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Zhong-Li Cai · SciRah

Researcher profile · Semantic Scholar

Zhong-Li Cai

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Zhong-Li Cai — researcher profile on SciRah

h-index: 31
Works: 84
Citations: 3,547

Most-cited papers

DNA strand breaks induced by 0-4 eV electrons: the role of shape resonances.
F. Martin, P. Burrow, Zhong-Li Cai, P. Cloutier +2 more
2004Physical Review Letters415 citations
Semantic Scholar
Implications on clinical scenario of gold nanoparticle radiosensitization in regards to photon energy, nanoparticle size, concentration and location
E. Lechtman, N. Chattopadhyay, Zhong-Li Cai, S. Mashouf +2 more
2011Physics in Medicine and Biology271 citations Open access
Semantic Scholar
111In-Labeled Trastuzumab (Herceptin) Modified with Nuclear Localization Sequences (NLS): An Auger Electron-Emitting Radiotherapeutic Agent for HER2/neu-Amplified Breast Cancer
Danny L. Costantini, C. Chan, Zhong-Li Cai, K. Vallis +1 more
2007Journal of Nuclear Medicine188 citations Open access
Semantic Scholar
Reinvestigation of the acid–base equilibrium of the (bi)carbonate radical and pH dependence of its reactivity with inorganic reactants
Zhi-Hua Zuo, Zhong-Li Cai, Y. Katsumura, N. Chitose +1 more
1999180 citations
Semantic Scholar
DFT Calculations of the Electron Affinities of Nucleic Acid Bases: Dealing with Negative Electron Affinities
Xi-Feng Li, Zhong-Li Cai, M. Sevilla
2002173 citations
Semantic Scholar
Molecularly targeted gold nanoparticles enhance the radiation response of breast cancer cells and tumor xenografts to X-radiation
N. Chattopadhyay, Zhong-Li Cai, Y. Kwon, E. Lechtman +2 more
2012Breast Cancer Research and Treatment158 citations
Semantic Scholar
Investigation of Proton Transfer within DNA Base Pair Anion and Cation Radicals by Density Functional Theory (DFT)
Xi-Feng Li, Zhong-Li Cai, M. Sevilla
2001156 citations
Semantic Scholar
Design and characterization of HER-2-targeted gold nanoparticles for enhanced X-radiation treatment of locally advanced breast cancer.
N. Chattopadhyay, Zhong-Li Cai, J. Pignol, B. Keller +3 more
2010Molecular Pharmaceutics122 citations
Semantic Scholar
Optimized digital counting colonies of clonogenic assays using ImageJ software and customized macros: Comparison with manual counting
Zhong-Li Cai, N. Chattopadhyay, W. Liu, C. Chan +2 more
2011International Journal of Radiation Biology115 citations
Semantic Scholar
Role of antibody-mediated tumor targeting and route of administration in nanoparticle tumor accumulation in vivo.
N. Chattopadhyay, H. Fonge, Zhong-Li Cai, D. Scollard +4 more
2012Molecular Pharmaceutics108 citations
Semantic Scholar
Intratumorally Injected 177Lu-Labeled Gold Nanoparticles: Gold Nanoseed Brachytherapy with Application for Neoadjuvant Treatment of Locally Advanced Breast Cancer
Simmyung Yook, Zhong-Li Cai, Yi-Jie Lu, M. Winnik +2 more
2016Journal of Nuclear Medicine100 citations Open access
Semantic Scholar
Energetics of the Radical Ions of the AT and AU Base Pairs: A Density Functional Theory (DFT) Study
Xi-Feng Li, Zhong-Li Cai, M. Sevilla
200287 citations
Semantic Scholar
Radiation Nanomedicine for EGFR-Positive Breast Cancer: Panitumumab-Modified Gold Nanoparticles Complexed to the β-Particle-Emitter, (177)Lu.
Simmyung Yook, Zhong-Li Cai, Yi-Jie Lu, M. Winnik +2 more
2015Molecular Pharmaceutics77 citations
Semantic Scholar
Local Radiation Treatment of HER2-Positive Breast Cancer Using Trastuzumab-Modified Gold Nanoparticles Labeled with 177Lu
Zhong-Li Cai, Simmyung Yook, Yi-Jie Lu, D. Bergstrom +3 more
2016Pharmaceutical Research74 citations
Semantic Scholar
Micro-SPECT/CT with 111In-DTPA-Pertuzumab Sensitively Detects Trastuzumab-Mediated HER2 Downregulation and Tumor Response in Athymic Mice Bearing MDA-MB-361 Human Breast Cancer Xenografts
K. McLarty, B. Cornelissen, Zhong-Li Cai, D. Scollard +3 more
2009Journal of Nuclear Medicine72 citations Open access
Semantic Scholar
111In-labeled trastuzumab-modified gold nanoparticles are cytotoxic in vitro to HER2-positive breast cancer cells and arrest tumor growth in vivo in athymic mice after intratumoral injection.
Zhong-Li Cai, N. Chattopadhyay, Kaiyu Yang, Y. Kwon +3 more
2016Nuclear Medicine and Biology69 citations Open access
Semantic Scholar
Cellular Dosimetry of 111In Using Monte Carlo N-Particle Computer Code: Comparison with Analytic Methods and Correlation with In Vitro Cytotoxicity
Zhong-Li Cai, J. Pignol, C. Chan, R. Reilly
2010Journal of Nuclear Medicine67 citations Open access
Semantic Scholar
Computational analysis of the number, area and density of γ-H2AX foci in breast cancer cells exposed to 111In-DTPA-hEGF or γ-rays using Image-J software
Zhong-Li Cai, K. Vallis, R. Reilly
2009International Journal of Radiation Biology67 citations
Semantic Scholar
Relationship Between Induction of Phosphorylated H2AX and Survival in Breast Cancer Cells Exposed to 111In-DTPA-hEGF
Zhong-Li Cai, Zhuo Chen, Kristy E Bailey, D. Scollard +2 more
2008Journal of Nuclear Medicine65 citations Open access
Semantic Scholar
Comparison between X-ray photon and secondary electron damage to DNA in vacuum.
Zhong-Li Cai, P. Cloutier, D. Hunting, L. Sanche
2005Journal of Physical Chemistry B55 citations
Semantic Scholar
Electron Spin Resonance Study of the Temperature Dependence of Electron Transfer in DNA: Competitive Processes of Tunneling, Protonation at Carbon, and Hopping
Zhong-Li Cai, Zhen-Yu Gu, M. Sevilla
200046 citations
Semantic Scholar
Monte Carlo N-Particle (MCNP) Modeling of the Cellular Dosimetry of 64Cu: Comparison with MIRDcell S Values and Implications for Studies of Its Cytotoxic Effects
Zhong-Li Cai, Y. Kwon, R. Reilly
2017Journal of Nuclear Medicine45 citations Open access
Semantic Scholar
111In-Bn-DTPA-nimotuzumab with/without modification with nuclear translocation sequence (NLS) peptides: an Auger electron-emitting radioimmunotherapeutic agent for EGFR-positive and trastuzumab (Herceptin)-resistant breast cancer
Aisha Fasih, H. Fonge, Zhong-Li Cai, Jeffrey V. Leyton +3 more
2012Breast Cancer Research and Treatment45 citations
Semantic Scholar
Dual-Receptor–Targeted Radioimmunotherapy of Human Breast Cancer Xenografts in Athymic Mice Coexpressing HER2 and EGFR Using 177Lu- or 111In-Labeled Bispecific Radioimmunoconjugates
Eva J Razumienko, J. Chen, Zhong-Li Cai, C. Chan +1 more
2016Journal of Nuclear Medicine42 citations Open access
Semantic Scholar
Stability and Biodistribution of Thiol-Functionalized and (177)Lu-Labeled Metal Chelating Polymers Bound to Gold Nanoparticles.
Simmyung Yook, Yi-Jie Lu, J. J. Jeong, Zhong-Li Cai +5 more
2016Biomacromolecules41 citations
Semantic Scholar
Epidermal Growth Factor Receptor Inhibition Modulates the Nuclear Localization and Cytotoxicity of the Auger Electron–Emitting Radiopharmaceutical 111In-DTPA–Human Epidermal Growth Factor
Kristy E Bailey, Danny L. Costantini, Zhong-Li Cai, D. Scollard +3 more
2007Journal of Nuclear Medicine41 citations Open access
Semantic Scholar
Investigation of the effects of cell model and subcellular location of gold nanoparticles on nuclear dose enhancement factors using Monte Carlo simulation.
Zhong-Li Cai, J. Pignol, N. Chattopadhyay, Y. Kwon +2 more
2013Medical Physics (Lancaster)38 citations
Semantic Scholar
Excess Electron Transfer in DNA: Effect of Base Sequence and Proton Transfer
Zhong-Li Cai, Xi-Feng Li, M. Sevilla
200238 citations
Semantic Scholar
Interaction of hydrated electron with dietary flavonoids and phenolic acids: rate constants and transient spectra studied by pulse radiolysis.
Zhong-Li Cai, Xi-Feng Li, Y. Katsumura
1999Free Radical Biology & Medicine38 citations
Semantic Scholar
Synthesis of polyglutamide-based metal-chelating polymers and their site-specific conjugation to trastuzumab for auger electron radioimmunotherapy.
Yi-Jie Lu, Ghislaine Ngo Ndjock Mbong, Peng Liu, C. Chan +5 more
2014Biomacromolecules33 citations
Semantic Scholar
Dosimetry of ultrasoft x-rays (1.5 keV AlKα) using radiochromatic films and colour scanners
Zhong-Li Cai, Xiao-Ning Pan, D. Hunting, P. Cloutier +2 more
200331 citations
Semantic Scholar
Radiolysis of Bicarbonate and Carbonate Aqueous Solutions: Product Analysis and Simulation of Radiolytic Processes
Zhong-Li Cai, Xi-Feng Li, Y. Katsumura, O. Urabe
200131 citations
Semantic Scholar
The human polynucleotide kinase/phosphatase (hPNKP) inhibitor A12B4C3 radiosensitizes human myeloid leukemia cells to Auger electron-emitting anti-CD123 ¹¹¹In-NLS-7G3 radioimmunoconjugates.
Arman Zereshkian, Jeffrey V. Leyton, Zhong-Li Cai, D. Bergstrom +2 more
2014Nuclear Medicine and Biology29 citations
Semantic Scholar
Trastuzumab Labeled to High Specific Activity with 111In by Conjugation to G4 PAMAM Dendrimers Derivatized with Multiple DTPA Chelators Exhibits Increased Cytotoxic Potency on HER2-Positive Breast Cancer Cells
C. Chan, Zhong-Li Cai, R. Reilly
2013Pharmaceutical Research27 citations
Semantic Scholar
Electron Spin Resonance Study of Electron and Hole Transfer in DNA: Effects of Hydration, Aliphatic Amine Cations, and Histone Proteins
Zhong-Li Cai, Zhen-Yu Gu, M. Sevilla
200127 citations
Semantic Scholar
Electron and Hole Transfer from DNA Base Radicals to Oxidized Products of Guanine in DNA
Zhong-Li Cai, M. Sevilla
2003Radiation Research25 citations
Semantic Scholar
Treatment of Orthotopic U251 Human Glioblastoma Multiforme Tumors in NRG Mice by Convection-Enhanced Delivery of Gold Nanoparticles Labeled with the β-Particle-Emitting Radionuclide, 177Lu
Constantine J. Georgiou, Zhong-Li Cai, Noor Alsaden, Hyungjun Cho +4 more
2022Molecular Pharmaceutics24 citations Open access
Semantic Scholar
Trastuzumab Labeled to High Specific Activity with (111)In by Site-Specific Conjugation to a Metal-Chelating Polymer Exhibits Amplified Auger Electron-Mediated Cytotoxicity on HER2-Positive Breast Cancer Cells.
Ghislaine Ngo Ndjock Mbong, Yi-Jie Lu, C. Chan, Zhong-Li Cai +4 more
2015Molecular Pharmaceutics24 citations
Semantic Scholar
Radiation nanomedicines for cancer treatment: a scientific journey and view of the landscape
R. Reilly, Constantine J. Georgiou, Madeline K. Brown, Zhong-Li Cai
2024EJNMMI Radiopharmacy and Chemistry23 citations Open access
Semantic Scholar
Enhanced DNA Damage Induced by Secondary Electron Emission from a Tantalum Surface Exposed to Soft X Rays
Zhong-Li Cai, P. Cloutier, D. Hunting, L. Sanche
2006Radiation Research22 citations
Semantic Scholar
Intracellular routing in breast cancer cells of streptavidin-conjugated trastuzumab Fab fragments linked to biotinylated doxorubicin-functionalized metal chelating polymers.
Peng Liu, Zhong-Li Cai, Jaewook Kang, Amanda J. Boyle +6 more
2014Biomacromolecules20 citations
Semantic Scholar
Dual receptor-targeted (DRT) radiation nanomedicine labeled with 177Lu is more potent for killing human breast cancer cells that co-express HER2 and EGFR than single receptor-targeted (SRT) radiation nanomedicines.
Simmyung Yook, Zhong-Li Cai, J. J. Jeong, Yi-Jie Lu +3 more
2020Molecular Pharmaceutics19 citations
Semantic Scholar
111In- or 99mTc-labeled recombinant VEGF bioconjugates: in vitro evaluation of their cytotoxicity on porcine aortic endothelial cells overexpressing Flt-1 receptors.
C. Chan, Zhong-Li Cai, Rui-Fen Su, R. Reilly
2010Nuclear Medicine and Biology18 citations
Semantic Scholar
[225Ac]Ac- and [111In]In-DOTA-trastuzumab theranostic pair: cellular dosimetry and cytotoxicity in vitro and tumour and normal tissue uptake in vivo in NRG mice with HER2-positive human breast cancer xenografts
Misaki Kondo, Zhong-Li Cai, C. Chan, Nubaira Forkan +1 more
2023EJNMMI Radiopharmacy and Chemistry16 citations Open access
Semantic Scholar
Induction of strand breaks by low-energy electrons (8-68 eV) in a self-assembled monolayer of oligonucleotides: effective cross sections and attenuation lengths.
Zhong-Li Cai, Marie-Eve Dextraze, P. Cloutier, D. Hunting +1 more
2006Journal of Chemical Physics16 citations
Semantic Scholar
Reactions of reducing and oxidizing radicals with caffeic acid:: a pulse radiolysis and theoretical study
Xi-Feng Li, Zhong-Li Cai, Y. Katsumura, Guozhong Wu +1 more
200116 citations
Semantic Scholar
Radioimmunotherapy of PANC-1 Human Pancreatic Cancer Xenografts in NRG Mice with Panitumumab Modified with Metal-Chelating Polymers Complexed to 177Lu.
Sadaf Aghevlian, Zhong-Li Cai, Yi-Jie Lu, D. Hedley +2 more
2018Molecular Pharmaceutics15 citations
Semantic Scholar
Tumor uptake and tumor/blood ratios for [89Zr]Zr-DFO-trastuzumab-DM1 on microPET/CT images in NOD/SCID mice with human breast cancer xenografts are directly correlated with HER2 expression and response to trastuzumab-DM1.
Noor Al-saden, Zhong-Li Cai, R. Reilly
2018Nuclear Medicine and Biology14 citations
Semantic Scholar
Preclinical Comparison of [111In]In- and [225Ac]Ac-DOTA-Trastuzumab IgG, F(ab′)2 and Fab for Theranostic SPECT/CT Imaging and α-Particle Radioimmunotherapy of HER2-Positive Human Breast Cancer
Misaki Kondo, Zhong-Li Cai, C. Chan, Madeline K. Brown +1 more
2024Molecular Pharmaceutics13 citations Open access
Semantic Scholar
MicroSPECT/CT Imaging of Cell-Line and Patient-Derived EGFR-Positive Tumor Xenografts in Mice with Panitumumab Fab Modified with Hexahistidine Peptides to Enable Labeling with 99mTc (I) Tricarbonyl Complex.
Anthony Ku, C. Chan, Sadaf Aghevlian, Zhong-Li Cai +5 more
2019Molecular Pharmaceutics13 citations Open access
Semantic Scholar

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