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S. Ihara · SciRah

Researcher profile · Semantic Scholar

S. Ihara

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S. Ihara — researcher profile on SciRah

h-index: 18
Works: 65
Citations: 1,040

Most-cited papers

TGF-β in inflammatory bowel disease: a key regulator of immune cells, epithelium, and the intestinal microbiota
S. Ihara, Y. Hirata, K. Koike
2017Journal of gastroenterology264 citations Open access
Semantic Scholar
Biliary epithelial injury-induced regenerative response by IL-33 promotes cholangiocarcinogenesis from peribiliary glands
Hayato Nakagawa, Nobumi Suzuki, Y. Hirata, Yohko Hikiba +13 more
2017Proceedings of the National Academy of Sciences of the United States of America81 citations Open access
Semantic Scholar
Prevalence of pks-positive Escherichia coli in Japanese patients with or without colorectal cancer
Takayuki Shimpoh, Y. Hirata, S. Ihara, Nobumi Suzuki +7 more
2017Gut Pathogens60 citations Open access
Semantic Scholar
Gastric Metaplasia Induced by Helicobacter pylori Is Associated with Enhanced SOX9 Expression via Interleukin-1 Signaling
T. Serizawa, Y. Hirata, Y. Hayakawa, Nobumi Suzuki +7 more
2015Infection and Immunity51 citations Open access
Semantic Scholar
Inhibition of autophagy exerts anti-colon cancer effects via apoptosis induced by p53 activation and ER stress
Kosuke Sakitani, Y. Hirata, Yohko Hikiba, Y. Hayakawa +12 more
2015BMC Cancer49 citations Open access
Semantic Scholar
BHLHA15-positive Secretory Precursor Cells Can Give Rise to Tumors in Intestine and Colon in Mice
Y. Hayakawa, Mayo Tsuboi, S. Asfaha, Hiroto Kinoshita +17 more
2018Gastroenterology42 citations Open access
Semantic Scholar
TGF-β Signaling in Dendritic Cells Governs Colonic Homeostasis by Controlling Epithelial Differentiation and the Luminal Microbiota
S. Ihara, Y. Hirata, T. Serizawa, Nobumi Suzuki +7 more
2016Journal of Immunology41 citations Open access
Semantic Scholar
Mature gastric chief cells are not required for the development of metaplasia.
Hiroto Kinoshita, Y. Hayakawa, Zheng-Chuan Niu, Mitsuru Konishi +9 more
2018American Journal of Physiology - Gastrointestinal and Liver Physiology39 citations Open access
Semantic Scholar
Association between Vonoprazan and the risk of gastric cancer after Helicobacter pylori eradication.
J. Arai, Atsushi Miyawaki, Tomonori Aoki, R. Niikura +5 more
2024Clinical Gastroenterology and Hepatology35 citations Open access
Semantic Scholar
Three types of metaplasia model through Kras activation, Pten deletion, or Cdh1 deletion in the gastric epithelium
Hiroto Kinoshita, Y. Hayakawa, Mitsuru Konishi, M. Hata +10 more
2018Journal of Pathology33 citations
Semantic Scholar
Targeting the complex interactions between microbiota, host epithelial and immune cells in inflammatory bowel disease.
Y. Hirata, S. Ihara, K. Koike
2016Pharmacological Research33 citations
Semantic Scholar
Impaired glycosylation of gastric mucins drives gastric tumorigenesis and serves as a novel therapeutic target
J. Arai, Y. Hayakawa, Hiroaki Tateno, K. Murakami +32 more
2024Gastroenterology31 citations Open access
Semantic Scholar
CXCR4-expressing Mist1+ progenitors in the gastric antrum contribute to gastric cancer development
Kosuke Sakitani, Y. Hayakawa, H. Deng, H. Ariyama +20 more
2017OncoTarget31 citations Open access
Semantic Scholar
Composite thermoresponsive hydrogel with auranofin-loaded nanoparticles for topical treatment of vaginal trichomonad infection
Yue Zhang, Y. Miyamoto, S. Ihara, Justin Z. Yang +6 more
2019Advances in Therapy29 citations Open access
Semantic Scholar
Adhesive Interactions between Mononuclear Phagocytes and Intestinal Epithelium Perturb Normal Epithelial Differentiation and Serve as a Therapeutic Target in Inflammatory Bowel Disease
S. Ihara, Y. Hirata, Yohko Hikiba, Aya Yamashita +11 more
2018Journal of Crohn's & Colitis28 citations Open access
Semantic Scholar
Non-Helicobacter pylori Gastric Microbiome Modulates Prooncogenic Responses and Is Associated With Gastric Cancer Risk
R. Niikura, Y. Hayakawa, N. Nagata, Tohru Miyoshi-Akiayama +21 more
2023Gastro Hep Advances26 citations Open access
Semantic Scholar
Click chemistry-facilitated comprehensive identification of proteins adducted by antimicrobial 5-nitroimidazoles for discovery of alternative drug targets against giardiasis
T. Lauwaet, Y. Miyamoto, S. Ihara, Christine H Y Le +7 more
2020PLoS Neglected Tropical Diseases19 citations Open access
Semantic Scholar
Gold(I) phosphine derivatives with improved selectivity as topically active drug leads to overcome 5-nitroheterocyclic drug resistance in Trichomonas vaginalis
Y. Miyamoto, S. Aggarwal, J. Celaje, S. Ihara +7 more
2021Journal of Medicinal Chemistry18 citations Open access
Semantic Scholar
c‐Jun N‐terminal kinase in pancreatic tumor stroma augments tumor development in mice
Takeshi Sato, W. Shibata, Yohko Hikiba, Y. Kaneta +13 more
2017Cancer Science18 citations Open access
Semantic Scholar
Characterization of a new small bowel adenocarcinoma cell line and screening of anti-cancer drug against small bowel adenocarcinoma.
Hirobumi Suzuki, Y. Hirata, Nobumi Suzuki, S. Ihara +10 more
2015American Journal of Pathology17 citations
Semantic Scholar
Co-Delivery of Antigens and Adjuvant in Polymeric Nanoparticles Coated with Native Parasite Membranes Induces Protective Mucosal Immunity against Giardia lamblia.
Jiarong Zhou, Y. Miyamoto, S. Ihara, Ashley V. Kroll +6 more
2022Journal of Infectious Diseases13 citations Open access
Semantic Scholar
Distinct Chemopreventive Effects of Aspirin in Diffuse and Intestinal-Type Gastric Cancer
R. Niikura, Y. Hayakawa, Y. Hirata, Mitsuru Konishi +7 more
2018Cancer Prevention Research12 citations Open access
Semantic Scholar
Conserved metabolic enzymes as vaccine antigens for giardiasis
S. Ihara, Y. Miyamoto, Christine H Y Le, Vivien N. Tran +4 more
2022PLoS Neglected Tropical Diseases10 citations Open access
Semantic Scholar
Alpha-Blockers As Colorectal Cancer Chemopreventive: Findings from a Case–Control Study, Human Cell Cultures, and In Vivo Preclinical Testing
Nobumi Suzuki, R. Niikura, S. Ihara, Yohko Hikiba +14 more
2019Cancer Prevention Research9 citations
Semantic Scholar
ARID1A mutation drives gastric tumorigenesis via activating type 2 immune dominant microenvironment
J. Arai, Yoku Hayakawa, Nobumi Suzuki, Hiroto Kinoshita +25 more
2025iScience8 citations Open access
Semantic Scholar
Upper gastrointestinal involvement of Behçet's disease in Japan: endoscopic findings and clinical features
K. Murakami, J. Arai, S. Ihara, Y. Tsuchida +8 more
2024Journal of Gastroenterology and Hepatology7 citations Open access
Semantic Scholar
Letter: Potassium‐competitive acid blockers may increase the risk of gastric cancer after Helicobacter pylori eradication a retrospective multicentre‐cohort analysis
J. Arai, Y. Hayakawa, R. Niikura, S. Ihara +11 more
2023Alimentary Pharmacology and Therapeutics6 citations Open access
Semantic Scholar
Extranodal NK/T-cell lymphoma of the nasal cavity developed in a patient with intestinal Epstein-Barr virus-positive T/NK-cell lymphoproliferative disorder.
Genta Furuya, Hiroyuki Abe, A. Shinozaki-Ushiku, Aya Yamashita +7 more
2018Pathology, Research and Practice5 citations
Semantic Scholar
Decline in perception of acid regurgitation symptoms from gastroesophageal reflux disease in diabetes mellitus patients
Kosuke Sakitani, Nobumi Suzuki, S. Ihara, Y. Hirata +3 more
2018PLoS ONE5 citations Open access
Semantic Scholar
3D Co-Culture System of Intestinal Organoids and Dendritic Cells to Study Epithelial Differentiation
S. Ihara, Y. Hayakawa, Mitsuru Konishi, Y. Hirata +1 more
20175 citations
Semantic Scholar
Metabolic Factors Associated with Endoscopic Atrophy, Intestinal Metaplasia, and Gastric Neoplasms in Helicobacter pylori-Positive Patients
J. Arai, Hiroaki Fujiwara, Tomonori Aoki, R. Niikura +5 more
2024Clinics and Practice4 citations Open access
Semantic Scholar
Severe obstructive colitis treated with repeated colonoscopic decompression
J. Arai, Nobumi Suzuki, Y. Hayakawa, Hiroyuki Matzuzaki +8 more
2023DEN Open4 citations Open access
Semantic Scholar
Mucosal vaccination in a murine gnotobiotic model of Giardia lamblia infection
S. Ihara, Brian V. Nguyen, Y. Miyamoto, Lars Eckmann
2024Infection and Immunity3 citations Open access
Semantic Scholar
Nodular Scleritis and Pyoderma Gangrenosum Associated with Active Ulcerative Colitis: A Case Report
Kazuki Yashiro, S. Ihara, H. Boki, Amane Yamamoto +1 more
2025Case Reports in Ophthalmology2 citations
Semantic Scholar
The first case report of de novo Crohn's disease after heart transplantation successfully treated with ustekinumab.
S. Okamura, Chie Bujo, E. Amiya, Ken Kurokawa +10 more
2024Journal of Cardiology Cases2 citations Open access
Semantic Scholar
First case report of intestinal lymphangiectasia with refractory bleeding from the duodenum, successfully treated by intra-abdominal lymphaticovenous anastomosis with venous ligation
Yu Miyakawa, S. Ihara, Saaya Ishii, Rui Yang +6 more
2024Clinical Journal of Gastroenterology2 citations Open access
Semantic Scholar
Muc6-expressing gastric isthmus progenitors contribute to regeneration and metaplasia supported by myeloid-mesenchymal interactions
J. Arai, Yusuke Iwata, A. Tsubosaka, Hiroto Kinoshita +30 more
2025bioRxiv1 citations Open access
Semantic Scholar
De novo Inflammatory Bowel Disease following Liver and Heart Transplantation: A Case Series Exploring the Role of IL-23 Pathway-Targeted Therapy
Chihiro Shiomi, Ken Kurokawa, S. Ihara, Yujiro Nishioka +11 more
2025Inflammatory Intestinal Diseases1 citations Open access
Semantic Scholar
101 - MIST1+ Secretory Progenitor Cells can give Rise to Cancer in the Intestine and Colon
Y. Hayakawa, S. Asfaha, Hiroto Kinoshita, Mitsuru Konishi +6 more
20181 citations
Semantic Scholar
First case report of de novo ulcerative colitis developing after orthotopic liver transplantation successfully treated by granulocyte and monocyte apheresis.
S. Ihara, Y. Yamaji, Hiroto Kinoshita, Atsuo Yamada +5 more
2014Transplantation Proceedings1 citations
Semantic Scholar
B-Cell Lymphoma-Extra Large Promotes Gastric Tumorigenesis via Apoptosis-Independent Wnt–β-Catenin Activation and Peroxisome Proliferator–Activated Receptor γ Suppression
Y. Oya, J. Arai, Yoku Hayakawa, Toshiro Shiokawa +14 more
2026Cellular and Molecular Gastroenterology and Hepatology0 citations Open access
Semantic Scholar
Predictive Factors for Abnormal Diagnostic Colonoscopy Findings among Pediatric Patients: A Retrospective Cohort Study
Kazuki Honjo, K. Murakami, J. Arai, S. Ihara +17 more
2026Digestive Diseases0 citations
Semantic Scholar
Sa1803: THE ROLE OF TGF-β SIGNALING ON DENDRITIC CELLS IN MODULATING OXIDATIVE STRESS AND SHAPING INTESTINAL MICROBIOTA
S. Ihara, K. Murakami, Yoku Hayakawa, Yoshihiro Hirata +1 more
2025Gastroenterology0 citations
Semantic Scholar
P0234 Predicting factors for long-term outcomes of intestinal Behçet's disease in Japan
K. Murakami, S. Ihara, M. Fujishiro
2025Journal of Crohn's & Colitis0 citations
Semantic Scholar
Tu1183: PROTEOBACTERIA DRIVES INTESTINAL FIBROSIS VIA CCR2+SPP1+ MONOCYTES
K. Murakami, S. Ihara, Yoku Hayakawa, M. Fujishiro
2025Gastroenterology0 citations
Semantic Scholar
Tu1784: LONG-TERM OUTCOMES AND RISK FACTORS FOR RELAPSE IN A JAPANESE COHORT OF PATIENTS WITH INTESTINAL BEHÇET’S DISEASE
K. Murakami, S. Ihara, M. Fujishiro
2025Gastroenterology0 citations
Semantic Scholar
Mo1295: SINGLE CELL AND SPATIAL TRANSCRIPTOMICS IDENTIFY DYNAMIC CELLULAR PLASTICITY IN GASTRIC NECK CELLS THAT CONTRIBUTES TO METAPLASIA AND REGENERATION.
J. Arai, Yusuke Iwata, Yoku Hayakawa, Hiroto Kinoshita +13 more
2025Gastroenterology0 citations
Semantic Scholar
Long-term outcomes and clinical factors associated with conventional therapy failure in intestinal Behçet's disease: A retrospective cohort study in Japan.
K. Murakami, J. Arai, S. Ihara, Y. Tsuchida +8 more
2025Digestion0 citations Open access
Semantic Scholar
Dr. Murakami et al reply
K. Murakami, J. Arai, S. Ihara, M. Fujishiro
2025Journal of Rheumatology0 citations
Semantic Scholar
Higher Processed Blood Volume of Granulocyte and Monocyte Adsorption Apheresis Ameliorates Long-Term Disease Activity in Ulcerative Colitis Patients
Y. Hamasaki, Ryo Matsuura, T. Shinagawa, S. Ishihara +4 more
2024Journal of Clinical Medicine Research0 citations
Semantic Scholar

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Y. Hirata×21
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Y. Hirata — researcher profile on SciRah
Nobumi Suzuki×21
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Nobumi Suzuki — researcher profile on SciRah
Hiroto Kinoshita×21
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Hiroto Kinoshita — researcher profile on SciRah
K. Koike×20
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K. Koike — researcher profile on SciRah

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Y. Hayakawa — researcher profile on SciRah

M. Fujishiro×17

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Mayo Tsuboi×14

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J. Arai — researcher profile on SciRah

Yoku Hayakawa×13

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Yoku Hayakawa — researcher profile on SciRah

K. Murakami×12

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K. Murakami — researcher profile on SciRah

Ken Kurokawa×10

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Hayato Nakagawa×9

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