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L. Johnson · SciRah

Researcher profile · Semantic Scholar

L. Johnson

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L. Johnson — researcher profile on SciRah

h-index: 28
Works: 66
Citations: 8,202

Most-cited papers

Tumor antigen-specific CD8 T cells infiltrating the tumor express high levels of PD-1 and are functionally impaired.
M. Ahmadzadeh, L. Johnson, B. Heemskerk, J. Wunderlich +3 more
2009Blood1,722 citations Open access
Semantic Scholar
Gene therapy with human and mouse T-cell receptors mediates cancer regression and targets normal tissues expressing cognate antigen.
L. Johnson, R. Morgan, M. Dudley, L. Cassard +21 more
2009Blood1,448 citations Open access
Semantic Scholar
Targeting Fibroblast Activation Protein in Tumor Stroma with Chimeric Antigen Receptor T Cells Can Inhibit Tumor Growth and Augment Host Immunity Without Severe Toxicity
Liang-Chuan S. Wang, Albert C. Lo, J. Scholler, Jing Sun +10 more
2013Cancer immunology research560 citations Open access
Semantic Scholar
Engineered CAR T Cells Targeting the Cancer-Associated Tn-Glycoform of the Membrane Mucin MUC1 Control Adenocarcinoma
A. Posey, Robert D Schwab, Alina C. Boesteanu, C. Steentoft +18 more
2016Immunity559 citations Open access
Semantic Scholar
Rational development and characterization of humanized anti–EGFR variant III chimeric antigen receptor T cells for glioblastoma
L. Johnson, J. Scholler, T. Ohkuri, A. Kosaka +25 more
2015Science Translational Medicine446 citations Open access
Semantic Scholar
Single and Dual Amino Acid Substitutions in TCR CDRs Can Enhance Antigen-Specific T Cell Functions
P. Robbins, Yong F Li, M. El-Gamil, Yang-Bing Zhao +11 more
2008Journal of Immunology393 citations Open access
Semantic Scholar
Gene Transfer of Tumor-Reactive TCR Confers Both High Avidity and Tumor Reactivity to Nonreactive Peripheral Blood Mononuclear Cells and Tumor-Infiltrating Lymphocytes1
L. Johnson, B. Heemskerk, D. Powell, C. Cohen +4 more
2006Journal of Immunology336 citations Open access
Semantic Scholar
Human effector CD8+ T cells derived from naive rather than memory subsets possess superior traits for adoptive immunotherapy.
Christian S. Hinrichs, Zachary A Borman, L. Gattinoni, Zhi-Ya Yu +13 more
2011Blood313 citations Open access
Semantic Scholar
Recognition of Glioma Stem Cells by Genetically Modified T Cells Targeting EGFRvIII and Development of Adoptive Cell Therapy for Glioma
R. Morgan, L. Johnson, Jeremy L. Davis, Zhi-Li Zheng +9 more
2012Human Gene Therapy309 citations Open access
Semantic Scholar
EGFRvIII mCAR-modified T-cell therapy cures mice with established intracerebral glioma and generates host immunity against tumor-antigen loss
J. Sampson, Bryan D. Choi, L. Sanchez-Perez, Carter M. Suryadevara +11 more
2013Clinical Cancer Research294 citations Open access
Semantic Scholar
Driving gene-engineered T cell immunotherapy of cancer
L. Johnson, C. June
2016Cell Research265 citations Open access
Semantic Scholar
T cell receptor affinity and avidity defines antitumor response and autoimmunity in T cell immunotherapy
M. Krogsgaard, Shi Zhong, K. Malecek, L. Johnson +11 more
2013Journal of Immunotherapy for Cancer179 citations Open access
Semantic Scholar
Checkpoint Blockade Reverses Anergy in IL-13Rα2 Humanized scFv-Based CAR T Cells to Treat Murine and Canine Gliomas
Yi-Bo Yin, Alina C. Boesteanu, Zev A. Binder, Chong Xu +19 more
2018Molecular Therapy: Oncolytics156 citations Open access
Semantic Scholar
Adoptive Cell Therapy for Patients with Melanoma, Using Tumor-Infiltrating Lymphocytes Genetically Engineered to Secrete Interleukin-2
B. Heemskerk, Ke Liu, M. Dudley, L. Johnson +8 more
2008Human Gene Therapy148 citations Open access
Semantic Scholar
Engineered T cells for cancer therapy
C. June, Marcela V. Maus, G. Plesa, L. Johnson +4 more
2014Cancer Immunology and Immunotherapy118 citations Open access
Semantic Scholar
EGFRvIII-Specific Chimeric Antigen Receptor T Cells Migrate to and Kill Tumor Deposits Infiltrating the Brain Parenchyma in an Invasive Xenograft Model of Glioblastoma
H. Miao, Bryan D. Choi, Carter M. Suryadevara, L. Sanchez-Perez +10 more
2014PLoS ONE118 citations Open access
Semantic Scholar
Ocular and Systemic Autoimmunity after Successful Tumor-Infiltrating Lymphocyte Immunotherapy for Recurrent, Metastatic Melanoma
S. Yeh, Neel K Karne, Sid P. Kerkar, Charles Heller +11 more
2009Ophthalmology (Rochester, Minn.)104 citations Open access
Semantic Scholar
Structures of MART-126/27-35 Peptide/HLA-A2 complexes reveal a remarkable disconnect between antigen structural homology and T cell recognition.
O. Borbulevych, Francis Insaidoo, Tiffany K. Baxter, D. Powell +3 more
2007Journal of Molecular Biology103 citations Open access
Semantic Scholar
Recognition and killing of autologous, primary glioblastoma tumor cells by human cytomegalovirus pp65-specific cytotoxic T cells
Smita K. Nair, G. D. de León, D. Boczkowski, R. Schmittling +8 more
2014Clinical Cancer Research88 citations Open access
Semantic Scholar
2D TCR–pMHC–CD8 kinetics determines T-cell responses in a self-antigen-specific TCR system
Bao-Yu Liu, Shi Zhong, K. Malecek, L. Johnson +3 more
2013European Journal of Immunology66 citations Open access
Semantic Scholar
Myeloablative Temozolomide Enhances CD8+ T-Cell Responses to Vaccine and Is Required for Efficacy against Brain Tumors in Mice
L. Sanchez-Perez, Bryan D. Choi, G. Archer, Xiu-Yu Cui +8 more
2013PLoS ONE64 citations Open access
Semantic Scholar
T-cell receptor affinity and avidity defines antitumor response and autoimmunity in T-cell immunotherapy
Shi Zhong, K. Malecek, L. Johnson, Zhi-Ya Yu +11 more
2013Proceedings of the National Academy of Sciences of the United States of America59 citations Open access
Semantic Scholar
Immunotherapy Approaches for Malignant Glioma From 2007 to 2009
L. Johnson, J. Sampson
2010Current Neurology and Neuroscience Reports46 citations Open access
Semantic Scholar
Specific increase in potency via structure-based design of a T cell receptor
K. Malecek, A. Grigoryan, Shi Zhong, Wei Gu +4 more
2014Journal of Immunology45 citations Open access
Semantic Scholar
Engineering improved T cell receptors using an alanine-scan guided T cell display selection system
K. Malecek, Shi Zhong, Katelyn McGary, C. Yu +4 more
2013JIM - Journal of Immunological Methods40 citations Open access
Semantic Scholar
Enhanced receptor expression and in vitro effector function of a murine-human hybrid MART-1-reactive T cell receptor following a rapid expansion
Stephanie L. Goff, L. Johnson, Mary A. Black, Hui Xu +5 more
2010Cancer Immunology and Immunotherapy37 citations Open access
Semantic Scholar
Adoptive T cell immunotherapy for medullary thyroid carcinoma targeting GDNF family receptor alpha 4
Vijay G. Bhoj, Lucy Z. Li, Kalpana Parvathaneni, Zheng Zhang +17 more
2021Molecular Therapy: Oncolytics32 citations Open access
Semantic Scholar
Factors influencing myeloid stem cell (CFU-C) survival after cryopreservation of human marrow and chronic granulocytic leukemia cells.
David D. F. Ma, L. Johnson, P. Chan, J. Biggs
1982Cryobiology30 citations
Semantic Scholar
Ex vivo generation of dendritic cells from cryopreserved, post-induction chemotherapy, mobilized leukapheresis from pediatric patients with medulloblastoma
Smita K. Nair, T. Driscoll, D. Boczkowski, R. Schmittling +8 more
2015Journal of Neuro-Oncology26 citations Open access
Semantic Scholar
Antibody, T-cell and dendritic cell immunotherapy for malignant brain tumors
V. Chandramohan, D. Mitchell, L. Johnson, J. Sampson +1 more
2013Future Oncology22 citations Open access
Semantic Scholar
Rapid Production of Clinical-Grade Gammaretroviral Vectors in Expanded Surface Roller Bottles Using a “Modified” Step-Filtration Process for Clearance of Packaging Cells
S. Feldman, Stephanie L. Goff, Hui Xu, Mary A. Black +9 more
2011Human Gene Therapy16 citations Open access
Semantic Scholar
2B4(CD244)-mediated activation of NK cells reduces metastases of B16F10 melanoma in mice.
L. Johnson, S. Vaidya, R. Goldfarb, P. Mathew
2003Anticancer Research14 citations
Semantic Scholar
Molecular imaging biomarkers for cell-based immunotherapies
Mohammad Haris, P. Bagga, H. Hariharan, Bevin McGettigan-Croce +2 more
2017Journal of Translational Medicine13 citations Open access
Semantic Scholar
Chimeric antigen receptor engineered T cells can eliminate brain tumors and initiate long-term protection against recurrence
L. Johnson, L. Sanchez-Perez, Carter M. Suryadevara, J. Sampson
2014Oncoimmunology8 citations Open access
Semantic Scholar
regression and targets normal tissues expressing cognate antigen Gene therapy with human and mouse T-cell receptors mediates cancer
Debbie-Ann N. Nathan, C. Laurencot, S. Rosenberg, C. Brewer +19 more
20097 citations
Semantic Scholar
Checkpoint antibody receptor modified ARMed CAR T circumvents the suppressive immunome in GBM
Danielle R. Cook, Alina C. Boesteanu, Yi-Bo Yin, R. Reid +6 more
2025Frontiers in Immunology6 citations Open access
Semantic Scholar
Pre-clinical validation of a humanized anti-EGFR variant III chimeric antigen receptor and phase I trial of CART-EGFRvIII in glioblastoma
L. Johnson, J. Scholler, T. Ohkuri, A. Kosaka +20 more
2014Journal of Immunotherapy for Cancer6 citations Open access
Semantic Scholar
NY-ESO-1 and LAGE1A: An emerging target for cell therapies in solid tumours
I. Eleftheriadou, S. Brett, A. Domogala, L. Patasic +16 more
2019Annals of Oncology4 citations Open access
Semantic Scholar
Model T Muscle CARs Can Treat Brain Tumors
L. Johnson
2012Clinical Cancer Research3 citations
Semantic Scholar
Backbone 1H, 15N and 13C resonance assignments of the 27kDa fluorescent protein mCherry
M. Sette, L. Johnson, R. Jimenez, Frans A. A. Mulder
2023Biomolecular NMR Assignments1 citations Open access
Semantic Scholar
Safety and activity of autologous T cells with enhanced NY-ESO-1–specific T-cell receptor (GSK3377794) in HLA-a*02+ previously-treated and -untreated patients with advanced metastatic/unresectable synovial sarcoma: A master protocol study design (IGNYTE-ESO).
S. D'Angelo, J. Blay, W. Chow, G. Demetri +16 more
20201 citations
Semantic Scholar
297 Modeling the efficacy of NY-ESO-1 TCR T cells (letetresgene autoleucel; GSK3377794) in patients with synovial sarcoma: correlations of response with transduced cell kinetics and biomarkers
A. Gyurdieva, S. Zajic, Ya-Fang Chang, E. Houseman +16 more
20201 citations Open access
Semantic Scholar
Abstract B139: Toxicity testing of EGFRvIII CAR-based immunotherapy of glioblastoma: From bench to bedside
Alexandria P. Cogdill, Alina C. Boesteanu, Chong Xu, K. Haines +14 more
2016Trials in Progress1 citations
Semantic Scholar
515. Targeting Hypoglycosylation with a Chimeric Antigen Receptor
A. Posey, Robert D Schwab, Alina Boestaneau, L. Johnson +1 more
20151 citations Open access
Semantic Scholar
Specific increase in T-cell potency via structure-based design of a T-cell receptor for adoptive immunotherapy.
K. Malecek, A. Grigoryan, Shi Zhong, Wei Gu +4 more
20141 citations Open access
Semantic Scholar
The Development of Adoptive T-Cell Immunotherapies for Cancer
D. Dow, S. Howe, M. Talekar, L. Johnson
20190 citations
Semantic Scholar
Toward Engineered Cells as Transformational and Broadly Available Medicines for the Treatment of Cancer
C. Britten, L. Johnson, A. Quintás-Cardama, N. Sheppard +1 more
20180 citations
Semantic Scholar
Combinatorial IL13Rα2 chimeric antigen receptor-T cells plus checkpoint blockade to treat solid tumors in murine and canine models.
Yi-Bo Yin, Alina C. Boesteanu, Chong Xu, A. Posey +7 more
20170 citations
Semantic Scholar
Molecular imaging biomarkers for cell-based immunotherapies
Mohammad Haris, P. Bagga, H. Hariharan, Bevin McGettigan-Croce +2 more
2017Journal of Translational Medicine0 citations Open access
Semantic Scholar
Chimeric Antigen Receptor Therapy of Brain Tumors
L. Sanchez-Perez, Carter M. Suryadevara, Bryan D. Choi, L. Johnson
20170 citations
Semantic Scholar

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