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Grace L. Guo · SciRah

Researcher profile · Semantic Scholar

Grace L. Guo

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Grace L. Guo — researcher profile on SciRah

h-index: 54
Works: 180
Citations: 9,989

Most-cited papers

Intake of stigmasterol and β-sitosterol alters lipid metabolism and alleviates NAFLD in mice fed a high-fat western-style diet
Si-Min Feng, Zhu-Qing Dai, A. Liu, Jinbao Huang +7 more
2018Biochimica et Biophysica Acta - Molecular and Cell Biology of Lipids193 citations Open access
Semantic Scholar
3D cell culture models: Drug pharmacokinetics, safety assessment, and regulatory consideration
Hong-Bing Wang, Paul C. Brown, E. Chow, L. Ewart +17 more
2021Clinical and Translational Science182 citations Open access
Semantic Scholar
Bile Acids and FXR: Novel Targets for Liver Diseases
Mary Stofan, Grace L. Guo
2020Frontiers in Medicine178 citations Open access
Semantic Scholar
Orally Administered Berberine Modulates Hepatic Lipid Metabolism by Altering Microbial Bile Acid Metabolism and the Intestinal FXR Signaling Pathway
Run-Bin Sun, Na Yang, B. Kong, B. Cao +18 more
2017Molecular Pharmacology173 citations Open access
Semantic Scholar
The Role of Bile Acids in Nonalcoholic Fatty Liver Disease and Nonalcoholic Steatohepatitis
Monica D. Chow, Yi-Horng Lee, Grace L. Guo
2017Molecular Aspects of Medicine133 citations Open access
Semantic Scholar
Fatty liver diseases, bile acids, and FXR
Yan Zhu, Hong-Xia Liu, Min Zhang, Grace L. Guo
2016Acta Pharmaceutica Sinica B114 citations Open access
Semantic Scholar
Fibroblast growth factor 15 deficiency impairs liver regeneration in mice.
B. Kong, Jian-Sheng Huang, Yan Zhu, Guodong Li +7 more
2014American Journal of Physiology - Gastrointestinal and Liver Physiology107 citations Open access
Semantic Scholar
Mechanistic Review of Drug-Induced Steatohepatitis
Justin D. Schumacher, Grace L. Guo
2015Toxicology and Applied Pharmacology99 citations Open access
Semantic Scholar
Bile acid homeostasis in female mice deficient in Cyp7a1 and Cyp27a1
D. Rizzolo, B. Kong, Rulaiha E. Taylor, Anita M. Brinker +3 more
2021Acta Pharmaceutica Sinica B97 citations Open access
Semantic Scholar
Role of FXR in Liver Inflammation during Nonalcoholic Steatohepatitis
Laura E. Armstrong, Grace L. Guo
2017Current Pharmacology Reports91 citations Open access
Semantic Scholar
FXR silencing in human colon cancer by DNA methylation and KRAS signaling.
Ann M. Bailey, L. Zhan, D. Maru, I. Shureiqi +10 more
2014American Journal of Physiology - Gastrointestinal and Liver Physiology89 citations Open access
Semantic Scholar
The Ubiquitin E3 Ligase TRIM21 Promotes Hepatocarcinogenesis by Suppressing the p62-Keap1-Nrf2 Antioxidant Pathway
Fang Wang, Ye Zhang, Jian-Liang Shen, Bin Yang +19 more
2021Cellular and Molecular Gastroenterology and Hepatology81 citations Open access
Semantic Scholar
Understanding environmental contaminants’ direct effects on non-alcoholic fatty liver disease progression
Laura E. Armstrong, Grace L. Guo
2019Current Environmental Health Reports77 citations Open access
Semantic Scholar
Farnesoid X receptor, the bile acid sensing nuclear receptor, in liver regeneration
Guodong Li, Grace L. Guo
2015Acta Pharmaceutica Sinica B73 citations Open access
Semantic Scholar
Intestinal FGF15/19 physiologically repress hepatic lipogenesis in the late fed-state by activating SHP and DNMT3A
Young-Chae Kim, Sunmi Seok, Yang Zhang, Jian Ma +4 more
2020Nature Communications72 citations Open access
Semantic Scholar
A postprandial FGF19‐SHP‐LSD1 regulatory axis mediates epigenetic repression of hepatic autophagy
S. Byun, Young-Chae Kim, Yang Zhang, B. Kong +5 more
2017EMBO Journal71 citations Open access
Semantic Scholar
Identification of Modulators of the Nuclear Receptor Peroxisome Proliferator-Activated Receptor α (PPARα) in a Mouse Liver Gene Expression Compendium
K. Oshida, Naresh Vasani, Russell S. Thomas, D. Applegate +7 more
2015PLoS ONE71 citations Open access
Semantic Scholar
FXR Deficiency Alters Bile Acid Pool Composition and Exacerbates Chronic Alcohol Induced Liver Injury
B. Kong, Min Zhang, Ming-Xing Huang, D. Rizzolo +5 more
2019Digestive and Liver Disease68 citations Open access
Semantic Scholar
Postprandial FGF19-induced phosphorylation by Src is critical for FXR function in bile acid homeostasis
S. Byun, Dong-Hyun Kim, D. Ryerson, Young-Chae Kim +7 more
2018Nature Communications67 citations Open access
Semantic Scholar
Regulation of Hepatic Stellate Cells and Fibrogenesis by Fibroblast Growth Factors
Justin D. Schumacher, Grace L. Guo
2016BioMed Research International66 citations Open access
Semantic Scholar
Organophosphate Flame-Retardants Alter Adult Mouse Homeostasis and Gene Expression in a Sex-Dependent Manner Potentially Through Interactions With ER&agr;
Elizabeth A. Krumm, Vipa J Patel, Taylor S Tillery, A. Yasrebi +5 more
2018Toxicological Sciences64 citations Open access
Semantic Scholar
Suppression of autophagic flux by bile acids in hepatocytes.
Sharon J. Manley, Hong-Min Ni, B. Kong, U. Apte +2 more
2014Toxicological Sciences63 citations Open access
Semantic Scholar
Genome-Wide Binding and Transcriptome Analysis of Human Farnesoid X Receptor in Primary Human Hepatocytes
L. Zhan, Hui-Xin Liu, Yaping Fang, B. Kong +5 more
2014PLoS ONE62 citations Open access
Semantic Scholar
Probiotic-derived Nanoparticles Inhibit ALD through Intestinal miR194 Suppression and Subsequent FXR Activation
Mengwei Jiang, Fengyuan Li, Yun-Huan Liu, Zelin Gu +12 more
2022Hepatology56 citations Open access
Semantic Scholar
AhR and SHP regulate phosphatidylcholine and S-adenosylmethionine levels in the one-carbon cycle
Young-Chae Kim, Sunmi Seok, S. Byun, B. Kong +6 more
2018Nature Communications55 citations Open access
Semantic Scholar
Interactions Between Nuclear receptor SHP and FOXA1 Maintain Oscillatory Homocysteine Homeostasis in Mice
H. Tsuchiya, K. da Costa, Sang-Min Lee, B. Renga +13 more
2015Gastroenterology55 citations Open access
Semantic Scholar
Soluble Expression of Disulfide Bond Containing Proteins FGF15 and FGF19 in the Cytoplasm of Escherichia coli
B. Kong, Grace L. Guo
2014PLoS ONE55 citations Open access
Semantic Scholar
Small Heterodimer Partner and Fibroblast Growth Factor 19 Inhibit Expression of NPC1L1 in Mouse Intestine and Cholesterol Absorption
Young-Chae Kim, S. Byun, Sunmi Seok, Grace L. Guo +3 more
2018Gastroenterology53 citations Open access
Semantic Scholar
Farnesoid X receptor regulates forkhead Box O3a activation in ethanol-induced autophagy and hepatotoxicity
Sharon J. Manley, Hong-Min Ni, Jessica A. Williams, B. Kong +3 more
2014Redox Biology53 citations Open access
Semantic Scholar
A Novel Fibroblast Growth Factor 15 Dependent- and Bile Acid Independent-Promotion of Liver Regeneration in Mice
B. Kong, Run-Bin Sun, Ming-Xing Huang, Monica D. Chow +4 more
2018Hepatology51 citations Open access
Semantic Scholar
Pharmacologic modulation of bile acid-FXR-FGF15/19 pathway for the treatment of non-alcoholic steatohepatitis
Justin D. Schumacher, Grace L. Guo
2019Handbook of Experimental Pharmacology49 citations Open access
Semantic Scholar
Sex- and age-dependent effects of maternal organophosphate flame-retardant exposure on neonatal hypothalamic and hepatic gene expression
S. Adams, Kimberly R. Wiersielis, A. Yasrebi, Kristie Conde +3 more
2020Reproductive Toxicology46 citations Open access
Semantic Scholar
Mice with hepatocyte-specific FXR deficiency are resistant to spontaneous but susceptible to cholic acid-induced hepatocarcinogenesis.
B. Kong, Yan Zhu, Guodong Li, Jessica A. Williams +4 more
2016American Journal of Physiology - Gastrointestinal and Liver Physiology44 citations Open access
Semantic Scholar
Altenusin, a Nonsteroidal Microbial Metabolite, Attenuates Nonalcoholic Fatty Liver Disease by Activating the Farnesoid X Receptor
Zhihui Zheng, Zan-Mei Zhao, Shu-Qiang Li, Xin-Huan Lu +11 more
2017Molecular Pharmacology42 citations Open access
Semantic Scholar
The Hypoglycemic Effect of Berberine and Berberrubine Involves Modulation of Intestinal Farnesoid X Receptor Signaling Pathway and Inhibition of Hepatic Gluconeogenesis
Run-Bin Sun, B. Kong, Na Yang, B. Cao +12 more
2020Drug Metabolism And Disposition41 citations Open access
Semantic Scholar
Phosphorylation of hepatic farnesoid X receptor by FGF19 signaling–activated Src maintains cholesterol levels and protects from atherosclerosis
S. Byun, Hyunkyung Jung, Jin-Jing Chen, Young-Chae Kim +5 more
2019Journal of Biological Chemistry40 citations Open access
Semantic Scholar
Enhanced Alcoholic Liver Disease in Mice with Intestine-specific Farnesoid X Receptor Deficiency
Ming-Xing Huang, B. Kong, Min Zhang, D. Rizzolo +8 more
2020Laboratory Investigation39 citations Open access
Semantic Scholar
Is CYP2C70 the key to new mouse models to understand bile acids in humans?1
Grace L. Guo, John Y. L. Chiang
2020Journal of Lipid Research38 citations Open access
Semantic Scholar
Farnesoid X Receptor Signaling Activates the Hepatic X-box Binding Protein 1 Pathway in vitro and in Mice
Xiao-Ying Liu, Grace L. Guo, B. Kong, David B Hilburn +7 more
2018Hepatology35 citations Open access
Semantic Scholar
Dysregulation of bile acid homeostasis in parenteral nutrition mouse model.
L. Zhan, I. Yang, B. Kong, Jian-Liang Shen +4 more
2016American Journal of Physiology - Gastrointestinal and Liver Physiology30 citations Open access
Semantic Scholar
Targeting hepatic kisspeptin receptor ameliorates nonalcoholic fatty liver disease in a mouse model
Stephania Guzman, M. Drăgan, H. Kwon, V. De Oliveira +17 more
2022Journal of Clinical Investigation29 citations Open access
Semantic Scholar
Restoration of Enterohepatic Bile Acid Pathways in Pregnant Mice Following Short Term Activation of Fxr by GW4064
Jamie E. Moscovitz, B. Kong, Kyle Buckley, B. Buckley +2 more
2016Toxicology and Applied Pharmacology29 citations Open access
Semantic Scholar
Diminished gallbladder filling, increased fecal bile acids, and promotion of colon epithelial cell proliferation and neoplasia in fibroblast growth factor 15-deficient mice
Kunrong Cheng, Melissa Metry, Jessica E. Felton, Aaron C. Shang +7 more
2018OncoTarget26 citations Open access
Semantic Scholar
FXR Deletion in Hepatocytes does not Affect the Severity of Alcoholic Liver Disease in Mice
Min Zhang, B. Kong, Ming-Xing Huang, Ruixuan Wan +6 more
2018Digestive and Liver Disease26 citations Open access
Semantic Scholar
Valproate Increases Dopamine Transporter Expression through Histone Acetylation and Enhanced Promoter Binding of Nurr1
Ashley L. Green, L. Zhan, A. Eid, H. Zarbl +2 more
2017Neuropharmacology26 citations Open access
Semantic Scholar
Farnesoid X receptor and fibroblast growth factor 15/19 as pharmacological targets
Syeda Maliha, Grace L. Guo
2021Liver Research25 citations Open access
Semantic Scholar
Hepatic Autophagy Deficiency Remodels Gut Microbiota for Adaptive Protection via FGF15-FGFR4 Signaling
Sheng-Min Yan, B. Khambu, Xiaoyun Chen, Zheng Dong +2 more
2020Cellular and Molecular Gastroenterology and Hepatology24 citations Open access
Semantic Scholar
FXR and NASH: an avenue for tissue-specific regulation
Zakiyah R. Henry, Vik Meadows, Grace L. Guo
2023Hepatology Communications23 citations Open access
Semantic Scholar
Regulation of Lung Macrophage Activation and Oxidative Stress Following Ozone Exposure by Farnesoid X Receptor.
M. Francis, Grace L. Guo, B. Kong, E. Abramova +4 more
2020Toxicological Sciences22 citations Open access
Semantic Scholar
Developmental Regulation of the Gut-Liver (FGF19-CYP7A1) Axis in Neonates
Naureen Memon, I. Griffin, Chris W. Lee, Aimee R. Herdt +5 more
2018Journal of Maternal-Fetal & Neonatal Medicine22 citations Open access
Semantic Scholar

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