on Hupresin®
O. Lockridge, E. David, L. Schopfer, P. Masson +2 more
2018Journal of chromatography. B, Analytical technologies in the biomedical and life sciences11 citations Open access
Semantic Scholar
Multifunctional, Fluorene‐Based Modulator of Cholinergic and GABAergic Neurotransmission as a Novel Drug Candidate for Palliative Treatment of Alzheimer's Disease
Dawid Panek, Anna Pasieka, Jakub Jończyk, Milena Gawlińska +28 more
2024Angewandte Chemie9 citations Open access
Semantic Scholar
Inhibition of Human Cholinesterases and in vitro β‐Amyloid Aggregation by Rationally Designed Peptides
Iván Sanchis, Roque Spinelli, J. Dias, X. Brazzolotto +3 more
2023ChemMedChem9 citations Open access
Semantic Scholar
Rapid discovery of a selective butyrylcholinesterase inhibitor using structure-based virtual screening.
J. Miles, J. S. Kapure, G. S. Deora, C. Courageux +5 more
2020Bioorganic & Medicinal Chemistry Letters8 citations Open access
Semantic Scholar
N-Propargylpyrrolidine-based butyrylcholinesterase and monoamine oxidase inhibitors.
U. Košak, D. Knez, A. Pišlar, Selena Horvat +6 more
2025Chemico-Biological Interactions7 citations Open access
Semantic Scholar
Grid‐Type Quaternary Metallosupramolecular Compounds Inhibit Human Cholinesterases through Dynamic Multivalent Interactions
F. Nachon, X. Brazzolotto, J. Dias, C. Courageux +4 more
2022ChemBioChem7 citations
Semantic Scholar
Characterization of four BCHE mutations associated with prolonged effect of suxamethonium
X. Brazzolotto, S. Courcelle, Christophe Sauvanet, V. Guillon +5 more
2020The Pharmacogenomics Journal7 citations
Semantic Scholar
Rapid discovery and crystallography study of highly potent and selective butylcholinesterase inhibitors based on oxime-containing libraries and conformational restriction strategies.
Lan-Lan Jing, Wenxiu Wei, Bairu Meng, F. Chantegreil +9 more
2023Bioorganic chemistry (Print)6 citations
Semantic Scholar
Discovery of drug‐like acetylcholinesterase inhibitors by rapid virtual screening of a 6.9 million compound database
J. Miles, Jia-Hui Ng, B. Sreenivas, C. Courageux +5 more
2021Chemical Biology and Drug Design6 citations
Semantic Scholar
Structural analysis of point mutations at the Vaccinia virus A20/D4 interface.
Céline Contesto-Richefeu, N. Tarbouriech, X. Brazzolotto, W. P. Burmeister +2 more
2016Acta Crystallographica Section F Structural Biology Communications5 citations Open access
Semantic Scholar
Targeting Neuroinflammation and Cognitive Decline: First-in-Class Dual Butyrylcholinesterase and p38α Mitogen-Activated Protein Kinase Inhibitors
Svit Ferjančič Benetik, M. Proj, D. Knez, U. Košak +24 more
2025Journal of Medicinal Chemistry4 citations Open access
Semantic Scholar
Chiral switch of a butyrylcholinesterase inhibitor for the treatment of Alzheimer's disease.
U. Košak, D. Knez, Svit Ferjančič Benetik, Peter Mastnak Sokolov +13 more
2025Chemico-Biological Interactions4 citations Open access
Semantic Scholar
A Thermophilic Bacterial Esterase for Scavenging Nerve Agents: A Kinetic, Biophysical and Structural Study
J. Bzdrenga, Elodie Trenet, F. Chantegreil, Kévin Bernal +2 more
2021Molecules4 citations Open access
Semantic Scholar
An evolutionary perspective on the first disulfide bond in members of the cholinesterase-carboxylesterase (COesterase) family: Possible outcomes for cholinesterase expression in prokaryotes.
A. Chatonnet, X. Brazzolotto, T. Hotelier, N. Lenfant +2 more
2019Chemico-Biological Interactions4 citations Open access
Semantic Scholar
Dual Cholinergic Modulation in Dementia: Quinuclidine Carbamates Targeting Butyrylcholinesterase and α7 Nicotinic Receptor.
Peter Mastnak-Sokolov, D. Knez, A. Meden, Nika Strašek Benedik +12 more
2025Chemico-Biological Interactions3 citations Open access
Semantic Scholar
Warfare Nerve Agents and Paraoxonase-1 as a Potential Prophylactic Therapy against Intoxication.
A. R. Satvik Iyengar, Prakash Y. Khandave, J. Bzdrenga, F. Nachon +2 more
2024Protein Peptide Letters3 citations
Semantic Scholar
Structure-guided design and synthesis of selective butyrylcholinesterase inhibitors
C. S. W. Law, Ying-Ha Zhe, X. Brazzolotto, K. Yeong
2026Journal of Molecular Structure1 citations Open access
Semantic Scholar
Combining β2-AR agonism with butyrylcholinesterase inhibition, a synergistic neuroprotective action against Alzheimer's disease.
Alice Wang, Thomas Curel, Sylvie Claeysen, Valentin Travers-Lesage +9 more
2026RSC Medicinal Chemistry1 citations Open access
Semantic Scholar
An improved nerve agent bioscavenger based on the fast self‐reactivation mechanism of porcine butyrylcholinesterase
X. Brazzolotto, Sofya Lushchekina, F. Nachon
2026Protein Science1 citations Open access
Semantic Scholar
Leveraging multitargeting BChE-MAO B inhibitors against microglia-related neuroinflammation: in vitro biological evaluation, structure-activity relationships, drug-like properties, and X-ray crystal complexes.
Mariagrazia Rullo, Gabriella La Spada, X. Brazzolotto, Sara Marchese +13 more
2026European journal of medicinal chemistry1 citations Open access
Semantic Scholar
The product of Ellman's reaction inhibits cholinesterases
J. Stojan, X. Brazzolotto
2025Protein Science1 citations
Semantic Scholar
Front Cover: Inhibition of Human Cholinesterases and in vitro β‐Amyloid Aggregation by Rationally Designed Peptides (ChemMedChem 12/2023)
Iván Sanchis, Roque Spinelli, J. Dias, X. Brazzolotto +3 more
2023ChemMedChem1 citations Open access
Semantic Scholar
Human Butyrylcholinesterase in complex with (S)-2-(butylamino)-N-(2-cycloheptylethyl)-3-(1H-indol-3-yl)propanamide
X. Brazzolotto, F. Nachon, M. Harst, D. Knez +1 more
20191 citations
Semantic Scholar

Frequent co-authors

Invite them to SciRah by sharing their profile.

F. Nachon×36
Invite
F. Nachon — researcher profile on SciRah
D. Knez×20
Invite
D. Knez — researcher profile on SciRah
S. Gobec×15
Invite
S. Gobec — researcher profile on SciRah
J. Dias×13
Invite
J. Dias — researcher profile on SciRah

×12

Invite

A. Pišlar — researcher profile on SciRah

Invite

U. Košak — researcher profile on SciRah

Invite

K. Sałat — researcher profile on SciRah

Invite

A. Igert — researcher profile on SciRah

Invite

S. Žakelj — researcher profile on SciRah

Invite

J. Stojan — researcher profile on SciRah

Invite

A. Meden — researcher profile on SciRah

F. Chantegreil×7

Invite

F. Chantegreil — researcher profile on SciRah