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D. Hedley · SciRah

Researcher profile · Semantic Scholar

D. Hedley

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D. Hedley — researcher profile on SciRah

h-index: 65
Works: 321
Citations: 16K

Most-cited papers

Guidelines for the use of flow cytometry and cell sorting in immunological studies
A. Cossarizza, Hyun-Dong Chang, Andreas Radbruch, M. Akdiş +232 more
2017European Journal of Immunology1,153 citations Open access
Semantic Scholar
Genomics-Driven Precision Medicine for Advanced Pancreatic Cancer: Early Results from the COMPASS Trial
K. Aung, S. Fischer, R. Denroche, G. Jang +30 more
2017Clinical Cancer Research530 citations Open access
Semantic Scholar
Germline BRCA Mutations in a Large Clinic-Based Cohort of Patients With Pancreatic Adenocarcinoma.
S. Holter, A. Borgida, A. Dodd, R. Grant +7 more
2015Journal of Clinical Oncology369 citations Open access
Semantic Scholar
Imaging Mass Cytometry
Qing Chang, O. Ornatsky, I. Siddiqui, A. Loboda +2 more
2017Cytometry Part A283 citations Open access
Semantic Scholar
Association of Distinct Mutational Signatures With Correlates of Increased Immune Activity in Pancreatic Ductal Adenocarcinoma
Ashton A. Connor, R. Denroche, G. Jang, Lee E. Timms +36 more
2017JAMA Oncology247 citations Open access
Semantic Scholar
Integration of Genomic and Transcriptional Features in Pancreatic Cancer Reveals Increased Cell Cycle Progression in Metastases
Ashton A. Connor, R. Denroche, Gun-Ho Jang, M. Lemire +41 more
2019Cancer Cell203 citations Open access
Semantic Scholar
The clinical significance of hypoxia in human cancers.
N. Dhani, A. Fyles, D. Hedley, M. Milosevic
2015Seminars in nuclear medicine190 citations
Semantic Scholar
Targeting of metastasis-promoting tumor-associated fibroblasts and modulation of pancreatic tumor-associated stroma with a carboxymethylcellulose-docetaxel nanoparticle
M. Ernsting, Bryan Hoang, I. Lohse, E. Undzys +6 more
2015Journal of Controlled Release123 citations Open access
Semantic Scholar
Biodistribution of cisplatin revealed by imaging mass cytometry identifies extensive collagen binding in tumor and normal tissues
Qing Chang, O. Ornatsky, I. Siddiqui, R. Straus +2 more
2016Scientific Reports101 citations Open access
Semantic Scholar
BRCA1 and BRCA2 mutations sensitize to chemotherapy in patient-derived pancreatic cancer xenografts
I. Lohse, Alexander Borgida, P. Cao, M. Cheung +9 more
2015British Journal of Cancer74 citations Open access
Semantic Scholar
A phase I study of elesclomol sodium in patients with acute myeloid leukemia
D. Hedley, A. Shamas-Din, S. Chow, Deborah Sanfelice +6 more
2016Leukemia and Lymphoma57 citations
Semantic Scholar
Whole genomes define concordance of matched primary, xenograft, and organoid models of pancreas cancer
Deena M. A. Gendoo, R. Denroche, Amy Zhang, N. Radulovich +15 more
2017bioRxiv56 citations Open access
Semantic Scholar
Measurement of Tumor Hypoxia in Patients with Advanced Pancreatic Cancer Based on 18F-Fluoroazomyin Arabinoside Uptake
C. Metran-Nascente, I. Yeung, D. Vines, U. Metser +5 more
2016Journal of Nuclear Medicine49 citations Open access
Semantic Scholar
Panitumumab Modified with Metal-Chelating Polymers (MCP) Complexed to 111In and 177Lu-An EGFR-Targeted Theranostic for Pancreatic Cancer.
Sadaf Aghevlian, Yi-Jie Lu, M. Winnik, D. Hedley +1 more
2018Molecular Pharmaceutics48 citations
Semantic Scholar
Activity of the novel polo-like kinase 4 inhibitor CFI-400945 in pancreatic cancer patient-derived xenografts
I. Lohse, J. Mason, P. Cao, M. Pintilie +2 more
2016OncoTarget48 citations Open access
Semantic Scholar
FOLFIRINOX for advanced pancreatic cancer: the Princess Margaret Cancer Centre experience
M. Chllamma, N. Cook, N. Dhani, Kazim Giby +5 more
2016British Journal of Cancer46 citations Open access
Semantic Scholar
Targeting hypoxic microenvironment of pancreatic xenografts with the hypoxia-activated prodrug TH-302
I. Lohse, Joanna Rasowski, P. Cao, M. Pintilie +4 more
2016OncoTarget45 citations Open access
Semantic Scholar
Novel regulatory role of neuropilin-1 in endothelial-to-mesenchymal transition and fibrosis in pancreatic ductal adenocarcinoma
Pratiek N. Matkar, Krishna K. Singh, D. Rudenko, Y. J. Kim +4 more
2016OncoTarget43 citations Open access
Semantic Scholar
Outcome of Adjuvant Therapy in Biliary Tract Cancers
M. McNamara, T. Walter, A. Horgan, E. Amir +12 more
2015American Journal of Clinical Oncology41 citations
Semantic Scholar
MicroPET/CT imaging of patient-derived pancreatic cancer xenografts implanted subcutaneously or orthotopically in NOD-scid mice using (64)Cu-NOTA-panitumumab F(ab')2 fragments.
Amanda J. Boyle, P. Cao, D. Hedley, S. Sidhu +2 more
2015Nuclear Medicine and Biology39 citations
Semantic Scholar
Single‐cell measurement of the uptake, intratumoral distribution and cell cycle effects of cisplatin using mass cytometry
Q. Chang, O. Ornatsky, Cameron J. Koch, N. Chaudary +4 more
2015International Journal of Cancer38 citations Open access
Semantic Scholar
Developing a Prognostic Micro-RNA Signature for Human Cervical Carcinoma
Christine How, M. Pintilie, J. Bruce, A. Hui +11 more
2015PLoS ONE33 citations Open access
Semantic Scholar
Patient-derived tumor xenograft and organoid models established from resected pancreatic, duodenal and biliary cancers
N. Pham, N. Radulovich, E. Ibrahimov, S. Martins-Filho +19 more
2021Scientific Reports31 citations Open access
Semantic Scholar
NOX4 links metabolic regulation in pancreatic cancer to endoplasmic reticulum redox vulnerability and dependence on PRDX4
P. Jain, A. Dvorkin-Gheva, Erik Mollen, Lucie Malbeteau +13 more
2020Science Advances30 citations Open access
Semantic Scholar
Staining of Frozen and Formalin‐Fixed, Paraffin‐Embedded Tissues with Metal‐Labeled Antibodies for Imaging Mass Cytometry Analysis
Qing Chang, O. Ornatsky, D. Hedley
2017Current Protocols in Cytometry30 citations
Semantic Scholar
Hedgehog inhibition enhances efficacy of radiation and cisplatin in orthotopic cervical cancer xenografts
N. Chaudary, M. Pintilie, D. Hedley, R. Hill +2 more
2016British Journal of Cancer30 citations Open access
Semantic Scholar
A phase I trial of the aurora kinase inhibitor, ENMD-2076, in patients with relapsed or refractory acute myeloid leukemia or chronic myelomonocytic leukemia
K. Yee, H. T. Chen, D. Hedley, S. Chow +11 more
2016Investigational new drugs30 citations
Semantic Scholar
Isotopologous Organotellurium Probes Reveal Dynamic Hypoxia In Vivo with Cellular Resolution.
L. Edgar, Ravi N. Vellanki, T. McKee, D. Hedley +2 more
2016Angewandte Chemie29 citations
Semantic Scholar
Chromosomal instability as a prognostic marker in cervical cancer
Christine How, J. Bruce, J. So, M. Pintilie +8 more
2015BMC Cancer27 citations Open access
Semantic Scholar
A phase II trial of GSK2256098 and trametinib in patients with advanced pancreatic ductal adenocarcinoma
K. Aung, E. Mcwhirter, S. Welch, Lisa Wang +17 more
2022Journal of Gastrointestinal Oncology26 citations Open access
Semantic Scholar
The ongoing challenge of large anal cancers: prospective long term outcomes of intensity-modulated radiation therapy with concurrent chemotherapy
A. Hosni, K. Han, L. Le, J. Ringash +14 more
2018OncoTarget26 citations Open access
Semantic Scholar
Molecular Profiling of Patients With Advanced Colorectal Cancer: Princess Margaret Cancer Centre Experience
J. Chiu, M. Krzyzanowska, S. Serra, J. Knox +16 more
2017Clinical colorectal cancer25 citations Open access
Semantic Scholar
Effects of Combined Treatment with Ionizing Radiation and the PARP Inhibitor Olaparib in BRCA Mutant and Wild Type Patient-Derived Pancreatic Cancer Xenografts
I. Lohse, R. Kumareswaran, P. Cao, B. Pitcher +3 more
2016PLoS ONE25 citations Open access
Semantic Scholar
Mobilization of Leukemic Cells Using Plerixafor as Part of a Myeloablative Preparative Regimen for Patients with Acute Myelogenous Leukemia Undergoing Allografting: Assessment of Safety and Tolerability.
F. Michelis, D. Hedley, S. Malhotra, S. Chow +7 more
2019Biology of Blood and Marrow Transplantation23 citations Open access
Semantic Scholar
Quantifying Reoxygenation in Pancreatic Cancer During Stereotactic Body Radiotherapy
Edward Taylor, Jitao Zhou, P. Lindsay, W. Foltz +8 more
2020Scientific Reports22 citations Open access
Semantic Scholar
A phase II study of the HSP90 inhibitor AUY922 in chemotherapy refractory advanced pancreatic cancer
D. Renouf, D. Hedley, M. Krzyzanowska, M. Schmuck +2 more
2016Cancer Chemotherapy and Pharmacology21 citations
Semantic Scholar
A phase II trial of GSK2256098 and trametinib in patients with advanced pancreatic ductal adenocarcinoma (PDAC) (MOBILITY-002 Trial, NCT02428270).
K. Aung, E. Mcwhirter, S. Welch, Lisa Wang +12 more
201820 citations
Semantic Scholar
Long term responders to palliative chemotherapy for advanced biliary tract cancer.
M. Doherty, M. McNamara, P. Aneja, Emma McInerney +8 more
2016Journal of Gastrointestinal Oncology18 citations Open access
Semantic Scholar
Porphysome nanoparticles for enhanced photothermal therapy in a patient-derived orthotopic pancreas xenograft cancer model: a pilot study
Christina M Maclaughlin, L. Ding, Cheng s. Jin, P. Cao +6 more
2016Journal of Biomedical Optics17 citations Open access
Semantic Scholar
A phase I trial of ANG1/2-Tie2 inhibitor trebaninib (AMG386) and temsirolimus in advanced solid tumors (PJC008/NCI♯9041)
J. Chiu, S. Hotte, C. Kollmannsberger, D. Renouf +13 more
2015Investigational new drugs17 citations Open access
Semantic Scholar
Pancreatic cancer growth promoted by bone marrow mesenchymal stromal cell-derived IL-6 is reversed predominantly by IL-6 blockade.
R. Antoon, Xing‐Hua Wang, Amr H. Saleh, J. Warrington +2 more
2022Cytotherapy15 citations Open access
Semantic Scholar
Combined Targeting of the Glutathione and Thioredoxin Antioxidant Systems in Pancreatic Cancer.
Francesco Fazzari, S. Chow, M. Cheung, Samir H. Barghout +3 more
2022ACS Pharmacology & Translational Science15 citations Open access
Semantic Scholar
Radioimmunotherapy of PANC-1 human pancreatic cancer xenografts in NOD/SCID or NRG mice with Panitumumab labeled with Auger electron emitting, 111In or β-particle emitting, 177Lu
Sadaf Aghevlian, Cai Zhongli, D. Hedley, M. Winnik +1 more
2020EJNMMI Radiopharmacy and Chemistry15 citations Open access
Semantic Scholar
Radioimmunotherapy of PANC-1 Human Pancreatic Cancer Xenografts in NRG Mice with Panitumumab Modified with Metal-Chelating Polymers Complexed to 177Lu.
Sadaf Aghevlian, Zhong-Li Cai, Yi-Jie Lu, D. Hedley +2 more
2018Molecular Pharmaceutics15 citations
Semantic Scholar
Randomised, Phase II study of selumetinib, an oral inhibitor of MEK, in combination with cisplatin and gemcitabine chemotherapy for patients with advanced biliary tract cancer
M. Doherty, V. Tam, M. McNamara, R. Jang +10 more
2022British Journal of Cancer13 citations Open access
Semantic Scholar
MicroSPECT/CT Imaging of Cell-Line and Patient-Derived EGFR-Positive Tumor Xenografts in Mice with Panitumumab Fab Modified with Hexahistidine Peptides to Enable Labeling with 99mTc (I) Tricarbonyl Complex.
Anthony Ku, C. Chan, Sadaf Aghevlian, Zhong-Li Cai +5 more
2019Molecular Pharmaceutics13 citations Open access
Semantic Scholar
Quantifying hypoxia in human cancers using static PET imaging
Edward Taylor, I. Yeung, H. Keller, B. Wouters +3 more
2016Physics in Medicine and Biology13 citations
Semantic Scholar
Predictive and prognostic values of ERCC1 and XRCC1 in biliary tract cancers
Muhtashim Mian, M. McNamara, M. Doherty, D. Hedley +2 more
2016Journal of Clinical Pathology13 citations
Semantic Scholar
Tumor Platinum Concentrations and Pathological Responses Following Cisplatin-Containing Chemotherapy in Gastric Cancer Patients
Yan-Shuo Cao, Qing Chang, M. Cabanero, Wen-Jiang Zhang +10 more
2018Journal of Gastrointestinal Cancer12 citations
Semantic Scholar
Cytokinetic effects of Wee1 disruption in pancreatic cancer
Q. Chang, M. Chandrashekhar, T. Ketela, Yaroslav Fedyshyn +2 more
2016Cell Cycle12 citations Open access
Semantic Scholar

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