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Qi-Yin Chen · SciRah

Researcher profile · Semantic Scholar

Qi-Yin Chen

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Qi-Yin Chen — researcher profile on SciRah

h-index: 17
Works: 41
Citations: 733

Most-cited papers

Gatorbulin-1, a distinct cyclodepsipeptide chemotype, targets a seventh tubulin pharmacological site
S. Matthew, Qi-Yin Chen, Ranjala Ratnayake, C. Fermaintt +10 more
2021Proceedings of the National Academy of Sciences of the United States of America79 citations Open access
Semantic Scholar
Systematic Chemical Mutagenesis Identifies a Potent Novel Apratoxin A/E Hybrid with Improved in Vivo Antitumor Activity
Qi-Yin Chen, Yanxia Liu, H. Luesch
2011ACS Medicinal Chemistry Letters79 citations Open access
Semantic Scholar
Improved Total Synthesis and Biological Evaluation of Potent Apratoxin S4 Based Anticancer Agents with Differential Stability and Further Enhanced Activity
Qi-Yin Chen, Yanxia Liu, W. Cai, H. Luesch
2014Journal of Medicinal Chemistry64 citations Open access
Semantic Scholar
Modulation of Activity Profiles for Largazole-Based HDAC Inhibitors through Alteration of Prodrug Properties.
Lilibeth A. Salvador, Heekwang Park, Fatma H. Al-Awadhi, Yanxia Liu +5 more
2014ACS Medicinal Chemistry Letters36 citations Open access
Semantic Scholar
Discovery of New A- and B-Type Laxaphycins with Synergistic Anticancer Activity
W. Cai, S. Matthew, Qi-Yin Chen, V. Paul +1 more
2018Bioorganic & Medicinal Chemistry35 citations Open access
Semantic Scholar
Development of Apratoxin S10 (Apra S10) as an Anti-pancreatic Cancer Agent and Its Preliminary Evaluation in an Orthotopic Patient-derived Xenograft (PDX) Model
W. Cai, Ranjala Ratnayake, M. Gerber, Qi-Yin Chen +4 more
2018Investigational new drugs32 citations Open access
Semantic Scholar
Process Development and Scale-up Total Synthesis of Largazole, a Potent Class I Histone Deacetylase Inhibitor
Qi-Yin Chen, P. Chaturvedi, H. Luesch
2018Organic Process Research & Development32 citations Open access
Semantic Scholar
Apratoxin S10, a Dual Inhibitor of Angiogenesis and Cancer Cell Growth To Treat Highly Vascularized Tumors.
W. Cai, Qi-Yin Chen, L. Dang, H. Luesch
2017ACS Medicinal Chemistry Letters32 citations Open access
Semantic Scholar
Evaluation of class I HDAC isoform selectivity of largazole analogues
Bumki Kim, Heekwang Park, Lilibeth A. Salvador, P. E. Serrano +8 more
2014Bioorganic & Medicinal Chemistry Letters32 citations Open access
Semantic Scholar
Total Synthesis of the Potent Marine-Derived Elastase Inhibitor Lyngbyastatin 7 and In Vitro Biological Evaluation in Model Systems for Pulmonary Diseases
D. Luo, Qi-Yin Chen, H. Luesch
2015Journal of Organic Chemistry30 citations Open access
Semantic Scholar
Biosynthesis of Dolastatin 10 in Marine Cyanobacteria, a Prototype for Multiple Approved Cancer Drugs
Dimitris Kallifidas, D. Dhakal, Man-Yun Chen, Qi-Yin Chen +7 more
2024Organic Letters26 citations Open access
Semantic Scholar
Largazole is a Brain-Penetrant Class I HDAC Inhibitor with Extended Applicability to Glioblastoma and CNS Diseases
Fatma H. Al-Awadhi, Lilibeth A. Salvador-Reyes, Lobna A Elsadek, Ranjala Ratnayake +2 more
2020ACS Chemical Neuroscience26 citations Open access
Semantic Scholar
Total synthesis and biological evaluation of apratoxin E and its C30 epimer: configurational reassignment of the natural product
Ping Wu, W. Cai, Qi-Yin Chen, Senhan Xu +4 more
2016Organic Letters25 citations Open access
Semantic Scholar
Seaweed Natural Products Modify the Host Inflammatory Response via Nrf2 Signaling and Alter Colon Microbiota Composition and Gene Expression
Michelle S Bousquet, Ranjala Ratnayake, Jillian L. Pope, Qi-Yin Chen +7 more
2019Free Radical Biology & Medicine21 citations Open access
Semantic Scholar
Sec61 Inhibitor Apratoxin S4 Potently Inhibits SARS-CoV-2 and Exhibits Broad-Spectrum Antiviral Activity
Marie O. Pohl, Laura Martin-Sancho, Ranjala Ratnayake, K. White +21 more
2022ACS Infectious Diseases20 citations Open access
Semantic Scholar
Discovery and total synthesis of doscadenamide A: a quorum sensing signaling molecule from a marine cyanobacterium
Xiao Liang, S. Matthew, Qi-Yin Chen, J. Kwan +2 more
2019Organic Letters19 citations Open access
Semantic Scholar
Apratyramide, a Marine-Derived Peptidic Stimulator of VEGF-A and Other Growth Factors with Potential Application in Wound Healing
W. Cai, Lilibeth A. Salvador-Reyes, Wei Zhang, Qi-Yin Chen +7 more
2017ACS Chemical Biology18 citations Open access
Semantic Scholar
Apratoxin S4 Inspired by a Marine Natural Product, a New Treatment Option for Ocular Angiogenic Diseases.
Bei-Ying Qiu, Alison Tan, A. B. Veluchamy, Yong Li +12 more
2019Investigative Ophthalmology and Visual Science15 citations Open access
Semantic Scholar
Largazole Pharmacokinetics in Rats by LC-MS/MS
Mingming Yu, Lilibeth A. Salvador, S. Sy, Yu-Fei Tang +6 more
2014Marine Drugs14 citations Open access
Semantic Scholar
Discovery, Total Synthesis and SAR of Anaenamides A and B: Anticancer Cyanobacterial Depsipeptides with a Chlorinated Pharmacophore
D. Brumley, S. Gunasekera, Qi-Yin Chen, V. Paul +1 more
2020Organic Letters13 citations Open access
Semantic Scholar
Epigenetic small-molecule screen for inhibition and reversal of acinar ductal metaplasia in mouse pancreatic organoids
K. Atanasova, Corey M. Perkins, Ranjala Ratnayake, Jin-Mai Jiang +3 more
2024Frontiers in Pharmacology12 citations Open access
Semantic Scholar
Largazole Inhibits Ocular Angiogenesis by Modulating the Expression of VEGFR2 and p21
Bei-Ying Qiu, Alison Tan, Yu Tan, Qi-Yin Chen +2 more
2021Marine Drugs12 citations Open access
Semantic Scholar
Ahp-Cyclodepsipeptides as tunable inhibitors of human neutrophil elastase and kallikrein 7: total synthesis of tutuilamide A, serine protease selectivity profile and comparison with lyngbyastatin7
Qi-Yin Chen, D. Luo, G. Seabra, H. Luesch
2020Bioorganic & Medicinal Chemistry10 citations Open access
Semantic Scholar
Heterologous production of the C33–C45 polyketide fragment of anticancer apratoxins in a cyanobacterial host
D. Dhakal, D. Kallifidas, Man-Yun Chen, Sofia Kokkaliari +4 more
2023Organic Letters9 citations
Semantic Scholar
Inhibition of cotranslational translocation by apratoxin S4: Effects on oncogenic receptor tyrosine kinases and the fate of transmembrane proteins produced in the cytoplasm
W. Cai, Ranjala Ratnayake, Mengxiong Wang, Qi-Yin Chen +4 more
2021Current Research in Pharmacology and Drug Discovery8 citations Open access
Semantic Scholar
Triazolothiadiazine derivative positively modulates CXCR4 signaling and improves diabetic wound healing
Satyamaheshwar Peddibhotla, Karly A. Caples, A. Mehta, Qi-Yin Chen +7 more
2023Biochemical Pharmacology7 citations Open access
Semantic Scholar
Discovery, Synthesis and Biological Evaluation of Anaenamides C and D from a New Marine Cyanobacterium, Hormoscilla sp.
D. Brumley, S. Gunasekera, T. Sauvage, Larissa A. H. dos Santos +3 more
2022Journal of Natural Products7 citations Open access
Semantic Scholar
Bifunctional Doscadenamides Activate Quorum Sensing in Gram-Negative Bacteria and Synergize with TRAIL to Induce Apoptosis in Cancer Cells
Xiao Liang, Qi-Yin Chen, G. Seabra, S. Matthew +4 more
2021Journal of Natural Products7 citations Open access
Semantic Scholar
VCP/p97 mediates nuclear targeting of non-ER-imported prion protein to maintain proteostasis
Papiya Banik, Koustav Ray, Janine Kamps, Qi-Yin Chen +3 more
2024Life Science Alliance5 citations Open access
Semantic Scholar
Chemical genetics in C. elegans identifies anticancer mycotoxins chaetocin and chetomin as potent inducers of a nuclear metal homeostasis response
Elijah Abraham, A. Athapaththu, K. Atanasova, Qi-Yin Chen +6 more
2024bioRxiv5 citations Open access
Semantic Scholar
Probing a Distinct Druggable Tubulin Binding Site with Gatorbulins 1–7, Their Metabolic and Physicochemical Properties, and Pharmacological Consequences
Qi-Yin Chen, Ranjala Ratnayake, R. Hortigüela, G. Seabra +4 more
2023Bioorganic & Medicinal Chemistry3 citations Open access
Semantic Scholar
Largazole targets Musashi protein expression via miR-125b-5p and sensitizes triple-negative breast cancer cells to radiation
Kathrin A. Gurke Brücksken, Lea Lappe, Qi-Yin Chen, Hendrik Luesch +12 more
2026Frontiers in Pharmacology1 citations Open access
Semantic Scholar
Biosynthesis, Chemical Synthesis, and Pharmacological Evaluation of Lyngbyapeptin A as a GPCR Antagonist of Motilin, Cannabinoid, and Amylin Receptors
Tam H. D. Pham, Man-Yun Chen, Jie Liu, Qi-Yin Chen +6 more
2025Journal of Natural Products1 citations
Semantic Scholar
Correction to "Apratoxin S10, a Dual Inhibitor of Angiogenesis and Cancer Cell Growth To Treat Highly Vascularized Tumors".
W. Cai, Qi-Yin Chen, L. Dang, H. Luesch
2017ACS Medicinal Chemistry Letters1 citations Open access
Semantic Scholar
Correction: Progress in the discovery and development of anticancer agents from marine cyanobacteria
Hendrik Luesch, Emma K. Ellis, Qi-Yin Chen, Ranjala Ratnayake
2026Natural product reports (Print)0 citations Open access
Semantic Scholar
Proteolytic processing of the Marburg virus glycoprotein depends on Sec61β and is required for cell entry
Katharina E. Decker, Anke-Dorothee Werner, M. Hoffmann, Heike Hofmann-Winkler +12 more
2025bioRxiv0 citations Open access
Semantic Scholar
Abstract B104: Epigenetic small molecule library screen to discover compounds that inhibit and reverse pancreatic acinar to ductal metaplasia
Corey M. Perkins, K. Atanasova, Ranjala Ratnayake, Jin-Mai Jiang +3 more
2024Cancer Research0 citations
Semantic Scholar
Nuclear quality control of non-imported secretory proteins attenuates proteostasis decline in the cytosol
Papiya Banik, J. Kamps, Qi-Yin Chen, H. Luesch +2 more
2023bioRxiv0 citations Open access
Semantic Scholar
Epigenetic Small-Molecule Screen for Inhibition and Reversal of Acinar Ductal Metaplasia in Mouse Pancreatic Organoids
K. Atanasova, Corey M. Perkins, Ranjala Ratnayake, Jin-Mai Jiang +3 more
2023bioRxiv0 citations Open access
Semantic Scholar
New tubulin binding site targeted by novel cyclodepsipeptide chemotype, gatorbulin-1 1
S. Matthew, Qi-Yin Chen, Ranjala Ratnayake, C. Fermaintt +11 more
20200 citations
Semantic Scholar
Retina Apratoxin S 4 Inspired by a Marine Natural Product , a New Treatment Option for Ocular Angiogenic Diseases
Bei-Ying Qiu, Alison Tan, A. B. Veluchamy, Yong Li +13 more
20190 citations
Semantic Scholar

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H. Luesch×33
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