Skip to content

Home Search Authors Pakistan News Saved

SciRah

SciRah does not host or store research papers. Results come live from free, official scholarly APIs, and every paper links back to its original source.

Data sources

OpenAlex
Semantic Scholar
Crossref
CORE
arXiv
PubMed

Privacy policy Terms of service

T. Hirokawa · SciRah

Researcher profile · Semantic Scholar

T. Hirokawa

Share profile

T. Hirokawa — researcher profile on SciRah

h-index: 33
Works: 204
Citations: 7,605

Most-cited papers

Potential anti-COVID-19 agents, cepharanthine and nelfinavir, and their usage for combination treatment
Hirofumi Ohashi, K. Watashi, Wakana Saso, Kaho Shionoya +26 more
2021iScience154 citations Open access
Semantic Scholar
Ligand binding to human prostaglandin E receptor EP4 at the lipid-bilayer interface
Yosuke Toyoda, Kazushi Morimoto, Ryoji Suno, S. Horita +29 more
2018Nature Chemical Biology113 citations
Semantic Scholar
Temperature-Sensitive Substrate and Product Binding Underlie Temperature-Compensated Phosphorylation in the Clock.
Y. Shinohara, Yohei M. Koyama, Maki Ukai-Tadenuma, T. Hirokawa +7 more
2017Molecules and Cells79 citations Open access
Semantic Scholar
Generation of KS-58 as the first K-Ras(G12D)-inhibitory peptide presenting anti-cancer activity in vivo
Kotaro Sakamoto, T. Masutani, T. Hirokawa
2020Scientific Reports76 citations Open access
Semantic Scholar
Molecular Mechanisms for Sweet-suppressing Effect of Gymnemic Acids*
Keisuke Sanematsu, Y. Kusakabe, Noriatsu Shigemura, T. Hirokawa +3 more
2014Journal of Biological Chemistry73 citations Open access
Semantic Scholar
Multidrug treatment with nelfinavir and cepharanthine against COVID-19
Hirofumi Ohashi, K. Watashi, Wakana Saso, Kaho Shionoya +23 more
2020bioRxiv68 citations Open access
Semantic Scholar
Current Challenges and Opportunities in Designing Protein–Protein Interaction Targeted Drugs
Woong-Hee Shin, Keiko Kumazawa, K. Imai, T. Hirokawa +1 more
2020Advances and Applications in Bioinformatics and Chemistry67 citations Open access
Semantic Scholar
Porin Associates with Tom22 to Regulate the Mitochondrial Protein Gate Assembly.
Haruka Sakaue, Takuya Shiota, Naoya Ishizaka, S. Kawano +10 more
2019Molecules and Cells65 citations
Semantic Scholar
Crystal Structures of Human Orexin 2 Receptor Bound to the Subtype-Selective Antagonist EMPA.
Ryoji Suno, K. Kimura, T. Nakane, K. Yamashita +20 more
2018Structure65 citations Open access
Semantic Scholar
Site-specific Interaction Mapping of Phosphorylated Ubiquitin to Uncover Parkin Activation*♦
Koji Yamano, B. Queliconi, Fumika Koyano, Y. Saeki +3 more
2015Journal of Biological Chemistry57 citations Open access
Semantic Scholar
A small-molecule compound inhibits a collagen-specific molecular chaperone and could represent a potential remedy for fibrosis
S. Ito, K. Ogawa, K. Takeuchi, Motoki Takagi +9 more
2017Journal of Biological Chemistry54 citations Open access
Semantic Scholar
Positive/Negative Allosteric Modulation Switching in an Umami Taste Receptor (T1R1/T1R3) by a Natural Flavor Compound, Methional
Yasuka Toda, Tomoya Nakagita, T. Hirokawa, Yuki Yamashita +5 more
2018Scientific Reports52 citations Open access
Semantic Scholar
Molecular action of larvicidal flavonoids on ecdysteroidogenic glutathione S-transferase Noppera-bo in Aedes aegypti
K. Inaba, Kana Ebihara, M. Senda, Ryunosuke Yoshino +21 more
2022BMC Biology43 citations Open access
Semantic Scholar
Inhibition of cellular RNA methyltransferase abrogates influenza virus capping and replication
Y. Tsukamoto, Takahiro Hiono, Shintaro Yamada, K. Matsuno +26 more
2023Science41 citations
Semantic Scholar
The transcriptional corepressor CtBP2 serves as a metabolite sensor orchestrating hepatic glucose and lipid homeostasis
Motohiro Sekiya, Kenta Kainoh, T. Sugasawa, Ryunosuke Yoshino +9 more
2021Nature Communications34 citations Open access
Semantic Scholar
A multipoint guidance mechanism for β-barrel folding on the SAM complex
H. Takeda, Jon V. Busto, Caroline Lindau, A. Tsutsumi +12 more
2023Nature Structural & Molecular Biology33 citations
Semantic Scholar
Attenuation of SARS‐CoV‐2 replication and associated inflammation by concomitant targeting of viral and host cap 2'‐O‐ribose methyltransferases
Valter Bergant, Shintaro Yamada, V. Grass, Y. Tsukamoto +25 more
2022EMBO Journal33 citations Open access
Semantic Scholar
Ignavine: a novel allosteric modulator of the μ opioid receptor
Katsuya Ohbuchi, C. Miyagi, Yasuyuki Suzuki, Y. Mizuhara +9 more
2016Scientific Reports33 citations Open access
Semantic Scholar
Structural insights into the differences among lactisole derivatives in inhibitory mechanisms against the human sweet taste receptor
Tomoya Nakagita, Akiko Ishida, Takumi Matsuya, Takuya Kobayashi +4 more
2019PLoS ONE32 citations Open access
Semantic Scholar
BDNF Binds Its Pro-Peptide with High Affinity and the Common Val66Met Polymorphism Attenuates the Interaction
K. Uegaki, H. Kumanogoh, T. Mizui, T. Hirokawa +2 more
2017International Journal of Molecular Sciences31 citations Open access
Semantic Scholar
Detailed Analysis of the Binding Mode of Vanilloids to Transient Receptor Potential Vanilloid Type I (TRPV1) by a Mutational and Computational Study
Katsuya Ohbuchi, Y. Mori, Kazuo Ogawa, E. Warabi +2 more
2016PLoS ONE31 citations Open access
Semantic Scholar
Identification of potential inhibitors based on compound proposal contest: Tyrosine-protein kinase Yes as a target
S. Chiba, K. Ikeda, T. Ishida, M. Gromiha +27 more
2015Scientific Reports31 citations Open access
Semantic Scholar
Analysis to Estimate Genetic Variations in the Idarubicin-Resistant Derivative MOLT-3
Tomoyoshi Komiyama, A. Ogura, T. Hirokawa, Zhi-Jing Miao +4 more
2016International Journal of Molecular Sciences29 citations Open access
Semantic Scholar
The Effect of Conformational Flexibility on Binding Free Energy Estimation between Kinases and Their Inhibitors
M. Araki, N. Kamiya, Miwa Sato, M. Nakatsui +2 more
2016Journal of Chemical Information and Modeling29 citations
Semantic Scholar
Protease-resistant modified human β-hexosaminidase B ameliorates symptoms in GM2 gangliosidosis model.
Keisuke Kitakaze, Y. Mizutani, Eiji Sugiyama, Chikako Tasaki +12 more
2016Journal of Clinical Investigation28 citations Open access
Semantic Scholar
Evaluating cepharanthine analogues as natural drugs against SARS‐CoV‐2
A. Hijikata, C. Shionyu-Mitsuyama, S. Nakae, M. Shionyu +6 more
2021FEBS Open Bio27 citations Open access
Semantic Scholar
Design and synthesis of a berberine dimer: a fluorescent ligand with high affinity towards G-quadruplexes.
Masayuki Tera, T. Hirokawa, S. Okabe, Kohtaro Sugahara +2 more
2015Chemistry26 citations
Semantic Scholar
An iterative compound screening contest method for identifying target protein inhibitors using the tyrosine-protein kinase Yes
S. Chiba, T. Ishida, K. Ikeda, M. Mochizuki +27 more
2017Scientific Reports25 citations Open access
Semantic Scholar
A prospective compound screening contest identified broader inhibitors for Sirtuin 1
S. Chiba, M. Ohue, Anastasiia Gryniukova, Petro O. Borysko +49 more
2019Scientific Reports24 citations Open access
Semantic Scholar
Probing the Hydrophobic Binding Pocket of G-Protein-Coupled Lysophosphatidylserine Receptor GPR34/LPS1 by Docking-Aided Structure-Activity Analysis.
Misa Sayama, A. Inoue, Sho Nakamura, Se-Jin Jung +8 more
2017Journal of Medicinal Chemistry22 citations Open access
Semantic Scholar
Privacy-preserving search for chemical compound databases
Kana Shimizu, Koji Nuida, Hiromi Arai, Shigeo Mitsunari +7 more
2015BMC Bioinformatics22 citations Open access
Semantic Scholar
Analysis by metadynamics simulation of binding pathway of influenza virus M2 channel blockers
Yuri Sakai, Atsushi Kawaguchi, K. Nagata, T. Hirokawa
2018Microbiology and immunology18 citations
Semantic Scholar
An integrated approach to unravel a crucial structural property required for the function of the insect steroidogenic Halloween protein Noppera-bo
K. Koiwai, K. Inaba, K. Morohashi, S. Enya +14 more
2020Journal of Biological Chemistry17 citations Open access
Semantic Scholar
Stratifin Inhibits SCFFBW7 Formation and Blocks Ubiquitination of Oncoproteins during the Course of Lung Adenocarcinogenesis
A. Shiba‐Ishii, Jeongmin Hong, T. Hirokawa, Yunjung Kim +6 more
2019Clinical Cancer Research17 citations
Semantic Scholar
Ibuprofen, a nonsteroidal anti-inflammatory drug, is a potent inhibitor of the human sweet taste receptor.
Tomoya Nakagita, Chiaki Taketani, M. Narukawa, T. Hirokawa +2 more
2020Chemical Sensors15 citations
Semantic Scholar
Design and synthesis of unsymmetric macrocyclic hexaoxazole compounds with an ability to induce distinct G-quadruplex topologies in telomeric DNA.
Mai Sakuma, Yue Ma, Yamato Tsushima, Keisuke Iida +2 more
2016Organic and biomolecular chemistry13 citations
Semantic Scholar
Total synthesis and characterization of thielocin B1 as a protein–protein interaction inhibitor of PAC3 homodimer
T. Doi, Masahito Yoshida, K. Ohsawa, K. Shin-ya +6 more
201413 citations
Semantic Scholar
Heme‐dependent recognition of 5‐aminolevulinate synthase by the human mitochondrial molecular chaperone ClpX
K. Nomura, Y. Kitagawa, Marina Aihara, Yusuke Ohki +2 more
2021FEBS Letters12 citations Open access
Semantic Scholar
Unnatural Tripeptides as Potent Positive Allosteric Modulators of T1R2/T1R3.
Kei Yamada, Masakazu Nakazawa, Kayo Matsumoto, Uno Tagami +6 more
2019ACS Medicinal Chemistry Letters12 citations Open access
Semantic Scholar
Synthesis and Telomeric G-Quadruplex-Stabilizing Ability of Macrocyclic Hexaoxazoles Bearing Three Side Chains
Yue Ma, Keisuke Iida, Shogo Sasaki, T. Hirokawa +3 more
2019Molecules12 citations Open access
Semantic Scholar
2-Carba-lysophosphatidic acid is a novel β-lysophosphatidic acid analogue with high potential for lysophosphatidic acid receptor activation and autotaxin inhibition
Keiko Fukasawa, M. Gotoh, Akiharu Uwamizu, T. Hirokawa +7 more
2021Scientific Reports11 citations Open access
Semantic Scholar
EFCAB2 is a novel calcium-binding protein in mouse testis and sperm
Hossam H. Shawki, Yu Ishikawa-Yamauchi, Akihiro Kawashima, Y. Katoh +8 more
2019PLoS ONE11 citations Open access
Semantic Scholar
Development of G-quadruplex ligands for selective induction of a parallel-type topology.
Yue Ma, Yamato Tsushima, Mai Sakuma, Shogo Sasaki +5 more
2018Organic and biomolecular chemistry11 citations
Semantic Scholar
Molecular Dynamics Simulation and Experimental Verification of the Interaction between Cyclin T1 and HIV-1 Tat Proteins
K. Asamitsu, T. Hirokawa, Yurina Hibi, T. Okamoto
2015PLoS ONE11 citations Open access
Semantic Scholar
Unfolding is the driving force for mitochondrial import and degradation of the Parkinson's disease-related protein DJ-1
B. Queliconi, Waka Kojima, M. Kimura, K. Imai +9 more
2021Journal of Cell Science10 citations Open access
Semantic Scholar
Relationship between Human Evolution and Neurally Mediated Syncope Disclosed by the Polymorphic Sites of the Adrenergic Receptor Gene α2B-AR
Tomoyoshi Komiyama, T. Hirokawa, Kyoko Sato, A. Oka +5 more
2015PLoS ONE10 citations Open access
Semantic Scholar
Discovery of Novel Indazole Derivatives as Orally Available β3-Adrenergic Receptor Agonists Lacking Off-Target-Based Cardiovascular Side Effects.
Yasuhiro Wada, S. Nakano, Akifumi Morimoto, Ken-ichi Kasahara +8 more
2017Journal of Medicinal Chemistry9 citations Open access
Semantic Scholar
Differences in Intestinal Hydrolytic Activities between Cynomolgus Monkeys and Humans: Evaluation of Substrate Specificities Using Recombinant Carboxylesterase 2 Isozymes.
Y. Igawa, Seiya Fujiwara, Kayoko Ohura, T. Hirokawa +4 more
2016Molecular Pharmaceutics9 citations
Semantic Scholar
Quantitative comparison of protein-protein interaction interface using physicochemical feature-based descriptors of surface patches
Woong-Hee Shin, Keiko Kumazawa, K. Imai, T. Hirokawa +1 more
2023Frontiers in Molecular Biosciences8 citations Open access
Semantic Scholar
Synthesis of C12-keto saxitoxin derivatives with unusual inhibitory activity against voltage-gated sodium channels.
Kanna Adachi, Tomoshi Yamada, Hayate Ishizuka, Mana Oki +10 more
2019Chemistry8 citations
Semantic Scholar

Frequent co-authors

Invite them to SciRah by sharing their profile.

Ryunosuke Yoshino×6
Invite
Ryunosuke Yoshino — researcher profile on SciRah
K. Imai×5
Invite
K. Imai — researcher profile on SciRah
Tomoya Nakagita×4
Invite
Tomoya Nakagita — researcher profile on SciRah
Takuya Kobayashi×4
Invite
Takuya Kobayashi — researcher profile on SciRah

×4

Invite

Woong-Hee Shin — researcher profile on SciRah

Invite

D. Kihara — researcher profile on SciRah

Invite

T. Honma — researcher profile on SciRah

Invite

K. Nagasawa — researcher profile on SciRah

Invite

K. Watashi — researcher profile on SciRah

Invite

S. Kanaya — researcher profile on SciRah

Invite

C. Motono — researcher profile on SciRah

Invite

M. Narukawa — researcher profile on SciRah