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M. Ladds · SciRah

Researcher profile · Semantic Scholar

M. Ladds

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M. Ladds — researcher profile on SciRah

h-index: 11
Works: 24
Citations: 540

Most-cited papers

Combining Native and ‘omics’ mass spectrometry to identify endogenous ligands bound to membrane proteins
Joseph Gault, I. Liko, M. Landreh, D. Shutin +15 more
2020Nature Methods138 citations Open access
Semantic Scholar
A DHODH inhibitor increases p53 synthesis and enhances tumor cell killing by p53 degradation blockage
M. Ladds, I. V. van Leeuwen, C. Drummond, S. Chu +42 more
2018Nature Communications86 citations Open access
Semantic Scholar
CD36 and LC3B initiated autophagy in B cells regulates the humoral immune response
Chenfei He, Shan Wang, Chi-Kai Zhou, Ming-Hui He +8 more
2021Autophagy58 citations Open access
Semantic Scholar
Autophagy suppresses the formation of hepatocyte-derived cancer-initiating ductular progenitor cells in the liver
V. Barthet, Martina Brucoli, M. Ladds, Christoph Nössing +10 more
2021Science Advances48 citations Open access
Semantic Scholar
Tenovin-D3, a Novel Small-Molecule Inhibitor of Sirtuin SirT2, Increases p21 (CDKN1A) Expression in a p53-Independent Manner
A. Mccarthy, M. C. C. Sachweh, M. Higgins, J. Campbell +6 more
2013Molecular Cancer Therapeutics41 citations
Semantic Scholar
Small molecule activators of the p53 response
M. Ladds, S. Laín
2019Journal of Molecular Cell Biology39 citations Open access
Semantic Scholar
Lipids Shape the Electron Acceptor-Binding Site of the Peripheral Membrane Protein Dihydroorotate Dehydrogenase
Joana Costeira-Paulo, Joseph Gault, Gergana Popova, M. Ladds +7 more
2018Cell Chemical Biology27 citations Open access
Semantic Scholar
ATG7 is a haploinsufficient repressor of tumor progression and promoter of metastasis
Jaclyn S. Long, E. Kania, David G. McEwan, V. Barthet +4 more
2022Proceedings of the National Academy of Sciences of the United States of America26 citations Open access
Semantic Scholar
DHODH inhibition modulates glucose metabolism and circulating GDF15, and improves metabolic balance
Juan Zhang, G. Terán, M. Popa, Harsha S. Madapura +9 more
2021iScience19 citations Open access
Semantic Scholar
Optimization of tetrahydroindazoles as inhibitors of human dihydroorotate dehydrogenase and evaluation of their activity and in vitro metabolic stability.
Gergana Popova, M. Ladds, L. Johansson, A. Saleh +11 more
2020Journal of Medicinal Chemistry19 citations Open access
Semantic Scholar
Exploitation of dihydroorotate dehydrogenase (DHODH) and p53 activation as therapeutic targets: A case study in polypharmacology
M. Ladds, Gergana Popova, Andrés Pastor-Fernández, S. Kannan +8 more
2020Journal of Biological Chemistry15 citations Open access
Semantic Scholar
Cancer Therapeutics Insights Tenovin-D 3 , a Novel Small-Molecule Inhibitor of Sirtuin SirT 2 , Increases p 21 ( CDKN 1 A ) Expression in a p 53-Independent Manner
Hiroyuki Monma, Nanae Harashima, Touko Inao, S. Okano +73 more
20139 citations
Semantic Scholar
Autophagic flux blockage by accumulation of weakly basic tenovins leads to elimination of B-Raf mutant tumour cells that survive vemurafenib
M. Ladds, Andrés Pastor-Fernández, Gergana Popova, I. V. van Leeuwen +13 more
2018PLoS ONE6 citations Open access
Semantic Scholar
Publisher Correction: A DHODH inhibitor increases p53 synthesis and enhances tumor cell killing by p53 degradation blockage
M. Ladds, I. V. van Leeuwen, C. Drummond, S. Chu +42 more
2018Nature Communications6 citations Open access
Semantic Scholar
Exploitation of dihydroorotate dehydrogenase (DHODH) and p53 activation as therapeutic targets: A case study in polypharmacology.
M. Ladds, Gergana Popova, Andrés Pastor-Fernández, S. Kannan +8 more
2020Journal of Biological Chemistry2 citations Open access
Semantic Scholar
Identification of serum protein biomarkers for pre‐cancerous lesions associated with pancreatic ductal adenocarcinoma
Hannah Mearns, Jaclyn S. Long, Sergio Lilla, K. Hodge +7 more
2026Molecular Oncology1 citations Open access
Semantic Scholar
Dihydroorotate dehydrogenase inhibition acts synergistically with tyrosine kinase inhibitors to induce apoptosis of mantle cell lymphoma cells
May Eriksen‐Gjerstad, Ida Tveit Karlsen, Zina Fandalyuk, Susanne Benjaminsen +7 more
2022eJHaem1 citations Open access
Semantic Scholar
Clickable Substrate Transport (CST): A High-Throughput Functional Assay for Solute Carrier Proteins.
Abigail L Macmillan-Jones, Phillip Biallas, Linda Kitching, M. Ladds +8 more
2026ACS Chemical Biology0 citations
Semantic Scholar
Publisher Correction: A DHODH inhibitor increases p53 synthesis and enhances tumor cell killing by p53 degradation blockage
M. Ladds, I. V. van Leeuwen, C. Drummond, S. Chu +42 more
2023Nature Communications0 citations Open access
Semantic Scholar
TUMOUR CELL DEATH AND AUTOPHAGY
Kevin Ryan Frse, M. Ladds, Annabel R. Minton, Jia Li +1 more
20210 citations
Semantic Scholar
Exploitation of DHODH and p53 activation as therapeutic targets - a case study in polypharmacology
M. Ladds, Gergana Popova, Andrés Pastor-Fernández, Srinivasaraghavan +9 more
20200 citations
Semantic Scholar
HUMAN DIHYDROOROTATE DEHYDROGENASE IN COMPLEX WITH CLASS III HISTONE DEACETYLASE INHIBITOR
M. Håkansson, M. Ladds, B. Walse, S. Lain
20190 citations
Semantic Scholar
p53 transcriptional activity as a tool to uncover novel and diverse druggable targets in cancer
M. Ladds
20180 citations
Semantic Scholar
Enhanced Targeting of FLT3-ITD+AML Stem Cells through Combined Inhibition of SIRT1 and Autophagic Flux
S. Chu, Yao-Te Hsieh, M. Ladds, S. Lane +1 more
20160 citations
Semantic Scholar

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S. Laín×11
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S. Laín — researcher profile on SciRah
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