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Yoshinobu Hashizume · SciRah

Researcher profile · Semantic Scholar

Yoshinobu Hashizume

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Yoshinobu Hashizume — researcher profile on SciRah

h-index: 12
Works: 33
Citations: 563

Most-cited papers

A Pyrrolo-Pyrimidine Derivative Targets Human Primary AML Stem Cells in Vivo
Y. Saito, H. Yuki, M. Kuratani, Yoshinobu Hashizume +25 more
2013Science Translational Medicine85 citations
Semantic Scholar
Autocrine BMP-4 Signaling Is a Therapeutic Target in Colorectal Cancer.
Y. Yokoyama, Toshiaki Watanabe, Yusuke Tamura, Yoshinobu Hashizume +2 more
2017Cancer Research69 citations Open access
Semantic Scholar
Pathogenic Mutation of ALK2 Inhibits Induced Pluripotent Stem Cell Reprogramming and Maintenance: Mechanisms of Reprogramming and Strategy for Drug Identification
M. Hamasaki, Yoshinobu Hashizume, Yoshinori Yamada, Tomohiko Katayama +7 more
2012Stem Cells67 citations
Semantic Scholar
The involvement of organic anion transporting polypeptide in the hepatic uptake of telmisartan in rats: PET studies with [¹¹C]telmisartan.
Tadayuki Takashima, Yoshinobu Hashizume, Yumiko Katayama, Machiko Murai +4 more
2011Molecular Pharmaceutics55 citations
Semantic Scholar
Whole-body distribution and radiation dosimetry of [11C]telmisartan as a biomarker for hepatic organic anion transporting polypeptide (OATP) 1B3.
Keiji Shimizu, Tadayuki Takashima, Tomohiko Yamane, M. Sasaki +6 more
2012Nuclear Medicine and Biology45 citations
Semantic Scholar
Design and pharmacological evaluation of PF-4840154, a non-electrophilic reference agonist of the TrpA1 channel.
T. Ryckmans, A. Aubdool, J. Bodkin, P. J. Cox +11 more
2011Bioorganic & Medicinal Chemistry Letters42 citations Open access
Semantic Scholar
The synthesis and biodistribution of [(11)C]metformin as a PET probe to study hepatobiliary transport mediated by the multi-drug and toxin extrusion transporter 1 (MATE1) in vivo.
W. Hume, T. Shingaki, Tadayuki Takashima, Yoshinobu Hashizume +7 more
2013Bioorganic & Medicinal Chemistry37 citations Open access
Semantic Scholar
BMP signaling is a therapeutic target in ovarian cancer
Tomohiko Fukuda, Risa Fukuda, Ryo Tanabe, D. Koinuma +5 more
2020Cell Death Discovery29 citations Open access
Semantic Scholar
Transforming growth factor β‐inhibitor Repsox downregulates collagen expression of scleroderma dermal fibroblasts and prevents bleomycin‐induced mice skin fibrosis
M. Ide, M. Jinnin, Yukiko Tomizawa, Zhongzhi Wang +5 more
2017Experimental Dermatology22 citations Open access
Semantic Scholar
A Fluorescent-Based High-Throughput Screening Assay for Small Molecules That Inhibit the Interaction of MdmX with p53
K. Tsuganezawa, Yukari Nakagawa, Miki Kato, Shigenao Taruya +15 more
2013Journal of biomolecular screening19 citations Open access
Semantic Scholar
Methods for Obtaining Better Diffractive Protein Crystals: From Sample Evaluation to Space Crystallization
Yoshinobu Hashizume, K. Inaka, N. Furubayashi, M. Kamo +2 more
2020Crystals17 citations Open access
Semantic Scholar
Structural Basis of Activin Receptor-Like Kinase 2 (R206H) Inhibition by Bis-heteroaryl Pyrazole-Based Inhibitors for the Treatment of Fibrodysplasia Ossificans Progressiva Identified by the Integration of Ligand-Based and Structure-Based Drug Design Approaches
Tomohiro Sato, Katsuhiko Sekimata, N. Sakai, Hisami Watanabe +12 more
2020ACS Omega14 citations Open access
Semantic Scholar
Bis-Heteroaryl Pyrazoles: Identification of Orally Bioavailable Inhibitors of Activin Receptor-Like Kinase-2 (R206H).
Katsuhiko Sekimata, Tomohiro Sato, N. Sakai, Hisami Watanabe +12 more
2019Chemical and pharmaceutical bulletin11 citations Open access
Semantic Scholar
First automatic radiosynthesis of 11C labeled Telmisartan using a multipurpose synthesizer for clinical research use
Hitoshi Iimori, Yoshinobu Hashizume, M. Sasaki, Yoshinobu Kajiwara +4 more
2011Annals of Nuclear Medicine10 citations
Semantic Scholar
Novel bicyclic pyrazoles as potent ALK2 (R206H) inhibitors for the treatment of fibrodysplasia ossificans progressiva.
Hirofumi Yamamoto, N. Sakai, Satoshi Ohte, Tomohiro Sato +13 more
2021Bioorganic & Medicinal Chemistry Letters9 citations Open access
Semantic Scholar
A new BMP type 1 receptor kinase inhibitor for safe and efficient oral treatment to prevent genetically induced heterotopic ossification in mice
Jingwen Yang, Hai-Chun Pan, Katsuhiko Sekimata, Charles D Hwang +12 more
2025Bone6 citations
Semantic Scholar
Synthesis and preliminary chemie- and bio-iuminescence studies of a novel photolabile coelenterazine analogue with a trifluoromethyl diazirine group
Fengjuan Chen, T. Hirano, Yoshinobu Hashizume, Y. Ohmiya +1 more
19946 citations
Semantic Scholar
Regiocontrolled Construction of Functionalized Spiro[4.4]Nonanones Through Mercury(II) Salt-Assisted and Acid-Induced Spiroannulation Reactions
Yoshinobu Hashizume, S. Maki, M. Ohashi, H. Niwa
19995 citations
Semantic Scholar
Synthesis of Dimethyl Gloiosiphone A
Yoshinobu Hashizume, S. Maki, M. Ohashi, H. Niwa
19985 citations
Semantic Scholar
The transcription factor LHX2 mediates and enhances oncogenic BMP signaling in medulloblastoma
Yae Ohata, M. M. Ali, Yutaro Tsubakihara, Yuka Itoh +20 more
2025Cell Death and Differentiation4 citations Open access
Semantic Scholar
Synthesis of L‐[5‐11C]Leucine and L‐α‐[5‐11C]Methylleucine via Pd0‐mediated 11C‐Methylation and Microfluidic Hydrogenation: Potentiality of Leucine PET Probes for Tumor Imaging
Shuhei Takataki, Tsuyoshi Tahara, Mieko Tsuji, Daiki Ozaki +6 more
2021ChemMedChem4 citations
Semantic Scholar
Monoclonal antibodies against human TMPRSS2 prevent infection by any SARS-CoV-2 variant
M. Harada, Takehisa Matsumoto, Mizuki Yamamoto, J. Goda +31 more
2025iScience2 citations Open access
Semantic Scholar
Activin A secretion by muscle-repairing macrophages induces heterotopic ossification in mice
Wenqian Yin, Kazuo Okamoto, Asuka Terashima, W. Pluemsakunthai +10 more
2026Journal of Clinical Investigation1 citations Open access
Semantic Scholar
Methods to Grow Better Diffractive Protein Crystals Acquired through Space Experiments
Yoshinobu Hashizume, K. Inaka, N. Furubayashi, M. Kamo +2 more
20191 citations Open access
Semantic Scholar
Front Cover: Synthesis of L‐[5‐ 11 C]Leucine and L‐α‐[5‐ 11 C]Methylleucine via Pd 0 ‐mediated 11 C‐Methylation and Microfluidic Hydrogenation: Potentiality of Leucine PET Probes for Tumor Imaging (ChemMedChem 21/2021)
Shuhei Takatani, Tsuyoshi Tahara, Mieko Tsuji, Daiki Ozaki +6 more
2021ChemMedChem0 citations
Semantic Scholar
Methods to Grow Better Diffractive Protein Crystals
Yoshinobu Hashizume, K. Inaka, N. Furubayashi, M. Kamo +3 more
20190 citations
Semantic Scholar
A capillary device for growing large protein crystals
K. Inaka, S. Takahashi, Bin Yan, Misako Koga +4 more
2019Acta Crystallographica Section A: Foundations and Advances0 citations Open access
Semantic Scholar
Methods and devices for protein crystal growth in space
Hiroaki Tanaka, S. Takahashi, Bin Yan, Misako Koga +4 more
2019Acta Crystallographica Section A: Foundations and Advances0 citations Open access
Semantic Scholar
Identification of transporters involved in the hepatobiliary transport of PET probe, 15R- [11C]TIC, change in its plasma and hepatic concentration by drug interaction in humans and its prediction from in vitro experiments
Y. Sugiyama, S. Kitamura, K. Maeda, H. Kusuhara +9 more
20090 citations
Semantic Scholar
TELMISARTAN IN RATS
Tadayuki Takashima, Yoshinobu Hashizume, Machiko Murai, Yumiko Katayama +13 more
20090 citations
Semantic Scholar
Sammenföjede aryl or heteroaryl compounds as anti-inflammatory and analgesic agents
Naomi Uneo, Kazunari Nakao, Y. Okumura, Miyako Matsumizu +7 more
20010 citations
Semantic Scholar
Regiocontrolled Construction of Functionalized Spiro[4.4]nonanones Through Mercury(II) Salt-Assisted and Acid-Induced Spiroannulation Reactions.
Yoshinobu Hashizume, S. Maki, M. Ohashi, H. Niwa
19990 citations
Semantic Scholar
Synthesis and Preliminary Chemi- and Bioluminescence Studies of a Novel Photolabile Coelenterazine Analogue with a Trifluoromethyl Diazirine Group.
Fengjuan Chen, T. Hirano, Yoshinobu Hashizume, Y. Ohmiya +1 more
19950 citations
Semantic Scholar

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