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K. Hellström · SciRah

Researcher profile · Semantic Scholar

K. Hellström

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K. Hellström — researcher profile on SciRah

h-index: 71
Works: 273
Citations: 20K

Most-cited papers

Costimulation of antitumor immunity by the B7 counterreceptor for the T lymphocyte molecules CD28 and CTLA-4.
Lie-Ping Chen, S. Ashe, W. Brady, I. Hellström +4 more
1992Cell1,172 citations
Semantic Scholar
Monoclonal antibodies against the 4-1BB T-cell activation molecule eradicate established tumors
I. Melero, W. Shuford, S. A. Newby, A. Aruffo +4 more
1997Nature Medicine1,006 citations
Semantic Scholar
The HE4 (WFDC2) protein is a biomarker for ovarian carcinoma.
I. Hellström, J. Raycraft, M. Hayden-Ledbetter, J. Ledbetter +5 more
2003Cancer Research778 citations
Semantic Scholar
Tumor immunogenicity determines the effect of B7 costimulation on T cell-mediated tumor immunity
Lie-Ping Chen, Patrick Mcgowan, S. Ashe, Janet V. Johnston +3 more
1994Journal of Experimental Medicine541 citations Open access
Semantic Scholar
Cure of xenografted human carcinomas by BR96-doxorubicin immunoconjugates.
P. Trail, D. Willner, S. Lasch, A. Henderson +5 more
1993Science536 citations
Semantic Scholar
Soluble member(s) of the mesothelin/megakaryocyte potentiating factor family are detectable in sera from patients with ovarian carcinoma.
N. Scholler, N. Fu, Yi Yang, Zhengmao Ye +3 more
1999Proceedings of the National Academy of Sciences of the United States of America322 citations Open access
Semantic Scholar
Human papillomavirus type 16 nucleoprotein E7 is a tumor rejection antigen.
Lie-Ping Chen, E. K. Thomas, Shiu-Lok Hu, I. Hellstrom +1 more
1991Proceedings of the National Academy of Sciences of the United States of America253 citations Open access
Semantic Scholar
Costimulation of tumor-reactive CD4+ and CD8+ T lymphocytes by B7, a natural ligand for CD28, can be used to treat established mouse melanoma.
Yiwen Li, Patrick Mcgowan, I. Hellstrom, K. Hellström +1 more
1994Journal of Immunology168 citations
Semantic Scholar
Gene therapy for cancer using single-chain Fv fragments specific for 4-1BB
Zhengmao Ye, I. Hellström, M. Hayden-Ledbetter, A. Dahlin +2 more
2002Nature Medicine163 citations
Semantic Scholar
Overexpression of HER-2 in ovarian carcinomas.
Ingegerd Hellstrom, G. Goodman, J. Pullman, Yi Yang +1 more
2001Cancer Research148 citations
Semantic Scholar
Cutting Edge: CD83 Regulates the Development of Cellular Immunity1
N. Scholler, M. Hayden-Ledbetter, A. Dahlin, I. Hellström +2 more
2002Journal of Immunology146 citations Open access
Semantic Scholar
Cloning and expression of the tumor-associated antigen L6.
J. Marken, G. Schieven, I. Hellstrom, K. Hellström +1 more
1992Proceedings of the National Academy of Sciences of the United States of America126 citations Open access
Semantic Scholar
B7-CD28 costimulation unveils the hierarchy of tumor epitopes recognized by major histocompatibility complex class I-restricted CD8+ cytolytic T lymphocytes
J. Johnston, Alison R. Malacko, M. T. Mizuno, Patrick Mcgowan +4 more
1996Journal of Experimental Medicine111 citations Open access
Semantic Scholar
The X-ray structure of an anti-tumour antibody in complex with antigen
P. Jeffrey, J. Bajorath, Chieh-Ying Y. Chang, D. Yelton +3 more
1995Nature Structural Biology97 citations
Semantic Scholar
CD4+ T cell clones specific for the human p97 melanoma-associated antigen can eradicate pulmonary metastases from a murine tumor expressing the p97 antigen.
M. Kahn, Hiroyuki Sugawara, Patrick Mcgowan, Kiyotaka Okuno +4 more
1991Journal of Immunology96 citations Open access
Semantic Scholar
Immunological ignorance of an E7-encoded cytolytic T-lymphocyte epitope in transgenic mice expressing the E7 and E6 oncogenes of human papillomavirus type 16
I. Melero, M. C. Singhal, Patrick Mcgowan, H. Haugen +5 more
1997Journal of Virology90 citations Open access
Semantic Scholar
Granule membrane protein 140 (GMP140) binds to carcinomas and carcinoma-derived cell lines.
A. Aruffo, Mary T. Dietsch, Helen Wan, K. Hellström +1 more
1992Proceedings of the National Academy of Sciences of the United States of America90 citations Open access
Semantic Scholar
Costimulation by CD48 and B7-1 induces immunity against poorly immunogenic tumors
Yi-Wen Li, K. Hellström, S. A. Newby, Lie-Ping Chen
1996Journal of Experimental Medicine88 citations Open access
Semantic Scholar
Human melanotransferrin (p97) has only one functional iron‐binding site
Edward N. Baker, H. Baker, Clyde A. Smith, Mark R. Stebbins +3 more
1992FEBS Letters86 citations
Semantic Scholar
Effect of adenovirus-mediated heat shock protein expression and oncolysis in combination with low-dose cyclophosphamide treatment on antitumor immune responses.
N. D. Di Paolo, S. Tuve, Shao-Heng Ni, K. Hellström +2 more
2006Cancer Research85 citations Open access
Semantic Scholar
Generation of 5-fluorouracil from 5-fluorocytosine by monoclonal antibody-cytosine deaminase conjugates.
P. Senter, Peter Su, T. Katsuragi, Takuo Sakai +3 more
1991Bioconjugate chemistry78 citations
Semantic Scholar
Anti-tumor antibody BR96 blocks cell migration and binds to a lysosomal membrane glycoprotein on cell surface microspikes and ruffled membranes
J. Garrigues, Joleene Anderson, K. Hellström, I. Hellstrom
1994Journal of Cell Biology77 citations Open access
Semantic Scholar
B7-1/CD80-transduced tumor cells elicit better systemic immunity than wild-type tumor cells admixed with Corynebacterium parvum.
Lie-Ping Chen, Patrick Mcgowan, S. Ashe, Janet V. Johnston +2 more
1994Cancer Research76 citations
Semantic Scholar
Generation of cytotoxic agents by targeted enzymes.
P. Senter, P. M. Wallace, H. Svensson, V. M. Vrudhula +3 more
1993Bioconjugate chemistry76 citations
Semantic Scholar
Antitumor activity of carcinoma-reactive BR96-doxorubicin conjugate against human carcinomas in athymic mice and rats and syngeneic rat carcinomas in immunocompetent rats.
H. Sjögren, M. Isaksson, D. Willner, I. Hellstrom +2 more
1997Cancer Research75 citations
Semantic Scholar
Radioimmunotherapy for advanced breast cancer using I-131-ChL6 antibody.
S. Denardo, L. F. O'Grady, C. Richman, D. Goldstein +7 more
1997Anticancer Research71 citations
Semantic Scholar
Evaluation of ovarian cancer remission markers HE4, MMP7 and Mesothelin by comparison to the established marker CA125
Michèl Schummer, C. Drescher, Robin M Forrest, Shirley Gough +4 more
2011Gynecologic Oncology70 citations Open access
Semantic Scholar
Monoclonal antibody conjugates of doxorubicin prepared with branched linkers: A novel method for increasing the potency of doxorubicin immunoconjugates.
H. King, Derek Yurgaitis, D. Willner, R. A. Firestone +4 more
1999Bioconjugate chemistry70 citations
Semantic Scholar
Use of combinatorial peptide libraries to construct functional mimics of tumor epitopes recognized by MHC class I-restricted cytolytic T lymphocytes
James Blake, Janet V. Johnston, K. Hellström, H. Marquardt +1 more
1996Journal of Experimental Medicine64 citations Open access
Semantic Scholar
A Combinatorial Library Strategy for the Rapid Humanization of Anticarcinoma BR96 Fab*
M. Rosok, D. Yelton, Linda J. Harris, J. Bajorath +7 more
1996Journal of Biological Chemistry62 citations Open access
Semantic Scholar
Regressions and cures of melanoma xenografts following treatment with monoclonal antibody beta-lactamase conjugates in combination with anticancer prodrugs.
D. E. Kerr, G. J. Schreiber, V. M. Vrudhula, H. Svensson +3 more
1995Cancer Research59 citations
Semantic Scholar
Ley specific antibody with potent anti-tumor activity is internalized and degraded in lysosomes.
J. Garrigues, Ursula Garrigues, I. Hellstrom, K. Hellström
1993American Journal of Pathology59 citations
Semantic Scholar
Enhanced delivery improves the efficacy of a tumor-specific doxorubicin immunoconjugate in a human brain tumor xenograft model.
L. G. Remsen, Pamela A. Trail, I. Hellström, K. Hellström +1 more
2000Neurosurgery56 citations
Semantic Scholar
Application of a filamentous phage pVIII fusion protein system suitable for efficient production, screening, and mutagenesis of F(ab) antibody fragments.
W. Huse, Timothy J. Stinchcombe, S. Glaser, Lisa D. Starr +4 more
1992Journal of Immunology54 citations Open access
Semantic Scholar
Antioxidant-induced changes in oxidized DNA
D. Malins, K. Hellström, Katie M. Anderson, P. M. Johnson +1 more
2002Proceedings of the National Academy of Sciences of the United States of America53 citations Open access
Semantic Scholar
Effect of linker variation on the stability, potency, and efficacy of carcinoma-reactive BR64-doxorubicin immunoconjugates.
P. A. Trail, D. Willner, J. Knipe, A. Henderson +16 more
1997Cancer Research53 citations
Semantic Scholar
B7-negative versus B7-positive P815 tumor: differential requirements for priming of an antitumor immune response in lymph nodes.
Gu-Chen Yang, M. T. Mizuno, K. Hellström, Lie-Ping Chen
1997Journal of Immunology47 citations
Semantic Scholar
CD3-mediated activation of tumor-reactive lymphocytes from patients with advanced cancer
I. Hellström, J. Ledbetter, N. Scholler, Yi Yang +5 more
2001Proceedings of the National Academy of Sciences of the United States of America46 citations Open access
Semantic Scholar
Effect of blood-brain barrier disruption on intact and fragmented monoclonal antibody localization in intracerebral lung carcinoma xenografts.
E. Neuwelt, P. Barnett, K. Hellström, I. Hellström +2 more
1994Journal of Nuclear Medicine46 citations
Semantic Scholar
Chimeric L6 anti-tumor antibody. Genomic construction, expression, and characterization of the antigen binding site.
H. Fell, M. Gayle, D. Yelton, L. Lipsich +6 more
1992Journal of Biological Chemistry46 citations Open access
Semantic Scholar
Tumor cells expressing anti-CD137 scFv induce a tumor-destructive environment.
Yi Yang, Shilin Yang, Zhengmao Ye, J. Jaffar +5 more
2007Cancer Research44 citations Open access
Semantic Scholar
Enhanced antitumor activity of paclitaxel in combination with the anticarcinoma immunoconjugate BR96-doxorubicin.
Pamela A. Trail, D. Willner, A. Bianchi, A. Henderson +5 more
1999Clinical Cancer Research44 citations
Semantic Scholar
An unmodified anticarcinoma antibody, BR96, localizes to and inhibits the outgrowth of human tumors in nude mice.
G. J. Schreiber, K. Hellström, I. Hellstrom
1992Cancer Research44 citations
Semantic Scholar
Construction, expression, and activities of L49-sFv-beta-lactamase, a single-chain antibody fusion protein for anticancer prodrug activation.
N. Siemers, D. E. Kerr, S. Yarnold, M. Stebbins +4 more
1997Bioconjugate chemistry43 citations
Semantic Scholar
Role of epidermal growth factor receptor family members in growth and differentiation of breast carcinoma.
B. D. Cohen, C. B. Siegall, S. Bacus, L. Foy +4 more
1998Biochemical Society Symposium41 citations
Semantic Scholar
In vitro and in vivo characterization of BR96 sFv-PE40. A single-chain immunotoxin fusion protein that cures human breast carcinoma xenografts in athymic mice and rats.
Clay B. Siegall, D. Chace, B. Mixan, U. Garrigues +5 more
1994Journal of Immunology41 citations Open access
Semantic Scholar
Differential processing and secretion of the melanoma-associated ME20 antigen.
Grace A. Maresh, Wei-Chun Wang, K. S. Beam, Alison R. Malacko +3 more
1994Archives of Biochemistry and Biophysics41 citations
Semantic Scholar
Modified cytokeratins expressed on the surface of carcinoma cells undergo endocytosis upon binding of human monoclonal antibody and its recombinant Fab fragment.
Henrik J. Ditzel, U. Garrigues, Claus B. Andersen, M. Larsen +5 more
1997Proceedings of the National Academy of Sciences of the United States of America37 citations Open access
Semantic Scholar
Tumor Immunology: An Overview
I. Hellström, K. Hellström
1993Annals of the New York Academy of Sciences37 citations
Semantic Scholar
Radioimmunotherapy for Breast Cancer: Treatment of a Patient with I-131 L6 Chimeric Monoclonal Antibody
S. Denardo, K. A. Warhoe, L. F. O'Grady, I. Hellstrom +5 more
1991International Journal of Biological Markers36 citations
Semantic Scholar

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Patrick Mcgowan×7
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D. Yelton — researcher profile on SciRah

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S. Ashe — researcher profile on SciRah