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Dagmar Silbert · SciRah

Researcher profile · Semantic Scholar

Dagmar Silbert

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Dagmar Silbert — researcher profile on SciRah

h-index: 21
Works: 66
Citations: 3,118

Most-cited papers

Complementary stimulation of hepatobiliary transport and detoxification systems by rifampicin and ursodeoxycholic acid in humans.
H. Marschall, Martin Wagner, G. Zollner, P. Fickert +10 more
2005Gastroenterology317 citations
Semantic Scholar
Adaptive changes in hepatobiliary transporter expression in primary biliary cirrhosis.
G. Zollner, P. Fickert, Dagmar Silbert, A. Fuchsbichler +4 more
2003Journal of Hepatology278 citations
Semantic Scholar
Role of farnesoid X receptor in determining hepatic ABC transporter expression and liver injury in bile duct-ligated mice.
Martin Wagner, P. Fickert, G. Zollner, A. Fuchsbichler +9 more
2003Gastroenterology276 citations
Semantic Scholar
Dual Farnesoid X Receptor/TGR5 Agonist INT-767 Reduces Liver Injury in the Mdr2−/− (Abcb4−/−) Mouse Cholangiopathy Model by Promoting Biliary HCO3− Output
A. Baghdasaryan, T. Claudel, J. Gumhold, Dagmar Silbert +8 more
2011Hepatology228 citations Open access
Semantic Scholar
Coordinated induction of bile acid detoxification and alternative elimination in mice: role of FXR-regulated organic solute transporter-alpha/beta in the adaptive response to bile acids.
G. Zollner, Martin Wagner, T. Moustafa, P. Fickert +7 more
2006American Journal of Physiology - Gastrointestinal and Liver Physiology207 citations
Semantic Scholar
Role of nuclear bile acid receptor, FXR, in adaptive ABC transporter regulation by cholic and ursodeoxycholic acid in mouse liver, kidney and intestine.
G. Zollner, P. Fickert, A. Fuchsbichler, Dagmar Silbert +7 more
2003Journal of Hepatology198 citations
Semantic Scholar
Bile acids trigger cholemic nephropathy in common bile‐duct–ligated mice
P. Fickert, E. Krones, M. Pollheimer, A. Thueringer +14 more
2013Hepatology171 citations Open access
Semantic Scholar
Alterations in lipid metabolism mediate inflammation, fibrosis, and proliferation in a mouse model of chronic cholestatic liver injury.
T. Moustafa, P. Fickert, C. Magnes, C. Guelly +13 more
2012Gastroenterology168 citations Open access
Semantic Scholar
AUTOIMMUNE, CHOLESTATIC AND BILIARY DISEASE Side Chain Structure Determines Unique Physiologic and Therapeutic Properties of norUrsodeoxycholic Acid in Mdr2 / Mice
E. Halilbasic, R. Fiorotto, P. Fickert, H. Marschall +12 more
2009155 citations
Semantic Scholar
Hepatobiliary transporter expression in human hepatocellular carcinoma
G. Zollner, Martin Wagner, P. Fickert, Dagmar Silbert +4 more
2005Liver international (Print)144 citations
Semantic Scholar
Expression of bile acid synthesis and detoxification enzymes and the alternative bile acid efflux pump MRP4 in patients with primary biliary cirrhosis
G. Zollner, Martin Wagner, P. Fickert, Dagmar Silbert +4 more
2007Liver international (Print)132 citations
Semantic Scholar
Fxr−/− mice adapt to biliary obstruction by enhanced phase I detoxification and renal elimination of bile acids Published, JLR Papers in Press, December 4, 2005.
H. Marschall, Martin Wagner, K. Bodin, G. Zollner +6 more
2006Journal of Lipid Research116 citations Open access
Semantic Scholar
Curcumin improves sclerosing cholangitis in Mdr2−/− mice by inhibition of cholangiocyte inflammatory response and portal myofibroblast proliferation
A. Baghdasaryan, T. Claudel, A. Kosters, J. Gumhold +6 more
2010Gut103 citations Open access
Semantic Scholar
Expression of the nuclear bile acid receptor/farnesoid X receptor is reduced in human colon carcinoma compared to nonneoplastic mucosa independent from site and may be associated with adverse prognosis
S. Lax, G. Schauer, K. Prein, M. Kapitan +4 more
2012International Journal of Cancer98 citations
Semantic Scholar
Differential effects of norUDCA and UDCA in obstructive cholestasis in mice
P. Fickert, M. Pollheimer, Dagmar Silbert, T. Moustafa +7 more
2013Journal of Hepatology94 citations Open access
Semantic Scholar
Absence of adipose triglyceride lipase protects from hepatic endoplasmic reticulum stress in mice
C. Fuchs, T. Claudel, P. Kumari, G. Haemmerle +8 more
2012Hepatology89 citations Open access
Semantic Scholar
Role of nuclear receptors and hepatocyte-enriched transcription factors for Ntcp repression in biliary obstruction in mouse liver.
G. Zollner, Martin Wagner, P. Fickert, A. Geier +8 more
2005American Journal of Physiology - Gastrointestinal and Liver Physiology87 citations
Semantic Scholar
Induction of short heterodimer partner 1 precedes downregulation of Ntcp in bile duct-ligated mice.
G. Zollner, P. Fickert, Dagmar Silbert, A. Fuchsbichler +4 more
2002American Journal of Physiology - Gastrointestinal and Liver Physiology71 citations
Semantic Scholar
The Role of Osteopontin and Tumor Necrosis Factor Alpha Receptor-1 in Xenobiotic-induced Cholangitis and Biliary Fibrosis in Mice
P. Fickert, A. Thueringer, T. Moustafa, Dagmar Silbert +6 more
2010Laboratory Investigation43 citations Open access
Semantic Scholar
Impact of experimental colitis on hepatobiliary transporter expression and bile duct injury in mice
J. Jahnel, P. Fickert, C. Langner, C. Högenauer +4 more
2009Liver international (Print)36 citations
Semantic Scholar
Role of hepatic phospholipids in development of liver injury in Mdr2 (Abcb4) knockout mice
A. Baghdasaryan, P. Fickert, A. Fuchsbichler, Dagmar Silbert +7 more
2008Liver international (Print)25 citations
Semantic Scholar
Imbalance of pro‐ and antifibrogenic genes and bile duct injury in murine Schistosoma mansoni infection–induced liver fibrosis
M. Loebermann, M. Sombetzki, C. Langner, A. Fuchsbichler +8 more
2009Tropical medicine & international health15 citations
Semantic Scholar
Combined Rifampicin and Ursodeoxycholic Acid Treatment Does Not Amplify Rifampicin Effects on Hepatic Detoxification and Transport Systems in Humans
H. Marschall, Martin Wagner, G. Zollner, P. Fickert +4 more
2012Digestion11 citations
Semantic Scholar
Hepatobiliary Transporter Expression in Intercellular Adhesion Molecule 1 Knockout and Fas Receptor-Deficient Mice after Common Bile Duct Ligation Is Independent of the Degree of Inflammation and Oxidative Stress
Martin Wagner, G. Zollner, P. Fickert, J. Gumhold +7 more
2007Drug Metabolism And Disposition11 citations
Semantic Scholar
The role of the hepatocyte cytokeratin network in bile formation and resistance to bile acid challenge and cholestasis in mice
P. Fickert, A. Fuchsbichler, Martin Wagner, Dagmar Silbert +3 more
2009Hepatology10 citations Open access
Semantic Scholar
Hepatobiliary transporter expression in ICAM -/- and lpr mice after common bile duct ligation is independent of the degree of inflammation and oxidative stress
Martin Wagner, G. Zollner, P. Fickert, J. Gumhold +8 more
20074 citations
Semantic Scholar
303 Comprehensive study of the effects of rifampicin and ursodeoxycholic acid on genes and proteins involved in regulation, transport and detoxification of biliary compounds in gallstone patients
H. Marschall, Martin Wagner, G. Zollner, P. Fickert +8 more
20044 citations
Semantic Scholar
Role of nuclear bile salt receptors Fxr and Pxr in mediating adaptive hepatobiliary transporter response to cholic acid (CA) in mouse liver
G. Zollner, P. Fickert, Dagmar Silbert, A. Fuchsbichler +6 more
20034 citations Open access
Semantic Scholar
125 SIDE CHAIN MODIFIED BILE ACIDS MODULATE ENDOPLASMIC RETICULUM STRESS IN MDR2−/− MICE IN VIVO AND BILE DUCT EPITHELIAL CELLS IN VITRO
T. Moustafa, E. Halilbasic, P. Fickert, A. Fuchsbichler +4 more
20083 citations
Semantic Scholar
[116] TAURINE-CONJUGATION CRITICALLY DETERMINES THE THERAPEUTIC EFFECTIVENESS OF 24-NOR-URSODEOXYCHOLIC ACID (NORUDCA) IN THE TREATMENT OF SCLEROSING CHOLANGITIS IN MDR2 (ABCB4) KNOCKOUT MICE
E. Halilbasic, P. Fickert, A. Fuchbichler, C. Langner +6 more
20073 citations
Semantic Scholar
557 Role of adaptive hepatobiliary transporter expression and regulation of bile acid synthetic enzymes in MDR2-/- Mice: A model for chronic cholestatic liver disease due to sclerosing cholangitis
Martin Wagner, P. Fickert, G. Zollner, A. Fuchsbichler +7 more
20043 citations
Semantic Scholar
70 Differential effects of ursodeoxycholic acid (UDCA) and cholic acid (CA) on hepatic and renal expression of MRP4 and MRP6, two novel ABC transporters, in mice
G. Zollner, E. Hallibasic, Martin Wagner, P. Fickert +6 more
20043 citations
Semantic Scholar
Alterations of hepatobiliary transporter expression in primary biliary cirrhosis (PBC)
G. Zollner, P. Fickert, Dagmar Silbert, A. Fuchsbichler +5 more
20022 citations
Semantic Scholar
Tu1033 High Levels of Ursodeoxycholic Acid Act as FXR Antagonist and Deplete Liver Cholesterol Due to Increased Bile Acid Synthesis in Morbidly Obese Patients
H. Marschall, Michaela Mueller, Martin Wagner, P. Fickert +5 more
20121 citations
Semantic Scholar
1307 HIGH LEVELS OF URSODEOXYCHOLIC ACID ACT AS FXR ANTAGONIST AND DEPLETE LIVER CHOLESTEROL DUE TO INCREASED BILE ACID SYNTHESIS IN MORBIDLY OBESE PATIENTS
H. Marschall, Michaela Mueller, Martin Wagner, P. Fickert +5 more
20121 citations
Semantic Scholar
913 THERAPEUTIC EFFECTS OF FXR AND TGR5 ACTIVATION IN THE MDR2 (ABCB4)−/− MOUSE MODEL OF SCLEROSING CHOLANGITIS
A. Baghdasaryan, T. Claudel, J. Gumhold, Dagmar Silbert +5 more
20101 citations Open access
Semantic Scholar
P244 - Impact of biliary and nutritional lack of phospholipids in a colitis mouse model
J. Jahnel, T. Claudel, A. Baghdasaryan, Dagmar Silbert +4 more
20091 citations Open access
Semantic Scholar
50 24-NOR-URSODEOXYCHOLIC ACID AS NOVEL THERAPEUTIC STRATEGY FOR INFLAMMATION-INDUCED LIVER FIBROSIS IN A MURINE MODEL OF SCHISTOSOMA MANSONI INFECTION
M. Sombetzki, P. Fickert, M. Loebermann, M. Holtfreter +6 more
20081 citations Open access
Semantic Scholar
Coordinated induction of bile acid detoxiﬁcation and alternative elimination in mice: role of FXR-regulated organic solute transporter- (cid:1) / (cid:2) in the adaptive response to bile acids
G. Zollner, Martin Wagner, T. Moustafa, P. Fickert +7 more
20061 citations
Semantic Scholar
320 3.5-Diethoxycarbonyl-1.4-dihydrocollidine (DDC) feeding induces cholestasis, chronic inflammatory bile duct damage and biliary fibrosis in mice
Ulrike Stöger, E. Fickert, A. Fuchsbichler, T. Moustafa +5 more
20061 citations Open access
Semantic Scholar
69 Nuclear receptor (PXR, CAR) agonists induce adaptive hepatic transporter and enzyme expression in mouse liver
Martin Wagner, E. Halibasic, P. Fickert, G. Zollner +6 more
20041 citations
Semantic Scholar
73 Adaptive renal ABC transporter expression in common bile duct-ligated mice
Martin Wagner, P. Fickert, G. Zollner, Dagmar Silbert +8 more
20041 citations
Semantic Scholar
1106 Hepatic and renal ABC transporter expression as critical determinants of ursodeoxycholic acid-induced bile infarcts in bile duct-ligated mice
Martin Wagner, P. Fickert, A. Fuchsbichler, Dagmar Silbert +6 more
20031 citations
Semantic Scholar
Fxr But Not Tgr5 Activation Stimulates Hco3-Rich Bile Secretion And Ameliorates Liver Damage In Mdr2-/- (Abcb4-/-) Mouse Model Of Chronic Liver Injury
A. Baghdasaryan, T. Claudel, J. Gumhold, Dagmar Silbert +5 more
20110 citations
Semantic Scholar
93 ATGL (PNPLA2) KNOCKOUT MICE ARE PROTECTED FROM HEPATIC ER-STRESS VIA OLEIC ACID ACCUMULATION
C. Fuchs, T. Claudel, P. Kumari, Tatjana Stojakovic +7 more
20110 citations Open access
Semantic Scholar
785 ADIPOSE TRIGLYCERIDE LIPASE (ATGL) IS A NOVEL MODULATOR OF HEPATIC ER-STRESS
C. Fuchs, T. Moustafa, G. Haemmerle, E. Halilbasic +5 more
20100 citations Open access
Semantic Scholar
50 PREGNANCY RESOLVES LIVER FIBROSIS AND IMPROVES SCLEROSING CHOLANGITIS IN MDR2 (ABCB4) −/− MICE VIA DIRECT ANTI-INFLAMMATORY EFFECTS OF SEX HORMONES
E. Halilbasic, T. Claudel, J. Gumhold, S. Halsegger +3 more
20100 citations Open access
Semantic Scholar
47 METABOLIC REPROGRAMMING OF LIPID METABOLISM BY THE SIDE-CHAIN MODIFIED BILE ACID, 24-NORURSODEOXYCHOLIC ACID, RESTORES INFLAMMATION-DRIVEN LIVER INJURY AND ABERRANT PROLIFERATION IN ABCB4−/− MICE
T. Moustafa, P. Fickert, C. Magnes, S. Frank +6 more
20100 citations Open access
Semantic Scholar
P012 Phospholipids and Colitis: Impact of Lack of Biliary and Nutritional Phospholipids on Chemically Induced Colitis in Mice
J. Jahnel, T. Claudel, A. Baghdasaryan, Dagmar Silbert +4 more
20090 citations
Semantic Scholar
Side-chain modification as critical determinant of the therapeutic properties of 24-norursodeoxycholic acid in Mdr2 (Abcb4) knockout mice
E. Halilbasic, P. Fickert, R. Fiorotto, H. Marschall +9 more
20090 citations
Semantic Scholar

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M. Trauner×48
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P. Fickert×44
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J. Gumhold×35
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H. Marschall×16

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