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A. K. Chaplin · SciRah

Researcher profile · Semantic Scholar

A. K. Chaplin

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A. K. Chaplin — researcher profile on SciRah

h-index: 21
Works: 63
Citations: 1,036

Most-cited papers

Cryo-EM of NHEJ supercomplexes provides insights into DNA repair
A. K. Chaplin, S. Hardwick, A. K. Stavridi, C. Buehl +8 more
2021Molecules and Cells98 citations Open access
Semantic Scholar
Dimers of DNA-PK create a stage for DNA double-strand break repair
A. K. Chaplin, S. Hardwick, Shikang Liang, Antonia Kefala Stavridi +5 more
2020Nature Structural & Molecular Biology98 citations Open access
Semantic Scholar
Structural insights into inhibitor regulation of the DNA repair protein DNA-PKcs
Shikang Liang, S. E. Thomas, A. K. Chaplin, S. Hardwick +2 more
2022Nature73 citations Open access
Semantic Scholar
GlxA is a new structural member of the radical copper oxidase family and is required for glycan deposition at hyphal tips and morphogenesis of Streptomyces lividans.
A. K. Chaplin, Marloes L. C. Petrus, G. Mangiameli, M. Hough +5 more
2015Biochemical Journal61 citations Open access
Semantic Scholar
Response to Copper Stress in Streptomyces lividans Extends beyond Genes under Direct Control of a Copper-sensitive Operon Repressor Protein (CsoR)*
Srivatsa Dwarakanath, A. K. Chaplin, M. Hough, S. Rigali +2 more
2012Journal of Biological Chemistry60 citations Open access
Semantic Scholar
The DyP-type peroxidase DtpA is a Tat-substrate required for GlxA maturation and morphogenesis in Streptomyces
Marloes L. C. Petrus, E. Vijgenboom, A. K. Chaplin, J. Worrall +2 more
2016Open Biology58 citations Open access
Semantic Scholar
Dose-resolved serial synchrotron and XFEL structures of radiation-sensitive metalloproteins
A. Ebrahim, T. Moreno-Chicano, M. Appleby, A. K. Chaplin +11 more
2019IUCrJ53 citations Open access
Semantic Scholar
Heterogeneity in the Histidine-brace Copper Coordination Sphere in Auxiliary Activity Family 10 (AA10) Lytic Polysaccharide Monooxygenases*
A. K. Chaplin, Michael T. Wilson, M. Hough, D. Svistunenko +4 more
2016Journal of Biological Chemistry50 citations Open access
Semantic Scholar
PAXX binding to the NHEJ machinery explains functional redundancy with XLF
Murielle Seif-El-Dahan, Antonia Kefala-Stavridi, P. Frit, S. Hardwick +13 more
2023Science Advances42 citations Open access
Semantic Scholar
Two distinct long-range synaptic complexes promote different aspects of end-processing prior to repair of DNA breaks by non-homologous end joining
C. Buehl, Noah J. Goff, S. Hardwick, M. Gellert +4 more
2023Molecules and Cells39 citations Open access
Semantic Scholar
Serial Femtosecond Zero Dose Crystallography Captures a Water‐Free Distal Heme Site in a Dye‐Decolorising Peroxidase to Reveal a Catalytic Role for an Arginine in FeIV=O Formation
M. Lučić, D. Svistunenko, Michael T. Wilson, A. K. Chaplin +11 more
2020Angewandte Chemie32 citations Open access
Semantic Scholar
High-throughput structures of protein–ligand complexes at room temperature using serial femtosecond crystallography
T. Moreno-Chicano, A. Ebrahim, D. Axford, M. Appleby +12 more
2019IUCrJ27 citations Open access
Semantic Scholar
A cytosolic copper storage protein provides a second level of copper tolerance in Streptomyces lividans.
M. Straw, A. K. Chaplin, M. Hough, Jordi Paps +4 more
2018Metallomics26 citations Open access
Semantic Scholar
Structural biology of multicomponent assemblies in DNA double-strand-break repair through non-homologous end joining.
A. K. Chaplin, T. Blundell
2019Current Opinion in Structural Biology25 citations
Semantic Scholar
Photoreduction and validation of haem–ligand intermediate states in protein crystals by in situ single-crystal spectroscopy and diffraction
D. Kekilli, T. Moreno-Chicano, A. K. Chaplin, S. Horrell +4 more
2017IUCrJ25 citations Open access
Semantic Scholar
An Aromatic Dyad Motif in Dye Decolourising Peroxidases Has Implications for Free Radical Formation and Catalysis.
A. K. Chaplin, T. M. Chicano, Bethany V. Hampshire, Michael T. Wilson +3 more
2019Chemistry24 citations Open access
Semantic Scholar
Using cryo-EM to understand antimycobacterial resistance in the catalase-peroxidase (KatG) from Mycobacterium tuberculosis
A. Munir, Michael T. Wilson, S. Hardwick, D. Chirgadze +3 more
2020Structure23 citations Open access
Semantic Scholar
Profiling of advanced glycation end products uncovers abiotic stress-specific target proteins in Arabidopsis
A. K. Chaplin, I. Chernukhin, U. Bechtold
2018Journal of Experimental Botany22 citations Open access
Semantic Scholar
Kinetic characterisation of a dye decolourising peroxidase from Streptomyces lividans: new insight into the mechanism of anthraquinone dye decolourisation.
A. K. Chaplin, Michael T. Wilson, J. Worrall
2017Dalton Transactions22 citations Open access
Semantic Scholar
SAP domain forms a flexible part of DNA aperture in Ku70/80
A. Hnízda, P. Tesina, Thanh-Binh Nguyen, Zdeněk Kukačka +6 more
2020The FEBS Journal21 citations Open access
Semantic Scholar
Copper trafficking in the CsoR regulon of Streptomyces lividans.
A. K. Chaplin, Benedict G. Tan, E. Vijgenboom, J. Worrall
2015Metallomics21 citations
Semantic Scholar
The Resolution Revolution in X-ray Diffraction, Cryo-EM and other Technologies.
T. Blundell, A. K. Chaplin
2021Progress in Biophysics and Molecular Biology19 citations
Semantic Scholar
Surface Passivation with a Perfluoroalkane Brush Improves the Precision of Single-Molecule Measurements
Carlos J Bueno-Alejo, Marina Santana Vega, A. K. Chaplin, Chloe Farrow +9 more
2022ACS Applied Materials and Interfaces16 citations Open access
Semantic Scholar
COSMIC Cancer Gene Census 3D database: understanding the impacts of mutations on cancer targets
Ali F. Alsulami, P. Torres, Ismail Moghul, S. Arif +3 more
2021Briefings Bioinform.14 citations Open access
Semantic Scholar
A subtle structural change in the distal haem pocket has a remarkable effect on tuning hydrogen peroxide reactivity in dye decolourising peroxidases from Streptomyces lividans.
M. Lučić, A. K. Chaplin, T. Moreno-Chicano, F. Dworkowski +4 more
2020Dalton Transactions14 citations Open access
Semantic Scholar
Tyrosine or Tryptophan? Modifying a Metalloradical Catalytic Site by Removal of the Cys-Tyr Cross-Link in the Galactose 6-Oxidase Homologue GlxA.
A. K. Chaplin, Caterina Bernini, A. Sinicropi, R. Basosi +2 more
2017Angewandte Chemie14 citations
Semantic Scholar
Stages, scaffolds and strings in the spatial organisation of non-homologous end joining: Insights from X-ray diffraction and Cryo-EM
Shikang Liang, A. K. Chaplin, A. K. Stavridi, Robert Appleby +2 more
2020Progress in Biophysics and Molecular Biology13 citations Open access
Semantic Scholar
Active-site maturation and activity of the copper-radical oxidase GlxA are governed by a tryptophan residue.
A. K. Chaplin, D. Svistunenko, M. Hough, Michael T. Wilson +2 more
2017Biochemical Journal13 citations Open access
Semantic Scholar
Structural and functional basis of inositol hexaphosphate stimulation of NHEJ through stabilization of Ku-XLF interaction
Antonia Kefala Stavridi, A. Gontier, Vincent Morin, P. Frit +20 more
2023Nucleic Acids Research10 citations Open access
Semantic Scholar
Genomics, Computational Biology and Drug Discovery for Mycobacterial Infections: Fighting the Emergence of Resistance
A. Munir, S. Vedithi, A. K. Chaplin, T. Blundell
2020Frontiers in Genetics10 citations Open access
Semantic Scholar
Druggable binding sites in the multicomponent assemblies that characterise DNA double-strand-break repair through non-homologous end joining
Antonia Kefala Stavridi, Robert Appleby, Shikang Liang, T. L. Blundell +1 more
2020Essays in Biochemistry7 citations Open access
Semantic Scholar
Cryo-EM structure of a DNA-PK trimer: higher order oligomerisation in NHEJ.
S. Hardwick, A. K. Stavridi, D. Chirgadze, T. D. de Oliveira +5 more
2023Structure6 citations Open access
Semantic Scholar
Metalloenzymes required for glycan processing and morphological development in Streptomyces lividans
A. K. Chaplin
20162 citations
Semantic Scholar
Evidence for Separate Functions for Two Distinct Non-Homologous End Joining Long-Range Synaptic Complexes
C. Buehl, Noah J. Goff, S. Hardwick, M. Gellert +4 more
2022Social Science Research Network1 citations Open access
Semantic Scholar
Author response for "SAP domain forms a flexible part of DNA aperture in Ku70/80"
A. Hnízda, P. Tesina, Thanh-Binh Nguyen, Zdeněk Kukačka +6 more
20211 citations
Semantic Scholar
A new platform for single molecule measurements using the fluorous effect
Marina Santana Vega, Carlos J Bueno-Alejo, Andrea Taladriz Sender, A. K. Chaplin +10 more
2023BiOS0 citations Open access
Semantic Scholar
The orchestration of NHEJ factors at DNA double-strand breaks by the Ku70/Ku80 heterodimer
M. El Dahan, A. K. Stavridi, P. Frit, Pierre Legrand +7 more
2022Acta Crystallographica Section A: Foundations and Advances0 citations Open access
Semantic Scholar
Cryo-EM structure of NHEJ super-complex (monomer)
A. K. Chaplin, S. W. Hardwick, A. K. Stavridi, D. Chirgadze +1 more
20210 citations
Semantic Scholar
T275P after heme uptake from M. tuberculosis
T. Blundell, A. K. Chaplin, A. Munir
20210 citations
Semantic Scholar
Cryo-EM structure of T275P KatG from M. tuberculosis
T. Blundell, A. K. Chaplin, A. Munir
20210 citations
Semantic Scholar
Cryo-EM structure of W107R after heme uptake (1heme molecule) KatG from M. tuberculosis
T. Blundell, A. K. Chaplin, A. Munir
20210 citations
Semantic Scholar
Cryo-EM structure of NHEJ super-complex (dimer)
A. K. Chaplin, S. W. Hardwick, A. K. Stavridi, D. Chirgadze +1 more
20210 citations
Semantic Scholar
Cryo-EM structure of W107R after heme uptake (2heme molecules) KatG from M. tuberculosis
T. Blundell, A. K. Chaplin, A. Munir
20210 citations
Semantic Scholar
Cryo-EM structure of W107R KatG from M. tuberculosis
T. Blundell, A. K. Chaplin, A. Munir
20210 citations
Semantic Scholar
Cryo-EM structure of wild-type KatG from M. tuberculosis
T. Blundell, A. K. Chaplin, A. Munir
20210 citations
Semantic Scholar
Cryo-EM structure of DNA-PKcs (State 2)
A. K. Chaplin, S. Hardwick, D. Chirgadze, T. Blundell
20200 citations
Semantic Scholar
Dimers of DNA-PK create a stage for DNA double-strand break repair
A. K. Chaplin, S. Hardwick, Shikang Liang, Antonia Kefala Stavridi +5 more
2020Nature Structural & Molecular Biology0 citations Open access
Semantic Scholar
Cryo-EM structure of DNA-PKcs (State 3)
A. K. Chaplin, S. Hardwick, D. Chirgadze, T. Blundell
20200 citations
Semantic Scholar
Cryo-EM structure of DNA-PKcs:Ku80ct194
A. K. Chaplin, S. Hardwick, D. Chirgadze, T. Blundell
20200 citations
Semantic Scholar
Cryo-EM structure of DNA-PK dimer
A. K. Chaplin, S. Hardwick, D. Chirgadze, T. Blundell
20200 citations
Semantic Scholar

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