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J. Gumhold · SciRah

Researcher profile · Semantic Scholar

J. Gumhold

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J. Gumhold — researcher profile on SciRah

h-index: 16
Works: 48
Citations: 1,925

Most-cited papers

Complementary stimulation of hepatobiliary transport and detoxification systems by rifampicin and ursodeoxycholic acid in humans.
H. Marschall, Martin Wagner, G. Zollner, P. Fickert +10 more
2005Gastroenterology317 citations
Semantic Scholar
Dual Farnesoid X Receptor/TGR5 Agonist INT-767 Reduces Liver Injury in the Mdr2−/− (Abcb4−/−) Mouse Cholangiopathy Model by Promoting Biliary HCO3− Output
A. Baghdasaryan, T. Claudel, J. Gumhold, Dagmar Silbert +8 more
2011Hepatology228 citations Open access
Semantic Scholar
Coordinated induction of bile acid detoxification and alternative elimination in mice: role of FXR-regulated organic solute transporter-alpha/beta in the adaptive response to bile acids.
G. Zollner, Martin Wagner, T. Moustafa, P. Fickert +7 more
2006American Journal of Physiology - Gastrointestinal and Liver Physiology207 citations
Semantic Scholar
Alterations in lipid metabolism mediate inflammation, fibrosis, and proliferation in a mouse model of chronic cholestatic liver injury.
T. Moustafa, P. Fickert, C. Magnes, C. Guelly +13 more
2012Gastroenterology168 citations Open access
Semantic Scholar
AUTOIMMUNE, CHOLESTATIC AND BILIARY DISEASE Side Chain Structure Determines Unique Physiologic and Therapeutic Properties of norUrsodeoxycholic Acid in Mdr2 / Mice
E. Halilbasic, R. Fiorotto, P. Fickert, H. Marschall +12 more
2009155 citations
Semantic Scholar
Expression of bile acid synthesis and detoxification enzymes and the alternative bile acid efflux pump MRP4 in patients with primary biliary cirrhosis
G. Zollner, Martin Wagner, P. Fickert, Dagmar Silbert +4 more
2007Liver international (Print)132 citations
Semantic Scholar
Fxr−/− mice adapt to biliary obstruction by enhanced phase I detoxification and renal elimination of bile acids Published, JLR Papers in Press, December 4, 2005.
H. Marschall, Martin Wagner, K. Bodin, G. Zollner +6 more
2006Journal of Lipid Research116 citations Open access
Semantic Scholar
Curcumin improves sclerosing cholangitis in Mdr2−/− mice by inhibition of cholangiocyte inflammatory response and portal myofibroblast proliferation
A. Baghdasaryan, T. Claudel, A. Kosters, J. Gumhold +6 more
2010Gut103 citations Open access
Semantic Scholar
Absence of adipose triglyceride lipase protects from hepatic endoplasmic reticulum stress in mice
C. Fuchs, T. Claudel, P. Kumari, G. Haemmerle +8 more
2012Hepatology89 citations Open access
Semantic Scholar
Role of nuclear receptors and hepatocyte-enriched transcription factors for Ntcp repression in biliary obstruction in mouse liver.
G. Zollner, Martin Wagner, P. Fickert, A. Geier +8 more
2005American Journal of Physiology - Gastrointestinal and Liver Physiology87 citations
Semantic Scholar
Signal transducer and activator of transcription 3 protects from liver injury and fibrosis in a mouse model of sclerosing cholangitis.
M. Mair, G. Zollner, D. Schneller, M. Musteanu +15 more
2010Gastroenterology77 citations
Semantic Scholar
Disruption of the Growth Hormone—Signal Transducer and Activator of Transcription 5—Insulinlike Growth Factor 1 Axis Severely Aggravates Liver Fibrosis in a Mouse Model of Cholestasis
L. Blaas, J. Kornfeld, D. Schramek, M. Musteanu +14 more
2010Hepatology59 citations Open access
Semantic Scholar
The Role of Osteopontin and Tumor Necrosis Factor Alpha Receptor-1 in Xenobiotic-induced Cholangitis and Biliary Fibrosis in Mice
P. Fickert, A. Thueringer, T. Moustafa, Dagmar Silbert +6 more
2010Laboratory Investigation43 citations Open access
Semantic Scholar
Impact of experimental colitis on hepatobiliary transporter expression and bile duct injury in mice
J. Jahnel, P. Fickert, C. Langner, C. Högenauer +4 more
2009Liver international (Print)36 citations
Semantic Scholar
Successful treatment of severe unconjugated hyperbilirubinemia via induction of UGT1A1 by rifampicin.
Ewa C. S. Ellis, Martin Wagner, F. Lammert, A. Németh +7 more
2006Journal of Hepatology35 citations Open access
Semantic Scholar
Role of hepatic phospholipids in development of liver injury in Mdr2 (Abcb4) knockout mice
A. Baghdasaryan, P. Fickert, A. Fuchsbichler, Dagmar Silbert +7 more
2008Liver international (Print)25 citations
Semantic Scholar
Imbalance of pro‐ and antifibrogenic genes and bile duct injury in murine Schistosoma mansoni infection–induced liver fibrosis
M. Loebermann, M. Sombetzki, C. Langner, A. Fuchsbichler +8 more
2009Tropical medicine & international health15 citations
Semantic Scholar
Hepatobiliary Transporter Expression in Intercellular Adhesion Molecule 1 Knockout and Fas Receptor-Deficient Mice after Common Bile Duct Ligation Is Independent of the Degree of Inflammation and Oxidative Stress
Martin Wagner, G. Zollner, P. Fickert, J. Gumhold +7 more
2007Drug Metabolism And Disposition11 citations
Semantic Scholar
Hepatobiliary transporter expression in ICAM -/- and lpr mice after common bile duct ligation is independent of the degree of inflammation and oxidative stress
Martin Wagner, G. Zollner, P. Fickert, J. Gumhold +8 more
20074 citations
Semantic Scholar
125 SIDE CHAIN MODIFIED BILE ACIDS MODULATE ENDOPLASMIC RETICULUM STRESS IN MDR2−/− MICE IN VIVO AND BILE DUCT EPITHELIAL CELLS IN VITRO
T. Moustafa, E. Halilbasic, P. Fickert, A. Fuchsbichler +4 more
20083 citations
Semantic Scholar
[116] TAURINE-CONJUGATION CRITICALLY DETERMINES THE THERAPEUTIC EFFECTIVENESS OF 24-NOR-URSODEOXYCHOLIC ACID (NORUDCA) IN THE TREATMENT OF SCLEROSING CHOLANGITIS IN MDR2 (ABCB4) KNOCKOUT MICE
E. Halilbasic, P. Fickert, A. Fuchbichler, C. Langner +6 more
20073 citations
Semantic Scholar
557 Role of adaptive hepatobiliary transporter expression and regulation of bile acid synthetic enzymes in MDR2-/- Mice: A model for chronic cholestatic liver disease due to sclerosing cholangitis
Martin Wagner, P. Fickert, G. Zollner, A. Fuchsbichler +7 more
20043 citations
Semantic Scholar
70 Differential effects of ursodeoxycholic acid (UDCA) and cholic acid (CA) on hepatic and renal expression of MRP4 and MRP6, two novel ABC transporters, in mice
G. Zollner, E. Hallibasic, Martin Wagner, P. Fickert +6 more
20043 citations
Semantic Scholar
913 THERAPEUTIC EFFECTS OF FXR AND TGR5 ACTIVATION IN THE MDR2 (ABCB4)−/− MOUSE MODEL OF SCLEROSING CHOLANGITIS
A. Baghdasaryan, T. Claudel, J. Gumhold, Dagmar Silbert +5 more
20101 citations Open access
Semantic Scholar
P244 - Impact of biliary and nutritional lack of phospholipids in a colitis mouse model
J. Jahnel, T. Claudel, A. Baghdasaryan, Dagmar Silbert +4 more
20091 citations Open access
Semantic Scholar
50 24-NOR-URSODEOXYCHOLIC ACID AS NOVEL THERAPEUTIC STRATEGY FOR INFLAMMATION-INDUCED LIVER FIBROSIS IN A MURINE MODEL OF SCHISTOSOMA MANSONI INFECTION
M. Sombetzki, P. Fickert, M. Loebermann, M. Holtfreter +6 more
20081 citations Open access
Semantic Scholar
Coordinated induction of bile acid detoxiﬁcation and alternative elimination in mice: role of FXR-regulated organic solute transporter- (cid:1) / (cid:2) in the adaptive response to bile acids
G. Zollner, Martin Wagner, T. Moustafa, P. Fickert +7 more
20061 citations
Semantic Scholar
320 3.5-Diethoxycarbonyl-1.4-dihydrocollidine (DDC) feeding induces cholestasis, chronic inflammatory bile duct damage and biliary fibrosis in mice
Ulrike Stöger, E. Fickert, A. Fuchsbichler, T. Moustafa +5 more
20061 citations Open access
Semantic Scholar
69 Nuclear receptor (PXR, CAR) agonists induce adaptive hepatic transporter and enzyme expression in mouse liver
Martin Wagner, E. Halibasic, P. Fickert, G. Zollner +6 more
20041 citations
Semantic Scholar
73 Adaptive renal ABC transporter expression in common bile duct-ligated mice
Martin Wagner, P. Fickert, G. Zollner, Dagmar Silbert +8 more
20041 citations
Semantic Scholar
1106 Hepatic and renal ABC transporter expression as critical determinants of ursodeoxycholic acid-induced bile infarcts in bile duct-ligated mice
Martin Wagner, P. Fickert, A. Fuchsbichler, Dagmar Silbert +6 more
20031 citations
Semantic Scholar
Fxr But Not Tgr5 Activation Stimulates Hco3-Rich Bile Secretion And Ameliorates Liver Damage In Mdr2-/- (Abcb4-/-) Mouse Model Of Chronic Liver Injury
A. Baghdasaryan, T. Claudel, J. Gumhold, Dagmar Silbert +5 more
20110 citations
Semantic Scholar
93 ATGL (PNPLA2) KNOCKOUT MICE ARE PROTECTED FROM HEPATIC ER-STRESS VIA OLEIC ACID ACCUMULATION
C. Fuchs, T. Claudel, P. Kumari, Tatjana Stojakovic +7 more
20110 citations Open access
Semantic Scholar
785 ADIPOSE TRIGLYCERIDE LIPASE (ATGL) IS A NOVEL MODULATOR OF HEPATIC ER-STRESS
C. Fuchs, T. Moustafa, G. Haemmerle, E. Halilbasic +5 more
20100 citations Open access
Semantic Scholar
50 PREGNANCY RESOLVES LIVER FIBROSIS AND IMPROVES SCLEROSING CHOLANGITIS IN MDR2 (ABCB4) −/− MICE VIA DIRECT ANTI-INFLAMMATORY EFFECTS OF SEX HORMONES
E. Halilbasic, T. Claudel, J. Gumhold, S. Halsegger +3 more
20100 citations Open access
Semantic Scholar
47 METABOLIC REPROGRAMMING OF LIPID METABOLISM BY THE SIDE-CHAIN MODIFIED BILE ACID, 24-NORURSODEOXYCHOLIC ACID, RESTORES INFLAMMATION-DRIVEN LIVER INJURY AND ABERRANT PROLIFERATION IN ABCB4−/− MICE
T. Moustafa, P. Fickert, C. Magnes, S. Frank +6 more
20100 citations Open access
Semantic Scholar
P012 Phospholipids and Colitis: Impact of Lack of Biliary and Nutritional Phospholipids on Chemically Induced Colitis in Mice
J. Jahnel, T. Claudel, A. Baghdasaryan, Dagmar Silbert +4 more
20090 citations
Semantic Scholar
Side-chain modification as critical determinant of the therapeutic properties of 24-norursodeoxycholic acid in Mdr2 (Abcb4) knockout mice
E. Halilbasic, P. Fickert, R. Fiorotto, H. Marschall +9 more
20090 citations
Semantic Scholar
448 CURCUMIN IMPROVES LIVER INJURY AND BILIARY FIBROSIS IN MDR2 (ABCB4) KNOCKOUT MICE BY INDUCING ANTI-OXIDATIVE RESPONSE, BUT NOT VIA MODIFICATION OF BILE ACID TRANSPORT/METABOLISM
A. Baghdasaryan, A. Kosters, T. Claudel, A. Fuchsbichler +6 more
20080 citations
Semantic Scholar
[309] IMPACT OF COLITIS ON BILE SECRETION AND HEPATOBILIARY TRANSPORTER EXPRESSION IN MICE: POSSIBLE IMPLICATIONS FOR PATHOGENESIS OF SCLEROSING CHOLANGITIS
J. Jahnel, Martin Wagner, C. Langner, C. Hoegenauer +6 more
20070 citations Open access
Semantic Scholar
[48] RETENTION OF TOXIC BILE ACIDS ACTIVATE THE MTOR, P70S6K/RPS6 SIGNALING PATHWAY IN MOUSE MODELS OF CHOLESTATIC LIVER INJURY
T. Moustafa, P. Fickert, P. Vesely, Dagmar Silbert +5 more
20070 citations
Semantic Scholar
[5] ABSENCE OF FXR PROTECTS MICE FROM BILE-INFARCTS IN BILIARY OBSTRUCTION BY REDUCTION OF BILE ACID-INDEPENDENT BILE FLOW: IMPLICATIONS FOR TARGETING FXR IN TREATMENT OF CHOLESTASIS?
Martin Wagner, T. Moustafa, P. Fickert, G. Zollner +6 more
20070 citations Open access
Semantic Scholar
62 Common bile-duct-ligation of FXR knockout mice results in severe hepatic steatosis due to enhancement in lipogenic gene expression
T. Moustafa, P. Fickert, A. Prokesch, Martin Wagner +6 more
20060 citations Open access
Semantic Scholar
321 Role of nuclear bile acid receptor FXR in regulation of bile acid detoxification and organic solute transporter (OST-α/β) expression in bile acid-fed mice
G. Zollner, Martin Wagner, T. Moustafa, P. Fickert +5 more
20060 citations Open access
Semantic Scholar
94 Transcriptional profiling of MDR2 knockout (MDR2−/−) mice treated with NOR-UDCA reveals global anti-inflammatory and anti-fibrotic effects
T. Moustafa, P. Fickert, C. Guelly, Dagmar Silbert +4 more
20060 citations
Semantic Scholar
LINICAL – LIVER , PANCREAS , AND BILIARY TRACT omplementary Stimulation of Hepatobiliary Transport and etoxification Systems by Rifampicin and Ursodeoxycholic Acid n Humans
U. Marschall, Martin Wagner, G. Zollner, P. Fickert +10 more
20050 citations
Semantic Scholar
307 Gender and pregnancy affect hepatic and renal ABC transporter expression in mice
Martin Wagner, P. Fickert, G. Zollner, Dagmar Silbert +6 more
20040 citations
Semantic Scholar
1107 Induction of intestinal multidrug resistance-associated proteins 2 and 3 (MRP2, MRP3) by cholic acid (CA) and ursodeoxycholic acid (UDCA) in mice
G. Zollner, P. Fickert, Martin Wagner, A. Fuchsbichler +5 more
20030 citations
Semantic Scholar

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Dagmar Silbert×45
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E. Halilbasic — researcher profile on SciRah