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G. Perini · SciRah

Researcher profile · Semantic Scholar

G. Perini

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G. Perini — researcher profile on SciRah

h-index: 41
Works: 120
Citations: 5,309

Most-cited papers

Histone Deacetylases (HDACs): Evolution, Specificity, Role in Transcriptional Complexes, and Pharmacological Actionability
G. Milazzo, D. Mercatelli, Giulia Di Muzio, Luca Triboli +3 more
2020Genes356 citations Open access
Semantic Scholar
Mutations in the 5' UTR of ANKRD26, the ankirin repeat domain 26 gene, cause an autosomal-dominant form of inherited thrombocytopenia, THC2.
T. Pippucci, A. Savoia, S. Perrotta, N. Pujol-Moix +19 more
2011American Journal of Human Genetics212 citations Open access
Semantic Scholar
SIRT1 Promotes N-Myc Oncogenesis through a Positive Feedback Loop Involving the Effects of MKP3 and ERK on N-Myc Protein Stability
G. Marshall, Pei Y. Liu, S. Gherardi, C. Scarlett +16 more
2011PLoS Genetics156 citations Open access
Semantic Scholar
Inhibition of polyamine synthesis and uptake reduces tumor progression and prolongs survival in mouse models of neuroblastoma
Laura D. Gamble, Stefania Purgato, J. Murray, Lin Xiao +29 more
2019Science Translational Medicine140 citations Open access
Semantic Scholar
Molecular and Cellular Pathobiology Cancer Research p 53 Is a Direct Transcriptional Target of MYCN in Neuroblastoma
Lin-Di Chen, N. Iraci, S. Gherardi, Laura D. Gamble +4 more
2010131 citations
Semantic Scholar
Effects of a novel long noncoding RNA, lncUSMycN, on N-Myc expression and neuroblastoma progression.
Pei Y. Liu, D. Erriquez, G. Marshall, Andrew E. Tee +15 more
2014Journal of the National Cancer Institute125 citations Open access
Semantic Scholar
Activation of tissue transglutaminase transcription by histone deacetylase inhibition as a therapeutic approach for Myc oncogenesis
Tao Liu, Andrew E. Tee, Antonio Porro, Stewart A. Smith +10 more
2007Proceedings of the National Academy of Sciences of the United States of America122 citations Open access
Semantic Scholar
APP-dependent up-regulation of Ptch1 underlies proliferation impairment of neural precursors in Down syndrome.
S. Trazzi, V. Mitrugno, E. Valli, C. Fuchs +5 more
2011Human Molecular Genetics115 citations
Semantic Scholar
Expression of spliced oncogenic Ikaros isoforms in Philadelphia-positive acute lymphoblastic leukemia patients treated with tyrosine kinase inhibitors: implications for a new mechanism of resistance.
I. Iacobucci, A. Lonetti, F. Messa, D. Cilloni +19 more
2008Blood114 citations
Semantic Scholar
Association between imatinib transporters and metabolizing enzymes genotype and response in newly diagnosed chronic myeloid leukemia patients receiving imatinib therapy
S. Angelini, S. Soverini, G. Ravegnini, M. Barnett +16 more
2013Haematologica110 citations Open access
Semantic Scholar
A SP1/MIZ1/MYCN repression complex recruits HDAC1 at the TRKA and p75NTR promoters and affects neuroblastoma malignancy by inhibiting the cell response to NGF.
N. Iraci, Daniel Diolaiti, A. Papa, Antonio Porro +7 more
2011Cancer Research108 citations Open access
Semantic Scholar
Direct and Coordinate Regulation of ATP-binding Cassette Transporter Genes by Myc Factors Generates Specific Transcription Signatures That Significantly Affect the Chemoresistance Phenotype of Cancer Cells*
Antonio Porro, M. Haber, Daniel Diolaiti, N. Iraci +12 more
2010Journal of Biological Chemistry104 citations Open access
Semantic Scholar
HDAC4: a key factor underlying brain developmental alterations in CDKL5 disorder.
S. Trazzi, C. Fuchs, Rocchina Viggiano, Marianna De Franceschi +8 more
2016Human Molecular Genetics99 citations
Semantic Scholar
IKAROS Deletions Dictate a Unique Gene Expression Signature in Patients with Adult B-Cell Acute Lymphoblastic Leukemia
I. Iacobucci, N. Iraci, M. Messina, A. Lonetti +18 more
2012PLoS ONE92 citations Open access
Semantic Scholar
ABCC Multidrug Transporters in Childhood Neuroblastoma: Clinical and Biological Effects Independent of Cytotoxic Drug Efflux
M. Henderson, M. Haber, Antonio Porro, Marcia A. Munoz +19 more
2011Journal of the National Cancer Institute92 citations Open access
Semantic Scholar
Transcriptional upregulation of histone deacetylase 2 promotes Myc-induced oncogenic effects
G. Marshall, S. Gherardi, N. Xu, Z. Neiron +16 more
2010Oncogene87 citations Open access
Semantic Scholar
The long noncoding RNA lncNB1 promotes tumorigenesis by interacting with ribosomal protein RPL35
Pei Y. Liu, Andrew E. Tee, G. Milazzo, K. Hannan +31 more
2019Nature Communications86 citations Open access
Semantic Scholar
WDR5 Supports an N-Myc Transcriptional Complex That Drives a Protumorigenic Gene Expression Signature in Neuroblastoma.
Yu-Ting Sun, Jessica L. Bell, Daniel R. Carter, S. Gherardi +23 more
2015Cancer Research86 citations Open access
Semantic Scholar
JMJD6 is a tumorigenic factor and therapeutic target in neuroblastoma
M. Wong, Yu-Ting Sun, Z. Xi, G. Milazzo +27 more
2019Nature Communications84 citations Open access
Semantic Scholar
The C-Terminal Domain of CENP-C Displays Multiple and Critical Functions for Mammalian Centromere Formation
S. Trazzi, G. Perini, R. Bernardoni, M. Zoli +3 more
2009PLoS ONE71 citations Open access
Semantic Scholar
Physical Interaction between MYCN Oncogene and Polycomb Repressive Complex 2 (PRC2) in Neuroblastoma
D. Corvetta, O. Chayka, S. Gherardi, C. D'Acunto +5 more
2013Journal of Biological Chemistry67 citations Open access
Semantic Scholar
The Histone Methyltransferase DOT1L Promotes Neuroblastoma by Regulating Gene Transcription.
M. Wong, Andrew E. Tee, G. Milazzo, J. Bell +15 more
2017Cancer Research65 citations Open access
Semantic Scholar
Centromere sliding on a mammalian chromosome
Stefania Purgato, Elisa Belloni, Francesca M. Piras, M. Zoli +10 more
2014Chromosoma64 citations Open access
Semantic Scholar
The DMD Locus Harbours Multiple Long Non-Coding RNAs Which Orchestrate and Control Transcription of Muscle Dystrophin mRNA Isoforms
M. Bovolenta, D. Erriquez, E. Valli, S. Brioschi +9 more
2012PLoS ONE63 citations Open access
Semantic Scholar
Lysine-specific demethylase (LSD1/KDM1A) and MYCN cooperatively repress tumor suppressor genes in neuroblastoma
Stefano Amente, G. Milazzo, Maria Cristina Sorrentino, Susanna Ambrosio +4 more
2015OncoTarget56 citations Open access
Semantic Scholar
CDKL5, a novel MYCN-repressed gene, blocks cell cycle and promotes differentiation of neuronal cells
E. Valli, S. Trazzi, C. Fuchs, D. Erriquez +3 more
2012Biochimica et Biophysica Acta55 citations Open access
Semantic Scholar
Restoration of the molecular clock is tumor suppressive in neuroblastoma
Myrthala Moreno-Smith, G. Milazzo, Ling Tao, B. Fekry +14 more
2021Nature Communications47 citations Open access
Semantic Scholar
c-MYC Oncoprotein Dictates Transcriptional Profiles of ATP-Binding Cassette Transporter Genes in Chronic Myelogenous Leukemia CD34+ Hematopoietic Progenitor Cells
Antonio Porro, N. Iraci, S. Soverini, Daniel Diolaiti +12 more
2011Molecular Cancer Research47 citations
Semantic Scholar
MYCN-mediated transcriptional repression in neuroblastoma: the other side of the coin
S. Gherardi, E. Valli, D. Erriquez, G. Perini
2013Frontiers in Oncology46 citations Open access
Semantic Scholar
The Amyloid Precursor Protein (APP) Triplicated Gene Impairs Neuronal Precursor Differentiation and Neurite Development through Two Different Domains in the Ts65Dn Mouse Model for Down Syndrome*
S. Trazzi, C. Fuchs, E. Valli, G. Perini +2 more
2013Journal of Biological Chemistry45 citations Open access
Semantic Scholar
MYC-Driven Neuroblastomas Are Addicted to a Telomerase-Independent Function of Dyskerin.
R. O'Brien, Sieu L. Tran, M. Maritz, Bing Liu +15 more
2016Cancer Research42 citations
Semantic Scholar
Epigenetic origin of evolutionary novel centromeres
D. Tolomeo, O. Capozzi, R. Stanyon, N. Archidiacono +9 more
2017Scientific Reports40 citations Open access
Semantic Scholar
PRDM15 is a key regulator of metabolism critical to sustain B-cell lymphomagenesis
Slim Mzoughi, Jia-Yi Fong, David Papadopoli, Cheryl M. Koh +35 more
2020Nature Communications39 citations Open access
Semantic Scholar
MYCN acts as a direct co-regulator of p53 in MYCN amplified neuroblastoma
Saurabh Agarwal, G. Milazzo, K. Rajapakshe, Ronald J. Bernardi +6 more
2018OncoTarget35 citations Open access
Semantic Scholar
Targeting the p53-MDM2 interaction by the small-molecule MDM2 antagonist Nutlin-3a: a new challenged target therapy in adult Philadelphia positive acute lymphoblastic leukemia patients
S. Trino, I. Iacobucci, D. Erriquez, I. Laurenzana +15 more
2016OncoTarget34 citations Open access
Semantic Scholar
Non-Coding RNAs in Muscle Dystrophies
D. Erriquez, G. Perini, A. Ferlini
2013International Journal of Molecular Sciences30 citations Open access
Semantic Scholar
Drugging MYCN oncogenic signalling through the MYCN-PA2G4 binding interface.
J. Koach, J. Holien, Hassina Massudi, Daniel R. Carter +29 more
2019Cancer Research27 citations Open access
Semantic Scholar
MYCN promotes neuroblastoma malignancy by establishing a regulatory circuit with transcription factor AP4
Cheng-Yuan Xue, Denise M. T. Yu, S. Gherardi, J. Koach +12 more
2016OncoTarget25 citations Open access
Semantic Scholar
SKP2 is a direct transcriptional target of MYCN and a potential therapeutic target in neuroblastoma.
L. Evans, Lin-Di Chen, G. Milazzo, S. Gherardi +4 more
2015Cancer Letters23 citations Open access
Semantic Scholar
A critical appraisal of tools available for monitoring epigenetic changes in clinical samples from patients with myeloid malignancies
K. Grønbæk, C. Müller-Tidow, G. Perini, S. Lehmann +4 more
2012Haematologica22 citations Open access
Semantic Scholar
CHAF1A Blocks Neuronal Differentiation and Promotes Neuroblastoma Oncogenesis via Metabolic Reprogramming
Ling Tao, Myrthala Moreno-Smith, Rodrigo Ibarra-García-Padilla, G. Milazzo +18 more
2021Advancement of science20 citations Open access
Semantic Scholar
Single-Cell Gene Network Analysis and Transcriptional Landscape of MYCN-Amplified Neuroblastoma Cell Lines
D. Mercatelli, Nicola Balboni, Alessandro Palma, E. Aleo +3 more
2021Biomolecules18 citations Open access
Semantic Scholar
The human Smoothened inhibitor PF-04449913 induces exit from quiescence and loss of multipotent Drosophila hematopoietic progenitor cells
G. Giordani, Marilena Barraco, A. Giangrande, G. Martinelli +4 more
2016OncoTarget17 citations Open access
Semantic Scholar
MYCN amplification confers enhanced folate dependence and methotrexate sensitivity in neuroblastoma
Diana T. Lau, C. Flemming, S. Gherardi, G. Perini +10 more
2015OncoTarget17 citations Open access
Semantic Scholar
N-Myc regulates expression of the detoxifying enzyme glutathione transferase GSTP1, a marker of poor outcome in neuroblastoma.
J. Fletcher, S. Gherardi, J. Murray, C. Burkhart +10 more
2012Cancer Research17 citations Open access
Semantic Scholar
The absence of dystrophin brain isoform expression in healthy human heart ventricles explains the pathogenesis of 5' X-linked dilated cardiomyopathy
M. Neri, E. Valli, G. Alfano, M. Bovolenta +7 more
2012BMC Medical Genetics17 citations Open access
Semantic Scholar
Off–label long acting injectable antipsychotics in real–world clinical practice: a cross-sectional analysis of prescriptive patterns from the STAR Network DEPOT study
A. D'Agostino, A. Aguglia, C. Barbui, F. Bartoli +153 more
2022BMC Psychiatry16 citations Open access
Semantic Scholar
Targeting Oncogenic Transcriptional Networks in Neuroblastoma: From N-Myc to Epigenetic Drugs
Roberto Ciaccio, Piergiuseppe De Rosa, S. Aloisi, Marta Viggiano +4 more
2021International Journal of Molecular Sciences16 citations Open access
Semantic Scholar
PRDM12 in Health and Diseases
M. Rienzo, E. di Zazzo, A. Casamassimi, P. Gazzerro +3 more
2021International Journal of Molecular Sciences16 citations Open access
Semantic Scholar
The Hidden Genomic and Transcriptomic Plasticity of Giant Marker Chromosomes in Cancer
G. Macchia, M. Severgnini, Stefania Purgato, D. Tolomeo +12 more
2017Genetics15 citations Open access
Semantic Scholar

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