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D. Hudig · SciRah

Researcher profile · Semantic Scholar

D. Hudig

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D. Hudig — researcher profile on SciRah

h-index: 23
Works: 88
Citations: 1,901

Most-cited papers

Granzymes (lymphocyte serine proteases): characterization with natural and synthetic substrates and inhibitors.
Chih-Min Kam, D. Hudig, J. Powers
2000Biochimica et Biophysica Acta181 citations
Semantic Scholar
Definition and Redesign of the Extended Substrate Specificity of Granzyme B*
J. Harris, E. Peterson, D. Hudig, N. Thornberry +1 more
1998Journal of Biological Chemistry181 citations Open access
Semantic Scholar
Sensitization of Tumor Cells to NK Cell-Mediated Killing by Proteasome Inhibition1
William H. D. Hallett, Erik Ames, Milad Motarjemi, I. Barão +5 more
2008Journal of Immunology147 citations
Semantic Scholar
The mechanism of cell-mediated cytotoxicity. I. Killing by murine cytotoxic T lymphocytes requires cell surface thiols and activated proteases.
D. Redelman, D. Hudig
1980Journal of Immunology142 citations
Semantic Scholar
Inhibition of human natural cytotoxicity by macromolecular antiproteases.
D. Hudig, T. Haverty, C. Fulcher, Doug Redelman +1 more
1981Journal of Immunology133 citations Open access
Semantic Scholar
Human granzyme B degrades aggrecan proteoglycan in matrix synthesized by chondrocytes.
Christopher J. Froelich, Xiaolan Zhang, Jane Turbov, D. Hudig +2 more
1993Journal of Immunology129 citations
Semantic Scholar
Granzyme B Induces Endothelial Cell Apoptosis and Contributes to the Development of Transplant Vascular Disease
J. Choy, Rani P. G. Cruz, A. Kerjner, Jennette Geisbrecht +7 more
2005American Journal of Transplantation91 citations Open access
Semantic Scholar
The function of lymphocyte proteases. Inhibition and restoration of granule-mediated lysis with isocoumarin serine protease inhibitors.
D. Hudig, N. Allison, T. M. Pickett, U. Winkler +2 more
1991Journal of Immunology83 citations Open access
Semantic Scholar
Induction of granzyme B and T cell cytotoxic capacity by IL-2 or IL-15 without antigens: multiclonal responses that are extremely lytic if triggered and short-lived after cytokine withdrawal.
David L. Tamang, D. Redelman, Bryce N. Alves, L. Vollger +2 more
2006Cytokine77 citations Open access
Semantic Scholar
Conversion of the substrate specificity of mouse proteinase granzyme B
A. Caputo, M. N. G. James, James C. Powers, D. Hudig +1 more
1994Nature Structural Biology71 citations
Semantic Scholar
The requirement for proteinase activity for human lymphocyte-mediated natural cytotoxicity (NK): evidence that the proteinase is serine dependent and has aromatic amino acid specificity of cleavage.
D. Hudig, D. Redelman, L. Minning
1984Journal of Immunology66 citations
Semantic Scholar
Dipeptidyl peptidase I: importance of progranzyme activation sequences, other dipeptide sequences, and the N-terminal amino group of synthetic substrates for enzyme activity.
T. V. Tran, K. Ellis, Chih-Min Kam, D. Hudig +1 more
2002Archives of Biochemistry and Biophysics53 citations
Semantic Scholar
Perforin Lytic Activity Is Controlled by Calreticulin1
Stephanie A. Fraser, Reza Karimi, M. Michalak, D. Hudig
2000Journal of Immunology52 citations Open access
Semantic Scholar
Design and evaluation of inhibitors for dipeptidyl peptidase I (Cathepsin C).
Chih-Min Kam, Marion G. Götz, G. Koot, M. Mcguire +3 more
2004Archives of Biochemistry and Biophysics50 citations
Semantic Scholar
NK Cells in Gamma-Interferon-Deficient Mice Suppress Lung Innate Immunity against Mycoplasma spp
M. Woolard, D. Hudig, L. Tabor, James A Ivey +1 more
2005Infection and Immunity40 citations Open access
Semantic Scholar
Interactions between human natural killer (NK) lymphocytes and yeast cells: human NK cells do not kill Candida albicans, although C. albicans blocks NK lysis of K562 cells
S. Zunino, D. Hudig
1988Infection and Immunity37 citations Open access
Semantic Scholar
Optimizing NK-92 serial killers: gamma irradiation, CD95/Fas-ligation, and NK or LAK attack limit cytotoxic efficacy
Lydia T Navarrete-Galvan, Michael J. Guglielmo, Judith Cruz Amaya, J. Smith-Gagen +3 more
2021Journal of Translational Medicine35 citations Open access
Semantic Scholar
Binding of Granzyme B in the Nucleus of Target Cells
M. Pinkoski, U. Winkler, D. Hudig, R. Bleackley
1996Journal of Biological Chemistry31 citations Open access
Semantic Scholar
IL-15-Mediated Induction of LFA-1 Is a Late Step Required for Cytotoxic Differentiation of Human NK Cells from CD34+Lin− Bone Marrow Cells1
I. Barão, D. Hudig, J. Ascensao
2003Journal of Immunology29 citations
Semantic Scholar
Mucosal Immunity and the Gut-Microbiota-Brain-Axis in Neuroimmune Disease
Kathryn G. Sterling, Griffin Kutler Dodd, Shatha Alhamdi, Peter G. Asimenios +4 more
2022International Journal of Molecular Sciences28 citations Open access
Semantic Scholar
Fractionation of perforin and granzymes by immobilized metal affinity chromatography (IMAC).
Ulrike Winkler, T. M. Pickett, D. Hudig
1996JIM - Journal of Immunological Methods27 citations
Semantic Scholar
Properties of Human Blood Monocytes II. Monocytes from Healthy Adults are Highly Heterogeneous Within and Among Individuals
D. Hudig, Kenneth W. Hunter, W. J. Diamond, D. Redelman
2013Cytometry. Part B, Clinical cytometry26 citations Open access
Semantic Scholar
Tissue Factor-Like Activity Of The Human Monocytic Tumor Cell Line U937
D. Hudig, S. Rapaport, S. Bajaj
1982Thrombosis and Haemostasis26 citations Open access
Semantic Scholar
Properties of Human Blood Monocytes I. CD91 expression and log orthogonal light scatter provide a robust method to identify monocytes that is more accurate than CD14 expression
D. Hudig, Kenneth W. Hunter, W. J. Diamond, D. Redelman
2013Cytometry. Part B, Clinical cytometry23 citations Open access
Semantic Scholar
Dipeptide vinyl sulfones suitable for intracellular inhibition of dipeptidyl peptidase I.
Gretchen E Korver, Chih-Min Kam, J. Powers, D. Hudig
2001International Immunopharmacology17 citations
Semantic Scholar
Antibody-Dependent Cell-mediated Cytotoxicity (ADCC) in Familial Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS)
Alexander P. Sung, J. Tang, Michael J. Guglielmo, J. Smith-Gagen +4 more
2020Fatigue : biomedicine, health & behavior11 citations Open access
Semantic Scholar
An improved method to quantify human NK cell-mediated antibody-dependent cell-mediated cytotoxicity (ADCC) per IgG FcR-positive NK cell without purification of NK cells.
Alexander P. Sung, J. Tang, Michael J. Guglielmo, D. Redelman +3 more
2018JIM - Journal of Immunological Methods11 citations
Semantic Scholar
The mechanism of cell-mediated cytotoxicity. IV. K-76 COONa, which inhibits the activity of Factor I and of C5, inhibits early events in cytotoxic T-lymphocyte-mediated cytolysis and in T-lymphocyte activation.
D. Redelman, D. Hudig
1984Cellular Immunology10 citations
Semantic Scholar
Regulation of perforin lysis: Implications for protein disulfide isomerase proteins
David L. Tamang, Bryce N. Alves, Viki Elliott, D. Redelman +3 more
2009Cellular Immunology7 citations Open access
Semantic Scholar
Pancreatic lipase‐related protein 2 (PLRP2) induction by IL‐4 in cytotoxic T lymphocytes (CTLs) and reevaluation of the negative effects of its gene ablation on cytotoxicity
Bryce N. Alves, J. Leong, David L. Tamang, Viki Elliott +7 more
2009Journal of Leukocyte Biology7 citations Open access
Semantic Scholar
EVIDENCE FOR PROTEASES WITH SPECIFICITY OF CLEAVAGE AT AROMATIC AMINO ACIDS IN HUMAN NATURAL CELL-MEDIATED CYTOTOXICITY
D. Hudig, D. Redelman, L. Minning
19827 citations
Semantic Scholar
Natural Killer (NK) Cell Expression of CD2 as a Predictor of Serial Antibody-Dependent Cell-Mediated Cytotoxicity (ADCC)
J. Tang, Alexander P. Sung, Michael J. Guglielmo, Lydia T Navarrete-Galvan +3 more
2020Antibodies6 citations Open access
Semantic Scholar
Lipid-dependent cytotoxicity by the lipase PLRP2 and by PLRP2-positive cytotoxic T lymphocytes (CTLs)
Bryce N. Alves, Kristen Marshall, David L. Tamang, Jeffrey W. Leong +4 more
2009Cell Biochemistry and Function6 citations Open access
Semantic Scholar
CELL SURFACE THIOLS IN HUMAN NATURAL CELL-MEDIATED CYTOTOXICITY
D. Hudig, D. Redelman, L. Minning
19826 citations
Semantic Scholar
Serum concentrations of α-macrofeto-protein (acute-phase α2-macroglobulin), a proteinase inhibitor, in pregnant and neonatal rats and in rats with acute inflammation
D. Hudig, S. Sell
1978Inflammation6 citations
Semantic Scholar
cDNA cloning of granzyme J
Gerald R. Ewoldt, P. Darcy, M. B. Snook, D. Hudig +1 more
1997Immunogenetics5 citations
Semantic Scholar
Rat α-Macrofetoprotein (Acute-Phase α2-Macroglobulin) during Hepatocarcinogenesis
D. Hudig, S. Sell, L. Newell, F. Becker
19795 citations
Semantic Scholar
Hydrolysis of tumor cell lipids after CTL-mediated death.
Bryce N. Alves, J. Leong, David L. Tamang, Viki Elliott +2 more
2009International Immunology4 citations Open access
Semantic Scholar
Dissociation of alpha-macrofetoprotein and alpha-fetoprotein production during experimental injury.
D. Hudig, S. Sell, L. Newell, E. Smuckler
1979Laboratory investigation; a journal of technical methods and pathology4 citations
Semantic Scholar
Low dose IL-15 induces snap arming of CD44(low) T lymphocytes in the absence of antigen.
David L. Tamang, Bryce N. Alves, Viki Elliott, Stephanie A. Fraser +2 more
2008Cellular Immunology3 citations Open access
Semantic Scholar
ENZYMES INVOLVED IN NATURAL KILLER CELL ACTIVITY: EVIDENCE FOR PHOSPHOLIPASES, LIPOXYGENASES, AND SERINE DEPENDENT PROTEINASES
D. Hudig, D. Redelman
19853 citations
Semantic Scholar
DNA synthesis and proliferation of human lymphocytes in vitro: III. Fate of cycling cells in aging cultures of phytohemagglutinin stimulated human lymphocytes
J. Mendelsohn, D. Hudig, J. Castagnola
1981Journal of Cellular Physiology3 citations
Semantic Scholar
Serum concentrations of alpha-macrofeto-protein (acute-phase alpha2-macroglobulin), a proteinase inhibitor, in pregnant and neonatal rats and in rats with acute inflammation.
D. Hudig, S. Sell
1978Inflammation3 citations
Semantic Scholar
NK-92 serial killers - characterization of potential limitations to cytotoxic capacity.
Lydia T Navarrete-Galvan, Michael J. Guglielmo, Alexander P. Sung, J. Smith-Gagen +3 more
2021Journal of Immunology2 citations
Semantic Scholar
Inclusion of family members without ME/CFS in research studies promotes discovery of biomarkers specific for ME/CFS
Keli Tokunaga, Alexander P. Sung, J. Tang, Michael J. Guglielmo +4 more
2020Work2 citations Open access
Semantic Scholar
The Stress of Intensive Training at Altitude in Winter After Training in the Desert
L. Castell, W. Ensign, D. Hudig, J. L. Knight +3 more
20032 citations
Semantic Scholar
Use of Protease Inhibitors as Probes for Biological Functions: Conditions, Controls, and Caveats
D. Hudig, J. Powers
19932 citations
Semantic Scholar
A serine proteinase as a "trigger" for human natural killer lymphocyte-mediated cytolysis.
D. Hudig, L. Minning, D. Redelman
1985Advances in Experimental Medicine and Biology2 citations
Semantic Scholar
ANALYSIS OF NK TARGET STRUCTURES. K562 MEMBRANE COMPONENTS ASSOCIATED WITH SUSCEPTIBILITY TO NK ATTACK
D. Hudig, L. Minning
19852 citations
Semantic Scholar
Cell surface thiols, methylation, and complement-like components are involved in the early events of CML whereas proteases participate in the later, Ca++-dependent events.
D. Redelman, D. Hudig
1985Advances in Experimental Medicine and Biology2 citations
Semantic Scholar

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