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J. Ledbetter · SciRah

Researcher profile · Semantic Scholar

J. Ledbetter

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J. Ledbetter — researcher profile on SciRah

h-index: 73
Works: 235
Citations: 30K

Most-cited papers

Monoclonal antibodies against the 4-1BB T-cell activation molecule eradicate established tumors
I. Melero, W. Shuford, S. A. Newby, A. Aruffo +4 more
1997Nature Medicine1,006 citations
Semantic Scholar
4-1BB Costimulatory Signals Preferentially Induce CD8+ T Cell Proliferation and Lead to the Amplification In Vivo of Cytotoxic T Cell Responses
W. Shuford, K. Klussman, Douglas D. Tritchler, D. Loo +10 more
1997Journal of Experimental Medicine891 citations Open access
Semantic Scholar
The HE4 (WFDC2) protein is a biomarker for ovarian carcinoma.
I. Hellström, J. Raycraft, M. Hayden-Ledbetter, J. Ledbetter +5 more
2003Cancer Research778 citations
Semantic Scholar
Differential expression of Fas (CD95) and Fas ligand on normal human phagocytes: implications for the regulation of apoptosis in neutrophils
W. Liles, P. Kiener, J. Ledbetter, A. Aruffo +1 more
1996Journal of Experimental Medicine638 citations Open access
Semantic Scholar
Apoptosis of malignant human B cells by ligation of CD20 with monoclonal antibodies.
Daming Shan, J. Ledbetter, O. Press
1998Blood635 citations
Semantic Scholar
CD40-CD40 ligand interactions in experimental allergic encephalomyelitis and multiple sclerosis.
K. Gerritse, J. Laman, R. Noelle, A. Aruffo +3 more
1996Proceedings of the National Academy of Sciences of the United States of America545 citations Open access
Semantic Scholar
A role for CD5 in TCR-mediated signal transduction and thymocyte selection.
A. Tarakhovsky, S. Kanner, J. Hombach, J. Ledbetter +3 more
1995Science502 citations
Semantic Scholar
Signaling events involved in anti-CD20-induced apoptosis of malignant human B cells
Daming Shan, J. Ledbetter, O. Press
2000Cancer Immunology and Immunotherapy415 citations
Semantic Scholar
Characterization of Human Inducible Costimulator Ligand Expression and Function1
A. Aicher, M. Hayden-Ledbetter, W. Brady, A. Pezzutto +5 more
2000Journal of Immunology271 citations
Semantic Scholar
Studies on the interdependence of gp39 and B7 expression and function during antigen‐specific immune responses
Meenakshi Roy, A. Aruffo, J. Ledbetter, P. Linsley +2 more
1995European Journal of Immunology258 citations
Semantic Scholar
Human monocytic cells contain high levels of intracellular Fas ligand: rapid release following cellular activation.
P. Kiener, P. M. Davis, B. M. Rankin, S. Klebanoff +3 more
1997Journal of Immunology233 citations
Semantic Scholar
Gene therapy for cancer using single-chain Fv fragments specific for 4-1BB
Zhengmao Ye, I. Hellström, M. Hayden-Ledbetter, A. Dahlin +2 more
2002Nature Medicine163 citations
Semantic Scholar
Cutting Edge: CD83 Regulates the Development of Cellular Immunity1
N. Scholler, M. Hayden-Ledbetter, A. Dahlin, I. Hellström +2 more
2002Journal of Immunology146 citations Open access
Semantic Scholar
Role of Oxidative Stress in the Action of Vanadium Phosphotyrosine Phosphatase Inhibitors
C. Krejsa, S. Nadler, J. Esselstyn, T. Kavanagh +2 more
1997Journal of Biological Chemistry133 citations Open access
Semantic Scholar
Association of 75/80-kDa Phosphoproteins and the Tyrosine Kinases Lyn, Fyn, and Lck with the B Cell Molecule CD20
J. Deans, L. Kalt, J. Ledbetter, G. Schieven +2 more
1995Journal of Biological Chemistry119 citations Open access
Semantic Scholar
Longitudinal exposure of human T lymphocytes to weak oxidative stress suppresses transmembrane and nuclear signal transduction.
E. Flescher, J. Ledbetter, G. Schieven, N. Vela‐Roch +4 more
1994Journal of Immunology114 citations Open access
Semantic Scholar
Rapid Activation of Glutamate Cysteine Ligase following Oxidative Stress*
C. Krejsa, C. C. Franklin, Collin C. White, J. Ledbetter +2 more
2010Journal of Biological Chemistry96 citations Open access
Semantic Scholar
Co-ligation of the Antigen and Fc Receptors Gives Rise to the Selective Modulation of Intracellular Signaling in B Cells
P. Kiener, M. Lioubin, L. Rohrschneider, J. Ledbetter +2 more
1997Journal of Biological Chemistry93 citations Open access
Semantic Scholar
TLR7/8 activation in neutrophils impairs immune complex phagocytosis through shedding of FcgRIIA
C. Lood, S. Arve, J. Ledbetter, K. Elkon
2017Journal of Experimental Medicine87 citations Open access
Semantic Scholar
CD83 Is a Sialic Acid-Binding Ig-Like Lectin (Siglec) Adhesion Receptor that Binds Monocytes and a Subset of Activated CD8+ T Cells1
N. Scholler, M. Hayden-Ledbetter, Karl Hellström, I. Hellström +1 more
2001Journal of Immunology81 citations Open access
Semantic Scholar
Identification of Amino Acid Residues Important for Ligand Binding to Fas
G. Starling, J. Bajorath, J. Emswiler, J. Ledbetter +2 more
1997Journal of Experimental Medicine79 citations Open access
Semantic Scholar
IL-2 and IL-15 Regulate CD154 Expression on Activated CD4 T Cells1
S. Skov, M. Bonyhadi, N. Ødum, J. Ledbetter
2000Journal of Immunology78 citations Open access
Semantic Scholar
Neutrophil extracellular traps enriched in oxidized mitochondrial DNA are interferogenic and contribute to lupus-like disease
C. Lood, Luz P. Blanco, M. Purmalek, C. Carmona-Rivera +6 more
2016Nature Medicine75 citations Open access
Semantic Scholar
Ligation of the T-cell Antigen Receptor (TCR) Induces Association of hSos1, ZAP-70, Phospolipase C-γ1, and Other Phosphoproteins with Grb2 and the ζ-Chain of the TCR (*)
A. Nel, Shalini Gupta, Leo M. Lee, J. Ledbetter +1 more
1995Journal of Biological Chemistry72 citations Open access
Semantic Scholar
Rapid and reliable cloning of antibody variable regions and generation of recombinant single chain antibody fragments.
L. Gilliland, N. Norris, H. Marquardt, T. Tsu +5 more
1996Tissue Antigens68 citations
Semantic Scholar
Anti-CD180 (RP105) activates B cells to rapidly produce polyclonal Ig via a T cell and MyD88-independent pathway
Jay W. Chaplin, S. Kasahara, E. Clark, J. Ledbetter
2011Journal of Immunology63 citations Open access
Semantic Scholar
A d-Amino Acid Peptide Inhibitor of NF-κB Nuclear Localization Is Efficacious in Models of Inflammatory Disease
S. M. Fujihara, J. Cleaveland, L. Grosmaire, K. Berry +6 more
2000Journal of Immunology61 citations Open access
Semantic Scholar
Increased RNase expression reduces inflammation and prolongs survival in TLR7 transgenic mice
Xi-Zhang Sun, A. Wiedeman, N. Agrawal, T. Teal +9 more
2013Journal of Immunology50 citations Open access
Semantic Scholar
CD3-mediated activation of tumor-reactive lymphocytes from patients with advanced cancer
I. Hellström, J. Ledbetter, N. Scholler, Yi Yang +5 more
2001Proceedings of the National Academy of Sciences of the United States of America46 citations Open access
Semantic Scholar
CD20-Directed Small Modular Immunopharmaceutical, TRU-015, Depletes Normal and Malignant B Cells
M. Hayden-Ledbetter, C. Cerveny, E. Espling, W. Brady +11 more
2009Clinical Cancer Research44 citations Open access
Semantic Scholar
T Cell Activation Inhibitors Reduce CD8+ T Cell and Pro-Inflammatory Macrophage Accumulation in Adipose Tissue of Obese Mice
V. Montes, M. S. Turner, S. Subramanian, Yi-Lei Ding +10 more
2013PLoS ONE38 citations Open access
Semantic Scholar
Lineage-specific Induction of B Cell Apoptosis and Altered Signal Transduction by the Phosphotyrosine Phosphatase Inhibitor Bis(maltolato)oxovanadium(IV) (*)
G. Schieven, A. F. Wahl, S. Myrdal, L. Grosmaire +1 more
1995Journal of Biological Chemistry37 citations Open access
Semantic Scholar
Activation of human B cells mediated through two distinct cell surface differentiation antigens, Bp35 and Bp50. Proc. Natl. Acad. Sci. 1986. 83: 4494-4498.
E. Clark, J. Ledbetter
2012Journal of Immunology32 citations
Semantic Scholar
Role of oxidative stress in the action of vanadium phosphotyrosine phosphatase inhibitors. Redox independent activation of NF-kappaB.
C. Krejsa, S. Nadler, J. Esselstyn, T. Kavanagh +2 more
1997Journal of Biological Chemistry26 citations
Semantic Scholar
Costimulation by CD28 sFv expressed on the tumor cell surface or as a soluble bispecific molecule targeted to the L6 carcinoma antigen.
M. S. Hayden, L. Grosmaire, N. Norris, L. Gilliland +8 more
1996Tissue Antigens24 citations
Semantic Scholar
CD28/CTLA-4 receptor structure, binding stoichiometry and aggregation during T-cell activation.
P. Linsley, J. Ledbetter, R. Peach, J. Bajorath
1995Research in Immunology24 citations
Semantic Scholar
CD83 is an I-type lectin adhesion receptor that binds monocytes and a subset of activated CD8+ T cells [corrected].
N. Scholler, M. Hayden-Ledbetter, K. E. Hellström, I. Hellström +1 more
2001Journal of Immunology23 citations Open access
Semantic Scholar
Pillars article: T-cell antigen CD28 mediates adhesion with B cells by interacting with activation antigen B7/BB-1. 1990. Proc. Natl. Acad. Sci. USA 87: 5031-5035.
P. Linsley, E. Clark, J. Ledbetter
2009Journal of Immunology19 citations
Semantic Scholar
Ligation of the T-cell antigen receptor (TCR) induces association of hSos1, ZAP-70, phospholipase C-gamma 1, and other phosphoproteins with Grb2 and the zeta-chain of the TCR.
A. Nel, S. Gupta, L. Lee, J. Ledbetter +1 more
1995Journal of Biological Chemistry17 citations
Semantic Scholar
Expression and characterization of recombinant soluble human CD3 molecules: presentation of antigenic epitopes defined on the native TCR-CD3 complex.
C. Law, M. Hayden-Ledbetter, Sonya Buckwalter, L. McNeill +5 more
2002International Immunology15 citations
Semantic Scholar
Tumor necrosis factor-alpha regulates the expression of inducible costimulator receptor ligand on CD34(+) progenitor cells during differentiation into antigen presenting cells.
G. Richter, M. Hayden-Ledbetter, M. Irgang, J. Ledbetter +6 more
2001Journal of Biological Chemistry15 citations
Semantic Scholar
Evolution of epitopes on human and nonhuman primate lymphocyte cell surface antigens
E. Clark, P. Martin, J. Hansen, J. Ledbetter
2004Immunogenetics14 citations
Semantic Scholar
Treatment with monoclonal antibodies (mAbs) against the 4-1BB T-cell activation molecule eradicate established tumors
I. Melero, W. Shuford, S. Ashe-Newby, A. Aruffo +4 more
199711 citations
Semantic Scholar
TRU-015, a novel CD20-directed biologic therapy, demonstrates significant anti-tumor activity in human tumor xenograft models
D. Barone, C. Nilsson, J. Ledbetter, M. Hayden-Ledbetter +1 more
20058 citations
Semantic Scholar
CD37−SMIPTM Drug Induced Caspase Independent Cellular Cytotoxicity Is Associated with Activation of Phosphotyrosine-Mediated Signaling Events in Primary Chronic Lymphocytic Leukemia (CLL) B Cells.
R. Lapalombella, Xiao-Bin Zhao, L. Grosmaire, J. Ledbetter +2 more
20067 citations
Semantic Scholar
Agonistic activity of a CD40-specific single-chain Fv constructed from the variable regions of mAb G28-5.
J. Ledbetter, J. A. Francisco, C. Siegall, L. Gilliland +11 more
1997Critical Reviews in Immunology7 citations
Semantic Scholar
Human thymic epithelial cells present superantigens to T-cell lines and thymocytes.
A. Jłrgensen, M. Nielsen, A. Svejgaard, J. Ledbetter +2 more
1996Experimental and Clinical Immunogenetics7 citations
Semantic Scholar
Antibody engineering.
M. S. Hayden, L. Gilliland, J. Ledbetter
1997Current Opinion in Immunology5 citations
Semantic Scholar
Novel Anti-CD37 Small Modular Immunopharmaceutical (SMIP) Induces B-Cell-Specific, Caspase-Independent Apoptosis in Human CLL Cells.
Xiao-Bin Zhao, S. Biswas, A. Mone, J. Ledbetter +8 more
20044 citations
Semantic Scholar
Apoptosis following interleukin-2-withdraw from T cells: Evidence for a regulatory role of CD18 (β2-integrin) molecules
A. Woetmann, P. Gladstone, J. Ledbetter, A. Svejgaard +2 more
19974 citations
Semantic Scholar

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G. Schieven — researcher profile on SciRah

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P. Kiener — researcher profile on SciRah

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L. Gilliland — researcher profile on SciRah