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S. Sy · SciRah

Researcher profile · Semantic Scholar

S. Sy

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S. Sy — researcher profile on SciRah

h-index: 22
Works: 93
Citations: 1,440

Most-cited papers

Mycobacterium tuberculosis Strains H37ra and H37rv have equivalent minimum inhibitory concentrations to most antituberculosis drugs
M. T. Heinrichs, R. J. May, Fabian Heider, Tobias Reimers +3 more
2018International Journal of Mycobacteriology73 citations Open access
Semantic Scholar
Use of a sparse sampling study design to assess transfer of tramadol and its O-desmethyl metabolite into transitional breast milk.
K. Ilett, M. Paech, M. Page-Sharp, S. Sy +5 more
2008British Journal of Clinical Pharmacology63 citations Open access
Semantic Scholar
Pharmacokinetics and pharmacodynamics in antibiotic dose optimization
S. Sy, L. Zhuang, H. Derendorf
2016Expert Opinion on Drug Metabolism & Toxicology58 citations
Semantic Scholar
Clinical Pharmacokinetics and Pharmacodynamics of Ceftazidime–Avibactam Combination: A Model-Informed Strategy for its Clinical Development
S. Sy, L. Zhuang, Serubbabel Sy, H. Derendorf
2018Clinical Pharmacokinetics56 citations
Semantic Scholar
Pharmacodynamic Evaluation of the Potential Clinical Utility of Fosfomycin and Meropenem in Combination Therapy against KPC-2-Producing Klebsiella pneumoniae
J. Albiero, S. Sy, J. Mazucheli, S. Caparroz-Assef +4 more
2016Antimicrobial Agents and Chemotherapy44 citations Open access
Semantic Scholar
Pharmacodynamic Attainment of the Synergism of Meropenem and Fosfomycin Combination against Pseudomonas aeruginosa Producing Metallo-β-Lactamase
J. Albiero, J. Mazucheli, Juliana Pimenta Dos Reis Barros, M. M. dos Anjos Szczerepa +6 more
2019Antimicrobial Agents and Chemotherapy43 citations Open access
Semantic Scholar
Population pharmacokinetic modeling of tramadol and its O-desmethyl metabolite in plasma and breast milk
S. Salman, S. Sy, K. Ilett, M. Page-Sharp +1 more
2011European Journal of Clinical Pharmacology40 citations
Semantic Scholar
In vitro pharmacokinetics/pharmacodynamics of the combination of avibactam and aztreonam against MDR organisms.
S. Sy, Marie-Eve Beaudoin, L. Zhuang, Kathrin I. Löblein +9 more
2016Journal of Antimicrobial Chemotherapy39 citations
Semantic Scholar
Pharmacokinetics of para-Aminosalicylic Acid in HIV-Uninfected and HIV-Coinfected Tuberculosis Patients Receiving Antiretroviral Therapy, Managed for Multidrug-Resistant and Extensively Drug-Resistant Tuberculosis
Lizanne de Kock, S. Sy, B. Rosenkranz, A. Diacon +5 more
2014Antimicrobial Agents and Chemotherapy37 citations Open access
Semantic Scholar
Modeling of human hepatic CYP3A4 enzyme kinetics, protein, and mRNA indicates deviation from log-normal distribution in CYP3A4 gene expression
S. Sy, A. Ciaccia, Wei Li, E. Roberts +3 more
2002European Journal of Clinical Pharmacology37 citations
Semantic Scholar
N-Acetyltransferase Genotypes and the Pharmacokinetics and Tolerability of para-Aminosalicylic Acid in Patients with Drug-Resistant Pulmonary Tuberculosis
S. Sy, Lizanne de Kock, A. Diacon, C. Werely +4 more
2015Antimicrobial Agents and Chemotherapy34 citations Open access
Semantic Scholar
Exposure–Efficacy Analysis of Asciminib in Philadelphia Chromosome–Positive Chronic Myeloid Leukemia in Chronic Phase
F. Combes, Ying-Fei Li, Matthias Hoch, S. Lorenzo +2 more
2022Clinical pharmacology and therapy32 citations
Semantic Scholar
Clinical Pharmacology of Asciminib: A Review
Matthias Hoch, Felix Huth, P. Manley, Ioannis Loisios-Konstantinidis +7 more
2024Clinical Pharmacokinetics30 citations Open access
Semantic Scholar
Physiologically based pharmacokinetic‐pharmacodynamic evaluation of meropenem plus fosfomycin in paediatrics
F. Martins, P. Zhu, M. T. Heinrichs, S. Sy
2020British Journal of Clinical Pharmacology29 citations
Semantic Scholar
Pharmacodynamic Effects of Sulbactam/Meropenem/Polymyxin-B Combination Against Extremely Drug Resistant Acinetobacter baumannii Using Checkerboard Information
T. C. Menegucci, N. H. Fedrigo, F. G. Lodi, J. Albiero +7 more
2019Microbial Drug Resistance29 citations
Semantic Scholar
A mathematical model-based analysis of the time–kill kinetics of ceftazidime/avibactam against Pseudomonas aeruginosa
S. Sy, L. Zhuang, Hui-Ming Xia, Marie-Eve Beaudoin +3 more
2018Journal of Antimicrobial Chemotherapy28 citations
Semantic Scholar
Population Pharmacokinetic and Covariate Analysis of Apatinib, an Oral Tyrosine Kinase Inhibitor, in Healthy Volunteers and Patients with Solid Tumors
Ming-Ming Yu, Zhi-Wei Gao, Xiao-Jian Dai, Hui Gong +4 more
2016Clinical Pharmacokinetics28 citations
Semantic Scholar
Dose optimization of moxifloxacin and linezolid against tuberculosis using mathematical modeling and simulation.
M. T. Heinrichs, G. Drusano, David W. Brown, Michael Maynard +5 more
2019International Journal of Antimicrobial Agents26 citations
Semantic Scholar
Pharmacodynamic Evaluation of Fosfomycin against Escherichia coli and Klebsiella spp. from Urinary Tract Infections and the Influence of pH on Fosfomycin Activities
N. H. Fedrigo, J. Mazucheli, J. Albiero, D. Shinohara +4 more
2017Antimicrobial Agents and Chemotherapy25 citations Open access
Semantic Scholar
Gentamicin dosing strategy in patients with end-stage renal disease receiving haemodialysis: evaluation using a semi-mechanistic pharmacokinetic/pharmacodynamic model.
L. Zhuang, Yang He, Hui-Ming Xia, Yajun Liu +2 more
2016Journal of Antimicrobial Chemotherapy25 citations
Semantic Scholar
Aztreonam/avibactam effect on pharmacodynamic indices for mutant selection of Escherichia coli and Klebsiella pneumoniae harbouring serine- and New Delhi metallo-β-lactamases.
Kun Feng, Nan Jia, P. Zhu, Serubbabel Sy +11 more
2021Journal of Antimicrobial Chemotherapy24 citations
Semantic Scholar
Potentiation of ceftazidime by avibactam against &bgr;-lactam-resistant Pseudomonas aeruginosa in an in vitro infection model
S. Sy, L. Zhuang, Marie-Eve Beaudoin, P. Kircher +7 more
2017Journal of Antimicrobial Chemotherapy24 citations
Semantic Scholar
Pharmacometrics in Bacterial Infections
S. Sy, H. Derendorf
201421 citations
Semantic Scholar
Effects of amikacin, polymyxin-B, and sulbactam combination on the pharmacodynamic indices of mutant selection against multi-drug resistant Acinetobacter baumannii
Shi-Ya Zhu, Chu Song, Jia-Yuan Zhang, Shuo Diao +6 more
2022Frontiers in Microbiology20 citations Open access
Semantic Scholar
Change in Topoisomerase 1–Positive Circulating Tumor Cells Affects Overall Survival in Patients with Advanced Breast Cancer after Treatment with Etirinotecan Pegol
H. Rugo, J. Cortés, A. Awada, J. O'Shaughnessy +11 more
2018Clinical Cancer Research20 citations
Semantic Scholar
Evaluation of in vitro synergy between vertilmicin and ceftazidime against Pseudomonas aeruginosa using a semi-mechanistic pharmacokinetic/pharmacodynamic model.
L. Zhuang, S. Sy, Hui-Ming Xia, R. Singh +3 more
2015International Journal of Antimicrobial Agents20 citations
Semantic Scholar
Physiologically‐based pharmacokinetics of ziprasidone in pregnant women
C. Biesdorf, F. Martins, S. Sy, A. Diniz
2019British Journal of Clinical Pharmacology19 citations Open access
Semantic Scholar
Predicting Pediatric Age-Matched Weight and Body Mass Index
S. Sy, E. Asín-Prieto, H. Derendorf, E. Samara
2014AAPS Journal19 citations Open access
Semantic Scholar
Population Pharmacokinetics of Asciminib in Tyrosine Kinase Inhibitor-Treated Patients with Philadelphia Chromosome-Positive Chronic Myeloid Leukemia in Chronic and Acute Phases
Ying-Fei Li, F. Combes, Matthias Hoch, S. Lorenzo +2 more
2022Clinical Pharmacokinetics18 citations
Semantic Scholar
A model-based analysis of pharmacokinetic-pharmacodynamic (PK/PD) indices of avibactam against Pseudomonas aeruginosa.
S. Sy, L. Zhuang, Hui-Ming Xia, Virna J. Schuck +2 more
2019Clinical Microbiology and Infection18 citations Open access
Semantic Scholar
Experimental design and modelling approach to evaluate efficacy of β-lactam/β-lactamase inhibitor combinations.
S. Sy, H. Derendorf
2017Clinical Microbiology and Infection18 citations Open access
Semantic Scholar
Pharmacodynamic evaluation of suppression of in vitro resistance in Acinetobacter baumannii strains using polymyxin B-based combination therapy
N. H. Fedrigo, D. Shinohara, J. Mazucheli, S. A. B. Nishiyama +6 more
2021Scientific Reports17 citations Open access
Semantic Scholar
Principles of Applied Pharmacokinetic–Pharmacodynamic Modeling
Benjamin Wu, S. Sy, H. Derendorf
201417 citations
Semantic Scholar
Introduction to Pharmacometrics and Quantitative Pharmacology with an Emphasis on Physiologically Based Pharmacokinetics
S. Sy, Xiao-Feng Wang, H. Derendorf
201416 citations
Semantic Scholar
Fixed-dose combinations: a potential means to boost drug development for selected drugs.
C. Oo, S. Sy
2017Drug Discovery Today15 citations
Semantic Scholar
Dermal pharmacokinetics of pyrazinamide determined by microdialysis sampling in rats.
N. M. F. Voelkner, Alexander Voelkner, J. Costa, S. Sy +4 more
2017International Journal of Antimicrobial Agents15 citations
Semantic Scholar
Characterization of intestinal absorption of C-glycoside flavonoid vicenin-2 from Lychnophora ericoides leafs in rats by nonlinear mixed effects modeling
G. Buqui, S. Sy, M. Merino-Sanjuán, D. R. Gouvea +5 more
201515 citations Open access
Semantic Scholar
Dose Justification for Asciminib in Patients with Philadelphia Chromosome-Positive Chronic Myeloid Leukemia with and Without the T315I Mutation
F. Combes, S. Sy, Ying-Fei Li, S. Lorenzo +4 more
2024Clinical Pharmacokinetics14 citations Open access
Semantic Scholar
Prediction of Tissue Exposures of Meropenem, Colistin, and Sulbactam in Pediatrics Using Physiologically Based Pharmacokinetic Modeling
Shi-Ya Zhu, Jia-Yuan Zhang, Zhi-Hua Lv, P. Zhu +3 more
2022Clinical Pharmacokinetics14 citations
Semantic Scholar
Largazole Pharmacokinetics in Rats by LC-MS/MS
Mingming Yu, Lilibeth A. Salvador, S. Sy, Yu-Fei Tang +6 more
2014Marine Drugs14 citations Open access
Semantic Scholar
Simultaneous quantification of seven active metabolites of roxifiban in human plasma by LC/MS/MS in the presence of an interfering displacer at millimolar concentrations.
Guo-En Shi, T. L. Lloyd, S. Sy, Q. Jiao +5 more
2003Journal of Pharmaceutical and Biomedical Analysis14 citations
Semantic Scholar
Safety, Tolerability, Pharmacokinetics, and Time Course of Pharmacologic Response of the Active Metabolite of Roxifiban, XV459, a Glycoprotein IIb/IIIa Antagonist, following Oral Administration in Healthy Volunteers
H. Pieniaszek, S. Sy, W. Ebling, M. Fossler +4 more
2002Journal of clinical pharmacology14 citations
Semantic Scholar
Physiologically-based pharmacokinetic modeling to inform combination dosing regimens of ceftaroline and daptomycin in special populations.
F. Martins, J. Martins, P. Severino, P. Annaert +1 more
2023British Journal of Clinical Pharmacology13 citations Open access
Semantic Scholar
Effect of reducing the paediatric stavudine dose by half: a physiologically-based pharmacokinetic model
S. Sy, R. Malmberg, A. Matsushima, E. Asín-Prieto +4 more
2015International Journal of Antimicrobial Agents13 citations Open access
Semantic Scholar
A Markov Chain Model to Evaluate the Effect of CYP3A5 and ABCB1 Polymorphisms on Adverse Events Associated with Tacrolimus in Pediatric Renal Transplantation
S. Sy, Jules Heuberger, S. Shilbayeh, D. Conrado +1 more
2013AAPS Journal13 citations Open access
Semantic Scholar
Pharmacokinetic/Pharmacodynamic Evaluation of Aztreonam/Amoxicillin/Clavulanate Combination against New Delhi Metallo-β-Lactamase and Serine-β-Lactamase Co-Producing Escherichia coli and Klebsiella pneumoniae
Jia-Yuan Zhang, Mengyuan Wu, Shuo Diao, Shi-Ya Zhu +8 more
2023Pharmaceutics12 citations Open access
Semantic Scholar
Learning and augmenting natural processes: potential means of combating antimicrobial resistance from a drug R&D perspective.
C. Oo, S. Sy
2019Drug Discovery Today12 citations
Semantic Scholar
The Use of Roxifiban (DMP754), a Novel Oral Platelet Glycoprotein IIb/IIIa Receptor Inhibitor, in Patients with Stable Coronary Artery Disease
Joseph G. Murphy, R. Wright, I. Gussak, B. Williams +8 more
2003American Journal of Cardiovascular Drugs12 citations
Semantic Scholar
Detailed characterization of experimentally derived human hepatic CYP1A1 activity and expression using differential inhibition of ethoxyresorufin O-deethylation by fluvoxamine
S. Sy, B. Tang, Aleksandra Pastrakuljic, E. Roberts +1 more
2001European Journal of Clinical Pharmacology12 citations
Semantic Scholar
Metabolomics revealed mechanism for the synergistic effect of sulbactam, polymyxin-B and amikacin combination against Acinetobacter baumannii
Shi-Ya Zhu, Jia-Li Yue, Xin-Tong Wang, Jia-Yuan Zhang +5 more
2023Frontiers in Microbiology11 citations Open access
Semantic Scholar

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