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Hesham Haffez · SciRah

Researcher profile · Semantic Scholar

Hesham Haffez

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Hesham Haffez — researcher profile on SciRah

h-index: 11
Works: 40
Citations: 388

Most-cited papers

Elevated Expression of MiR-17 in Microglia of Alzheimer’s Disease Patients Abrogates Autophagy-Mediated Amyloid-β Degradation
Shady Z. K. Estfanous, Kylene P. Daily, M. Eltobgy, N. Deems +19 more
2021Frontiers in Immunology64 citations Open access
Semantic Scholar
Growth Inhibition and Apoptotic Effect of Pine Extract and Abietic Acid on MCF-7 Breast Cancer Cells via Alteration of Multiple Gene Expressions Using In Vitro Approach
Hesham Haffez, Shimaa Osman, Hassan Y. Ebrahim, Z. Hassan
2022Molecules32 citations Open access
Semantic Scholar
Gasdermin D restricts Burkholderia cenocepacia infection in vitro and in vivo
Shady Z. K. Estfanous, K. Krause, Midhun N. K. Anne, M. Eltobgy +14 more
2021Scientific Reports32 citations Open access
Semantic Scholar
The molecular basis of the interactions between synthetic retinoic acid analogues and the retinoic acid receptors.
Hesham Haffez, D. Chisholm, R. Valentine, E. Pohl +2 more
2017MedChemComm31 citations Open access
Semantic Scholar
Augmented Therapeutic Potential of EC-Synthetic Retinoids in Caco-2 Cancer Cells Using an In Vitro Approach
M. Abdelaal, E. Ibrahim, Mohamed R. Elnagar, S. Soror +1 more
2022International Journal of Molecular Sciences28 citations Open access
Semantic Scholar
Revealing the Potential Application of EC-Synthetic Retinoid Analogues in Anticancer Therapy
M. Abdelaal, S. Soror, Mohamed R. Elnagar, Hesham Haffez
2021Molecules24 citations Open access
Semantic Scholar
Raptinal silver nanoparticles: new therapeutic advances in hepatocellular carcinoma mouse model
Heba Taha, Nourhan Elfar, Hesham Haffez, Z. A. Hassan
2020Naunyn-Schmiedeberg's Archives of Pharmacology19 citations
Semantic Scholar
Synthesis, biological evaluation and molecular docking studies of novel thiopyrimidine analogue as apoptotic agent with potential anticancer activity.
Hesham Haffez, Heba Taha, M. Rabie, S. Awad +1 more
2020Bioorganic chemistry (Print)18 citations
Semantic Scholar
The potential roles of retinoids in combating drug resistance in cancer: implications of ATP-binding cassette (ABC) transporters
M. Abdelaal, Hesham Haffez
2022Open Biology17 citations Open access
Semantic Scholar
Probing biological activity through structural modelling of ligand-receptor interactions of 2,4-disubstituted thiazole retinoids
Hesham Haffez, D. Chisholm, N. Tatum, R. Valentine +4 more
2018Bioorganic & Medicinal Chemistry15 citations Open access
Semantic Scholar
Neurogenesis in Response to Synthetic Retinoids at Different Temporal Scales
Hesham Haffez, Thabat Khatib, P. McCaffery, S. Przyborski +2 more
2017Molecular Neurobiology12 citations Open access
Semantic Scholar
Synergistic effects of abietic acid combined with doxorubicin on apoptosis induction in a human colorectal cancer cell line
Hesham Haffez, Hend H Sanad, Hassan Y. Ebrahim, Z. A. Hassan
2025Scientific Reports11 citations Open access
Semantic Scholar
Novel N-Arylmethyl-aniline/chalcone hybrids as potential VEGFR inhibitors: synthesis, biological evaluations, and molecular dynamic simulations
Hesham Haffez, Nosaiba A. Elsayed, Marwa F. Ahmed, Samar S. Fatahala +8 more
2023Journal of Enzyme Inhibition and Medicinal Chemistry11 citations Open access
Semantic Scholar
Novel thienopyrimidine analogues as potential metabotropic glutamate receptors inhibitors and anticancer activity: Synthesis, In-vitro, In-silico, and SAR approaches.
M. Khedr, K. Abu-Zied, W. Zaghary, A. Aly +2 more
2021Bioorganic chemistry (Print)11 citations
Semantic Scholar
New phenothiazine conjugates as apoptosis inducing agents: Design, synthesis, In-vitro anti-cancer screening and 131I-radiolabeling for in-vivo evaluation.
Mona O Sarhan, Hesham Haffez, Nosaiba A. Elsayed, Radwan Elhaggar +1 more
2023Bioorganic chemistry (Print)8 citations
Semantic Scholar
IN-VITRO SCREENING OF SOME PLANT EXTRACTS FOR THEIR POTENTIAL ANTICANCER ACTIVITY
Hassan Y. Ebrahim, Shaimaa Osman, Hesham Haffez, Z. Hassan
2020African Journal of Traditional Complementary and Alternative Medicines8 citations Open access
Semantic Scholar
Biological Screening and Radiolabeling of Raptinal as a Potential Anticancer Novel Drug in Hepatocellular Carcinoma Model.
Hesham Haffez, Heba Taha, N. Farrag, A. Amin +1 more
2020European Journal of Pharmaceutical Sciences8 citations
Semantic Scholar
Common Applications of Black Cumin Seed (Nigella sativa) Oil in Folk Medicine
Rehab Hosni, Hesham Haffez, Hatem Elkordy
2023Journal of Advanced Pharmacy Research6 citations Open access
Semantic Scholar
Design and synthesis of novel Hydroxamate and non-Hydroxamate HDAC inhibitors based on Chromone and Quinazolone scaffolds.
Rosaline Ashraf, Mai Adel, Rabah A. T. Serya, Esraa Ibrahim +3 more
2025Bioorganic chemistry (Print)5 citations
Semantic Scholar
Anti-inflammatory potential of black cumin seed oil and its nanoemulsion formulation against lipopolysaccharide-induced liver injury in mice
Hesham Haffez, Rehab Hosni, Shady A. Swidan, Hatem K. Amin
2024Asian Pacific Journal of Tropical Biomedicine5 citations Open access
Semantic Scholar
Scaffold-hopping strategy for pyrazolo[3,4-d]pyrimidines: In vitro and in silico studies of dual c-Met/STAT3 inhibition for enhanced antitumor activity.
S. I. El-Desouky, Mohamed S. Nafie, Hesham Haffez, M. A. Moustafa +1 more
2025Bioorganic chemistry (Print)4 citations Open access
Semantic Scholar
Towards the discovery of potent epigenetic modulators: Design, synthesis, biological evaluation, and SAR investigation of novel indole-based derivatives targeting HDAC1 and HDAC6.
S. Shawky, T. E. Ahmed, Hesham Haffez, A. Sobhy +5 more
2026Bioorganic chemistry (Print)3 citations
Semantic Scholar
Role of single nucleotide polymorphisms of the HSD3B1 gene (rs6203 and rs33937873) in the prediction of prostate cancer risk
Yasmine M. Amrousy, Hesham Haffez, D. Abdou, Hanaa B. Atya
2022Molecular Medicine Reports3 citations Open access
Semantic Scholar
The link between diabetes and male infertility: mechanisms and implications
Hesham Haffez, Mohamed Mosaad, A. Y. Rezk, A. Sayed +1 more
2026Scientific Reports2 citations Open access
Semantic Scholar
Repair and Regeneration of Low Dose Ionizing Radiation to Injured Muscles using Barium Chloride in a Rat Model
Esraa A Aboelfadl, Hesham Haffez, Soheir S. Koraa, A. A. Abdel Moneim +2 more
2025Trends in advanced sciences and technology2 citations
Semantic Scholar
miRNA-sequencing and bioinformatics analyses of key miRNAs and their associated genes regulated by EC-synthetic retinoids treatment in Caco-2 cancer cells
Hesham Haffez, A. Sayed
2025Gene Reports2 citations
Semantic Scholar
Association of cytokine levels with treatment duration and patient family history in Egyptian multiple sclerosis patients
Esraa Mohsen, Hesham Haffez, Sandra Ahmed, T. El-Mahdy +1 more
2026Scientific Reports1 citations Open access
Semantic Scholar
Lead Discovery via Scaffold Refinement: Structure‐Guided Optimization of 1,2,4‐Triazolo[1,5‐a]Pyrimidines as Potent Dual EGFR/CDK‐2 Inhibitors Targeting Colorectal Carcinoma
Rowida Nasr, Hesham Haffez, Mohamed S. Nafie, M. A. Moustafa +2 more
2026Drug development research (Print)1 citations
Semantic Scholar
Palbociclib in endocrine-resistant metastatic breast cancer patients: gene polymorphism- based study
Abdel-Hameed Ibrahim Mohamed Ebid, Yasmine Magdy Fahim Genina, Hesham Haffez, Sherif Hassanien Ahmed Hakam +2 more
2025Pharmacological Reports1 citations
Semantic Scholar
New Fluorescent Synthetic Retinoids as Potential RAR Agonists with Anticancer, Molecular Docking and ADME Assessments
Esraa Ibrahim, Y. Mansour, Sameh Soror, Hesham Haffez
2025Journal of Fluorescence1 citations Open access
Semantic Scholar
Unravelling the potency of the 4-oxo-2-thioxo-1,2,3,4-tetrahydropyrimidine-5-carbonitrile scaffold with S-arylamide hybrids as PIM-1 kinase inhibitors: synthesis, biological activity and in silico studies.
S. Abdelhadi, Manar A. Eldinary, Amna Ghith, Hesham Haffez +2 more
2025RSC Medicinal Chemistry1 citations Open access
Semantic Scholar
Black cumin seed oil as inhibitor of cyclooxygenase-2 and 5-lipoxygenase in LPS-induced acute liver injury in mice
Hesham Haffez, Rehab Hosni, Hatem K. Amin
2024Egyptian Journal of Chemistry1 citations
Semantic Scholar
Author Correction: Gasdermin D restricts Burkholderia cenocepacia infection in vitro and in vivo
Shady Z. K. Estfanous, K. Krause, Midhun N. K. Anne, M. Eltobgy +14 more
2021Scientific Reports1 citations Open access
Semantic Scholar
Regulation of Adipose Tissue by Long Non-Coding RNAs: Potential Biomarkers and Therapeutic Targets in Obesity
R. Moawad, R. Elbeltagy, Hesham Haffez, O. El-Habit
2026Advances in Basic and Applied Sciences0 citations
Semantic Scholar
Thieno[2,3-d]pyrimidine scaffold optimization for synergistic c-Met/STAT3 blockade: Synthesis, structure-activity relationships, in vitro potency, and apoptotic pathways in colorectal cancer.
S. I. El-Desouky, Hesham Haffez, Mohamed S. Nafie, M. A. Moustafa +1 more
2026Bioorganic chemistry (Print)0 citations
Semantic Scholar
Synthesis and crystal structure of ethyl 2-{[4-amino-5-cyano-6-(3,4-dimethoxyphenyl)pyrimidin-2-yl]sulfanyl}acetate
Manar M. Abuzahra, W. Zaghary, N. Ahmed, M. Khedr +3 more
2026Acta Crystallographica Section E: Crystallographic Communications0 citations Open access
Semantic Scholar
TLR3 polymorphism protects against multiple sclerosis onset but not progression in Egyptian patients.
E. Mohsen, Hesham Haffez, Sandra Ahmed, Selwan Hamed +1 more
2026Multiple Sclerosis and Related Disorders0 citations
Semantic Scholar
Thiazole‐Derived Dual EGFR/CDK‐2 Inhibitors: Rational Design, Synthesis, In Vitro Anticancer Evaluation, Mechanistic Profiling, and Computational Binding Analysis
Rowida Nasr, Mohamed S. Nafie, Hesham Haffez, M. A. Moustafa +2 more
2026Archiv der Pharmazie0 citations Open access
Semantic Scholar
Deposited in DRO : 10 April 2018 Version of attached le : Peer-review status of attached
Hesham Haffez, D. Chisholm, N. Tatum, R. Valentine +4 more
20180 citations
Semantic Scholar
SBML Model Report Model name : “ Haffez 2017-RAR interaction with synthetic analogues ” 2
Varun B. Kothamachu, Hesham Haffez, C. Redfern, A. Whiting +4 more
20170 citations
Semantic Scholar
Design, synthesis and biological evaluation of small molecules for controlling cellular development
Hesham Haffez
20160 citations
Semantic Scholar
Cystatin C Is a Future Magic Bio-Marker in Type 2 Diabetes Mellitus
Hesham Haffez, Z. Hassan, Sameh Sorror
20120 citations
Semantic Scholar

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