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D. Melton · SciRah

Researcher profile · Semantic Scholar

D. Melton

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D. Melton — researcher profile on SciRah

h-index: 114
Works: 263
Citations: 71K

Most-cited papers

Generation of functional human pancreatic β cells in vitro
F. Pagliuca, J. Millman, Mads Gürtler, Michael Segel +5 more
2014Cell1,899 citations Open access
Semantic Scholar
A Single-Cell Transcriptomic Map of the Human and Mouse Pancreas Reveals Inter- and Intra-cell Population Structure
Maayan Baron, A. Veres, Samuel L. Wolock, Aubrey L. Faust +8 more
2016Cell Systems1,365 citations Open access
Semantic Scholar
Long term Glycemic Control Using Polymer Encapsulated, Human Stem-Cell Derived β-cells in Immune Competent mice
A. Vegas, O. Veiseh, Mads Gürtler, J. Millman +20 more
2016Nature Medicine583 citations Open access
Semantic Scholar
Charting cellular identity during human in vitro β-cell differentiation
A. Veres, Aubrey L. Faust, H. Bushnell, Elise N. Engquist +8 more
2019Nature496 citations Open access
Semantic Scholar
Identifying gene expression programs of cell-type identity and cellular activity with single-cell RNA-Seq
Dylan Kotliar, A. Veres, M. Nagy, S. Tabrizi +3 more
2018bioRxiv487 citations Open access
Semantic Scholar
Betatrophin: a hormone that controls pancreatic β cell proliferation
Peng Yi, Ji-Sun Park, D. Melton
2013Cell435 citations Open access
Semantic Scholar
Generation of stem cell-derived β-cells from patients with type 1 diabetes
J. Millman, Chunhui Xie, A. V. VanDervort, Mads Gürtler +2 more
2016Nature Communications368 citations Open access
Semantic Scholar
Functional β-cells maturation is marked by an increase in the glucose threshold for insulin secretion and by expression of urocortin3
B. Blum, S. Hrvatin, C. Schuetz, C. Bonal +2 more
2012Nature Biotechnology347 citations Open access
Semantic Scholar
Pancreas regeneration
Qiao Zhou, D. Melton
2018Nature339 citations Open access
Semantic Scholar
An intrinsic circadian clock of the pancreas is required for normal insulin release and glucose homeostasis
L. A. Sadacca, Katja A. Lamia, A. deLemos, B. Blum +2 more
2010Diabetologia323 citations Open access
Semantic Scholar
Sox17 promotes differentiation in mouse embryonic stem cells by directly regulating extraembryonic gene expression and indirectly antagonizing self-renewal.
Kathy K. Niakan, H. Ji, René Maehr, S. Vokes +8 more
2010Genes & Development318 citations Open access
Semantic Scholar
Differentiated human stem cells resemble fetal, not adult, β cells
S. Hrvatin, Charles W. O’Donnell, Francis Deng, J. Millman +5 more
2014Proceedings of the National Academy of Sciences of the United States of America309 citations Open access
Semantic Scholar
Generation of hypoimmunogenic human pluripotent stem cells
Xiao-feng Han, Mengning Wang, Song-Wei Duan, P. J. Franco +9 more
2019Proceedings of the National Academy of Sciences of the United States of America307 citations Open access
Semantic Scholar
Turning straw into gold: directing cell fate for regenerative medicine
Dena E. Cohen, D. Melton
2011Nature reviews genetics280 citations Open access
Semantic Scholar
How to make a functional β-cell
F. Pagliuca, D. Melton
2013Development215 citations Open access
Semantic Scholar
A simple tool to improve pluripotent stem cell differentiation
Sundari Chetty, F. Pagliuca, Christian Honoré, Anastasie Kweudjeu +2 more
2013Nature Methods181 citations Open access
Semantic Scholar
Circadian Entrainment Triggers Maturation of Human In Vitro Islets.
J. Alvarez-Dominguez, Julie Donaghey, Niloofar Rasouli, Jennifer H. R. Kenty +5 more
2019Cell Stem Cell167 citations Open access
Semantic Scholar
Correction: Corrigendum: A SARS-like cluster of circulating bat coronaviruses shows potential for human emergence
A. Vegas, O. Veiseh, Madsörtler G, J. Millman +20 more
2016Nature Medicine163 citations Open access
Semantic Scholar
Regenerating the field of cardiovascular cell therapy
K. Chien, J. Frisén, R. Fritsche-Danielson, D. Melton +2 more
2019Nature Biotechnology159 citations
Semantic Scholar
YAP inhibition enhances the differentiation of functional stem cell-derived insulin-producing β cells
E. Rosado-Olivieri, K. Anderson, Jennifer H. R. Kenty, D. Melton
2019Nature Communications149 citations Open access
Semantic Scholar
Adenosine kinase inhibition selectively promotes rodent and porcine islet β-cell replication
Justin P. Annes, J. Ryu, Kelvin T. Lam, Peter J. Carolan +6 more
2012Proceedings of the National Academy of Sciences of the United States of America143 citations Open access
Semantic Scholar
In vivo reprogramming of pancreatic acinar cells to three islet endocrine subtypes
Wei-Da Li, Mio Nakanishi, A. Zumsteg, Matthew A. Shear +3 more
2014eLife138 citations Open access
Semantic Scholar
Reprogrammed Stomach Tissue as a Renewable Source of Functional β Cells for Blood Glucose Regulation
Chaiyaboot Ariyachet, Alessio Tovaglieri, Guanjue Xiang, Jia-Qi Lu +11 more
2016Cell Stem Cell136 citations Open access
Semantic Scholar
Self-renewal of embryonic-stem-cell-derived progenitors by organ-matched mesenchyme
J. B. Sneddon, M. Borowiak, D. Melton
2012Nature128 citations Open access
Semantic Scholar
MARIS: Method for Analyzing RNA following Intracellular Sorting
S. Hrvatin, Francis Deng, Charles W. O'Donnell, D. Gifford +1 more
2014PLoS ONE119 citations Open access
Semantic Scholar
A Peninsular Structure Coordinates Asynchronous Differentiation with Morphogenesis to Generate Pancreatic Islets
N. Sharon, Raghav Chawla, Jonas W. Mueller, Jordan Vanderhooft +8 more
2019Cell117 citations Open access
Semantic Scholar
Wnt Signaling Separates the Progenitor and Endocrine Compartments during Pancreas Development
N. Sharon, Jordan Vanderhooft, J. Straubhaar, J. Mueller +6 more
2019Cell Reports114 citations Open access
Semantic Scholar
Alginate‐microencapsulation of human stem cell–derived β cells with CXCL12 prolongs their survival and function in immunocompetent mice without systemic immunosuppression
David A. Alagpulinsa, Jenny J. L. Cao, Riley K. Driscoll, R. F. Sîrbulescu +7 more
2019American Journal of Transplantation113 citations Open access
Semantic Scholar
Wnt Signaling Specifies and Patterns Intestinal Endoderm
Richard I. Sherwood, René Maehr, E. Mazzoni, D. Melton
2011Mechanisms of Development112 citations Open access
Semantic Scholar
A nutrient sensing transition at birth triggers glucose-responsive insulin secretion
Aharon Helman, Andrew L. Cangelosi, Jeffrey C. Davis, Q. Pham +5 more
2020Cell Metabolism111 citations Open access
Semantic Scholar
An improved ScoreCard to assess the differentiation potential of human pluripotent stem cells
Alexander M. Tsankov, V. Akopian, R. Pop, Sundari Chetty +5 more
2015Nature Biotechnology108 citations Open access
Semantic Scholar
Reversal of β cell de-differentiation by a small molecule inhibitor of the TGFβ pathway
B. Blum, Adam N Roose, Ornella Barrandon, René Maehr +6 more
2014eLife108 citations Open access
Semantic Scholar
Glucose Response by Stem Cell-Derived β Cells In Vitro Is Inhibited by a Bottleneck in Glycolysis
Jeffrey C. Davis, T. Alves, Aharon Helman, Jonathan C. Chen +5 more
2020Cell Reports103 citations Open access
Semantic Scholar
Inhibition of mTOR signaling enhances maturation of cardiomyocytes derived from human induced pluripotent stem cells via p53-induced quiescence
J. Garbern, Aharon Helman, Rebecca Sereda, Mohsen Sarikhani +11 more
2019Circulation103 citations Open access
Semantic Scholar
Genome scale in vivo CRISPR screen identifies RNLS as a target for beta cell protection in type 1 diabetes
E. Cai, Yuki Ishikawa, Wei Zhang, N. Leite +9 more
2020Nature Metabolism89 citations Open access
Semantic Scholar
The promise of stem cell-derived islet replacement therapy
D. Melton
2021Diabetologia87 citations Open access
Semantic Scholar
Handbook of stem cells
R. Lanza, J. Gearhart, B. Hogan, D. Melton +3 more
201387 citations
Semantic Scholar
A method for the generation of human stem cell-derived alpha cells
Quinn P. Peterson, A. Veres, Li-Hua Chen, Michael Q. Slama +11 more
2020Nature Communications77 citations Open access
Semantic Scholar
Synchronized Stimulation and Continuous Insulin Sensing in a Microfluidic Human Islet on a Chip Designed for Scalable Manufacturing
Aaron L Glieberman, Benjamin D. Pope, J. Zimmerman, Qihan Liu +9 more
2019Lab on a Chip77 citations Open access
Semantic Scholar
Cell Maturation: Hallmarks, Triggers, and Manipulation
J. Alvarez-Dominguez, D. Melton
2021Cell76 citations Open access
Semantic Scholar
Engineering human stem cell-derived islets to evade immune rejection and promote localized immune tolerance
Dario Gerace, Quan Zhou, Jennifer H. R. Kenty, A. Veres +5 more
2022Cell Reports Medicine75 citations Open access
Semantic Scholar
Modeling Type 1 Diabetes In Vitro Using Human Pluripotent Stem Cells
N. Leite, Elad Sintov, T. Meissner, M. Brehm +3 more
2020Cell Reports71 citations Open access
Semantic Scholar
Reprogramming within hours following nuclear transfer into mouse but not human zygotes
D. Egli, Alice E. Chen, G. Saphier, J. Ichida +10 more
2011Nature Communications70 citations Open access
Semantic Scholar
Report of the Key Opinion Leaders Meeting on Stem Cell-derived Beta Cells
J. Odorico, J. Markmann, D. Melton, J. Greenstein +32 more
2018Transplantation69 citations Open access
Semantic Scholar
Functional evaluation of ES cell-derived endodermal populations reveals differences between Nodal and Activin A-guided differentiation
Alice E. Chen, M. Borowiak, Richard I. Sherwood, Anastasie Kweudjeu +1 more
2013Development56 citations Open access
Semantic Scholar
Retraction Notice to: Betatrophin: A Hormone that Controls Pancreatic β Cell Proliferation
Peng Yi, Ji-Sun Park, D. Melton
2017Cell55 citations Open access
Semantic Scholar
Blastemal progenitors modulate immune signaling during early limb regeneration
S. Tsai, Clara Baselga-Garriga, D. Melton
2019Development51 citations Open access
Semantic Scholar
A therapeutic convection–enhanced macroencapsulation device for enhancing β cell viability and insulin secretion
Kisuk Yang, E. O'Cearbhaill, Sophie S. Liu, Angela Zhou +13 more
2021Proceedings of the National Academy of Sciences of the United States of America49 citations Open access
Semantic Scholar
Resolving Discrepant Findings on ANGPTL8 in β-Cell Proliferation: A Collaborative Approach to Resolving the Betatrophin Controversy
A. Cox, Ornella Barrandon, E. Cai, J. Rios +6 more
2016PLoS ONE49 citations Open access
Semantic Scholar
A Stem Cell Approach to Cure Type 1 Diabetes.
Aharon Helman, D. Melton
2020Cold Spring Harbor Perspectives in Biology47 citations Open access
Semantic Scholar

Frequent co-authors

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F. Pagliuca×8
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F. Pagliuca — researcher profile on SciRah
Jennifer H. R. Kenty×8
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Jennifer H. R. Kenty — researcher profile on SciRah
D. Greiner×6
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D. Greiner — researcher profile on SciRah
J. Millman×5
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J. Millman — researcher profile on SciRah

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Mads Gürtler — researcher profile on SciRah

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A. Veres — researcher profile on SciRah

Aharon Helman×5

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Aharon Helman — researcher profile on SciRah

Quinn P. Peterson×4

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Quinn P. Peterson — researcher profile on SciRah

J. Hollister-Lock×4

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J. Hollister-Lock — researcher profile on SciRah

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Peng Yi — researcher profile on SciRah

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A. Rezania — researcher profile on SciRah

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D. Gifford — researcher profile on SciRah