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S. Bacus · SciRah

Researcher profile · Semantic Scholar

S. Bacus

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S. Bacus — researcher profile on SciRah

h-index: 49
Works: 133
Citations: 8,585

Most-cited papers

Cyclin E and survival in patients with breast cancer.
K. Keyomarsi, S. Tucker, T. Buchholz, M. Callister +8 more
2002New England Journal of Medicine595 citations Open access
Semantic Scholar
A model of acquired autoresistance to a potent ErbB2 tyrosine kinase inhibitor and a therapeutic strategy to prevent its onset in breast cancer
W. Xia, S. Bacus, P. Hegde, I. Husain +8 more
2006Proceedings of the National Academy of Sciences of the United States of America393 citations
Semantic Scholar
Study of the biologic effects of lapatinib, a reversible inhibitor of ErbB1 and ErbB2 tyrosine kinases, on tumor growth and survival pathways in patients with advanced malignancies.
N. Spector, W. Xia, H. Burris, H. Hurwitz +16 more
2005Journal of Clinical Oncology383 citations Open access
Semantic Scholar
Taxol-induced apoptosis depends on MAP kinase pathways (ERK and p38) and is independent of p53
S. Bacus, A. Gudkov, Michael Lowe, L. Lyass +5 more
2001Oncogene375 citations Open access
Semantic Scholar
Transgenic mice with p53‐responsive lacZ: p53 activity varies dramatically during normal development and determines radiation and drug sensitivity in vivo
E. Komarova, M. Chernov, R. Franks, Kaihua Wang +6 more
1997EMBO Journal291 citations Open access
Semantic Scholar
Synergistic down-regulation of receptor tyrosine kinases by combinations of mAbs: implications for cancer immunotherapy.
L. Friedman, Ariel Rinon, B. Schechter, L. Lyass +4 more
2005Proceedings of the National Academy of Sciences of the United States of America243 citations Open access
Semantic Scholar
A reciprocal tensin-3–cten switch mediates EGF-driven mammary cell migration
M. Katz, I. Amit, A. Citri, T. Shay +19 more
2007Nature Cell Biology219 citations
Semantic Scholar
Multi-parameter in vitro toxicity testing of crizotinib, sunitinib, erlotinib, and nilotinib in human cardiomyocytes.
K. Doherty, R. Wappel, Dominique R. Talbert, P. Trusk +5 more
2013Toxicology and Applied Pharmacology168 citations
Semantic Scholar
Epiregulin Is a Potent Pan-ErbB Ligand That Preferentially Activates Heterodimeric Receptor Complexes*
Maya Shelly, R. Pinkas-Kramarski, B. C. Guarino, H. Waterman +8 more
1998Journal of Biological Chemistry168 citations Open access
Semantic Scholar
Regulation of survivin by ErbB2 signaling: therapeutic implications for ErbB2-overexpressing breast cancers.
W. Xia, J. Bisi, J. Strum, Lei-Hua Liu +10 more
2006Cancer Research163 citations Open access
Semantic Scholar
Phase II, Randomized Trial to Compare Anastrozole Combined with Gefitinib or Placebo in Postmenopausal Women with Hormone Receptor–Positive Metastatic Breast Cancer
M. Cristofanilli, V. Valero, A. Mangalik, M. Royce +9 more
2010Clinical Cancer Research160 citations Open access
Semantic Scholar
AKT2 is frequently upregulated in HER-2/neu-positive breast cancers and may contribute to tumor aggressiveness by enhancing cell survival
S. Bacus, D. Altomare, L. Lyass, D. Chin +4 more
2002Oncogene158 citations
Semantic Scholar
Lapatinib antitumor activity is not dependent upon phosphatase and tensin homologue deleted on chromosome 10 in ErbB2-overexpressing breast cancers.
W. Xia, I. Husain, Lei-Hua Liu, S. Bacus +6 more
2007Cancer Research150 citations
Semantic Scholar
ErbB Tyrosine Kinases and the Two Neuregulin Families Constitute a Ligand-Receptor Network
R. Pinkas-Kramarski, Maya Shelly, B. C. Guarino, Ling-Mei Wang +13 more
1998Molecular and Cellular Biology148 citations Open access
Semantic Scholar
An heregulin-EGFR-HER3 autocrine signaling axis can mediate acquired lapatinib resistance in HER2+ breast cancer models
W. Xia, Emanual F. Iii Petricoin, Sumin Zhao, Lei-Hua Liu +9 more
2013Breast Cancer Research147 citations Open access
Semantic Scholar
Pharmacodynamic evaluation of the epidermal growth factor receptor inhibitor OSI-774 in human epidermis of cancer patients.
Shazli N. Malik, L. Siu, E. Rowinsky, L. Degraffenried +6 more
2003Clinical Cancer Research131 citations
Semantic Scholar
Prognostic significance of phosphorylated P38 mitogen‐activated protein kinase and HER‐2 expression in lymph node‐positive breast carcinoma
F. Esteva, Aysegul A. Sahin, T. Smith, Ying Yang +6 more
2004Cancer123 citations Open access
Semantic Scholar
Activation of AMP-activated protein kinase by human EGF receptor 2/EGF receptor tyrosine kinase inhibitor protects cardiac cells
N. Spector, Y. Yarden, Bradley L. Smith, L. Lyass +6 more
2007Proceedings of the National Academy of Sciences of the United States of America121 citations Open access
Semantic Scholar
Epigen, the Last Ligand of ErbB Receptors, Reveals Intricate Relationships between Affinity and Mitogenicity*
B. Kochupurakkal, D. Harari, A. Di Segni, G. Maik-Rachline +12 more
2005Journal of Biological Chemistry112 citations Open access
Semantic Scholar
The oncogenic ErbB-2/ErbB-3 heterodimer is a surrogate receptor of the epidermal growth factor and betacellulin
R. Pinkas-Kramarski, A. Lenferink, S. Bacus, L. Lyass +6 more
1998Oncogene105 citations Open access
Semantic Scholar
EGF103009, a phase II trial of lapatinib monotherapy in patients with relapsed/refractory inflammatory breast cancer (IBC): Clinical activity and biologic predictors of response.
N. Spector, K. Blackwell, J. Hurley, J. Harris +6 more
2006Journal of Clinical Oncology84 citations
Semantic Scholar
Phase II Trial of Dasatinib in Patients with Metastatic Breast Cancer Using Real-Time Pharmacodynamic Tissue Biomarkers of Src Inhibition to Escalate Dosing
C. Herold, V. Chadaram, B. Peterson, P. Marcom +7 more
2011Clinical Cancer Research79 citations Open access
Semantic Scholar
A multi-parameter in vitro screen in human stem cell-derived cardiomyocytes identifies ponatinib-induced structural and functional cardiac toxicity.
Dominique R. Talbert, K. Doherty, P. Trusk, Diarmuid Moran +2 more
2015Toxicological Sciences77 citations Open access
Semantic Scholar
Structural and functional screening in human induced-pluripotent stem cell-derived cardiomyocytes accurately identifies cardiotoxicity of multiple drug types.
K. Doherty, Dominique R. Talbert, P. Trusk, Diarmuid Moran +2 more
2015Toxicology and Applied Pharmacology76 citations
Semantic Scholar
HER2 therapy. Small molecule HER-2 tyrosine kinase inhibitors
N. Spector, W. Xia, I. El-Hariry, Y. Yarden +1 more
2007Breast Cancer Research65 citations Open access
Semantic Scholar
Neu differentiation factor (Heregulin) activates a p53-dependent pathway in cancer cells.
S. Bacus, Y. Yarden, M. Oren, D. Chin +11 more
1996Oncogene63 citations
Semantic Scholar
Activation of AMPK is necessary for killing cancer cells and sparing cardiac cells
S. Shell, L. Lyass, P. Trusk, Karen Pry +2 more
2008Cell Cycle62 citations Open access
Semantic Scholar
Resistance to ErbB2 Tyrosine Kinase Inhibitors in Breast Cancer Is Mediated by Calcium-Dependent Activation of RelA
W. Xia, S. Bacus, I. Husain, Lei-Hua Liu +7 more
2010Molecular Cancer Therapeutics55 citations Open access
Semantic Scholar
KRAS Mutation Status Is Associated with Enhanced Dependency on Folate Metabolism Pathways in Non–Small Cell Lung Cancer Cells
Diarmuid Moran, P. Trusk, Karen Pry, K. Paz +2 more
2014Molecular Cancer Therapeutics54 citations
Semantic Scholar
Genomic and Immunological Tumor Profiling Identifies Targetable Pathways and Extensive CD8+/PDL1+ Immune Infiltration in Inflammatory Breast Cancer Tumors
C. Hamm, Diarmuid Moran, K. Rao, P. Trusk +6 more
2016Molecular Cancer Therapeutics50 citations
Semantic Scholar
Cytoplasmic Cyclin E Predicts Recurrence in Patients with Breast Cancer
K. Hunt, Cansu Karakas, Jin-Ha Min, Anna Biernacka +12 more
2016Clinical Cancer Research49 citations Open access
Semantic Scholar
Intracellular localization of p53 tumor suppressor protein in gamma-irradiated cells is cell cycle regulated and determined by the nucleus.
E. Komarova, Carolyn R. Zelnick, D. Chin, M. Zeremski +3 more
1997Cancer Research49 citations
Semantic Scholar
Truncated ErbB2 expressed in tumor cell nuclei contributes to acquired therapeutic resistance to ErbB2 kinase inhibitors
W. Xia, Zu-Guo Liu, Rongrong Zong, Lei-Hua Liu +13 more
2011Molecular Cancer Therapeutics47 citations Open access
Semantic Scholar
Expression of erbB/HER receptors, heregulin and p38 in primary breast cancer using quantitative immunohistochemistry
F. Esteva, G. Hortobagyi, A. Sahin, T. Smith +5 more
2009Pathology Oncology Research44 citations
Semantic Scholar
Role of epidermal growth factor receptor family members in growth and differentiation of breast carcinoma.
B. D. Cohen, C. B. Siegall, S. Bacus, L. Foy +4 more
1998Biochemical Society Symposium41 citations
Semantic Scholar
A recombinant decoy comprising EGFR and ErbB-4 inhibits tumor growth and metastasis
M. Lindzen, S. Carvalho, A. Starr, N. Ben-Chetrit +6 more
2011Oncogene36 citations Open access
Semantic Scholar
Approaches and limitations of phosphatidylinositol-3-kinase pathway activation status as a predictive biomarker in the clinical development of targeted therapy
C. M. Coughlin, D. S. Johnston, A. Strahs, M. Burczynski +5 more
2010Breast Cancer Research and Treatment30 citations
Semantic Scholar
Lapatinib Plasma and Tumor Concentrations and Effects on HER Receptor Phosphorylation in Tumor
N. Spector, Faith C Robertson, S. Bacus, K. Blackwell +9 more
2015PLoS ONE26 citations Open access
Semantic Scholar
Expression of erbB Receptors and their Ligands in Breast Cancer: Implications to Biological Behavior and Therapeutic Response
S. Bacus, A. V. Gudkov, F. Esteva, Yosef Yarden
2000Breast Disease26 citations
Semantic Scholar
Absence of type I estrogen receptors in choroidal melanoma: analysis of Collaborative Ocular Melanoma Study (COMS) eyes.
R. Grostern, Ilona Slusker Shternfeld, S. Bacus, K. Gilchrist +2 more
2001American journal of ophthalmology-glaucoma19 citations
Semantic Scholar
Potential use of image analysis for the evaluation of cellular predicting factors for therapeutic response in breast cancers.
S. Bacus, D. Chin, J. Stewart, Carolyn R. Zelnick +2 more
1997Analytical and quantitative cytology and histology11 citations
Semantic Scholar
Betacellulin-Pseudomonas toxin fusion proteins bind but are not cytotoxic to cells expressing HER4; correlation of EGFR for cytotoxic activity
B. Mixan, B. D. Cohen, S. Bacus, H. Fell +1 more
1998Oncogene8 citations Open access
Semantic Scholar
ErbB Tyrosine Kinases and the Two Neuregulin Families Constitute a Ligand-Receptor Network
R. Pinkas-Kramarski, Maya Shelly, B. C. Guarino, Ling-Mei Wang +13 more
1998Molecular and Cellular Biology8 citations Open access
Semantic Scholar
Immune profiling reveals the diverse nature of the immune response in NSCLC and reveals signaling pathways that may influence the anti-tumor immune response.
C. Hamm, Karen Pry, Jim Z. Lu, S. Bacus
2019Experimental and molecular pathology (Print)6 citations
Semantic Scholar
Cancer drugs with high repositioning potential for Alzheimer’s disease
Jad Majeed, Marwan N. Sabbagh, Min H. Kang, J. Lawrence +5 more
2023Expert Opinion on Emerging Drugs5 citations Open access
Semantic Scholar
The Role of Myc and the miR-17~92 Cluster in Histone Deacetylase Inhibitor Induced Apoptosis of Solid Tumors
Dominique R. Talbert, R. Wappel, Diarmuid Moran, S. Shell +1 more
20135 citations Open access
Semantic Scholar
Therapeutic Discovery Truncated ErbB 2 Expressed in Tumor Cell Nuclei Contributes to Acquired Therapeutic Resistance to ErbB 2 Kinase Inhibitors
W. Xia, Zuguo Liu, Rongrong Zong, Lei-Hua Liu +13 more
20115 citations
Semantic Scholar
The era of ErbB-receptor-targeted therapies: advances toward personalized medicine.
S. Bacus, N. Spector, Y. Yarden
2005Personalized Medicine5 citations
Semantic Scholar
Cell-free DNA fragmentomes for noninvasive detection of liver cirrhosis and other diseases
A. Annapragada, Z. Foda, Hope Orjuela, Carter Norton +33 more
2026Science Translational Medicine4 citations Open access
Semantic Scholar
Molecular marker correlates of clinical outcome in a phase II study of gefitinib or placebo in combination with anastrozole in postmenopausal women with hormone receptor-positive metastatic breast cancer.
V. Valero, S. Bacus, A. Mangalik, I. Rabinowitz +6 more
20094 citations
Semantic Scholar

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