1e:I[23489,["/_next/static/immutable/chunks/0cmb0ng968nlp.js","/_next/static/immutable/chunks/1c7dg80qt12uw.js","/_next/static/immutable/chunks/2bmdwv49ba1qx.js","/_next/static/immutable/chunks/3ld61_1ghpsxn.js"],"ShareMenu"] 1f:I[55078,["/_next/static/immutable/chunks/0cmb0ng968nlp.js","/_next/static/immutable/chunks/1c7dg80qt12uw.js","/_next/static/immutable/chunks/2bmdwv49ba1qx.js","/_next/static/immutable/chunks/3ld61_1ghpsxn.js"],"AuthorMetricsPanel"] 20:I[39060,["/_next/static/immutable/chunks/0cmb0ng968nlp.js","/_next/static/immutable/chunks/1c7dg80qt12uw.js","/_next/static/immutable/chunks/2bmdwv49ba1qx.js","/_next/static/immutable/chunks/3ld61_1ghpsxn.js"],"AuthorPapers"] 36:I[49310,["/_next/static/immutable/chunks/0cmb0ng968nlp.js","/_next/static/immutable/chunks/1c7dg80qt12uw.js"],"IconMark"] 21:T5ec,Obtaining an emergent EEG for the diagnosis of nonconvulsive status epilepticus and conconvulsive seizures in the intensive care unit raises logistic problems in most hospitals. Previous studies have looked into the hairline EEG for a broader population than the critically ill, with controversial conclusions. The authors created a montage sufficiently simple to be performed and interpreted by residents and rapidly achievable to meet the time constraints of a busy on-call schedule. Seven electrodes (Fp1, Fp2, T3, T4, O1, O2, and Cz), easily applied without the need for tape measure by using only anatomic landmarks (pupils, ears, vertex, and inion), were used to configure three different montages: double diamond, circumferential, and Cz referential. EEG records obtained with the full 10-20 system in critically ill patients were reformatted into these montages and reviewed retrospectively independently by neurology attending physicians with expertise in EEG interpretation and senior neurology residents. A comparison was done with the previously studied hairline EEG. The average sensitivity of the study montage for seizure detection was 92.5%, whereas the average specificity was 93.5%. These results suggest that the seven-electrode montage could potentially be a quick and reliable EEG montage for the detection of seizures in the intensive care unit, when technical support is not available. Further prospective studies are required to validate these promising results in a larger population sample.22:T4b9,The artery of Percheron (AOP) is a variant of the paramedian thalamic vasculature that supplies blood to the medial aspect of the thalamus and the rostral midbrain. The presentation of an infarct in this territory varies widely and is often characterized by nonspecific neurological deficits, with altered mental status, decreased level of consciousness, and memory impairment being among the most common. AOP infarcts are often missed on initial computed tomography (CT) scan, and additional imaging is usually not done due to low suspicion for stroke in most cases. There have been an increasing number of reports of AOP infarction, illustrating the diversity of clinical presentations and the challenge this presents to clinicians in the acute setting. Lacking the classic signs of stroke, many of these patients experience a delay in recognition and treatment, with the majority of diagnoses occurring outside the tissue plasminogen activator (tPA) window. This case highlights the unusual presentation and diagnostic difficulty of a patient with an AOP infarct, and serves as a reminder to include thalamic pathology in patients presenting with vague neurological symptoms and no obvious signs of stroke.23:T6d4,Abstract Background: Globally, more than 5.7% of the population reside above 1,500 m of elevation. It has been hypothesized that acute short-term hypoxia exposure could increase the risk of developing a stroke. Studies assessing the effect of altitude on stroke have provided conflicting results, some analysis suggest that long-term chronic exposure could be associated with reduced mortality and lower stroke incidence rates. Methods:An ecological analysis of all stroke hospital admissions, mortality rates and disability adjusted life years in Ecuador was performed from 2001-2017. The cases and population at risk were categorized in low (<1,500 m), moderate (1,500-2,500 m), high (2,500-3,500 m) and very high altitude (3,500-5,500 m) according to place of residence. The derived crude and direct standardized age-sex adjusted mortality and hospital admission rates were calculated. Results: A total of 38,201 deaths and 75,893 stroke-related hospital admissions were reported. High-altitude populations (HAP) had lower stroke mortality in men (RR: 0.91 [0.88 - 0.95]) and women (RR: 0.83 [0.79 - 0.86]). In addition, HAP had a significant lower risk of getting admitted to the hospital when compared with the low altitude group in men (RR: 0.55 [CI95% 0.54 - 0.56]) and women (RR: 0.65 [CI95% [0.64 - 0.66]). Conclusions: This is the first epidemiological study that aims to elucidate the association between stroke and altitude using four different elevation ranges. Our findings suggest that living at higher elevations offers a reduction or the risk of dying due to stroke as well as a reduction in the probability of being admitted to the hospital. Nevertheless, this protective factor has the stronger effect between 2,000 m to 3,500 m.24:T71d,OBJECTIVE: To assess the efficacy and safety of eslicarbazepine acetate (ESL) monotherapy. METHODS: This post hoc pooled analysis of 2 randomized double-blind studies (093-045 and -046) included adults with partial-onset seizures medically uncontrolled by 1 or 2 antiepileptic drugs (AEDs). Following the baseline period (8 weeks), eligible patients were randomized 2:1 to receive ESL 1,600 mg or 1,200 mg once daily for 18 weeks; the primary endpoint was study exit by meeting predefined exit criteria (signifying worsening seizure control). In each study, treatment was considered effective if the upper 95% confidence limit for exit rate was lower than the historical control threshold (65.3%). RESULTS: Pooled exit rates were as follows: ESL 1,600 mg = 20.6% (95% confidence interval: 15.6%-26.8%); ESL 1,200 mg = 30.8% (23.0%-40.5%). Use of 2 baseline AEDs or rescue medication, US location, epilepsy duration ≥20 years, and higher maximum baseline seizure frequency were associated with higher exit risks. Median percent reductions in standardized seizure frequency between baseline and the 18-week double-blind period were as follows: ESL 1,600 mg = 43.2%; ESL 1,200 mg = 35.7%; baseline carbamazepine use was associated with smaller reductions. Safety profiles were similar between ESL doses. CONCLUSIONS: Exit rates for ESL monotherapy (1,600 mg and 1,200 mg once daily) were lower than the historical control threshold, irrespective of baseline AED use and region, with no additional safety concerns identified. Clinical factors and location clearly influence treatment responses in conversion-to-monotherapy trials. CLASSIFICATION OF EVIDENCE: This pooled analysis provides Class IV evidence that for adults with medically uncontrolled partial-onset seizures, ESL monotherapy is well tolerated and effective.25:T844,OBJECTIVE: Traumatic brain injury (TBI) is a public health problem worldwide. Information regarding TBI from low- and middle-income countries is scarce. The objectives of this study are to determine the incidence, mortality and geodemographic distribution of TBI in Ecuador. METHODS: A population-based analytical study from 2004 to 2016 was conducted in Ecuador. Men and women with a diagnosis of TBI from all ages (0-110 years) were included. Data was obtained from official hospital-discharges records and retrieved from the National Institute of Statistics and Census (INEC) Database. We analyzed data by region, province and canton with a monthly resolution. The incidence, mortality, case fatality rates and the risk of developing TBI within the population were calculated based on the last 13 years of available data. RESULTS: A total of 124,576 hospital admissions and 5,264 deaths due to TBI were registered in Ecuador from 2004 to 2016. The overall TBI-related hospital admission rate was 70.68 per 100,000. The sex- and age-specific rate was 90.1 per 100,000 for men and 64.1 per 100,000 for women. Mestizos' population has the highest adjusted incidence rate of 195.6 per 100,000, followed by the indigenous with 61.4 per 100,000 and Afro-Americans with 14.2 per 100,000. The overall annual mortality rate during the study ranged from 2.11 to 3.35 per 100,000. Case fatality rates were significantly higher in older populations, becoming fatal in up to 27% of men >90 years/old and in 15% of women older than 90 years/old. CONCLUSION: This is the first recorded epidemiological study of the socio-demographic distribution of TBI in Ecuador to date. The study found that young men were almost 4 times more likely to be hospitalized due to TBI than women of this age. Fatalities due to TBI were less likely to occur among younger age groups, increasing significantly among the elderly population. The national incidence rate of TBI has been decreasing since 2011, which coincides with the introduction of stricter alcohol regulation, suggesting that this measure might have played a role in this reduction.26:T6a1,OBJECTIVE: Larger brains may contain more neurons and synaptic connections, providing a greater reserve against cognitive decline in Alzheimer's disease (AD). Larger head circumference (HC) may therefore be associated with later detection and diagnosis of AD. We investigated HC in nondemented individuals and AD patients using cross-sectional and prospective analyses. METHODS: The cross sectional analysis compared mean HC between 592 AD patients and 459 nondemented controls. Prospective analysis was based on the same initially normal controls who were followed longitudinally for conversion to dementia. Diagnosis of AD was made by neurologists using NINDS-ADRDA criteria. RESULTS: When compared to AD patients, controls had a significantly larger mean HC by 0.58 cm in men and by 0.31 cm in women, but these differences were no longer significant after adjustment for age and years of education. HC varied inversely with age and directly with years of education but did not vary with presence/absence of dementia in first-degree relatives or with apolipoprotein-E (ApoE) genotype. In the prospective analysis, the hazard ratio for time to conversion to AD was not significant for HC when adjusted for age at entry, ApoE allele status, family history of dementia, gender, and years of education. ApoE allele status, first degree relative with dementia, and baseline age conferred an increased risk for conversion to AD, consistent with other studies. CONCLUSIONS: We observed a smaller HC in AD patients compared to nondemented individuals, but AD per se accounted for little of this difference. HC was not a statistically significant predictor for conversion to AD in our longitudinal group.27:T695,OBJECTIVES To review the autoimmune and rheumatic manifestations of patients with malignancy. METHODS A Medline search of all published papers using keywords related to malignancies, autoimmunity, rheumatic diseases, and paraneoplastic syndromes. RESULTS Patients with malignant diseases may develop autoimmune phenomena and rheumatic diseases as a result of (a) generation of autoantibodies against various autoantigens, including oncoproteins (P185, 1-myc, c-myc, c-myb), tumour suppression genes (P53), proliferation associated antigens (cyclin A, B1, D1, E; CENP-F; CDK, U3-RNP), onconeural antigens (Hu, Yo, Ri, Tr), cancer/testis antigens (MAGE, GAGE, BAGE, SSX, ESO, SCP, CT7), and rheumatic disease associated antigens (RNP, Sm). The clinical significance of the various autoantibodies is not clear. Anti-oncoprotein and anti-tumour suppression gene antigens are detected before the diagnosis of the cancer or in the early stages of the malignant disease, suggesting a potential diagnostic or prognostic role. Anti-onconeural antibodies are pathogenic and are associated with specific clinical neurological syndromes (anti-Hu syndrome and others). (b) Paraneoplastic syndromes, a wide range of clinical syndromes, including classic autoimmune rheumatic diseases that develop among patients with cancer. (c) Rheumatism after chemotherapy, a clinical entity characterised by the development of musculoskeletal symptoms after combination chemotherapy for malignancy. CONCLUSION Autoimmune and rheumatic features are not rare among patients with malignancies. They are the result of various diverse mechanisms and occasionally they may be associated with serious clinical entities.28:T5a0,A 28-year-old right-handed man with no medical history presented with sudden onset of double vision.The patient stated that the double vision was worse when looking to the right, and he was not able to move his eyes to the left.On examination, the patient had a conjugate gaze palsy to the left and impaired adduction in the left eye (video), which persisted during saccades, pursuit, and oculocephalic movements.Vertical eye movements were normal, and no ocular bobbing was observed.MRI showed multiple periventricular white matter lesions and a central lesion in the pontine tegmentum (figure).One-and-a-half syndrome is a gaze abnormality characterized by a conjugate horizontal gaze palsy in one direction plus an internuclear ophthalmoplegia in the other. 1 The syndrome is usually caused by a single unilateral lesion of the paramedian pontine reticular formation or the abducens nucleus on one side (causing the conjugate gaze palsy to the side of the lesion), with interruption of internuclear fibers of the ipsilateral medial longitudinal fasciculus after it has crossed the midline from its site of origin in the contralateral abducens nucleus (causing failure of adduction of the ipsilateral eye). 1 One-and-a-half syndrome is most often caused by multiple sclerosis (MS), brain stem stroke, brain stem tumors, and arteriovenous malformations. 1 This patient was diagnosed with MS in accordance with the McDonald Criteria for MS.29:T6ae,Objective To assess the prevalence of and risk factors for cognitive decline and dementia in individuals greater than 65 years of age in Cumbayá, Quito, Ecuador. Methods This is a cross-sectional observational study that was carried out in adults over age 65. The Mini Mental State Examination (MMSE), Ascertain Dementia Eight-Item Informant Questionnaire (AD8), and Mini Nutritional Assessment (MNA) were used to assess the cognitive status and nutritional habits of this population. Results A total of 144 patients (mean age 75.3 years, 77.1% female) participated in this study. Forty percent of patients had AD8 and MMSE scores consistent with cognitive impairment and possible dementia. Age (p < 0.01), lower educational level (p < 0.01), history of stroke (p < 0.01), history of intracerebral hemorrhage (p < 0.01), diabetes mellitus (p < 0.01), and malnutrition (p < 0.01) were statistically significant risk factors for cognitive impairment. Exercise was found to be protective against cognitive decline in our study group (p < 0.03). Gender, ethnicity, location, head trauma, Parkinson disease, hypercholesterolemia, myocardial infarction, thyroid disease, depression, anxiety, and family history of dementia were not found to be associated with cognitive decline in this population. Conclusions The prevalence of cognitive impairment and possible dementia is 18-21% at age 65 and 54-60% at age 85 in Cumbayá, Quito, Ecuador. The major risk factors for cognitive impairment in this population are age, low educational level, malnutrition, prior stroke, prior intracerebral hemorrhage, and diabetes. Protective factors for cognitive decline include exercise and possibly modest consumption of alcohol.2a:T51b,Leber hereditary optic neuropathy (LHON) is a genetic condition that typically presents with unilateral, painless, sub-acute central vision loss followed by contralateral vision loss after a few weeks to months. It is a rare disease that typically affects young adults - men more than women - and is a relatively common cause of blindness. It is due to a mutation in mitochondrial DNA (mtDNA). The majority (more than 95%) of patients have one of three mtDNA point mutations: m.14484T→C, m.3460G→A, or m.11778G→A. These mutations lead to disruption of the mitochondrial respiratory chain activating pro-apoptotic pathways. For reasons unknown, this insult tends to affect the retinal ganglion cells more than any other cell in the body, leading to the disease state. Due to its low prevalence in the United States (1:50,000), this diagnosis is often overlooked, misdiagnosed, and mismanaged, which may exacerbate symptoms. It is essential then for physicians to recognize the presentation of and understand the diagnostic work-up for LHON. In this case report, we present the diagnostic challenges of a patient who presented with progressive vision loss, discuss the various differential diagnoses, review the literature on LHON, and propose an explanatory model for vision loss in patients with LHON.2b:T4f6,Intervertebral disc herniation is a common cause of radiculopathy. Disc herniations occurring in the lumbar spine typically affect the nerve root exiting under the pedicle of the vertebral body, one level caudal. However, in rare cases, a disc herniation can cause remote isolated radicular symptoms. The authors present the case of a 70-year-old male who presented with an acute, new-onset, left-sided foot drop, low back pain, and a classic L5 monoradiculopathy. Imaging revealed a large, left-sided paracentral extruded L2-3 disc and the absence of any pathology at the L4/5 level. Although the patient's clinical presentation and imaging did not classically correlate, it was felt that the L2-L3 disc was the etiology of the patient's L5 radiculopathy and a left L2-3 microsurgical discectomy was performed. At the six-week follow-up, his foot drop was near normal, sensation was intact with minimal paresthesias, and he remained pain-free. At the one-year follow-up, he experienced full resolution of his foot drop and remained symptom-free. Although rare, disc herniations may cause isolated, remote, painful mononeuropathies not related to the direct level of nerve root compression and should be considered along with other etiologies of peripheral neuropathies.2c:T949,Charles Bonnet syndrome (CBS) refers to the experience of visual hallucinations in the context of visual impairment. The underlying pathology may be localized anywhere along the visual pathway from the eye itself to visual cortical centers. It is sometimes compared to phantom limb syndrome; both involve decreased sensory input, as in loss of a limb or declining vision, resulting in overactivity in areas of the brain controlling sensory perception. Definitive diagnostic criteria are still lacking and may vary by discipline. However, the following features are generally agreed upon: visual hallucinations, impaired vision, and intact cognition and insight. Psychiatric symptoms, cognitive decline, and hallucinations of other sensory modalities are often excluded, although this remains an area of debate. Certain non-classic cases of CBS have inspired the designation of atypical CBS, which encompasses a wide spectrum of sensory experiences and associated symptoms. Auditory hallucinations in the hearing-impaired, a well-described phenomenon thought to have a similar pathogenesis, share with CBS the important risk factor of increased age. In patients experiencing both types of hallucinations with deterioration in both sensory domains, the distinction between a CBS variant and two independent processes may not be straightforward. In addition to the ongoing diagnostic dilemma posed by multimodal hallucinations, these phenomena tend to be underreported by patients likely due to concern that they will be diagnosed with mental illness. Although many patients with this condition are indifferent to it, some suffer distress from their hallucinations and would benefit from recognition, reassurance, and in some cases correction of the underlying cause or pharmacologic treatment. Here we present the case of an elderly woman with a history of macular degeneration and chronic hearing loss who experienced complex auditory and visual hallucinations surrounding an episode of severe anxiety. We postulate that her anxiety acted as a precipitant to her hallucinatory experiences and may partially explain their abrupt onset in the absence of other clear pathologic processes. This case serves to reinforce CBS as a possible etiology of visual hallucinations in the elderly population, while also generating discussion of how to classify her particular set of symptoms.2d:T711,The article “An epileptologist brings EEG to the Ecuadorian Amazon jungle” in the December 2009 issue of Neurology Today caught Dr. Laccheo's attention. She contacted Dr. Espinosa, an Ecuadorian neurologist trained in neurophysiology and epilepsy in the United States. Dr. Espinosa chairs a nonprofit organization providing free health care in Quito, and he leads a mission to provide health care in rural Ecuador. We participated in providing neurologic services to an underserved population in rural Ecuador in April 2011 during Dr. Laccheo's last year of residency. Ecuador ranked 97th among 175 countries in the world according to the United Nations' Human Development Index in 2003—the second to last in South America. Thirty-one percent of the population lives in extreme poverty, with an income of less than 1 dollar per day. In the Amazon region, 66% lack access to a sewage system and 44% to electricity. Up to 50% of children under age 6 suffer from malnutrition and the mortality rate of children under 5 is 24/1,000.1 Thirty percent of the population lacks regular access to health services and two-thirds have no health insurance. Indigenous ethnicity is a strong predictor for less frequent use of health care services in Ecuador.2 Our neurology mission took place in Tena, located in a rural Amazon rainforest region east of the Andes Mountains at the junction of the Rio Tena and Rio Pano, about 200 km (5 hours drive) away from the capital, Quito (figure). Tena has a population of 45,000 that is mostly derived from the descendants of those who fled the Spanish invasion in the Andes in the 16th century. The thick rainforest is home to many natives and remains isolated from the rest of Ecuador with limited access to major cities and health care. The local hospital of Tena, Jose …2e:T5e5,Objective To assess the cognitive function, prevalence, and risk factors associated with cognitive decline and dementia in people above 65 years of age in Santa Cruz Island, Galápagos, Ecuador. Methods This is a cross-sectional observational study that was carried out in adults over 65 years of age in Santa Cruz Island, Galápagos, Ecuador. The mini-mental state examination (MMSE) and ascertain dementia eight-item informant questionnaire (AD8)-validated Ecuador Spanish versions were used to assess cognition. Results There were a total of 80 participants, 55 (67%) women and 25 (31.2%) men. The majority of participants were Mestizos (85.3%), with the remainder classified as White (4.8%), Afro-Ecuadorians (2.4%), or Indigenous (3.6%). The prevalence of cognitive impairment is 30.0%-43.7%. The MMSE results showed that older age and lack of education are risk factors for cognitive decline (p < 0.01). There was high correlation between MMSE and AD8 scores. The AD8 showed that older age, widowhood, and living in Santa Rosa were risk factors for cognitive decline (p < 0.01). According to the AD8, the group with the highest education (six years or more) had the lowest risk of cognitive decline and dementia (p < 0.01). Conclusions The main risk factors for cognitive decline and dementia in individuals above 65 years old in Santa Cruz Island, Galápagos, Ecuador are increased age, lack of education, and widowhood. The prevalence of cognitive impairment is similar to previous studies in Ecuador.2f:T4fa,Silicone oils are used for ocular endotamponade to treat complicated retinal detachments. Neurological complications of silicone oil endotamponade are uncommon. Case reports have documented optic nerve atrophy and migration of the silicone oil into the subarachnoid space and ventricular system. However, optic neuritis contralateral to the treated eye has not been previously described. We report a 60 year-old-woman who underwent repair of retinal detachment with silicone oil in the left eye and later developed optic neuritis in the right eye. Immediately after the introduction of the silicone oil, the patient complained of severe pain in the left orbit with radiation into the left temporal and occipital areas. Subsequently, she developed vision loss in the previously unaffected right eye. She received a high dose intravenous steroids for three days with subsequent full recovery of vision in the right eye. Two weeks later, she had a second episode of decreased vision in the right eye, however this time, the vision in her right eye did not improve. MR imaging shows inflammation on the optic nerves and silicone oil in the ventricular system. Conclusions: Silicone oil can migrate into the nervous system and may provoke optic neuritis in the contralateral eye.30:T52d,Introduction Ischemic stroke is among the leading causes of death and disability. Approximately 50% of cryptogenic strokes are embolic strokes of undetermined source (ESUS). The most common cause of ESUS is atrial fibrillation. Therefore, the detection of atrial fibrillation with long-term implantable devices is needed. Neurologists are directly involved with acute and post-acute stroke care and have direct access to the management of stroke patients. Therefore, there is a need for neurologists to recommend, implant, and monitor cardiac implantable devices in patients with ESUS. Methods From November 2022 to October 2023, our group implanted 32 ESUS patients with Confirm Rx™ insertable cardiac monitors (Abbott, USA). Atrial fibrillation detection was supervised and monitored daily. Results In 24 months, atrial fibrillation was detected in 12.5% of patients (four patients), sinus bradycardia in 6.25% of patients (two patients), paroxysmal supraventricular tachycardia in 9.4% of patients (three patients), and asystole in one patient. Conclusion Our study shows that neurologists involved in the treatment of stroke care can safely implant, monitor, and detect atrial fibrillation accurately. Our rate of detection of atrial fibrillation in patients with ESUS was 12.8%, which is consistent with prior studies.31:T55d,The proverbial "zebras" in neurology are often times missed due to their low prevalence and incidence in the community. The number of misdiagnoses and improper therapeutic interventions that occur are further increased when patients with these rare diseases present with signs and symptoms of more common disorders. One such disease is sporadic Creutzfeldt-Jakob disease (sCJD), a prion disease that causes neuronal derangement and classically presents as a rapidly progressing dementia with extrapyramidal signs, ataxia, behavioural problems, and myoclonus in the advanced stage. It falls into the category of neurodegenerative disease, which also includes Alzheimer's disease, Huntington's disease, Parkinson's disease, and other Parkinson-related diseases. Though these diseases have overlapping symptomologies - such as cognitive impairment and neuromuscular dysfunction - they can be differentiated from one another based on the time course of the illness and the specific constellation of signs and symptoms. Our case report describes a patient who was found to have sCJD after months of treatment for Parkinson's disease and trigeminal neuralgia. Thus, we are highlighting the importance of recognizing rare diseases so that proper management can be initiated in a timely manner. Furthermore, we review the current literature on the diagnosis and management of sCJD.32:T9ed,Donanemab is an immunoglobulin G1 (IgG1) monoclonal antibody that was recently approved by the United States Food and Drug Administration for the treatment of early symptomatic Alzheimer's disease (AD). The drug was approved with boxed warnings for amyloid-related imaging abnormalities (ARIA). While seizures are recognized adverse events, they are predominantly characterized in the context of ARIA and accompanied by edema (ARIA-E) or hemosiderin deposition (ARIA-H). The precise epileptogenic mechanisms of anti-amyloid immunotherapies independent of macroscopic ARIA remain poorly understood. We report the case of a 90-year-old man with mild cognitive impairment due to AD and a history of well-controlled focal epilepsy on levetiracetam, who experienced two generalized tonic-clonic seizures. Each paroxysmal event occurred within two hours of completing his fifth and sixth monthly donanemab (1,400 mg intravenous) infusions. Inter-ictal magnetic resonance imaging (MRI), including fluid-attenuated inversion recovery (FLAIR) and susceptibility-weighted imaging (SWI) sequences, demonstrated no evidence of ARIA-E or ARIA-H. Routine electroencephalography (EEG) revealed no interictal epileptiform discharges. Seizure recurrence necessitated an escalation of his levetiracetam dosage to 750 mg twice daily and the immediate discontinuation of donanemab therapy, after which he remained seizure-free. The temporal proximity of the seizures to the infusions, the positive rechallenge, and the absence of identifiable structural, metabolic, or infectious precipitants raise the possibility of an association with donanemab. However, causality cannot be established from a single case report. Several biologically plausible mechanisms may explain this temporal association, including rapid amyloid-beta (Aβ) clearance, microglial activation, neuroinflammatory responses, and transient blood-brain barrier dysfunction, which may lower the seizure threshold in a patient with pre-existing epileptogenic networks. However, these mechanisms remain hypothetical and were not directly demonstrated in this patient. Clinicians should maintain a high index of suspicion for acute post-infusion seizures in patients receiving donanemab, particularly those with a history of epilepsy, even in the absence of radiographically detectable ARIA. Clinicians should be aware of this potential safety signal in patients with pre-existing epilepsy. Additional studies are needed before specific monitoring or treatment recommendations can be established.33:T5d7,Moyamoya disease, well described in literature, is a chronic cerebrovascular occlusive disorder. It is characterized by progressive stenosis/occlusion of the terminal portions of the internal carotid arteries (ICA) and the proximal portions of the middle cerebral arteries (MCA). Less frequently described is Moyamoya syndrome, the name given to radiographic findings consistent with Moyamoya disease, but with an identifiable cause. The diseases associated with Moyamoya Syndrome include Sickle Cell Disease (SCD), Thalassemias, and Down's Syndrome to name a few. Common complications of Moyamoya include both ischemic and hemorrhagic strokes. Upon literature review, Moyamoya syndrome caused by SCD is not well described. When it is, the discussion is centered around the pediatric patient population and surgical management. Our case report describes a 22-year-old African American female with SCD who initially presented with Acute Chest Syndrome. Her hospital course was complicated by development of overt debilitating neurologic deficits. Subsequently, she was found to have Moyamoya Syndrome on neuroimaging. She was successfully treated with medical management without any surgical intervention. This case highlights the necessity of thorough examination, differential diagnosis, imaging findings, and consideration of predisposing syndromes in the work-up for Moyamoya syndrome; especially individuals with Sickle Cell Disease. Disclosures No relevant conflicts of interest to declare.34:T5c1,OBJECTIVE: To assess the efficacy of perampanel in patients with GBM with refractory epilepsy. BACKGROUND: Malignant gliomas are known to release glutamate which is involved in tumor expansion and epileptogenesis. By blocking α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptors stimulated by glutamate, seizure control may be achieved. Perampanel, a noncompetitive AMPA glutamate receptor antagonist, has been shown to be an effective adjunctive treatment in patients with epilepsy. DESIGN/METHODS: We describe 3 patients with GBM and refractory epilepsy that achieved seizure control with the addition of perampanel to their current regimen. RESULTS: Case1. Patient is a 61 year old woman with recurrent seizures on levetiracetam and oxcarbazepine. Perampanel was added and the patient has been seizure free for over 3 months. Case 2. Patient is a 64 year old man with GBM and partial status epilepticus on valproic acid, levetiracetam and lacosamide. Perampanel was added and the focal seizures decreased significantly. The patient passed away after 5 weeks due to complications of GBM. Case 3. Patient 68 year old man with GBM status post 2 surgeries and epilepsia partialis continua on levetiracetam, valproic acid and carbamazepine. Perampanel was added and he has remained seizure free for over 5 weeks. CONCLUSIONS: Perampanel is efficacious and well tolerated as an adjunctive anti-epileptic drug in our patients with GBM and refractory seizures.16:["$","div",null,{"className":"mx-auto max-w-6xl px-4 py-6 sm:px-6 sm:py-10","children":[["$","header",null,{"className":"grid gap-6 lg:grid-cols-[1fr_22rem] lg:items-end","children":[["$","div",null,{"children":[["$","p",null,{"className":"label mb-2 text-accent","children":["Researcher profile · ","OpenAlex"]}],["$","h1",null,{"className":"text-3xl font-bold sm:text-4xl","children":"Patricio S Espinosa"}],["$","ul",null,{"className":"mt-3 flex flex-col gap-1 text-[15px]","children":[["$","li","Boca Raton Regional Hospital",{"className":"flex items-center gap-2","children":[["$","span",null,{"className":"font-medium","children":"Boca Raton Regional Hospital"}],["$","p",null,{"className":"mt-1.5 max-w-2xl text-sm text-muted","children":"Neurology, Marcus Neuroscience Institute, Boca Raton Regional Hospital, Boca Raton, USA"}],["$","span",null,{"className":"tag","children":"US"}]]}],["$","li","Florida Atlantic University",{"className":"flex items-center gap-2","children":[["$","span",null,{"className":"font-medium","children":"Florida Atlantic University"}],["$","p",null,{"className":"mt-1.5 max-w-2xl text-sm text-muted","children":"Neurology, Marcus Neuroscience Institute, Boca Raton Regional Hospital, Boca Raton, USA"}],["$","span",null,{"className":"tag","children":"US"}]]}]]}],["$","div",null,{"className":"mt-4 flex flex-wrap gap-2","children":[["$","$L1e",null,{"path":"/author/openalex%3AA5103408930","title":"Patricio S Espinosa — researcher profile on SciRah","buttonLabel":"Share profile","className":"btn-ghost py-1.5"}],"$undefined","$undefined"]}],"$undefined","$undefined"]}],["$","$L1f",null,{"authorId":"openalex:A5103408930","initial":{"works":85,"citations":1783,"hIndex":19,"i10Index":24}}]]}],["$","div",null,{"className":"mt-6 flex flex-wrap gap-1.5","children":[["$","span","Epilepsy research and treatment",{"className":"tag","children":"Epilepsy research and treatment"}],["$","span","Dementia and Cognitive Impairment Research",{"className":"tag","children":"Dementia and Cognitive Impairment Research"}],["$","span","Acute Ischemic Stroke Management",{"className":"tag","children":"Acute Ischemic Stroke Management"}]]}],["$","div",null,{"className":"relative h-8 w-full my-8","aria-hidden":"true","children":["$","svg",null,{"viewBox":"0 0 1200 40","preserveAspectRatio":"none","className":"absolute inset-0 h-full w-full","children":[["$","path",null,{"d":"M0 20 C 120 6, 240 34, 360 20 S 600 6, 720 20 S 960 34, 1080 20 S 1200 12, 1200 12","fill":"none","stroke":"var(--line)","strokeWidth":"6","strokeLinecap":"round","vectorEffect":"non-scaling-stroke"}],["$","path",null,{"d":"M0 20 C 120 6, 240 34, 360 20 S 600 6, 720 20 S 960 34, 1080 20 S 1200 12, 1200 12","fill":"none","stroke":"var(--primary)","strokeOpacity":"0.55","strokeWidth":"1.25","strokeDasharray":"6 9","vectorEffect":"non-scaling-stroke"}]]}]}],["$","div",null,{"className":"grid gap-8 lg:grid-cols-[1fr_20rem]","children":[["$","section",null,{"aria-labelledby":"works","className":"min-w-0","children":[["$","h2",null,{"id":"works","className":"mb-4 text-xl font-semibold","children":"Most-cited papers"}],["$","$L20",null,{"authorId":"openalex:A5103408930","papers":[{"ids":{"openalex":"W3010897008","doi":"10.7759/cureus.7352","pmid":"32328364"},"title":"Neurological Complications of Coronavirus Disease (COVID-19): Encephalopathy","abstract":"Coronavirus disease 2019 (COVID-19) is a pandemic. 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We report a second case of a patient who presented with COVID-19 infection and encephalopathy to our institution. In addition, we report MRI brain and cerebrospinal fluid data. COVID-19 does not seem to cross the blood-brain barrier. The exact mechanisms of encephalopathy and pathological response of COVID-19 are unknown.","authors":[{"name":"Patricio S Espinosa","id":"openalex:A5103408930","affiliation":"Boca Raton Regional Hospital","institutionId":"I2802769386","institutionUrl":"https://ror.org/01phhgk62","affiliations":["Neurology, Marcus Neuroscience Institute, Boca Raton Regional Hospital, Boca Raton, USA","Neurology, Charles E. Schmidt College of Medicine, Florida Atlantic University, Boca Raton, USA"],"corresponding":true},{"name":"Zufe Rizvi","id":"openalex:A5076811456","affiliation":"Boca Raton Regional Hospital","institutionId":"I2802769386","institutionUrl":"https://ror.org/01phhgk62","affiliations":["Neurology, Charles E. 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Wechsler","id":"openalex:A5012220015","orcid":"https://orcid.org/0000-0002-3146-986X"},{"name":"Michael Yuecheung Xu","id":"openalex:A5108559679","affiliation":"Thomas Jefferson University","institutionId":"I149251103","institutionUrl":"https://ror.org/00ysqcn41","affiliations":["Department of Neurology (M.P.J.), Temple University School of Medicine, Philadelphia, PA","FireKite (M.G.), Macclesfield, UK","From Thomas Jefferson University (M.R.S.), Philadelphia, PA","New York University Comprehensive Epilepsy Center (J.F.), New York, NY","Sunovion Pharmaceuticals Inc. (H.C., T.G., D.B), Marlborough, MA","Vestra Clinics s.r.o. (L.P.), Rychnov nad Kneznou, Czech Republic"]},{"name":"V A Abramov","id":"openalex:A5103939519"},{"name":"Michal Bar","id":"openalex:A5045839758","orcid":"https://orcid.org/0000-0002-5049-5844"},{"name":"Andrea Bajacekova","id":"openalex:A5097859097"},{"name":"Robert Beach"},{"name":"Jay Berke","id":"openalex:A5112060559"},{"name":"Perminder Bhatia","id":"openalex:A5012722318","orcid":"https://orcid.org/0000-0002-1238-3921"},{"name":"Valeny Bitenskyy","id":"openalex:A5097512582"},{"name":"Alexis D. Boro","id":"openalex:A5017658636","orcid":"https://orcid.org/0009-0004-6832-1107"},{"name":"Plamen Stoyanov Bozhinov","id":"openalex:A5010518223"},{"name":"Олег Чабан","id":"openalex:A5011155500","orcid":"https://orcid.org/0000-0001-9702-7629"},{"name":"Andriy Dubenko","id":"openalex:A5110488627"},{"name":"Evan J. Fertig","id":"openalex:A5034314958"},{"name":"E Green","id":"openalex:A5112010260"},{"name":"Mercedes P. Jacobson","id":"openalex:A5084327924","affiliation":"Thomas Jefferson University","institutionId":"I149251103","institutionUrl":"https://ror.org/00ysqcn41","affiliations":["From Thomas Jefferson University (M.R.S.), Philadelphia, PA","New York University Comprehensive Epilepsy Center (J.F.), New York, NY","Department of Neurology (M.P.J.), Temple University School of Medicine, Philadelphia, PA","Vestra Clinics s.r.o. (L.P.), Rychnov nad Kneznou, Czech Republic","FireKite (M.G.), Macclesfield, UK; and Sunovion Pharmaceuticals Inc. (H.C., T.G., D.B), Marlborough, MA","FireKite (M.G.), Macclesfield, UK","Sunovion Pharmaceuticals Inc. (H.C., T.G., D.B), Marlborough, MA"]},{"name":"Росен Калпачки","id":"openalex:A5127061299"},{"name":"Sasho Hristov Kastrev","id":"openalex:A5097512583"},{"name":"Svitlana Kazakova","id":"openalex:A5030970413"},{"name":"David M. Labiner","id":"openalex:A5040175821","orcid":"https://orcid.org/0000-0002-3806-4734","affiliation":"Thomas Jefferson University","institutionId":"I149251103","institutionUrl":"https://ror.org/00ysqcn41","affiliations":["Department of Neurology (M.P.J.), Temple University School of Medicine, Philadelphia, PA","FireKite (M.G.), Macclesfield, UK","From Thomas Jefferson University (M.R.S.), Philadelphia, PA","New York University Comprehensive Epilepsy Center (J.F.), New York, NY","Sunovion Pharmaceuticals Inc. (H.C., T.G., D.B), Marlborough, MA","Vestra Clinics s.r.o. (L.P.), Rychnov nad Kneznou, Czech Republic"]},{"name":"Tetyana Litovchenko","id":"openalex:A5026084643","orcid":"https://orcid.org/0000-0002-4647-8507"},{"name":"Farid Marquez","id":"openalex:A5110278872"},{"name":"Patrick E Matoole","id":"openalex:A5097512584"},{"name":"Maja Milovanović","id":"openalex:A5100608403","orcid":"https://orcid.org/0000-0002-9683-3941"},{"name":"Svitlana Moroz","id":"openalex:A5007063980"},{"name":"Evžen Nešpor","id":"openalex:A5040957808"},{"name":"Joel M. Oster","id":"openalex:A5062870795","orcid":"https://orcid.org/0000-0002-1895-4326"}],"venue":"Neurology","venueId":"S79704628","publisher":"Lippincott Williams & Wilkins","publisherId":"P4310315671","year":2016,"publishedDate":"2016-02-25","type":"article","citationCount":36,"referenceCount":9,"isOpenAccess":true,"sourceUrl":"https://doi.org/10.1212/wnl.0000000000002497","oaUrl":"https://n.neurology.org/content/neurology/86/12/1095.full.pdf","pdfUrl":"https://n.neurology.org/content/neurology/86/12/1095.full.pdf","topics":[{"id":"T10094","name":"Epilepsy research and treatment","score":0.9990000128746033,"subfieldId":"2738","subfield":"Psychiatry and Mental health","fieldId":"27","field":"Medicine"},{"id":"T12229","name":"Pharmacological Effects and Toxicity Studies","score":0.0003000000142492354,"subfieldId":"2735","subfield":"Pediatrics, Perinatology and Child Health","fieldId":"27","field":"Medicine"},{"id":"T12267","name":"Diet and metabolism studies","score":0.00009999999747378752,"subfieldId":"2737","subfield":"Physiology","fieldId":"27","field":"Medicine"}],"sources":["openalex"],"id":"openalex:W2311740243"},{"ids":{"openalex":"W2045606427","doi":"10.1001/archneur.62.5.817","pmid":"15883271"},"title":"Brachial Amyotrophic Diplegia in a Patient With Human Immunodeficiency Virus Infection","abstract":"Although amyotrophic lateral sclerosis and progressive spinal muscular atrophy have been recognized to occur in association with human immunodeficiency virus infection, to our knowledge, brachial amyotrophic diplegia, a form of segmental motor neuron disease, has not been previously reported. Brachial amyotrophic diplegia results in severe lower motor neuron weakness and atrophy of the upper extremities in the absence of bulbar or lower extremity involvement, pyramidal features, bowel and bladder incontinence, and sensory loss. We describe a human immunodeficiency virus-seropositive man without severe immunosuppression or prior AIDS-defining illnesses who had brachial amyotrophic diplegia. This disorder may represent one end of a spectrum of motor neuron diseases occurring with this retrovirus infection.","authors":[{"name":"Joseph R. Berger","id":"openalex:A5066505115","orcid":"https://orcid.org/0000-0002-1540-496X","affiliation":"University of Kentucky","institutionId":"I143302722","institutionUrl":"https://ror.org/02k3smh20","affiliations":["Department of Neurology, University of Kentucky College of Medicine, Lexington, KY 40536-0284, USA. jrbneuro@uky.edu"]},{"name":"Patricio S Espinosa","id":"openalex:A5103408930"},{"name":"John T. Kissel","id":"openalex:A5110577160"}],"venue":"Archives of Neurology","venueId":"S4210230857","publisher":"American Medical Association","publisherId":"P4310320259","year":2005,"publishedDate":"2005-05-01","type":"article","citationCount":33,"referenceCount":49,"isOpenAccess":false,"sourceUrl":"https://doi.org/10.1001/archneur.62.5.817","topics":[{"id":"T10855","name":"Amyotrophic Lateral Sclerosis Research","score":0.7172999978065491,"subfieldId":"2728","subfield":"Neurology","fieldId":"27","field":"Medicine"},{"id":"T11735","name":"Peripheral Neuropathies and Disorders","score":0.14839999377727509,"subfieldId":"2728","subfield":"Neurology","fieldId":"27","field":"Medicine"},{"id":"T10112","name":"HIV Research and Treatment","score":0.03790000081062317,"subfieldId":"2406","subfield":"Virology","fieldId":"24","field":"Immunology and Microbiology"}],"sources":["openalex"],"id":"openalex:W2045606427"},{"ids":{"openalex":"W3020532403","doi":"10.1016/j.mehy.2020.109780","pmid":"32353795"},"title":"Mindfulness with paced breathing reduces blood pressure","authors":[{"name":"Jacqueline Brenner","id":"openalex:A5110842635","affiliation":"Pennsylvania State University","institutionId":"I130769515","institutionUrl":"https://ror.org/04p491231","affiliations":["Accelerated Premedical-Medical Program BS/MD at Penn State and Sidney Kimmel Medical College at Thomas Jefferson University, United States"]},{"name":"Suzanne D. Leblang","id":"openalex:A5077020709","orcid":"https://orcid.org/0000-0001-7329-6138","affiliation":"Florida Atlantic University","institutionId":"I63772739","institutionUrl":"https://ror.org/05p8w6387","affiliations":["Charles E. Schmidt College of Medicine, Florida Atlantic University, United States. Electronic address: sleblang31@gmail.com","Charles E. Schmidt College of Medicine, Florida Atlantic University, United States"],"corresponding":true},{"name":"Michelle Lizotte‐Waniewski","id":"openalex:A5052658856","orcid":"https://orcid.org/0000-0001-7556-3607","affiliation":"Florida Atlantic University","institutionId":"I63772739","institutionUrl":"https://ror.org/05p8w6387","affiliations":["Charles E. Schmidt College of Medicine, Florida Atlantic University, United States"]},{"name":"Barbara Schmidt","id":"openalex:A5116130593","orcid":"https://orcid.org/0000-0001-8677-2164","affiliation":"Florida Atlantic University","institutionId":"I63772739","institutionUrl":"https://ror.org/05p8w6387","affiliations":["Charles E. Schmidt College of Medicine, Florida Atlantic University, United States"]},{"name":"Patricio S Espinosa","id":"openalex:A5103408930","affiliation":"Boca Raton Regional Hospital","institutionId":"I2802769386","institutionUrl":"https://ror.org/01phhgk62","affiliations":["Charles E. Schmidt College of Medicine, Florida Atlantic University, United States","Marcus Neurosciences Institute, Boca Raton Regional Hospital and Baptist Health South Florida, United States"]},{"name":"David L. DeMets","id":"openalex:A5049652855","orcid":"https://orcid.org/0000-0003-3348-8754","affiliation":"University of Wisconsin–Madison","institutionId":"I135310074","institutionUrl":"https://ror.org/01y2jtd41","affiliations":["Department of Biostatistics and Informatics, University of Wisconsin, School of Medicine & Public Health, United States"]},{"name":"Andrew B. Newberg","id":"openalex:A5033687321","orcid":"https://orcid.org/0000-0001-8230-1752","affiliation":"Thomas Jefferson University","institutionId":"I149251103","institutionUrl":"https://ror.org/00ysqcn41","affiliations":["Marcus Institute for Integrative Health, Thomas Jefferson University, United States"]},{"name":"Charles H. Hennekens","id":"openalex:A5006554574","orcid":"https://orcid.org/0000-0003-1214-1663","affiliation":"Florida Atlantic University","institutionId":"I63772739","institutionUrl":"https://ror.org/05p8w6387","affiliations":["Charles E. Schmidt College of Medicine, Florida Atlantic University, United States"]}],"venue":"Medical Hypotheses","venueId":"S27514295","publisher":"Elsevier BV","publisherId":"P4310320990","year":2020,"publishedDate":"2020-04-22","type":"article","citationCount":29,"referenceCount":49,"isOpenAccess":false,"sourceUrl":"https://doi.org/10.1016/j.mehy.2020.109780","topics":[{"id":"T10708","name":"Mindfulness and Compassion Interventions","score":0.5005000233650208,"subfieldId":"3203","subfield":"Clinical Psychology","fieldId":"32","field":"Psychology"},{"id":"T10144","name":"Blood Pressure and Hypertension Studies","score":0.4255000054836273,"subfieldId":"2705","subfield":"Cardiology and Cardiovascular Medicine","fieldId":"27","field":"Medicine"},{"id":"T10745","name":"Heart Rate Variability and Autonomic Control","score":0.04569999873638153,"subfieldId":"2705","subfield":"Cardiology and Cardiovascular 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Mascialino","id":"openalex:A5030109155","orcid":"https://orcid.org/0000-0001-7408-6546","affiliation":"Universidad de Las Américas","institutionId":"I4210102282","institutionUrl":"https://ror.org/0198j4566","affiliations":["School of psychology, Universidad de Las Americas, Quito, Ecuador"]},{"name":"Clara Paz","id":"openalex:A5086373827","orcid":"https://orcid.org/0000-0003-1106-9567","affiliation":"Universidad de Las Américas","institutionId":"I4210102282","institutionUrl":"https://ror.org/0198j4566","affiliations":["School of psychology, Universidad de Las Americas, Quito, Ecuador"]},{"name":"Alberto Rodríguez‐Lorenzana","id":"openalex:A5063038833","orcid":"https://orcid.org/0000-0003-0394-9230","affiliation":"Universidad de Las Américas","institutionId":"I4210102282","institutionUrl":"https://ror.org/0198j4566","affiliations":["School of psychology, Universidad de Las Americas, Quito, Ecuador"]},{"name":"Lenin Gómez‐Barreno","id":"openalex:A5006349442","orcid":"https://orcid.org/0000-0002-4499-0304","affiliation":"Universidad de Las Américas","institutionId":"I4210102282","institutionUrl":"https://ror.org/0198j4566","affiliations":["One Health Research Group, Faculty of Health Science, Universidad de Las Américas, Quito, Ecuador"]},{"name":"Katherine Simbaña‐Rivera","id":"openalex:A5062391754","orcid":"https://orcid.org/0000-0002-8130-5361","affiliation":"Universidad de Las Américas","institutionId":"I4210102282","institutionUrl":"https://ror.org/0198j4566","affiliations":["One Health Research Group, Faculty of Health Science, Universidad de Las Américas, Quito, Ecuador"]},{"name":"Ana Maria Diaz","id":"openalex:A5107392808","affiliation":"Universidad de Las Américas","institutionId":"I4210102282","institutionUrl":"https://ror.org/0198j4566","affiliations":["One Health Research Group, Faculty of Health Science, Universidad de Las Américas, Quito, Ecuador"]},{"name":"Marco Coral-Almeida","id":"openalex:A5008772087","orcid":"https://orcid.org/0000-0003-0211-2906","affiliation":"Universidad de Las Américas","institutionId":"I4210102282","institutionUrl":"https://ror.org/0198j4566","affiliations":["One Health Research Group, Faculty of Health Science, Universidad de Las Américas, Quito, Ecuador"]},{"name":"Patricio S Espinosa","id":"openalex:A5103408930","affiliation":"Florida Atlantic University","institutionId":"I63772739","institutionUrl":"https://ror.org/05p8w6387","affiliations":["Chief of Neurology, Marcus Neuroscience Institute, Florida Atlantic University, Boca Raton, Florida, USA","Chief of Neurology, Marcus Neuroscience Institute, Florida Atlantic University, Boca Raton, FL, USA"]}],"venue":"Neuroepidemiology","venueId":"S21771311","publisher":"Karger Publishers","publisherId":"P4310317820","year":2019,"publishedDate":"2019-08-28","type":"article","citationCount":27,"referenceCount":47,"isOpenAccess":true,"sourceUrl":"https://doi.org/10.1159/000502580","oaUrl":"https://academica-e.unavarra.es/bitstreams/06e3cd29-68d6-4f23-958a-522b4778500c/download","pdfUrl":"https://academica-e.unavarra.es/bitstreams/06e3cd29-68d6-4f23-958a-522b4778500c/download","topics":[{"id":"T10706","name":"Traumatic Brain Injury and Neurovascular Disturbances","score":0.9047999978065491,"subfieldId":"2728","subfield":"Neurology","fieldId":"27","field":"Medicine"},{"id":"T10416","name":"Traumatic Brain Injury Research","score":0.07039999961853027,"subfieldId":"2713","subfield":"Epidemiology","fieldId":"27","field":"Medicine"},{"id":"T11467","name":"Trauma and Emergency Care Studies","score":0.009399999864399433,"subfieldId":"2711","subfield":"Emergency Medicine","fieldId":"27","field":"Medicine"}],"sources":["openalex"],"id":"openalex:W2970994869"},{"ids":{"openalex":"W2052908340","doi":"10.1016/j.clineuro.2011.03.011","pmid":"21507568"},"title":"Association of antiepileptic drugs, vitamin D, and calcium supplementation with bone fracture occurrence in epilepsy patients","authors":[{"name":"Patricio S Espinosa","id":"openalex:A5103408930","affiliation":"Centro Internacional en Neurociencias, 5 Finch, Mandeville, LA 70471, United States. ps.espinosa@cien-ecuador.org","affiliations":["Centro Internacional en Neurociencias, 5 Finch, Mandeville, LA 70471, United States. ps.espinosa@cien-ecuador.org","Centro Internacional en Neurociencias, 5 Finch, Mandeville, LA 70471, United States"],"corresponding":true},{"name":"David L. Perez","id":"openalex:A5077957501","orcid":"https://orcid.org/0000-0003-2721-583X","affiliation":"Brigham and Women's Hospital","institutionId":"I1283280774","institutionUrl":"https://ror.org/04b6nzv94","affiliations":["Department of Neurology, Brigham and Women's Hospital, 75 Francis Street, Boston, MA 02115, United States","Department of Neurology, Massachusetts General Hospital, 55 Fruit Street, Boston, MA 02114, United States"]},{"name":"Erin L. Abner","id":"openalex:A5048341091","orcid":"https://orcid.org/0000-0002-9566-4111","affiliation":"University of Kentucky","institutionId":"I143302722","institutionUrl":"https://ror.org/02k3smh20","affiliations":["Center on Aging, University of Kentucky, Lexington, KY 40506, United States"]},{"name":"Melody Ann Ryan","id":"openalex:A5046702420","orcid":"https://orcid.org/0000-0002-2098-3775","affiliation":"University of Kentucky","institutionId":"I143302722","institutionUrl":"https://ror.org/02k3smh20","affiliations":["College of Pharmacy of the University of Kentucky, Lexington, KY 40506, United States","Department of Neurology, University of Kentucky, Lexington, KY 40506, United States"]}],"venue":"Clinical Neurology and Neurosurgery","venueId":"S165396890","publisher":"Elsevier BV","publisherId":"P4310320990","year":2011,"publishedDate":"2011-04-21","type":"article","citationCount":27,"referenceCount":41,"isOpenAccess":false,"sourceUrl":"https://doi.org/10.1016/j.clineuro.2011.03.011","topics":[{"id":"T12229","name":"Pharmacological Effects and Toxicity Studies","score":0.47290000319480896,"subfieldId":"2735","subfield":"Pediatrics, Perinatology and Child Health","fieldId":"27","field":"Medicine"},{"id":"T10277","name":"Vitamin D Research Studies","score":0.2759000062942505,"subfieldId":"2734","subfield":"Pathology and Forensic Medicine","fieldId":"27","field":"Medicine"},{"id":"T10071","name":"Bone health and osteoporosis research","score":0.18970000743865967,"subfieldId":"2732","subfield":"Orthopedics and Sports Medicine","fieldId":"27","field":"Medicine"}],"sources":["openalex"],"id":"openalex:W2052908340"},{"ids":{"openalex":"W2892727895","doi":"10.7759/cureus.3371","pmid":"30510881"},"title":"Case Reports of Pembrolizumab-induced Acute Inflammatory Demyelinating Polyneuropathy","abstract":"Pembrolizumab is a humanized monoclonal antibody that blocks the programmed cell death 1 (PD-1) pathway, thereby enhancing antitumor immunity. As the use of immune checkpoint inhibitors becomes more prevalent, so do immune-related adverse events associated with their use. The immune-related adverse events linked with this class of drugs are commonly seen and most of the time are classified as mild adverse events. These are easily treated with steroids if recognition of symptomatology and treatment are promptly established. However, neurologic immune-related adverse events are less understood and have been infrequently cited in the medical literature, thus representing a challenge for clinicians.","authors":[{"name":"Rupesh Manam","id":"openalex:A5074846694","affiliation":"Boca Raton Regional Hospital","institutionId":"I2802769386","institutionUrl":"https://ror.org/01phhgk62","affiliations":["Internal Medicine, Florida Atlantic University Charles E. Schmidt College of Medicine, Boca Raton, USA","Neuro-Oncology, Marcus Neuroscience Institute, Boca Raton, USA","Neurology, Marcus Neuroscience Institute -Boca Raton Regional Hospital, Boca Raton, USA","Oncology, Lynn Cancer Institute, Boca Raton, USA"],"corresponding":true},{"name":"Jasmine L Martin","id":"openalex:A5104082682","affiliation":"Boca Raton Regional Hospital","institutionId":"I2802769386","institutionUrl":"https://ror.org/01phhgk62","affiliations":["Internal Medicine, Florida Atlantic University Charles E. Schmidt College of Medicine, Boca Raton, USA","Neuro-Oncology, Marcus Neuroscience Institute, Boca Raton, USA","Neurology, Marcus Neuroscience Institute -Boca Raton Regional Hospital, Boca Raton, USA","Oncology, Lynn Cancer Institute, Boca Raton, USA"]},{"name":"Joshua A Gross","id":"openalex:A5031465675","affiliation":"Boca Raton Regional Hospital","institutionId":"I2802769386","institutionUrl":"https://ror.org/01phhgk62","affiliations":["Internal Medicine, Florida Atlantic University Charles E. Schmidt College of Medicine, Boca Raton, USA","Neuro-Oncology, Marcus Neuroscience Institute, Boca Raton, USA","Neurology, Marcus Neuroscience Institute -Boca Raton Regional Hospital, Boca Raton, USA","Oncology, Lynn Cancer Institute, Boca Raton, USA"]},{"name":"Dhishna Chaudhary","id":"openalex:A5037051138","affiliation":"Boca Raton Regional Hospital","institutionId":"I2802769386","institutionUrl":"https://ror.org/01phhgk62","affiliations":["Internal Medicine, Florida Atlantic University Charles E. Schmidt College of Medicine, Boca Raton, USA","Neuro-Oncology, Marcus Neuroscience Institute, Boca Raton, USA","Neurology, Marcus Neuroscience Institute -Boca Raton Regional Hospital, Boca Raton, USA","Oncology, Lynn Cancer Institute, Boca Raton, USA"]},{"name":"Sajeel A. Chowdhary","id":"openalex:A5003877580","affiliation":"Boca Raton Regional Hospital","institutionId":"I2802769386","institutionUrl":"https://ror.org/01phhgk62","affiliations":["Neuro-Oncology, Marcus Neuroscience Institute, Boca Raton, USA","Internal Medicine, Florida Atlantic University Charles E. Schmidt College of Medicine, Boca Raton, USA","Neurology, Marcus Neuroscience Institute -Boca Raton Regional Hospital, Boca Raton, USA","Oncology, Lynn Cancer Institute, Boca Raton, USA"]},{"name":"Patricio S Espinosa","id":"openalex:A5103408930","affiliation":"Boca Raton Regional Hospital","institutionId":"I2802769386","institutionUrl":"https://ror.org/01phhgk62","affiliations":["Neurology, Marcus Neuroscience Institute, Boca Raton, USA","Internal Medicine, Florida Atlantic University Charles E. 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Patel","id":"openalex:A5102971774","orcid":"https://orcid.org/0009-0001-4976-5069","affiliation":"Boca Raton Regional Hospital","institutionId":"I2802769386","institutionUrl":"https://ror.org/01phhgk62","affiliations":["Neurology, Marcus Neuroscience Institute at Boca Raton Regional Hospital, Boca Raton, USA"]},{"name":"Patricio S Espinosa","id":"openalex:A5103408930","affiliation":"Boca Raton Regional Hospital","institutionId":"I2802769386","institutionUrl":"https://ror.org/01phhgk62","affiliations":["Neurology, Marcus Neuroscience Institute at Boca Raton Regional Hospital, Boca Raton, USA"]}],"venue":"Cureus","venueId":"S2738950867","publisher":"Cureus, Inc.","publisherId":"P4310316779","year":2019,"publishedDate":"2019-01-16","type":"article","citationCount":12,"referenceCount":2,"isOpenAccess":true,"sourceUrl":"https://doi.org/10.7759/cureus.3902","oaUrl":"https://assets.cureus.com/uploads/case_report/pdf/16741/1612428421-1612428417-20210204-30437-109rzo4.pdf","pdfUrl":"https://assets.cureus.com/uploads/case_report/pdf/16741/1612428421-1612428417-20210204-30437-109rzo4.pdf","topics":[{"id":"T11334","name":"Psychosomatic Disorders and Their Treatments","score":1,"subfieldId":"2738","subfield":"Psychiatry and Mental health","fieldId":"27","field":"Medicine"},{"id":"T11950","name":"Cardiovascular Syncope and Autonomic Disorders","score":0,"subfieldId":"2746","subfield":"Surgery","fieldId":"27","field":"Medicine"},{"id":"T10094","name":"Epilepsy research and treatment","score":0,"subfieldId":"2738","subfield":"Psychiatry and Mental health","fieldId":"27","field":"Medicine"}],"sources":["openalex"],"id":"openalex:W2909032447"},{"ids":{"openalex":"W2889992824","doi":"10.7759/cureus.3269","pmid":"30430058"},"title":"Cognitive Decline in Adults Aged 65 and Older in Cumbayá, Quito, Ecuador: Prevalence and Risk Factors","abstract":"$29","authors":[{"name":"Patricio H Espinosa del Pozo","id":"openalex:A5062583475","affiliation":"Central University of Ecuador","institutionId":"I141930428","institutionUrl":"https://ror.org/010n0x685","affiliations":["Neurosciences, Universidad Central Del Ecuador, Quito, ECU"]},{"name":"Patricio S Espinosa","id":"openalex:A5103408930","affiliation":"Central University of Ecuador","institutionId":"I141930428","institutionUrl":"https://ror.org/010n0x685","affiliations":["Neurology, Marcus Neuroscience Institute, Boca Raton Regional Hospital, Boca Raton, USA","Clinical Biomedical Science, Florida Atlantic University Charles E. Schmidt College of Medicine, Boca Raton, USA","Departamento De Clinica, Facultad De Medicina Ribeirão Preto, Universidad De São Paulo, Ribeirão Preto, BRA","Departamento De Geriatria, Facultad De Medicina Ribeirão Preto, Universidad De São Paulo, Ribeirão, BRA","Neurology, Marcus Neuroscience Institute, Boca Raton, USA","Neurosciences Unit, College of Medical Sciences, Central University of Ecuador, Quito, ECU","Social Medicine, Ribeirão Preto Medical School, University of São Paulo, Ribeirão Preto, BRA","Statistics, Universidad Nacional De Colombia (national University of Colombia), Medellín, COL","Unidad De Neurociencias, Facultad De Ciencias Médicas, Universidad Central Del Ecuador, Quito, ECU"],"corresponding":true},{"name":"Eduardo Antônio Donadi","id":"openalex:A5061587246","orcid":"https://orcid.org/0000-0002-9457-9601","affiliation":"Central University of Ecuador","institutionId":"I141930428","institutionUrl":"https://ror.org/010n0x685","affiliations":["Departamento De Clinica, Facultad De Medicina Ribeirão Preto, Universidad De São Paulo, Ribeirão Preto, BRA","Clinical Biomedical Science, Florida Atlantic University Charles E. Schmidt College of Medicine, Boca Raton, USA","Departamento De Geriatria, Facultad De Medicina Ribeirão Preto, Universidad De São Paulo, Ribeirão, BRA","Neurology, Marcus Neuroscience Institute, Boca Raton, USA","Neurosciences Unit, College of Medical Sciences, Central University of Ecuador, Quito, ECU","Social Medicine, Ribeirão Preto Medical School, University of São Paulo, Ribeirão Preto, BRA","Statistics, Universidad Nacional De Colombia (national University of Colombia), Medellín, COL","Unidad De Neurociencias, Facultad De Ciencias Médicas, Universidad Central Del Ecuador, Quito, ECU"]},{"name":"Edson Zangiacomí Martínez","id":"openalex:A5007368183","orcid":"https://orcid.org/0000-0002-0949-3222","affiliation":"Central University of Ecuador","institutionId":"I141930428","institutionUrl":"https://ror.org/010n0x685","affiliations":["Social Medicine, Ribeirão Preto Medical School, University of São Paulo, Ribeirão Preto, BRA","Clinical Biomedical Science, Florida Atlantic University Charles E. Schmidt College of Medicine, Boca Raton, USA","Departamento De Clinica, Facultad De Medicina Ribeirão Preto, Universidad De São Paulo, Ribeirão Preto, BRA","Departamento De Geriatria, Facultad De Medicina Ribeirão Preto, Universidad De São Paulo, Ribeirão, BRA","Neurology, Marcus Neuroscience Institute, Boca Raton, USA","Neurosciences Unit, College of Medical Sciences, Central University of Ecuador, Quito, ECU","Statistics, Universidad Nacional De Colombia (national University of Colombia), Medellín, COL","Unidad De Neurociencias, Facultad De Ciencias Médicas, Universidad Central Del Ecuador, Quito, ECU"]},{"name":"Juan Carlos Salazar-Uribe","id":"openalex:A5101829308","orcid":"https://orcid.org/0000-0003-2400-405X","affiliation":"Central University of Ecuador","institutionId":"I141930428","institutionUrl":"https://ror.org/010n0x685","affiliations":["Statistics, Universidad Nacional De Colombia (national University of Colombia), Medellín, COL","Clinical Biomedical Science, Florida Atlantic University Charles E. Schmidt College of Medicine, Boca Raton, USA","Departamento De Clinica, Facultad De Medicina Ribeirão Preto, Universidad De São Paulo, Ribeirão Preto, BRA","Departamento De Geriatria, Facultad De Medicina Ribeirão Preto, Universidad De São Paulo, Ribeirão, BRA","Neurology, Marcus Neuroscience Institute, Boca Raton, USA","Neurosciences Unit, College of Medical Sciences, Central University of Ecuador, Quito, ECU","Social Medicine, Ribeirão Preto Medical School, University of São Paulo, Ribeirão Preto, BRA","Unidad De Neurociencias, Facultad De Ciencias Médicas, Universidad Central Del Ecuador, Quito, ECU"]},{"name":"Marco Guerrero","id":"openalex:A5051709729","orcid":"https://orcid.org/0000-0001-9236-4183","affiliation":"Central University of Ecuador","institutionId":"I141930428","institutionUrl":"https://ror.org/010n0x685","affiliations":["Neurosciences Unit, College of Medical Sciences, Central University of Ecuador, Quito, ECU","Clinical Biomedical Science, Florida Atlantic University Charles E. Schmidt College of Medicine, Boca Raton, USA","Departamento De Clinica, Facultad De Medicina Ribeirão Preto, Universidad De São Paulo, Ribeirão Preto, BRA","Departamento De Geriatria, Facultad De Medicina Ribeirão Preto, Universidad De São Paulo, Ribeirão, BRA","Neurology, Marcus Neuroscience Institute, Boca Raton, USA","Social Medicine, Ribeirão Preto Medical School, University of São Paulo, Ribeirão Preto, BRA","Statistics, Universidad Nacional De Colombia (national University of Colombia), Medellín, COL","Unidad De Neurociencias, Facultad De Ciencias Médicas, Universidad Central Del Ecuador, Quito, ECU"]},{"name":"Júlio César Moriguti","id":"openalex:A5021449446","orcid":"https://orcid.org/0000-0001-5499-3552","affiliation":"Central University of Ecuador","institutionId":"I141930428","institutionUrl":"https://ror.org/010n0x685","affiliations":["Departamento De Geriatria, Facultad De Medicina Ribeirão Preto, Universidad De São Paulo, Ribeirão, BRA","Clinical Biomedical Science, Florida Atlantic University Charles E. Schmidt College of Medicine, Boca Raton, USA","Departamento De Clinica, Facultad De Medicina Ribeirão Preto, Universidad De São Paulo, Ribeirão Preto, BRA","Neurology, Marcus Neuroscience Institute, Boca Raton, USA","Neurosciences Unit, College of Medical Sciences, Central University of Ecuador, Quito, ECU","Social Medicine, Ribeirão Preto Medical School, University of São Paulo, Ribeirão Preto, BRA","Statistics, Universidad Nacional De Colombia (national University of Colombia), Medellín, COL","Unidad De Neurociencias, Facultad De Ciencias Médicas, Universidad Central Del Ecuador, Quito, ECU"]},{"name":"Mishell Cecibel Colcha Valdivieso","id":"openalex:A5025554051","affiliation":"Central University of Ecuador","institutionId":"I141930428","institutionUrl":"https://ror.org/010n0x685","affiliations":["Neurosciences Unit, College of Medical Sciences, Central University of Ecuador, Quito, ECU","Clinical Biomedical Science, Florida Atlantic University Charles E. Schmidt College of Medicine, Boca Raton, USA","Departamento De Clinica, Facultad De Medicina Ribeirão Preto, Universidad De São Paulo, Ribeirão Preto, BRA","Departamento De Geriatria, Facultad De Medicina Ribeirão Preto, Universidad De São Paulo, Ribeirão, BRA","Neurology, Marcus Neuroscience Institute, Boca Raton, USA","Social Medicine, Ribeirão Preto Medical School, University of São Paulo, Ribeirão Preto, BRA","Statistics, Universidad Nacional De Colombia (national University of Colombia), Medellín, COL","Unidad De Neurociencias, Facultad De Ciencias Médicas, Universidad Central Del Ecuador, Quito, ECU"]},{"name":"Susana E Garcia","id":"openalex:A5083213194","affiliation":"Central University of Ecuador","institutionId":"I141930428","institutionUrl":"https://ror.org/010n0x685","affiliations":["Unidad De Neurociencias, Facultad De Ciencias Médicas, Universidad Central Del Ecuador, Quito, ECU","Clinical Biomedical Science, Florida Atlantic University Charles E. Schmidt College of Medicine, Boca Raton, USA","Departamento De Clinica, Facultad De Medicina Ribeirão Preto, Universidad De São Paulo, Ribeirão Preto, BRA","Departamento De Geriatria, Facultad De Medicina Ribeirão Preto, Universidad De São Paulo, Ribeirão, BRA","Neurology, Marcus Neuroscience Institute, Boca Raton, USA","Neurosciences Unit, College of Medical Sciences, Central University of Ecuador, Quito, ECU","Social Medicine, Ribeirão Preto Medical School, University of São Paulo, Ribeirão Preto, BRA","Statistics, Universidad Nacional De Colombia (national University of Colombia), Medellín, COL"]},{"name":"Raquel Naranjo","id":"openalex:A5038890936","affiliation":"Central University of Ecuador","institutionId":"I141930428","institutionUrl":"https://ror.org/010n0x685","affiliations":["Neurosciences Unit, College of Medical Sciences, Central University of Ecuador, Quito, ECU","Clinical Biomedical Science, Florida Atlantic University Charles E. Schmidt College of Medicine, Boca Raton, USA","Departamento De Clinica, Facultad De Medicina Ribeirão Preto, Universidad De São Paulo, Ribeirão Preto, BRA","Departamento De Geriatria, Facultad De Medicina Ribeirão Preto, Universidad De São Paulo, Ribeirão, BRA","Neurology, Marcus Neuroscience Institute, Boca Raton, USA","Social Medicine, Ribeirão Preto Medical School, University of São Paulo, Ribeirão Preto, BRA","Statistics, Universidad Nacional De Colombia (national University of Colombia), Medellín, COL","Unidad De Neurociencias, Facultad De Ciencias Médicas, Universidad Central Del Ecuador, Quito, ECU"]},{"name":"Wilson E Altamirano","id":"openalex:A5021241646","affiliation":"Central University of Ecuador","institutionId":"I141930428","institutionUrl":"https://ror.org/010n0x685","affiliations":["Neurosciences Unit, College of Medical Sciences, Central University of Ecuador, Quito, ECU","Clinical Biomedical Science, Florida Atlantic University Charles E. Schmidt College of Medicine, Boca Raton, USA","Departamento De Clinica, Facultad De Medicina Ribeirão Preto, Universidad De São Paulo, Ribeirão Preto, BRA","Departamento De Geriatria, Facultad De Medicina Ribeirão Preto, Universidad De São Paulo, Ribeirão, BRA","Neurology, Marcus Neuroscience Institute, Boca Raton, USA","Social Medicine, Ribeirão Preto Medical School, University of São Paulo, Ribeirão Preto, BRA","Statistics, Universidad Nacional De Colombia (national University of Colombia), Medellín, COL","Unidad De Neurociencias, Facultad De Ciencias Médicas, Universidad Central Del Ecuador, Quito, ECU"]},{"name":"Adriana Y Koek","id":"openalex:A5018462665","orcid":"https://orcid.org/0000-0002-4806-3743","affiliation":"Central University of Ecuador","institutionId":"I141930428","institutionUrl":"https://ror.org/010n0x685","affiliations":["Clinical Biomedical Science, Florida Atlantic University Charles E. Schmidt College of Medicine, Boca Raton, USA","Departamento De Clinica, Facultad De Medicina Ribeirão Preto, Universidad De São Paulo, Ribeirão Preto, BRA","Departamento De Geriatria, Facultad De Medicina Ribeirão Preto, Universidad De São Paulo, Ribeirão, BRA","Neurology, Marcus Neuroscience Institute, Boca Raton, USA","Neurosciences Unit, College of Medical Sciences, Central University of Ecuador, Quito, ECU","Social Medicine, Ribeirão Preto Medical School, University of São Paulo, Ribeirão Preto, BRA","Statistics, Universidad Nacional De Colombia (national University of Colombia), Medellín, COL","Unidad De Neurociencias, Facultad De Ciencias Médicas, Universidad Central Del Ecuador, Quito, ECU"]}],"venue":"Cureus","venueId":"S2738950867","publisher":"Cureus, Inc.","publisherId":"P4310316779","year":2018,"publishedDate":"2018-09-07","type":"article","citationCount":12,"referenceCount":20,"isOpenAccess":true,"sourceUrl":"https://doi.org/10.7759/cureus.3269","oaUrl":"https://assets.cureus.com/uploads/original_article/pdf/14464/1545165843-20181218-881-1un3dy.pdf","pdfUrl":"https://assets.cureus.com/uploads/original_article/pdf/14464/1545165843-20181218-881-1un3dy.pdf","topics":[{"id":"T10009","name":"Dementia and Cognitive Impairment Research","score":1,"subfieldId":"2738","subfield":"Psychiatry and Mental health","fieldId":"27","field":"Medicine"},{"id":"T10397","name":"Nutrition and Health in Aging","score":0,"subfieldId":"2737","subfield":"Physiology","fieldId":"27","field":"Medicine"},{"id":"T12811","name":"Aging, Health, and Disability","score":0,"subfieldId":"2739","subfield":"Public Health, Environmental and Occupational Health","fieldId":"27","field":"Medicine"}],"sources":["openalex"],"id":"openalex:W2889992824"},{"ids":{"openalex":"W3016388152","doi":"10.7759/cureus.7745","pmid":"32454526"},"title":"Leber Hereditary Optic Neuropathy: Case Report and Literature Review","abstract":"$2a","authors":[{"name":"Asia Filatov","id":"openalex:A5041650964","orcid":"https://orcid.org/0009-0003-0911-6405","affiliation":"Boca Raton Regional Hospital","institutionId":"I2802769386","institutionUrl":"https://ror.org/01phhgk62","affiliations":["Neurology, Charles E. Schmidt College of Medicine, Florida Atlantic University, Boca Raton, USA","Neurology","Marcus Neuroscience Institute, Boca Raton Regional Hospital, Boca Raton, USA"],"corresponding":true},{"name":"Javed L Khanni","id":"openalex:A5033129069","affiliation":"Boca Raton Regional Hospital","institutionId":"I2802769386","institutionUrl":"https://ror.org/01phhgk62","affiliations":["Neurology, Charles E. Schmidt College of Medicine, Florida Atlantic University, Boca Raton, USA","Neurology","Marcus Neuroscience Institute, Boca Raton Regional Hospital, Boca Raton, USA"]},{"name":"Patricio S Espinosa","id":"openalex:A5103408930","affiliation":"Boca Raton Regional Hospital","institutionId":"I2802769386","institutionUrl":"https://ror.org/01phhgk62","affiliations":["Neurology, Marcus Neuroscience Institute, Boca Raton Regional Hospital, Boca Raton, USA","Neurology","Neurology, Charles E. Schmidt College of Medicine, Florida Atlantic University, Boca Raton, USA","Marcus Neuroscience Institute, Boca Raton Regional Hospital, Boca Raton, USA"]}],"venue":"Cureus","venueId":"S2738950867","publisher":"Cureus, Inc.","publisherId":"P4310316779","year":2020,"publishedDate":"2020-04-20","type":"article","citationCount":8,"referenceCount":11,"isOpenAccess":true,"sourceUrl":"https://doi.org/10.7759/cureus.7745","oaUrl":"https://www.cureus.com/articles/27807-leber-hereditary-optic-neuropathy-case-report-and-literature-review.pdf","pdfUrl":"https://www.cureus.com/articles/27807-leber-hereditary-optic-neuropathy-case-report-and-literature-review.pdf","topics":[{"id":"T10301","name":"Mitochondrial Function and Pathology","score":0.8349999785423279,"subfieldId":"1312","subfield":"Molecular Biology","fieldId":"13","field":"Biochemistry, Genetics and Molecular Biology"},{"id":"T10250","name":"Glaucoma and retinal disorders","score":0.10220000147819519,"subfieldId":"2731","subfield":"Ophthalmology","fieldId":"27","field":"Medicine"},{"id":"T12331","name":"Hereditary Neurological Disorders","score":0.012199999764561653,"subfieldId":"2804","subfield":"Cellular and Molecular Neuroscience","fieldId":"28","field":"Neuroscience"}],"sources":["openalex"],"id":"openalex:W3016388152"},{"ids":{"openalex":"W2039323496","doi":"10.1016/j.pediatrneurol.2007.12.014","pmid":"18358411"},"title":"Elastosis Perforans Serpiginosa, Down Syndrome, and Moyamoya Disease","authors":[{"name":"Patricio S Espinosa","id":"openalex:A5103408930","affiliation":"University of Kentucky","institutionId":"I143302722","institutionUrl":"https://ror.org/02k3smh20","affiliations":["Department of Neurology, University of Kentucky College of Medicine, Lexington, Kentucky 40536-0284, USA. psespi2@email.uky.edu","Department of Neurology University of Kentucky College of Medicine Lexington Kentucky"],"corresponding":true},{"name":"Robert J. Baumann","id":"openalex:A5103764879","affiliation":"University of Kentucky","institutionId":"I143302722","institutionUrl":"https://ror.org/02k3smh20","affiliations":["Department of Neurology, University of Kentucky College of Medicine, Lexington, Kentucky","Department of Neurology University of Kentucky College of Medicine Lexington Kentucky"]},{"name":"Anand Girish Vaishnav","id":"openalex:A5090373668","orcid":"https://orcid.org/0000-0002-3909-4898","affiliation":"University of Kentucky","institutionId":"I143302722","institutionUrl":"https://ror.org/02k3smh20","affiliations":["Department of Neurology, University of Kentucky College of Medicine, Lexington, Kentucky","Department of Neurology University of Kentucky College of Medicine Lexington Kentucky"]}],"venue":"Pediatric Neurology","venueId":"S165686931","publisher":"Elsevier BV","publisherId":"P4310320990","year":2008,"publishedDate":"2008-03-21","type":"article","citationCount":8,"referenceCount":13,"isOpenAccess":false,"sourceUrl":"https://doi.org/10.1016/j.pediatrneurol.2007.12.014","topics":[{"id":"T12747","name":"Moyamoya disease diagnosis and treatment","score":0.9990000128746033,"subfieldId":"2745","subfield":"Rheumatology","fieldId":"27","field":"Medicine"},{"id":"T12924","name":"Dermatological and Skeletal Disorders","score":0.0008999999845400453,"subfieldId":"1311","subfield":"Genetics","fieldId":"13","field":"Biochemistry, Genetics and Molecular Biology"},{"id":"T12433","name":"Skin Diseases and Diabetes","score":0,"subfieldId":"2708","subfield":"Dermatology","fieldId":"27","field":"Medicine"}],"sources":["openalex"],"id":"openalex:W2039323496"},{"ids":{"openalex":"W2946365491","doi":"10.7759/cureus.4738","pmid":"31355097"},"title":"Neurological Disorders Associated with Glutamic Acid Decarboxylase Antibodies","abstract":"Anti-glutamic acid decarboxylase (GAD) antibodies have been discovered in a variety of neurological syndromes with unique presentations. These syndromes include limbic encephalitis (LE), stiff person syndrome (SPS), opsoclonus-myoclonus-ataxia syndrome, cerebellar ataxia, status epilepticus, and palatal myoclonus among others. We present two patients who presented with Guillain-Barré (GBS) and myasthenia gravis (MG) like syndromes, who were found to have anti-GAD antibodies. These case reports highlight the complex presentation of patients with neurological disorders associated with anti-GAD antibodies. The proper identification of anti-GAD antibody's presence has proven to be beneficial in treatment and provide enhanced quality of life.","authors":[{"name":"Kimberly Herard","id":"openalex:A5081200284","affiliation":"Boca Raton Regional Hospital","institutionId":"I2802769386","institutionUrl":"https://ror.org/01phhgk62","affiliations":["Internal Medicine, Florida Atlantic University Charles E. Schmidt College of Medicine, Boca Raton, USA","Emergency Medicine, Florida Atlantic University Charles E. Schmidt College of Medicine, Boca Raton, USA","Neurology, Florida Atlantic University Charles E. Schmidt College of Medicine, Boca Raton, USA","Neurology, Marcus Neuroscience Institute -Boca Raton Regional Hospital, Boca Raton, USA"],"corresponding":true},{"name":"Javed L Khanni","id":"openalex:A5033129069","affiliation":"Boca Raton Regional Hospital","institutionId":"I2802769386","institutionUrl":"https://ror.org/01phhgk62","affiliations":["Neurology, Florida Atlantic University Charles E. Schmidt College of Medicine, Boca Raton, USA","Emergency Medicine, Florida Atlantic University Charles E. Schmidt College of Medicine, Boca Raton, USA","Internal Medicine, Florida Atlantic University Charles E. Schmidt College of Medicine, Boca Raton, USA","Neurology, Marcus Neuroscience Institute -Boca Raton Regional Hospital, Boca Raton, USA"]},{"name":"Kettia Alusma-Hibbert","id":"openalex:A5114113038","affiliation":"Boca Raton Regional Hospital","institutionId":"I2802769386","institutionUrl":"https://ror.org/01phhgk62","affiliations":["Emergency Medicine, Florida Atlantic University Charles E. Schmidt College of Medicine, Boca Raton, USA","Internal Medicine, Florida Atlantic University Charles E. Schmidt College of Medicine, Boca Raton, USA","Neurology, Florida Atlantic University Charles E. Schmidt College of Medicine, Boca Raton, USA","Neurology, Marcus Neuroscience Institute -Boca Raton Regional Hospital, Boca Raton, USA"]},{"name":"Courtland R Samuels","id":"openalex:A5079526235","affiliation":"Boca Raton Regional Hospital","institutionId":"I2802769386","institutionUrl":"https://ror.org/01phhgk62","affiliations":["Emergency Medicine, Florida Atlantic University Charles E. Schmidt College of Medicine, Boca Raton, USA","Internal Medicine, Florida Atlantic University Charles E. Schmidt College of Medicine, Boca Raton, USA","Neurology, Florida Atlantic University Charles E. Schmidt College of Medicine, Boca Raton, USA","Neurology, Marcus Neuroscience Institute -Boca Raton Regional Hospital, Boca Raton, USA"]},{"name":"Patricio S Espinosa","id":"openalex:A5103408930","affiliation":"Boca Raton Regional Hospital","institutionId":"I2802769386","institutionUrl":"https://ror.org/01phhgk62","affiliations":["Neurology, Marcus Neuroscience Institute at Boca Raton Regional Hospital, Boca Raton, USA","Emergency Medicine, Florida Atlantic University Charles E. Schmidt College of Medicine, Boca Raton, USA","Internal Medicine, Florida Atlantic University Charles E. Schmidt College of Medicine, Boca Raton, USA","Neurology, Florida Atlantic University Charles E. Schmidt College of Medicine, Boca Raton, USA","Neurology, Marcus Neuroscience Institute -Boca Raton Regional Hospital, Boca Raton, USA"]}],"venue":"Cureus","venueId":"S2738950867","publisher":"Cureus, Inc.","publisherId":"P4310316779","year":2019,"publishedDate":"2019-05-23","type":"article","citationCount":7,"referenceCount":15,"isOpenAccess":true,"sourceUrl":"https://doi.org/10.7759/cureus.4738","oaUrl":"https://assets.cureus.com/uploads/case_report/pdf/18651/1563900846-20190723-9815-ltdofs.pdf","pdfUrl":"https://assets.cureus.com/uploads/case_report/pdf/18651/1563900846-20190723-9815-ltdofs.pdf","topics":[{"id":"T11627","name":"Autoimmune Neurological Disorders and Treatments","score":1,"subfieldId":"2728","subfield":"Neurology","fieldId":"27","field":"Medicine"},{"id":"T11735","name":"Peripheral Neuropathies and Disorders","score":0.00009999999747378752,"subfieldId":"2728","subfield":"Neurology","fieldId":"27","field":"Medicine"},{"id":"T11271","name":"Myasthenia Gravis and Thymoma","score":0.00009999999747378752,"subfieldId":"2728","subfield":"Neurology","fieldId":"27","field":"Medicine"}],"sources":["openalex"],"id":"openalex:W2946365491"},{"ids":{"openalex":"W2903012344","doi":"10.7759/cureus.3668","pmid":"30761221"},"title":"Case Report: An Incidental Finding of Fahr's Disease in a Patient with Hypochondria","abstract":"Idiopathic basal ganglia calcification (IBGC), commonly referred to as Fahr's disease, is a rare neurological disorder characterized by the abnormal, symmetrical, and bilateral calcification of the basal ganglia and other brain regions. Patients typically present in their forties and fifties with various neurologic and/or psychiatric symptoms, including movement disorders, Parkinsonism, psychosis, and depression. The pathophysiology of this disease is not completely understood; however, several gene mutations have been identified in the pathogenesis of Fahr's disease. These mutations display an autosomal dominant inheritance pattern. Furthermore, the regional phenotypic expression of calcifications differs greatly from patient to patient, as do their clinical presentations. Here, we describe a patient who presented with psychiatric manifestations and imaging consistent with Fahr's disease.","authors":[{"name":"Courtland R Samuels","id":"openalex:A5079526235","affiliation":"Florida Atlantic University","institutionId":"I63772739","institutionUrl":"https://ror.org/05p8w6387","affiliations":["Emergency Medicine, Florida Atlantic University Charles E. Schmidt College of Medicine, Boca Raton, USA","Internal Medicine, Florida Atlantic University Charles E. Schmidt College of Medicine, Boca Raton, USA","Neurology, Florida Atlantic University Charles E. Schmidt College of Medicine, Boca Raton, USA","Neurology, Marcus Neuroscience Institute, Boca Raton, USA"],"corresponding":true},{"name":"Javed L Khanni","id":"openalex:A5033129069","affiliation":"Florida Atlantic University","institutionId":"I63772739","institutionUrl":"https://ror.org/05p8w6387","affiliations":["Neurology, Florida Atlantic University Charles E. Schmidt College of Medicine, Boca Raton, USA","Emergency Medicine, Florida Atlantic University Charles E. Schmidt College of Medicine, Boca Raton, USA","Internal Medicine, Florida Atlantic University Charles E. Schmidt College of Medicine, Boca Raton, USA","Neurology, Marcus Neuroscience Institute, Boca Raton, USA"]},{"name":"Patricio S Espinosa","id":"openalex:A5103408930","affiliation":"Florida Atlantic University","institutionId":"I63772739","institutionUrl":"https://ror.org/05p8w6387","affiliations":["Neurology, Marcus Neuroscience Institute, Boca Raton, USA","Emergency Medicine, Florida Atlantic University Charles E. Schmidt College of Medicine, Boca Raton, USA","Internal Medicine, Florida Atlantic University Charles E. Schmidt College of Medicine, Boca Raton, USA","Neurology, Florida Atlantic University Charles E. Schmidt College of Medicine, Boca Raton, USA"]},{"name":"Kory Barkley","id":"openalex:A5036103436","affiliation":"Florida Atlantic University","institutionId":"I63772739","institutionUrl":"https://ror.org/05p8w6387","affiliations":["Internal Medicine, Florida Atlantic University Charles E. Schmidt College of Medicine, Boca Raton, USA","Emergency Medicine, Florida Atlantic University Charles E. Schmidt College of Medicine, Boca Raton, USA","Neurology, Florida Atlantic University Charles E. Schmidt College of Medicine, Boca Raton, USA","Neurology, Marcus Neuroscience Institute, Boca Raton, USA"]},{"name":"Mishah Azhar","id":"openalex:A5101794722","orcid":"https://orcid.org/0000-0002-4323-8292","affiliation":"Florida Atlantic University","institutionId":"I63772739","institutionUrl":"https://ror.org/05p8w6387","affiliations":["Internal Medicine, Florida Atlantic University Charles E. Schmidt College of Medicine, Boca Raton, USA","Emergency Medicine, Florida Atlantic University Charles E. Schmidt College of Medicine, Boca Raton, USA","Neurology, Florida Atlantic University Charles E. Schmidt College of Medicine, Boca Raton, USA","Neurology, Marcus Neuroscience Institute, Boca Raton, USA"]}],"venue":"Cureus","venueId":"S2738950867","publisher":"Cureus, Inc.","publisherId":"P4310316779","year":2018,"publishedDate":"2018-12-01","type":"article","citationCount":7,"referenceCount":9,"isOpenAccess":true,"sourceUrl":"https://doi.org/10.7759/cureus.3668","oaUrl":"https://www.cureus.com/articles/15165-case-report-an-incidental-finding-of-fahrs-disease-in-a-patient-with-hypochondria.pdf","pdfUrl":"https://www.cureus.com/articles/15165-case-report-an-incidental-finding-of-fahrs-disease-in-a-patient-with-hypochondria.pdf","topics":[{"id":"T13481","name":"Neurological diseases and metabolism","score":0.5727999806404114,"subfieldId":"2808","subfield":"Neurology","fieldId":"28","field":"Neuroscience"},{"id":"T13966","name":"Neurological and metabolic disorders","score":0.41990000009536743,"subfieldId":"2712","subfield":"Endocrinology, Diabetes and Metabolism","fieldId":"27","field":"Medicine"},{"id":"T10919","name":"Neurological disorders and treatments","score":0.0017000000225380063,"subfieldId":"2728","subfield":"Neurology","fieldId":"27","field":"Medicine"}],"sources":["openalex"],"id":"openalex:W2903012344"},{"ids":{"openalex":"W2802012445","doi":"10.7759/cureus.2552","pmid":"30410818"},"title":"Report of an Isolated L5 Radiculopathy Caused by an L2-3 Disc Herniation and Review of the Literature","abstract":"$2b","authors":[{"name":"Alan A. Stein","id":"openalex:A5088215092","orcid":"https://orcid.org/0000-0002-0582-5891","affiliation":"Boca Raton Regional Hospital","institutionId":"I2802769386","institutionUrl":"https://ror.org/01phhgk62","affiliations":["Boca Raton Regional Hospital, Marcus Neuroscience Institute, Boca Raton, USA","Neurological Surgery, Marcus Neuroscience Institute, Boca Raton, USA","Neurological Surgery, UC Health, Cincinatti, USA","Neurology, Marcus Neuroscience Institute, Boca Raton Regional Hospital, Boca Raton, USA"],"corresponding":true},{"name":"Frank D. Vrionis","id":"openalex:A5017095860","orcid":"https://orcid.org/0009-0006-0259-8618","affiliation":"Boca Raton Regional Hospital","institutionId":"I2802769386","institutionUrl":"https://ror.org/01phhgk62","affiliations":["Neurological Surgery, Marcus Neuroscience Institute, Boca Raton, USA","Boca Raton Regional Hospital, Marcus Neuroscience Institute, Boca Raton, USA","Neurological Surgery, UC Health, Cincinatti, USA","Neurology, Marcus Neuroscience Institute, Boca Raton Regional Hospital, Boca Raton, USA"]},{"name":"Patricio S Espinosa","id":"openalex:A5103408930","affiliation":"Boca Raton Regional Hospital","institutionId":"I2802769386","institutionUrl":"https://ror.org/01phhgk62","affiliations":["Neurology, Marcus Neuroscience Institute, Boca Raton Regional Hospital, Boca Raton, USA","Boca Raton Regional Hospital, Marcus Neuroscience Institute, Boca Raton, USA","Neurological Surgery, Marcus Neuroscience Institute, Boca Raton, USA","Neurological Surgery, UC Health, Cincinatti, USA"]},{"name":"Shaye I. Moskowitz","id":"openalex:A5086746349","affiliation":"Boca Raton Regional Hospital","institutionId":"I2802769386","institutionUrl":"https://ror.org/01phhgk62","affiliations":["Neurological Surgery, UC Health, Cincinatti, USA","Boca Raton Regional Hospital, Marcus Neuroscience Institute, Boca Raton, USA","Neurological Surgery, Marcus Neuroscience Institute, Boca Raton, USA","Neurology, Marcus Neuroscience Institute, Boca Raton Regional Hospital, Boca Raton, USA"]}],"venue":"Cureus","venueId":"S2738950867","publisher":"Cureus, Inc.","publisherId":"P4310316779","year":2018,"publishedDate":"2018-04-30","type":"article","citationCount":6,"referenceCount":11,"isOpenAccess":true,"sourceUrl":"https://doi.org/10.7759/cureus.2552","oaUrl":"https://www.cureus.com/articles/12201-report-of-an-isolated-l5-radiculopathy-caused-by-an-l2-3-disc-herniation-and-review-of-the-literature.pdf","pdfUrl":"https://www.cureus.com/articles/12201-report-of-an-isolated-l5-radiculopathy-caused-by-an-l2-3-disc-herniation-and-review-of-the-literature.pdf","topics":[{"id":"T10238","name":"Spine and Intervertebral Disc Pathology","score":0.9965999722480774,"subfieldId":"2734","subfield":"Pathology and Forensic Medicine","fieldId":"27","field":"Medicine"},{"id":"T11518","name":"Cervical and Thoracic Myelopathy","score":0.0015999999595806003,"subfieldId":"2746","subfield":"Surgery","fieldId":"27","field":"Medicine"},{"id":"T10954","name":"Peripheral Nerve Disorders","score":0.0006000000284984708,"subfieldId":"2741","subfield":"Radiology, Nuclear Medicine and Imaging","fieldId":"27","field":"Medicine"}],"sources":["openalex"],"id":"openalex:W2802012445"},{"ids":{"openalex":"W3016363103","doi":"10.7759/cureus.7746","pmid":"32455064"},"title":"Pulmonary Edema and Stunned Myocardium in Subarachnoid Hemorrhage","abstract":"Aneurysmal subarachnoid hemorrhage is a life-threatening event that can cause permanent disability. This life-threatening event can be further complicated by subsequent cardiac and pulmonary disability. The presence of a neurogenic cardiomyopathy and pulmonary edema increases the morbidity and mortality of patients who suffer from aneurysmal subarachnoid hemorrhage. In this paper, we discuss a 39-year-old woman who presented to the emergency department (ED) with a chief complaint of a pounding headache with associated nausea and vomiting for the past three days. She had a past medical history significant only for migraines. During her stay in the ED, she began to exhibit signs of altered consciousness, hemoptysis, and respiratory compromise. Neuroimaging showed evidence of subarachnoid hemorrhage. The exact source of her subarachnoid hemorrhage could not be located with neuroimaging or angiography. Her clinical course was complicated by pulmonary edema and neurogenic stunned myocardium, and is still ongoing.","authors":[{"name":"Ryan Naum","id":"openalex:A5041902079","affiliation":"West Virginia School of Osteopathic Medicine","institutionId":"I111146913","institutionUrl":"https://ror.org/01s8dqw53","affiliations":["Osteopathy, West Virginia School of Osteopathic Medicine, Lewisburg, USA","Neurology, Charles E. Schmidt College of Medicine, Florida Atlantic University, Boca Raton, USA","Neurology, Marcus Neuroscience Institute, Boca Raton Regional Hospital, Boca Raton, USA"],"corresponding":true},{"name":"Asia Filatov","id":"openalex:A5041650964","orcid":"https://orcid.org/0009-0003-0911-6405","affiliation":"West Virginia School of Osteopathic Medicine","institutionId":"I111146913","institutionUrl":"https://ror.org/01s8dqw53","affiliations":["Neurology, Charles E. Schmidt College of Medicine, Florida Atlantic University, Boca Raton, USA","Neurology, Marcus Neuroscience Institute, Boca Raton Regional Hospital, Boca Raton, USA","Osteopathy, West Virginia School of Osteopathic Medicine, Lewisburg, USA"]},{"name":"Kettia Alusma-Hibbert","id":"openalex:A5114113038","affiliation":"West Virginia School of Osteopathic Medicine","institutionId":"I111146913","institutionUrl":"https://ror.org/01s8dqw53","affiliations":["Neurology, Marcus Neuroscience Institute, Boca Raton Regional Hospital, Boca Raton, USA","Neurology, Charles E. Schmidt College of Medicine, Florida Atlantic University, Boca Raton, USA","Osteopathy, West Virginia School of Osteopathic Medicine, Lewisburg, USA"]},{"name":"Patricio S Espinosa","id":"openalex:A5103408930","affiliation":"West Virginia School of Osteopathic Medicine","institutionId":"I111146913","institutionUrl":"https://ror.org/01s8dqw53","affiliations":["Neurology, Marcus Neuroscience Institute, Boca Raton Regional Hospital, Boca Raton, USA","Neurology, Charles E. Schmidt College of Medicine, Florida Atlantic University, Boca Raton, USA","Osteopathy, West Virginia School of Osteopathic Medicine, Lewisburg, USA"]}],"venue":"Cureus","venueId":"S2738950867","publisher":"Cureus, Inc.","publisherId":"P4310316779","year":2020,"publishedDate":"2020-04-20","type":"article","citationCount":5,"referenceCount":17,"isOpenAccess":true,"sourceUrl":"https://doi.org/10.7759/cureus.7746","oaUrl":"https://www.cureus.com/articles/26990-pulmonary-edema-and-stunned-myocardium-in-subarachnoid-hemorrhage.pdf","pdfUrl":"https://www.cureus.com/articles/26990-pulmonary-edema-and-stunned-myocardium-in-subarachnoid-hemorrhage.pdf","topics":[{"id":"T12082","name":"Takotsubo Cardiomyopathy and Associated Phenomena","score":0.9984999895095825,"subfieldId":"2705","subfield":"Cardiology and Cardiovascular Medicine","fieldId":"27","field":"Medicine"},{"id":"T10420","name":"Intracranial Aneurysms: Treatment and Complications","score":0.0007999999797903001,"subfieldId":"2728","subfield":"Neurology","fieldId":"27","field":"Medicine"},{"id":"T11763","name":"Intracerebral and Subarachnoid Hemorrhage Research","score":0.00009999999747378752,"subfieldId":"2728","subfield":"Neurology","fieldId":"27","field":"Medicine"}],"sources":["openalex"],"id":"openalex:W3016363103"},{"ids":{"openalex":"W2887998786","doi":"10.7759/cureus.3191","pmid":"30402359"},"title":"Ave Maria and Visions of Children: Atypical Charles Bonnet Syndrome or Two Coexisting Deafferentation Phenomena?","abstract":"$2c","authors":[{"name":"Adriana Y Koek","id":"openalex:A5018462665","orcid":"https://orcid.org/0000-0002-4806-3743","affiliation":"Boca Raton Regional Hospital","institutionId":"I2802769386","institutionUrl":"https://ror.org/01phhgk62","affiliations":["Clinical Biomedical Science, Florida Atlantic University Charles E. Schmidt College of Medicine, Boca Raton, USA","Neurology, Marcus Neuroscience Institute, Boca Raton Regional Hospital, Boca Raton, USA"],"corresponding":true},{"name":"Patricio S Espinosa","id":"openalex:A5103408930","affiliation":"Boca Raton Regional Hospital","institutionId":"I2802769386","institutionUrl":"https://ror.org/01phhgk62","affiliations":["Neurology, Marcus Neuroscience Institute, Boca Raton Regional Hospital, Boca Raton, USA","Clinical Biomedical Science, Florida Atlantic University Charles E. Schmidt College of Medicine, Boca Raton, USA"]}],"venue":"Cureus","venueId":"S2738950867","publisher":"Cureus, Inc.","publisherId":"P4310316779","year":2018,"publishedDate":"2018-08-23","type":"article","citationCount":5,"referenceCount":20,"isOpenAccess":true,"sourceUrl":"https://doi.org/10.7759/cureus.3191","oaUrl":"https://www.cureus.com/articles/14360-ave-maria-and-visions-of-children-atypical-charles-bonnet-syndrome-or-two-coexisting-deafferentation-phenomena.pdf","pdfUrl":"https://www.cureus.com/articles/14360-ave-maria-and-visions-of-children-atypical-charles-bonnet-syndrome-or-two-coexisting-deafferentation-phenomena.pdf","topics":[{"id":"T13397","name":"Hallucinations in medical conditions","score":0.9990000128746033,"subfieldId":"2805","subfield":"Cognitive Neuroscience","fieldId":"28","field":"Neuroscience"},{"id":"T10427","name":"Visual perception and processing mechanisms","score":0.00009999999747378752,"subfieldId":"2805","subfield":"Cognitive Neuroscience","fieldId":"28","field":"Neuroscience"},{"id":"T12608","name":"Spatial Neglect and Hemispheric Dysfunction","score":0,"subfieldId":"2805","subfield":"Cognitive Neuroscience","fieldId":"28","field":"Neuroscience"}],"sources":["openalex"],"id":"openalex:W2887998786"},{"ids":{"openalex":"W2043788168","doi":"10.1212/wnl.0b013e318248ded7","pmid":"22371418"},"title":"International Issues: Neurology mission in the Ecuadorian Amazon rainforest","abstract":"$2d","authors":[{"name":"Ikuko Laccheo","id":"openalex:A5060857417","affiliation":"Vanderbilt University","institutionId":"I200719446","institutionUrl":"https://ror.org/02vm5rt34","affiliations":["From the Department of Neurology (I.L.), Vanderbilt University Medical Center, Nashville, TN; and Centro Internacional en Neurociencias (P.S.E.), Quito, Ecuador","Centro Internacional en Neurociencias (P.S.E.), Quito, Ecuador"]},{"name":"Patricio S Espinosa","id":"openalex:A5103408930","affiliation":"Vanderbilt University","institutionId":"I200719446","institutionUrl":"https://ror.org/02vm5rt34","affiliations":["From the Department of Neurology (I.L.), Vanderbilt University Medical Center, Nashville, TN; and Centro Internacional en Neurociencias (P.S.E.), Quito, Ecuador","Centro Internacional en Neurociencias (P.S.E.), Quito, Ecuador"]}],"venue":"Neurology","venueId":"S79704628","publisher":"Lippincott Williams & Wilkins","publisherId":"P4310315671","year":2012,"publishedDate":"2012-02-27","type":"article","citationCount":4,"referenceCount":7,"isOpenAccess":false,"sourceUrl":"https://doi.org/10.1212/wnl.0b013e318248ded7","topics":[{"id":"T11731","name":"Global Health and Surgery","score":0.8461999893188477,"subfieldId":"2739","subfield":"Public Health, Environmental and Occupational Health","fieldId":"27","field":"Medicine"},{"id":"T11990","name":"Global Health Workforce Issues","score":0.07169999927282333,"subfieldId":"3604","subfield":"Emergency Medical Services","fieldId":"36","field":"Health Professions"},{"id":"T12778","name":"History of Medicine and Tropical Health","score":0.016499999910593033,"subfieldId":"1202","subfield":"History","fieldId":"12","field":"Arts and Humanities"}],"sources":["openalex"],"id":"openalex:W2043788168"},{"ids":{"openalex":"W3092277250","doi":"10.7759/cureus.10826","pmid":"33173633"},"title":"Detecting Cognitive Decline and Dementia in Santa Cruz, Galápagos Islands, Ecuador","abstract":"$2e","authors":[{"name":"Patricio H Espinosa del Pozo","id":"openalex:A5062583475","affiliation":"Central University of Ecuador","institutionId":"I141930428","institutionUrl":"https://ror.org/010n0x685","affiliations":["Neuroscience, Universidad Central del Ecuador, Quito, ECU"]},{"name":"Patricio S Espinosa","id":"openalex:A5103408930","affiliation":"Boca Raton Regional Hospital","institutionId":"I2802769386","institutionUrl":"https://ror.org/01phhgk62","affiliations":["Neurology, Marcus Neuroscience Institute, Boca Raton Regional Hospital Baptist Health System, Boca Raton, USA"]},{"name":"Eduardo Antônio Donadi","id":"openalex:A5061587246","orcid":"https://orcid.org/0000-0002-9457-9601","affiliation":"Universidade de São Paulo","institutionId":"I17974374","institutionUrl":"https://ror.org/036rp1748","affiliations":["Departamento De Clinica, Facultad De Medicina Ribeirão Preto, Universidad De São Paulo, Ribeirão Preto, BRA"]},{"name":"Lenin Rogel","id":"openalex:A5055378563","affiliation":"Central University of Ecuador","institutionId":"I141930428","institutionUrl":"https://ror.org/010n0x685","affiliations":["Educación y Ciencias Sociales, Universidad Central del Ecuador, Santa Cruz, ECU"]},{"name":"Raquel Naranjo","id":"openalex:A5038890936","affiliation":"Central University of Ecuador","institutionId":"I141930428","institutionUrl":"https://ror.org/010n0x685","affiliations":["Neurosciences Unit, College of Medical Sciences, Central University of Ecuador, Quito, ECU"]},{"name":"Gabriela E Haro","id":"openalex:A5039858722","affiliation":"Central University of Ecuador","institutionId":"I141930428","institutionUrl":"https://ror.org/010n0x685","affiliations":["Neurosciences Unit, College of Medical Sciences, Central University of Ecuador, Quito, ECU"]},{"name":"Diana C. Riera","id":"openalex:A5044291194","affiliation":"Central University of Ecuador","institutionId":"I141930428","institutionUrl":"https://ror.org/010n0x685","affiliations":["Neurosciences Unit, College of Medical Sciences, Central University of Ecuador, Quito, ECU"]},{"name":"Gabriela Mendoza","id":"openalex:A5026349516","affiliation":"Central University of Ecuador","institutionId":"I141930428","institutionUrl":"https://ror.org/010n0x685","affiliations":["Neurosciences Unit, College of Medical Sciences, Central University of Ecuador, Quito, ECU"]},{"name":"Nicole A Garzón","id":"openalex:A5076024578","affiliation":"Central University of Ecuador","institutionId":"I141930428","institutionUrl":"https://ror.org/010n0x685","affiliations":["Neurosciences Unit, College of Medical Sciences, Central University of Ecuador, Quito, ECU"]},{"name":"Nicolas F Andrade","id":"openalex:A5082603826","affiliation":"Webster University","institutionId":"I97098773","institutionUrl":"https://ror.org/01x8j4206","affiliations":["Biological Sciences, Webster University, St. Louis, USA"]}],"venue":"Cureus","venueId":"S2738950867","publisher":"Cureus, Inc.","publisherId":"P4310316779","year":2020,"publishedDate":"2020-10-06","type":"article","citationCount":3,"referenceCount":5,"isOpenAccess":true,"sourceUrl":"https://doi.org/10.7759/cureus.10826","oaUrl":"https://assets.cureus.com/uploads/original_article/pdf/35875/1612430684-1612430677-20210204-18590-t9dek8.pdf","pdfUrl":"https://assets.cureus.com/uploads/original_article/pdf/35875/1612430684-1612430677-20210204-18590-t9dek8.pdf","topics":[{"id":"T10009","name":"Dementia and Cognitive Impairment Research","score":1,"subfieldId":"2738","subfield":"Psychiatry and Mental health","fieldId":"27","field":"Medicine"},{"id":"T14434","name":"Historical and Modern Theater Studies","score":0,"subfieldId":"3203","subfield":"Clinical Psychology","fieldId":"32","field":"Psychology"},{"id":"T12811","name":"Aging, Health, and Disability","score":0,"subfieldId":"2739","subfield":"Public Health, Environmental and Occupational Health","fieldId":"27","field":"Medicine"}],"sources":["openalex"],"id":"openalex:W3092277250"},{"ids":{"openalex":"W2106982862","doi":"10.4172/2155-9562.1000112"},"title":"Contralateral Optic Neuritis Following Silicone Oil Endotamponade for Retinal Detachment","abstract":"$2f","authors":[{"name":"Patricio S Espinosa","id":"openalex:A5103408930"},{"name":"Patricio H Espinosa","id":"openalex:A5012965836"}],"venue":"Journal of Neurology & Neurophysiology","venueId":"S2764899252","publisher":"OMICS Publishing Group","publisherId":"P4310320466","year":2014,"publishedDate":"2014-09-03","type":"article","citationCount":3,"referenceCount":12,"isOpenAccess":false,"sourceUrl":"https://doi.org/10.4172/2155-9562.1000112","topics":[{"id":"T11377","name":"Retinal and Macular Surgery","score":0.9603999853134155,"subfieldId":"2741","subfield":"Radiology, Nuclear Medicine and Imaging","fieldId":"27","field":"Medicine"},{"id":"T11929","name":"Cerebral Venous Sinus Thrombosis","score":0.008100000210106373,"subfieldId":"2728","subfield":"Neurology","fieldId":"27","field":"Medicine"},{"id":"T13467","name":"Drug-Induced Ocular Toxicity","score":0.00570000009611249,"subfieldId":"2731","subfield":"Ophthalmology","fieldId":"27","field":"Medicine"}],"sources":["openalex"],"id":"openalex:W2106982862"},{"ids":{"openalex":"W1565348683","doi":"10.1016/s0072-9752(07)85002-0","pmid":"18808973"},"title":"Neuroepidemiology of HIV/AIDS","authors":[{"name":"Robert J. Baumann","id":"openalex:A5103764879","affiliation":"University of Kentucky","institutionId":"I143302722","institutionUrl":"https://ror.org/02k3smh20","affiliations":["Department of Neurology, University of Kentucky, Lexington, KY, USA"],"corresponding":true},{"name":"Patricio S Espinosa","id":"openalex:A5103408930","affiliation":"University of Kentucky","institutionId":"I143302722","institutionUrl":"https://ror.org/02k3smh20","affiliations":["Department of Neurology, University of Kentucky, Lexington, KY, USA"]}],"venue":"Handbook of clinical neurology","venueId":"S113297301","publisher":"Elsevier BV","publisherId":"P4310320990","year":2007,"publishedDate":"2007-01-01","type":"book-chapter","citationCount":3,"referenceCount":271,"isOpenAccess":false,"sourceUrl":"https://doi.org/10.1016/s0072-9752(07)85002-0","topics":[{"id":"T10112","name":"HIV Research and Treatment","score":0.948199987411499,"subfieldId":"2406","subfield":"Virology","fieldId":"24","field":"Immunology and Microbiology"},{"id":"T11381","name":"Infectious Diseases and Tuberculosis","score":0.028599999845027924,"subfieldId":"2746","subfield":"Surgery","fieldId":"27","field":"Medicine"},{"id":"T11655","name":"HIV-related health complications and treatments","score":0.006300000008195639,"subfieldId":"2711","subfield":"Emergency Medicine","fieldId":"27","field":"Medicine"}],"sources":["openalex"],"id":"openalex:W1565348683"},{"ids":{"openalex":"W4235993468","doi":"10.1212/01.wnl.0000180351.66206.a6","pmid":"16157893"},"title":"Volitional opsoclonus","abstract":"Opsoclonus (saccadomania) is defined as random, uncalled-for, large-amplitude, back-to-back saccades without intersaccadic intervals. An abnormality of the omnipause neurons in the brain stem nucleus raphe interpositus has been suggested, but not proven, as the etiology of opsoclonus. 1 Opsoclonus occurs with paraneoplastic, infectious, postinfectious, toxic, or metabolic disorders; however, it is often idiopathic. Intentional fixation instability may result in ocular movements closely resembling opsoclonus.","authors":[{"name":"Patricio S Espinosa","id":"openalex:A5103408930","affiliation":"Lexington, KY","affiliations":["Lexington, KY"]},{"name":"Joseph R. Berger","id":"openalex:A5066505115","orcid":"https://orcid.org/0000-0002-1540-496X","affiliation":"Lexington, KY","affiliations":["Lexington, KY"]}],"venue":"Neurology","venueId":"S79704628","publisher":"Lippincott Williams & Wilkins","publisherId":"P4310315671","year":2005,"publishedDate":"2005-09-13","type":"article","citationCount":3,"referenceCount":2,"isOpenAccess":true,"sourceUrl":"https://doi.org/10.1212/01.wnl.0000180351.66206.a6","oaUrl":"https://n.neurology.org/content/neurology/65/5/E11.full.pdf","pdfUrl":"https://n.neurology.org/content/neurology/65/5/E11.full.pdf","topics":[{"id":"T11627","name":"Autoimmune Neurological Disorders and Treatments","score":0.3889000117778778,"subfieldId":"2728","subfield":"Neurology","fieldId":"27","field":"Medicine"},{"id":"T10542","name":"Vestibular and auditory disorders","score":0.29829999804496765,"subfieldId":"2808","subfield":"Neurology","fieldId":"28","field":"Neuroscience"},{"id":"T13966","name":"Neurological and metabolic disorders","score":0.1177000030875206,"subfieldId":"2712","subfield":"Endocrinology, Diabetes and Metabolism","fieldId":"27","field":"Medicine"}],"sources":["openalex"],"id":"openalex:W4235993468"},{"ids":{"openalex":"W4390274977","doi":"10.7759/cureus.51168","pmid":"38283509"},"title":"Paroxysmal Atrial Fibrillation (PFA) Detection With Cardiac Monitoring Devices Implanted by Neurologists in Patients With Embolic Strokes of Undetermined Source (ESUS)","abstract":"$30","authors":[{"name":"Patricio S Espinosa","id":"openalex:A5103408930","affiliation":"Neurology Department Stroke Division, The Espinosa Neuroscience Institute, Boca Raton, USA","affiliations":["Neurology Department Stroke Division, The Espinosa Neuroscience Institute, Boca Raton, USA"]},{"name":"Patricio H Espinosa del Pozo","id":"openalex:A5062583475","affiliation":"Central University of Ecuador","institutionId":"I141930428","institutionUrl":"https://ror.org/010n0x685","affiliations":["Neuroscience, Universidad Central Del Ecuador, Quito, ECU"]},{"name":"Nicolas F Andrade","id":"openalex:A5082603826","affiliation":"Webster University","institutionId":"I97098773","institutionUrl":"https://ror.org/01x8j4206","affiliations":["Biological Sciences Department, Webster University, St. Louis, USA"]},{"name":"Kettia Alusma-Hibbert","id":"openalex:A5114113038","affiliation":"Neurology Department Stroke Division, The Espinosa Neuroscience Institute, Boca Raton, USA","affiliations":["Neurology Department Stroke Division, The Espinosa Neuroscience Institute, Boca Raton, USA"]}],"venue":"Cureus","venueId":"S2738950867","publisher":"Cureus, Inc.","publisherId":"P4310316779","year":2023,"publishedDate":"2023-12-27","type":"article","citationCount":2,"referenceCount":15,"isOpenAccess":true,"sourceUrl":"http://dx.doi.org/10.7759/cureus.51168","oaUrl":"https://assets.cureus.com/uploads/original_article/pdf/205116/20231227-21538-1x5jdcb.pdf","pdfUrl":"https://assets.cureus.com/uploads/original_article/pdf/205116/20231227-21538-1x5jdcb.pdf","topics":[{"id":"T10065","name":"Atrial Fibrillation Management and Outcomes","score":0.9580000042915344,"subfieldId":"2705","subfield":"Cardiology and Cardiovascular Medicine","fieldId":"27","field":"Medicine"},{"id":"T11579","name":"Cardiovascular and Diving-Related Complications","score":0.019300000742077827,"subfieldId":"2740","subfield":"Pulmonary and Respiratory Medicine","fieldId":"27","field":"Medicine"},{"id":"T10227","name":"Acute Ischemic Stroke Management","score":0.0052999998442828655,"subfieldId":"2713","subfield":"Epidemiology","fieldId":"27","field":"Medicine"}],"sources":["openalex"],"id":"openalex:W4390274977"},{"ids":{"openalex":"W4200479486","doi":"10.1177/15333175211062413","pmid":"34935509"},"title":"Proton Pump Inhibitors and Risk of Dementia: A Hypothesis Generated but Not Adequately Tested","abstract":"We reviewed the evidence on proton pump inhibitors (PPIs) and dementia. PPIs are among the most widely utilized drugs in the world. Dementia affects roughly 5% of the population of the United States (US) and world aged 60 years and older. With respect to PPIs and dementia, basic research has suggested plausible mechanisms but descriptive and analytic epidemiological studies are not inconsistent. In addition, a single large-scale randomized trial showed no association. When the evidence is incomplete, it is appropriate for clinicians and researchers to remain uncertain. Regulatory or public health authorities sometimes need to make real-world decisions based on real-world data. When the evidence is complete, then the most rational judgments for individual patients the health of the general public are possible At present, the evidence on PPIs and dementia suggests more reassurance than alarm. Further large-scale randomized evidence is necessary to do so.","authors":[{"name":"Mishah Azhar","id":"openalex:A5101794722","orcid":"https://orcid.org/0000-0002-4323-8292","affiliation":"Boca Raton Regional Hospital","institutionId":"I2802769386","institutionUrl":"https://ror.org/01phhgk62","affiliations":["PGY-3 Internal Medicine Resident, Charles E. Schmidt College of Medicine, Graduate Medical Education Consortium (Bethesda Hospital, Boca Raton Regional Hospital, Delray Medical Center, St Mary’s Medical Center, West Boca Raton Hospital), Florida Atlantic University, Boca Raton, FL, USA","PGY-3 Internal Medicine Resident, Charles E. Schmidt College of Medicine, Graduate Medical Education Consortium (Bethesda Hospital, Boca Raton Regional Hospital, Delray Medical Center, St Mary's Medical Center, West Boca Raton Hospital), Florida Atlantic University, Boca Raton, FL, USA"],"corresponding":true},{"name":"Lawrence M. Fiedler","id":"openalex:A5056009465","orcid":"https://orcid.org/0000-0003-1297-8316","affiliation":"Florida Atlantic University","institutionId":"I63772739","institutionUrl":"https://ror.org/05p8w6387","affiliations":["Charles E. Schmidt College of Medicine, Florida Atlantic University, Boca Raton, FL, USA"]},{"name":"Patricio S Espinosa","id":"openalex:A5103408930","affiliation":"Neurologist in Private Practice, Boca Raton, FL, USA","affiliations":["Neurologist in Private Practice, Boca Raton, FL, USA"]},{"name":"Charles H. Hennekens","id":"openalex:A5006554574","orcid":"https://orcid.org/0000-0003-1214-1663","affiliation":"Florida Atlantic University","institutionId":"I63772739","institutionUrl":"https://ror.org/05p8w6387","affiliations":["Charles E. Schmidt College of Medicine, Florida Atlantic University, Boca Raton, FL, USA"]}],"venue":"American Journal of Alzheimer s Disease & Other Dementias®","venueId":"S1037846118","publisher":"SAGE Publishing","publisherId":"P4310320017","year":2021,"publishedDate":"2021-01-01","type":"article","citationCount":2,"referenceCount":17,"isOpenAccess":true,"sourceUrl":"https://doi.org/10.1177/15333175211062413","oaUrl":"https://journals.sagepub.com/doi/pdf/10.1177/15333175211062413","pdfUrl":"https://journals.sagepub.com/doi/pdf/10.1177/15333175211062413","topics":[{"id":"T10009","name":"Dementia and Cognitive Impairment Research","score":0.7226999998092651,"subfieldId":"2738","subfield":"Psychiatry and Mental health","fieldId":"27","field":"Medicine"},{"id":"T10496","name":"Pharmaceutical Practices and Patient Outcomes","score":0.2223999947309494,"subfieldId":"2717","subfield":"Geriatrics and Gerontology","fieldId":"27","field":"Medicine"},{"id":"T10671","name":"Gastroesophageal reflux and treatments","score":0.013799999840557575,"subfieldId":"2715","subfield":"Gastroenterology","fieldId":"27","field":"Medicine"}],"sources":["openalex"],"id":"openalex:W4200479486"},{"ids":{"openalex":"W3020036211","doi":"10.7759/cureus.7767","pmid":"32461843"},"title":"Sporadic Creutzfeldt-Jakob Disease: Case Report and Literature Review","abstract":"$31","authors":[{"name":"Asia Filatov","id":"openalex:A5041650964","orcid":"https://orcid.org/0009-0003-0911-6405","affiliation":"Boca Raton Regional Hospital","institutionId":"I2802769386","institutionUrl":"https://ror.org/01phhgk62","affiliations":["Neurology, Charles E. Schmidt College of Medicine, Florida Atlantic University, Boca Raton, USA","Neurology, Boca Raton Regional Hospital, Boca Raton, USA","Neurology, Marcus Neuroscience Institute, Boca Raton Regional Hospital, Boca Raton, USA"],"corresponding":true},{"name":"Javed L Khanni","id":"openalex:A5033129069","affiliation":"Boca Raton Regional Hospital","institutionId":"I2802769386","institutionUrl":"https://ror.org/01phhgk62","affiliations":["Neurology, Charles E. Schmidt College of Medicine, Florida Atlantic University, Boca Raton, USA","Neurology, Boca Raton Regional Hospital, Boca Raton, USA","Neurology, Marcus Neuroscience Institute, Boca Raton Regional Hospital, Boca Raton, USA"]},{"name":"Kettia Alusma-Hibbert","id":"openalex:A5114113038","affiliation":"Boca Raton Regional Hospital","institutionId":"I2802769386","institutionUrl":"https://ror.org/01phhgk62","affiliations":["Neurology, Boca Raton Regional Hospital, Boca Raton, USA","Neurology, Charles E. Schmidt College of Medicine, Florida Atlantic University, Boca Raton, USA","Neurology, Marcus Neuroscience Institute, Boca Raton Regional Hospital, Boca Raton, USA"]},{"name":"Patricio S Espinosa","id":"openalex:A5103408930","affiliation":"Boca Raton Regional Hospital","institutionId":"I2802769386","institutionUrl":"https://ror.org/01phhgk62","affiliations":["Neurology, Marcus Neuroscience Institute, Boca Raton Regional Hospital, Boca Raton, USA","Neurology, Boca Raton Regional Hospital, Boca Raton, USA","Neurology, Charles E. Schmidt College of Medicine, Florida Atlantic University, Boca Raton, USA"]}],"venue":"Cureus","venueId":"S2738950867","publisher":"Cureus, Inc.","publisherId":"P4310316779","year":2020,"publishedDate":"2020-04-21","type":"article","citationCount":2,"referenceCount":13,"isOpenAccess":true,"sourceUrl":"https://doi.org/10.7759/cureus.7767","oaUrl":"https://www.cureus.com/articles/28586-sporadic-creutzfeldt-jakob-disease-case-report-and-literature-review.pdf","pdfUrl":"https://www.cureus.com/articles/28586-sporadic-creutzfeldt-jakob-disease-case-report-and-literature-review.pdf","topics":[{"id":"T11335","name":"Prion Diseases and Protein Misfolding","score":1,"subfieldId":"1312","subfield":"Molecular Biology","fieldId":"13","field":"Biochemistry, Genetics and Molecular Biology"},{"id":"T11305","name":"Amyloidosis: Diagnosis, Treatment, Outcomes","score":0,"subfieldId":"1312","subfield":"Molecular Biology","fieldId":"13","field":"Biochemistry, Genetics and Molecular Biology"},{"id":"T10949","name":"Genetic Neurodegenerative Diseases","score":0,"subfieldId":"2804","subfield":"Cellular and Molecular Neuroscience","fieldId":"28","field":"Neuroscience"}],"sources":["openalex"],"id":"openalex:W3020036211"},{"ids":{"openalex":"W7166843854","doi":"10.7759/cureus.111911","pmid":"42541080"},"title":"Donanemab Infusion and Recurrent Seizures in a Patient With Alzheimer’s Disease and Epilepsy in the Absence of Amyloid-Related Imaging Abnormalities (ARIA)","abstract":"$32","authors":[{"name":"Patricio S Espinosa","id":"openalex:A5103408930","affiliation":"Boca Raton Regional Hospital","institutionId":"I2802769386","institutionUrl":"https://ror.org/01phhgk62","affiliations":["Neurology, Espinosa Neuroscience Institute, Boca Raton Regional Hospital, Boca Raton, USA"]},{"name":"Sarah Li","id":"openalex:A5049088446","affiliation":"Florida Atlantic University","institutionId":"I63772739","institutionUrl":"https://ror.org/05p8w6387","affiliations":["College of Medicine, Florida Atlantic University, Boca Raton, USA"]},{"name":"Johanna Preisler","id":"openalex:A5133098597","affiliation":"Neurology, Espinosa Neuroscience Institute, Boca Raton, USA","affiliations":["Neurology, Espinosa Neuroscience Institute, Boca Raton, USA"]},{"name":"Charles H. Hennekens","id":"openalex:A5006554574","orcid":"https://orcid.org/0000-0003-1214-1663","affiliation":"Florida Atlantic University","institutionId":"I63772739","institutionUrl":"https://ror.org/05p8w6387","affiliations":["Preventive Medicine/Cardiology/Internal Medicine, Charles E. Schmidt College of Medicine, Florida Atlantic University, Boca Raton, USA"]}],"venue":"Cureus","venueId":"S2738950867","publisher":"Cureus, Inc.","publisherId":"P4310316779","year":2026,"publishedDate":"2026-07-01","type":"article","citationCount":1,"referenceCount":8,"isOpenAccess":true,"sourceUrl":"https://doi.org/10.7759/cureus.111911","oaUrl":"https://www.cureus.com/articles/407395-donanemab-infusion-and-recurrent-seizures-in-a-patient-with-alzheimers-disease-and-epilepsy-in-the-absence-of-amyloid-related-imaging-abnormalities-aria.pdf","pdfUrl":"https://www.cureus.com/articles/407395-donanemab-infusion-and-recurrent-seizures-in-a-patient-with-alzheimers-disease-and-epilepsy-in-the-absence-of-amyloid-related-imaging-abnormalities-aria.pdf","topics":[{"id":"T10086","name":"Alzheimer's disease research and treatments","score":0.8490999937057495,"subfieldId":"2737","subfield":"Physiology","fieldId":"27","field":"Medicine"},{"id":"T10094","name":"Epilepsy research and treatment","score":0.07400000095367432,"subfieldId":"2738","subfield":"Psychiatry and Mental health","fieldId":"27","field":"Medicine"},{"id":"T10009","name":"Dementia and Cognitive Impairment Research","score":0.026599999517202377,"subfieldId":"2738","subfield":"Psychiatry and Mental health","fieldId":"27","field":"Medicine"}],"sources":["openalex"],"id":"openalex:W7166843854"},{"ids":{"openalex":"W3096950923","doi":"10.1182/blood-2020-134202"},"title":"Case Report: Acute Stroke in Young Adult Patient with Moyamoya Syndrome Secondary to Sickle Cell Disease","abstract":"$33","authors":[{"name":"Oladipo Cole","id":"openalex:A5062737577","orcid":"https://orcid.org/0000-0002-5194-2247","affiliation":"Florida Atlantic University","institutionId":"I63772739","institutionUrl":"https://ror.org/05p8w6387","affiliations":["Department of Medicine, Florida Atlantic University, Boca Raton, FL"]},{"name":"Asia Filatov","id":"openalex:A5041650964","orcid":"https://orcid.org/0009-0003-0911-6405","affiliation":"Florida Atlantic University","institutionId":"I63772739","institutionUrl":"https://ror.org/05p8w6387","affiliations":["Neurology, Florida Atlantic University Charles E. Schmidt, Boca Raton, FL"]},{"name":"Javed L Khanni","id":"openalex:A5033129069","affiliation":"Florida Atlantic University","institutionId":"I63772739","institutionUrl":"https://ror.org/05p8w6387","affiliations":["College of Medicine, Florida Atlantic University Charles E. Schdmit, Boca Raton, FL"]},{"name":"Patricio S Espinosa","id":"openalex:A5103408930","affiliation":"Boca Raton Regional Hospital","institutionId":"I2802769386","institutionUrl":"https://ror.org/01phhgk62","affiliations":["Marcus Neuroscience Institute/Neurology, Florida Atlantic University Charles E. Schdmit/Boca Raton Regional Hospital, Boca Raton, FL"]}],"venue":"Blood","venueId":"S200071133","publisher":"Elsevier BV","publisherId":"P4310320990","year":2020,"publishedDate":"2020-11-04","type":"conference-abstract","citationCount":1,"referenceCount":0,"isOpenAccess":false,"sourceUrl":"https://doi.org/10.1182/blood-2020-134202","topics":[{"id":"T12747","name":"Moyamoya disease diagnosis and treatment","score":1,"subfieldId":"2745","subfield":"Rheumatology","fieldId":"27","field":"Medicine"},{"id":"T10554","name":"Hemoglobinopathies and Related Disorders","score":0,"subfieldId":"2716","subfield":"Genetics","fieldId":"27","field":"Medicine"},{"id":"T11929","name":"Cerebral Venous Sinus Thrombosis","score":0,"subfieldId":"2728","subfield":"Neurology","fieldId":"27","field":"Medicine"}],"sources":["openalex"],"id":"openalex:W3096950923"},{"ids":{"openalex":"W3098200790","doi":"10.46997/revecuatneurol29200078"},"title":"Complicaciones Neurológicas del COVID-19 (SARS-CoV-2), revisión de la Literatura.","abstract":"Tras el diagnóstico de la primera persona infectada con el coronavirus SARS-CoV-2 este ha llegado a expandirse por todo el mundo, ocasionando una pandemia y poniendo en alerta a los sistemas de salud. Actualmente, la evidencia indica que los efectos de este coronavirus en humanos no siempre se limitan al tracto respiratorio, pueden invadir el sistema nervioso central ocasionado dolor de cabeza, convulsiones y alteraciones de conciencia. Por esta razón, se recomienda pensar en una infección con SARS-CoV-2 como un diagnóstico diferencial en pacientes que presentan manifestaciones neurológicas.","authors":[{"name":"Esteban Ortiz‐Prado","id":"openalex:A5025003605","orcid":"https://orcid.org/0000-0002-1895-7498","affiliation":"Universidad de Las Américas","institutionId":"I4210102282","institutionUrl":"https://ror.org/0198j4566","affiliations":["Chief of Neurology, Marcus Neuroscience Institute, Florida Atlantic University, Boca Raton, FL, USA","One Health Research Group, Faculty of Medicine, Universidad de Las Américas, Quito, Ecuador","One Health Research Group, Universidad de las Américas, Quito, Ecuador Calle de los Colimes y Avenida De los Granados, Quito 170137, Ecuador"],"corresponding":true},{"name":"Cristina Escobar-Espinoza","id":"openalex:A5098241516"},{"name":"Jorge Vásconez-González","id":"openalex:A5025087893","orcid":"https://orcid.org/0000-0003-4573-6217"},{"name":"Clara Paz","id":"openalex:A5086373827","orcid":"https://orcid.org/0000-0003-1106-9567"},{"name":"Patricio S Espinosa","id":"openalex:A5103408930"}],"venue":"Revista Ecuatoriana de Neurologia","venueId":"S1020798745","publisher":null,"year":2020,"publishedDate":"2020-01-01","type":"article","citationCount":1,"referenceCount":18,"isOpenAccess":true,"sourceUrl":"https://doi.org/10.46997/revecuatneurol29200078","oaUrl":"http://revecuatneurol.com/wp-content/uploads/2020/11/2631-2581-rneuro-26-02-00078.pdf","pdfUrl":"http://revecuatneurol.com/wp-content/uploads/2020/11/2631-2581-rneuro-26-02-00078.pdf","topics":[{"id":"T11368","name":"Long-Term Effects of COVID-19","score":1,"subfieldId":"2728","subfield":"Neurology","fieldId":"27","field":"Medicine"},{"id":"T13201","name":"Infectious Encephalopathies and Encephalitis","score":0,"subfieldId":"2725","subfield":"Infectious Diseases","fieldId":"27","field":"Medicine"},{"id":"T10041","name":"COVID-19 Clinical Research Studies","score":0,"subfieldId":"2725","subfield":"Infectious Diseases","fieldId":"27","field":"Medicine"}],"sources":["openalex"],"id":"openalex:W3098200790"},{"ids":{"openalex":"W2963480135","doi":"10.7759/cureus.5211","pmid":"31565615"},"title":"Delayed Identification of Cortical Superficial Siderosis in a Patient with Recurrent Transient Focal Neurological Symptoms: A Case Report","abstract":"Cortical superficial siderosis (cSS), also referred to as sulcal siderosis, is a neurological condition characterized by hemosiderin subpial deposits in the cortical sulci over the convexities of cerebral hemispheres. These deposits are further found sparingly in the spinal cord, brainstem, and cerebellum. Patients typically present with transient focal neurological symptoms that make cSS challenging to differentiate from other acute neurological processes such as transient ischemic attacks (TIA), focal seizures, and acute convexity subarachnoid hemorrhage (cSAH). This condition is presently recognized as a characteristic feature of the age-associated disorder referred to as cerebral amyloid angiopathy (CAA). This paper describes a patient who presented with transient neurologic symptoms, first suspected to be secondary to acute subarachnoid hemorrhage (SAH), found to have cSS and cerebral amyloid angiopathy.","authors":[{"name":"Kristina A Rankine","id":"openalex:A5009570337","orcid":"https://orcid.org/0009-0007-2413-4168","affiliation":"Boca Raton Regional Hospital","institutionId":"I2802769386","institutionUrl":"https://ror.org/01phhgk62","affiliations":["Neurology, Charles E. Schmidt College of Medicine, Florida Atlantic University, Boca Raton, USA","Neurology, Marcus Neuroscience Institute -Boca Raton Regional Hospital, Boca Raton, USA","College of Medicine, Florida Atlantic University, Boca Raton, USA"],"corresponding":true},{"name":"Asia Filatov","id":"openalex:A5041650964","orcid":"https://orcid.org/0009-0003-0911-6405","affiliation":"Boca Raton Regional Hospital","institutionId":"I2802769386","institutionUrl":"https://ror.org/01phhgk62","affiliations":["Neurology, Charles E. Schmidt College of Medicine, Florida Atlantic University, Boca Raton, USA","Neurology, Marcus Neuroscience Institute -Boca Raton Regional Hospital, Boca Raton, USA","College of Medicine, Florida Atlantic University, Boca Raton, USA"]},{"name":"Pamraj Sharma","id":"openalex:A5010366429","affiliation":"Boca Raton Regional Hospital","institutionId":"I2802769386","institutionUrl":"https://ror.org/01phhgk62","affiliations":["Neurology, Charles E. Schmidt College of Medicine, Florida Atlantic University, Boca Raton, USA","Neurology, Marcus Neuroscience Institute -Boca Raton Regional Hospital, Boca Raton, USA","College of Medicine, Florida Atlantic University, Boca Raton, USA"]},{"name":"Kettia Alusma-Hibbert","id":"openalex:A5114113038","affiliation":"Boca Raton Regional Hospital","institutionId":"I2802769386","institutionUrl":"https://ror.org/01phhgk62","affiliations":["Neurology, Marcus Neuroscience Institute -Boca Raton Regional Hospital, Boca Raton, USA","College of Medicine, Florida Atlantic University, Boca Raton, USA"]},{"name":"Patricio S Espinosa","id":"openalex:A5103408930","affiliation":"Boca Raton Regional Hospital","institutionId":"I2802769386","institutionUrl":"https://ror.org/01phhgk62","affiliations":["Neurology, Marcus Neuroscience Institute - Boca Raton Regional Hospital, Boca Raton, USA","Neurology, Marcus Neuroscience Institute -Boca Raton Regional Hospital, Boca Raton, USA","College of Medicine, Florida Atlantic University, Boca Raton, USA"]}],"venue":"Cureus","venueId":"S2738950867","publisher":"Cureus, Inc.","publisherId":"P4310316779","year":2019,"publishedDate":"2019-07-23","type":"article","citationCount":1,"referenceCount":8,"isOpenAccess":true,"sourceUrl":"https://doi.org/10.7759/cureus.5211","oaUrl":"https://www.cureus.com/articles/21305-delayed-identification-of-cortical-superficial-siderosis-in-a-patient-with-recurrent-transient-focal-neurological-symptoms-a-case-report.pdf","pdfUrl":"https://www.cureus.com/articles/21305-delayed-identification-of-cortical-superficial-siderosis-in-a-patient-with-recurrent-transient-focal-neurological-symptoms-a-case-report.pdf","topics":[{"id":"T11763","name":"Intracerebral and Subarachnoid Hemorrhage Research","score":0.9824000000953674,"subfieldId":"2728","subfield":"Neurology","fieldId":"27","field":"Medicine"},{"id":"T13481","name":"Neurological diseases and metabolism","score":0.008999999612569809,"subfieldId":"2808","subfield":"Neurology","fieldId":"28","field":"Neuroscience"},{"id":"T12464","name":"Neurological Complications and Syndromes","score":0.0017000000225380063,"subfieldId":"2738","subfield":"Psychiatry and Mental health","fieldId":"27","field":"Medicine"}],"sources":["openalex"],"id":"openalex:W2963480135"},{"ids":{"openalex":"W2492851275","doi":"10.1212/wnl.86.16_supplement.p2.057"},"title":"Perampanel as an Adjunctive Treatment in 3 Patients with Glioblastoma Multiforme (GBM) with Refractory Seizures (P2.057)","abstract":"$34","authors":[{"name":"Patricio S Espinosa","id":"openalex:A5103408930","affiliation":"Florida Atlantic University","institutionId":"I63772739","institutionUrl":"https://ror.org/05p8w6387","affiliations":["Marcus Neuroscience Institute/Florida Atlantic University Boca Raton FL United States","Neurology Department Florida Atlantic University Boca Raton FL United States"]},{"name":"R. Perez Sotelo","id":"openalex:A5062987201","affiliation":"Neurology Department Marcus Neuroscience Institute Boca Raton FL United States","affiliations":["Neurology Department Marcus Neuroscience Institute Boca Raton FL United States"]},{"name":"Armand Golchin","id":"openalex:A5063699239","orcid":"https://orcid.org/0000-0001-5376-3288","affiliation":"Florida Atlantic University","institutionId":"I63772739","institutionUrl":"https://ror.org/05p8w6387","affiliations":["Internal Medicine Florida Atlantic University Boca Raton FL United States"]},{"name":"Rima Bakhda","id":"openalex:A5006599173","affiliation":"Florida Atlantic University","institutionId":"I63772739","institutionUrl":"https://ror.org/05p8w6387","affiliations":["Internal Medicine Florida Atlantic University Boca Raton FL United States"]},{"name":"Jose Valdes","id":"openalex:A5110482781","affiliation":"Neurology & Neuropsychiatry Marcus Neuroscience Institute Boca Raton FL United States","affiliations":["Neurology &","Neuropsychiatry Marcus Neuroscience Institute Boca Raton FL United States"]},{"name":"Patricio H Espinosa del Pozo","id":"openalex:A5062583475","affiliation":"Central University of Ecuador","institutionId":"I141930428","institutionUrl":"https://ror.org/010n0x685","affiliations":["Cumbaya Quito Ecuador","Unidad de Neurociencias Universidad Central del Ecuador Quito Ecuador"]}],"venue":"Neurology","venueId":"S79704628","publisher":"Lippincott Williams & Wilkins","publisherId":"P4310315671","year":2016,"publishedDate":"2016-04-05","type":"article","citationCount":1,"referenceCount":0,"isOpenAccess":false,"sourceUrl":"https://doi.org/10.1212/wnl.86.16_supplement.p2.057","topics":[{"id":"T10094","name":"Epilepsy research and treatment","score":0.9940999746322632,"subfieldId":"2738","subfield":"Psychiatry and Mental health","fieldId":"27","field":"Medicine"},{"id":"T10129","name":"Glioma Diagnosis and Treatment","score":0.0034000000450760126,"subfieldId":"2716","subfield":"Genetics","fieldId":"27","field":"Medicine"},{"id":"T12229","name":"Pharmacological Effects and Toxicity Studies","score":0.0003000000142492354,"subfieldId":"2735","subfield":"Pediatrics, Perinatology and Child Health","fieldId":"27","field":"Medicine"}],"sources":["openalex"],"id":"openalex:W2492851275"},{"ids":{"openalex":"W1270906772","doi":"10.3233/pnr-14186"},"title":"Symptomatic focal cerebral arteriopathy in a young man","abstract":"Arteriopathy is the leading cause of acute ischemic stroke in children and young adults, with intracranial arterial dissection (IAD) and transient cerebral arteriopathy (TCA) most commonly reported. The etiology and pathophysiology of childhood cereb","authors":[{"name":"Tatiana Chacón-Quesada","id":"openalex:A5010083085","affiliation":"Texas Tech University Health Sciences Center","institutionId":"I926076166","institutionUrl":"https://ror.org/033ztpr93","affiliations":["Center of Excellence in Neurosciences, Texas Tech University Health Sciences Center, El Paso, TX, USA"]},{"name":"Luis R. Ramos-Duran","id":"openalex:A5033037484","affiliation":"Texas Tech University Health Sciences Center","institutionId":"I926076166","institutionUrl":"https://ror.org/033ztpr93","affiliations":["Department of Radiology, Texas Tech University Health Sciences Center, El Paso, TX, USA"]},{"name":"Salvador Cruz‐Flores","id":"openalex:A5076579473","orcid":"https://orcid.org/0000-0003-4998-1471","affiliation":"Texas Tech University Health Sciences Center","institutionId":"I926076166","institutionUrl":"https://ror.org/033ztpr93","affiliations":["Department of Neurology, Texas Tech University Health Sciences Center, El Paso, TX, USA"]},{"name":"Patricio S Espinosa","id":"openalex:A5103408930","affiliation":"Centro Internacional en Neurociencias, Mandeville, LA, USA","affiliations":["Centro Internacional en Neurociencias, Mandeville, LA, USA"]},{"name":"Gustavo Jose Rodriguez","id":"openalex:A5066933773","orcid":"https://orcid.org/0000-0003-2781-5034","affiliation":"Texas Tech University Health Sciences Center","institutionId":"I926076166","institutionUrl":"https://ror.org/033ztpr93","affiliations":["Department of Neurology, Texas Tech University Health Sciences Center, El Paso, TX, USA"]},{"name":"Alberto Maud","id":"openalex:A5000298565","orcid":"https://orcid.org/0000-0001-5576-7717","affiliation":"Texas Tech University Health Sciences Center","institutionId":"I926076166","institutionUrl":"https://ror.org/033ztpr93","affiliations":["Department of Neurology, Texas Tech University Health Sciences Center, El Paso, TX, USA"],"corresponding":true}],"venue":"Journal of Pediatric Neuroradiology","venueId":"S2764451425","publisher":"Thieme Medical Publishers (Germany)","publisherId":"P4310320000","year":2015,"publishedDate":"2015-07-29","type":"article","citationCount":1,"referenceCount":14,"isOpenAccess":false,"sourceUrl":"https://doi.org/10.3233/pnr-14186","topics":[{"id":"T10816","name":"Cerebrovascular and Carotid Artery Diseases","score":0.46970000863075256,"subfieldId":"2740","subfield":"Pulmonary and Respiratory Medicine","fieldId":"27","field":"Medicine"},{"id":"T12464","name":"Neurological Complications and Syndromes","score":0.21199999749660492,"subfieldId":"2738","subfield":"Psychiatry and Mental health","fieldId":"27","field":"Medicine"},{"id":"T10227","name":"Acute Ischemic Stroke Management","score":0.11739999800920486,"subfieldId":"2713","subfield":"Epidemiology","fieldId":"27","field":"Medicine"}],"sources":["openalex"],"id":"openalex:W1270906772"},{"ids":{"openalex":"W3172608288"},"title":"Acute Stroke Management","authors":[{"name":"Patricio S Espinosa","id":"openalex:A5103408930","corresponding":true}],"year":2011,"publishedDate":"2011-01-01","type":"article","citationCount":1,"referenceCount":0,"isOpenAccess":false,"sourceUrl":"https://works.bepress.com/patricio-espinosa/39/","topics":[{"id":"T10227","name":"Acute Ischemic Stroke Management","score":0.9994999766349792,"subfieldId":"2713","subfield":"Epidemiology","fieldId":"27","field":"Medicine"},{"id":"T10292","name":"Acute Myocardial Infarction Research","score":0.00009999999747378752,"subfieldId":"2705","subfield":"Cardiology and Cardiovascular Medicine","fieldId":"27","field":"Medicine"},{"id":"T10816","name":"Cerebrovascular and Carotid Artery Diseases","score":0.00009999999747378752,"subfieldId":"2740","subfield":"Pulmonary and Respiratory Medicine","fieldId":"27","field":"Medicine"}],"sources":["openalex"],"id":"openalex:W3172608288"},{"ids":{"openalex":"W2050497756","doi":"10.1097/wnp.0b013e3181d64a04","pmid":"20375715"},"title":"Effects of Seizures on Cardiac Function","abstract":"Espinosa, Patricio S. 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