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Kayoko Ohura · SciRah

Researcher profile · Semantic Scholar

Kayoko Ohura

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Kayoko Ohura — researcher profile on SciRah

h-index: 11
Works: 38
Citations: 801

Most-cited papers

Species difference of esterase expression and hydrolase activity in plasma.
F. Bahar, Kayoko Ohura, T. Ogihara, T. Imai
2012Journal of Pharmacy and Science263 citations
Semantic Scholar
Carboxylesterase in the liver and small intestine of experimental animals and human.
Megumi Taketani, Mayumi Shii, Kayoko Ohura, S. Ninomiya +1 more
2007Life Science216 citations
Semantic Scholar
The role of intestinal carboxylesterase in the oral absorption of prodrugs.
T. Imai, Kayoko Ohura
2010Current drug metabolism90 citations
Semantic Scholar
Development of a Novel System for Estimating Human Intestinal Absorption Using Caco-2 Cells in the Absence of Esterase Activity
Kayoko Ohura, Hisae Sakamoto, S. Ninomiya, T. Imai
2010Drug Metabolism And Disposition35 citations
Semantic Scholar
Evaluation of transport mechanism of prodrugs and parent drugs formed by intracellular metabolism in Caco-2 cells with modified carboxylesterase activity: temocapril as a model case.
Kayoko Ohura, Takaaki Nozawa, Koichi Murakami, T. Imai
2011Journal of Pharmacy and Science31 citations
Semantic Scholar
3D-fibroblast tissues constructed by a cell-coat technology enhance tight-junction formation of human colon epithelial cells.
M. Matsusaki, Daichi Hikimoto, A. Nishiguchi, Koji Kadowaki +3 more
2015Biochemical and Biophysical Research Communications - BBRC24 citations Open access
Semantic Scholar
Distinct Patterns of Aging Effects on the Expression and Activity of Carboxylesterases in Rat Liver and Intestine
Kayoko Ohura, K. Tasaka, Mitsuru Hashimoto, T. Imai
2014Drug Metabolism And Disposition19 citations
Semantic Scholar
Establishment and Characterization of a Novel Caco-2 Subclone with a Similar Low Expression Level of Human Carboxylesterase 1 to Human Small Intestine
Kayoko Ohura, Hikaru Nishiyama, S. Saco, K. Kurokawa +1 more
2016Drug Metabolism And Disposition15 citations Open access
Semantic Scholar
Monitoring of the effects of transfection with baculovirus on Sf9 cell line and expression of human dipeptidyl peptidase IV
Özlem Üstün-Aytekin, I. Gurhan, Kayoko Ohura, T. Imai +1 more
2013Cytotechnology (Dordrecht)12 citations Open access
Semantic Scholar
Effect of intestinal first-pass hydrolysis on the oral bioavailability of an ester prodrug of fexofenadine.
Kayoko Ohura, Toshimitsu Soejima, Ryoichi Nogata, Y. Adachi +2 more
2012Journal of Pharmacy and Science12 citations Open access
Semantic Scholar
Development of a Caco-2 Cell Line Carrying the Human Intestine-Type CES Expression Profile as a Promising Tool for Ester-Containing Drug Permeability Studies.
Y. Ishizaki, Tomomi Furihata, Yusuke Oyama, Kayoko Ohura +4 more
2018Biological and Pharmaceutical Bulletin11 citations Open access
Semantic Scholar
Design of Fexofenadine Prodrugs Based on Tissue-Specific Esterase Activity and Their Dissimilar Recognition by P-Glycoprotein.
Kayoko Ohura, Yuichiro Nakada, S. Kotani, T. Imai
2015Journal of Pharmacy and Science10 citations Open access
Semantic Scholar
Differences in Intestinal Hydrolytic Activities between Cynomolgus Monkeys and Humans: Evaluation of Substrate Specificities Using Recombinant Carboxylesterase 2 Isozymes.
Y. Igawa, Seiya Fujiwara, Kayoko Ohura, T. Hirokawa +4 more
2016Molecular Pharmaceutics9 citations
Semantic Scholar
A novel quantification method for serine hydrolases in cellular expression system using fluorophosphonate‐biotin probe
Amira Abdel‐Daim, Kayoko Ohura, T. Imai
2018European Journal of Pharmaceutical Sciences8 citations
Semantic Scholar
Pharmaceutics, Drug Delivery and Pharmaceutical Technology Expression of Carboxylesterase Isozymes and Their Role in the Behavior of a Fexofenadine Prodrug in Rat Skin
T. Imai, S. Ariyoshi, Kayoko Ohura, T. Sawada +1 more
20166 citations
Semantic Scholar
Effect of alcohol on skin permeation and metabolism of an ester‐type prodrug in Yucatan micropig skin
M. Fujii, Rieko Ohara, Azusa Matsumi, Kayoko Ohura +3 more
2017European Journal of Pharmaceutical Sciences5 citations
Semantic Scholar
The Association of the Cholesterol Efflux Capacity with theParaoxonase 1 Q192R Genotype and the Paraoxonase Activity
K. Oniki, Kayoko Ohura, Megumi Endo, Daniel Akatwijuka +8 more
2024Journal of atherosclerosis and thrombosis4 citations Open access
Semantic Scholar
[Evaluation of the Oral Absorption of Ester-type Prodrugs].
Kayoko Ohura
2020Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan4 citations Open access
Semantic Scholar
Analysis of carboxylesterase 2 transcript variants in cynomolgus macaque liver
Y. Uno, Y. Igawa, Maori Tanaka, Kayoko Ohura +2 more
2019Xenobiotica; the fate of foreign compounds in biological systems4 citations Open access
Semantic Scholar
Elucidation of the Intestinal Absorption of para-Aminobenzoic Acid, a Marker for Dietary Intake.
T. Imai, Keiichiro Tanaka, Takahiro Yonemitsu, Y. Yakushiji +1 more
2017Journal of Pharmacy and Science4 citations
Semantic Scholar
Identification of Major Esterase Involved in Hydrolysis of Soft Anticholinergic (2R3'R-SGM) Designed From Glycopyrrolate in Human and Rat Tissues.
A. Samir, Kayoko Ohura, N. Bodor, T. Imai
2019Journal of Pharmacy and Science3 citations
Semantic Scholar
Development of simultaneous quantification method of loteprednol etabonate (LE) and its acidic metabolites, and analysis of LE metabolism in rat
A. Samir, A. Kage, Kayoko Ohura, T. Imai
2018Xenobiotica; the fate of foreign compounds in biological systems3 citations
Semantic Scholar
Bioconversion and P-gp-mediated transport of depot fluphenazine prodrugs after intramuscular injection.
Kayoko Ohura, Yuichiro Nakada, T. Imai
2023Journal of Pharmacy and Science2 citations Open access
Semantic Scholar
Esterases Involved in the Rapid Bioconversion of Esmolol after Intravenous Injection in Humans.
T. Imai, Mizuki Isozaki, Kayoko Ohura
2022Biological and Pharmaceutical Bulletin2 citations Open access
Semantic Scholar
Identification and Characterization of a New Carboxylesterase 2 Isozyme, mfCES2C, in the Small Intestine of Cynomolgus Monkeys
Kayoko Ohura, Y. Igawa, Maori Tanaka, Kana Matsumoto +5 more
2019Drug Metabolism And Disposition2 citations Open access
Semantic Scholar
Actual Condition Survey on Aseptic Dispensing of Medical Narcotic Injections for Terminally Ill Cancer Patients at Pharmacies
Y. Iida, Yukie Kiriyama, Kayoko Ohura, M. Honda +4 more
2025Iryo Yakugaku (Japanese Journal of Pharmaceutical Health Care and Sciences)1 citations
Semantic Scholar
[Comparative Study of Hydrolase Activity in Skin with Liver and Intestine, and Its Aging Relation of Carboxylesterase Expression in Cynomolgus Monkey and Beagle Dog].
T. Imai, Yuichiro Nakada, Kayoko Ohura
2019Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan1 citations Open access
Semantic Scholar
Effect of calcium on the hydrolysis activity of human butyrylcholinesterase.
T. Imai, F. Bahar, Kayoko Ohura, A. Toda
2019Journal of Pharmacy and Science1 citations
Semantic Scholar
Molecular characterization and polymorphisms of butyrylcholinesterase in cynomolgus macaques
Y. Uno, Shotaro Uehara, Hassan M D Mahadhi, Kayoko Ohura +2 more
2018Journal of medical primatology1 citations
Semantic Scholar
ELUCIDATION OF CATALYTIC PROPERTY AND STRUCTURAL FEATURE OF HUMAN CARBOXYLESTERASE2
so tanoue, Korechika Tanaka, Seiya Fujihara, Kayoko Ohura +1 more
20171 citations
Semantic Scholar
Production of recombinant human dipeptidyl peptidase IV from Sf9cells in microbial fermenters
Ö. Aytekin, S. Gurhan, Kayoko Ohura, T. Imai +1 more
20161 citations
Semantic Scholar
Production of recombinant human dipeptidyl peptidase IV from Sf 9 cells in microbial fermenters
Ö. Aytekin, S. Gurhan, Kayoko Ohura, T. Imai +1 more
20151 citations
Semantic Scholar
Pharmaceutical Care and Follow-Up Practices by Community Pharmacists for Patients Receiving CAPOX Therapy at Specialized Medical Institution Cooperation Pharmacies
Kayoko Ohura, M. Honda, Junpei Kondo, Yukari Shimokawa
2026Iryo Yakugaku (Japanese Journal of Pharmaceutical Health Care and Sciences)0 citations Open access
Semantic Scholar
Functional Analysis of Modified Caco-2 Cells Carrying CES2A1 as a Model for Intestinal Absorption of Prodrugs.
Teruko Imai, Masanari Isasaka, Yusuke Oyama, Yusuke Takagi +3 more
2025Biological and Pharmaceutical Bulletin0 citations Open access
Semantic Scholar
INVOLVEMENT OF CARBOXYLESTERASE IN THE HYDROLYSIS OF ESTER DERIVATIVES OF VARIOUS STEROID COMPOUNDS
A. Kage, Kayoko Ohura, T. Imai
20170 citations
Semantic Scholar
EVALUATION OF P-GLYCOPROTEIN-MEDIATED TRANSPORT OF ESTER PRODRUGS AND EXPRESSION OF ESTERASES IN LLC-GA5-COL300 CELLS
Kayoko Ohura, T. Imai
20170 citations
Semantic Scholar
Establishment and Characterization of a Novel Caco-2 Subclone with a Similar Low Expression Level of Human Carboxylesterase 1 to Human Small Intestine s
Kayoko Ohura, Hikaru Nishiyama, S. Saco, K. Kurokawa +1 more
20160 citations
Semantic Scholar
Expression and Activity of Plasma Esterases in Several Animals and Human
F. Bahar, Kayoko Ohura, T. Imai
20100 citations
Semantic Scholar

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Yusuke Oyama×2

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