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G. Zenke · SciRah

Researcher profile · Semantic Scholar

G. Zenke

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G. Zenke — researcher profile on SciRah

h-index: 23
Works: 75
Citations: 2,941

Most-cited papers

SDZ RAD, a new rapamycin derivative: pharmacological properties in vitro and in vivo.
W. Schuler, R. Sedrani, S. Cottens, B. Häberlin +5 more
1997Transplantation558 citations Open access
Semantic Scholar
SDZ RAD, a new rapamycin derivative: synergism with cyclosporine.
H. Schuurman, S. Cottens, S. Fuchs, J. Joergensen +5 more
1997Transplantation257 citations Open access
Semantic Scholar
Interleukin-3 is a differentiation factor for human basophils.
P. Valent, G. Schmidt, J. Besemer, P. Mayer +6 more
1989Blood223 citations Open access
Semantic Scholar
The Potent Protein Kinase C-Selective Inhibitor AEB071 (Sotrastaurin) Represents a New Class of Immunosuppressive Agents Affecting Early T-Cell Activation
J. Evenou, Jürgen Wagner, G. Zenke, V. Brinkmann +14 more
2009Journal of Pharmacology and Experimental Therapeutics170 citations
Semantic Scholar
Mode of action of SDZ NIM 811, a nonimmunosuppressive cyclosporin A analog with activity against human immunodeficiency virus (HIV) type 1: interference with HIV protein-cyclophilin A interactions
A. Billich, F. Hammerschmid, P. Peichl, R. Wenger +3 more
1995Journal of Virology170 citations Open access
Semantic Scholar
Sanglifehrins A, B, C and D, novel cyclophilin-binding compounds isolated from Streptomyces sp. A92-308110. I. Taxonomy, fermentation, isolation and biological activity.
Jean-Jacques Sanglier, V. Quesniaux, T. Fehr, H. Hofmann +7 more
1999Journal of antibiotics (Tokyo. 1968)135 citations Open access
Semantic Scholar
Discovery of 3-(1H-indol-3-yl)-4-[2-(4-methylpiperazin-1-yl)quinazolin-4-yl]pyrrole-2,5-dione (AEB071), a potent and selective inhibitor of protein kinase C isotypes.
J. Wagner, P. von Matt, R. Sedrani, R. Albert +12 more
2009Journal of Medicinal Chemistry132 citations Open access
Semantic Scholar
Immunosuppressive and Nonimmunosuppressive Cyclosporine Analogs Are Toxic to the Opportunistic Fungal Pathogen Cryptococcus neoformans via Cyclophilin-Dependent Inhibition of Calcineurin
M. Cruz, M. del Poeta, Ping-ping Wang, R. Wenger +6 more
2000Antimicrobial Agents and Chemotherapy128 citations Open access
Semantic Scholar
Deficiency of MALT1 Paracaspase Activity Results in Unbalanced Regulatory and Effector T and B Cell Responses Leading to Multiorgan Inflammation
F. Bornancin, F. Renner, Ratiba Touil, Heiko Sic +26 more
2015Journal of Immunology127 citations Open access
Semantic Scholar
Improved cancer immunotherapy by a CD25-mimobody conferring selectivity to human interleukin-2
Natalia Arenas-Ramirez, Chao Zou, S. Popp, D. Zingg +10 more
2016Science Translational Medicine123 citations
Semantic Scholar
Sanglifehrin A, a Novel Cyclophilin-Binding Compound Showing Immunosuppressive Activity with a New Mechanism of Action
G. Zenke, U. Strittmatter, S. Fuchs, V. Quesniaux +7 more
2001Journal of Immunology112 citations Open access
Semantic Scholar
Sanglifehrin-cyclophilin interaction: degradation work, synthetic macrocyclic analogues, X-ray crystal structure, and binding data.
R. Sedrani, J. Kallen, L. M. Martin-Cabrejas, C. D. Papageorgiou +10 more
2003Journal of the American Chemical Society94 citations
Semantic Scholar
Molecular mechanisms of immunosuppression.
G. Baumann, G. Zenke, Roland Wenger, Peter C. Hiestand +3 more
1992Journal of Autoimmunity58 citations
Semantic Scholar
The critical role of kinase activity of interleukin-1 receptor-associated kinase 4 in animal models of joint inflammation.
Magdalena Koziczak-Holbro, A. Littlewood-Evans, B. Pöllinger, J. Kovarik +5 more
2009Arthritis & Rheumatism52 citations
Semantic Scholar
Molecular Mechanisms of Immunosuppression by Cyclosporins
G. Zenke, G. Baumann, R. Wenger, P. Hiestand +3 more
1993Annals of the New York Academy of Sciences51 citations
Semantic Scholar
Nephrotoxicity of cyclosporin A and FK506: inhibition of calcineurin phosphatase.
Qing-Xiang Su, Liz Weber, M. le Hir, G. Zenke +1 more
1995Renal Physiology and Biochemistry48 citations
Semantic Scholar
Inhibition of T-cell signaling pathways by immunophilin drug complexes: are side effects inherent to immunosuppressive properties?
M. Schreier, G. Baumann, G. Zenke
1993Transplantation Proceedings45 citations
Semantic Scholar
Autocrine or paracrine transforming growth factor-beta modulates the phenotype of chick embryo sternal chondrocytes in serum-free agarose culture.
T. Tschan, Kathrin Bohme, M. Conscience-Egli, G. Zenke +2 more
1993Journal of Biological Chemistry41 citations Open access
Semantic Scholar
Structure-activity relationship and pharmacokinetic studies of sotrastaurin (AEB071), a promising novel medicine for prevention of graft rejection and treatment of psoriasis.
J. Wagner, P. von Matt, B. Faller, N. Cooke +9 more
2011Journal of Medicinal Chemistry39 citations Open access
Semantic Scholar
Total Synthesis and Biological Evaluation of Glycolipids Plakosides A, B and Their Analogs
K. Nicolaou, Jim Li, G. Zenke
200038 citations
Semantic Scholar
Structure of Human Cyclophilin A in Complex with the Novel Immunosuppressant Sanglifehrin A at 1.6 Å Resolution*
J. Kallen, R. Sedrani, G. Zenke, J. Wagner
2005Journal of Biological Chemistry37 citations Open access
Semantic Scholar
Structure‐activity relationship study of human interleukin‐3: role of the C‐terminal region for biological activity.
N. Lokker, G. Zenke, U. Strittmatter, B. Fagg +1 more
1991EMBO Journal36 citations
Semantic Scholar
Macrolide Analogues of the Novel Immunosuppressant Sanglifehrin: New Application of the Ring-Closing Metathesis Reaction.
L. M. Martin-Cabrejas, S. Rohrbach, D. Wagner, Jörg Kallen +2 more
1999Angewandte Chemie32 citations
Semantic Scholar
High‐level expression of a human immunoglobulin γ1 transgene depends on switch region sequences
H. Gram, G. Zenke, S. Geisse, Beate Kleuser +1 more
1992European Journal of Immunology21 citations
Semantic Scholar
7-Oxa[2.2.1]bicycloheptane-2,3-dicarboxylic acid derivatives as phosphatase inhibitors
A. Enz, G. Zenke, E. Pombo-Villar
199720 citations
Semantic Scholar
PIMECROLIMUS: ABSORPTION, DISTRIBUTION, METABOLISM, AND EXCRETION IN HEALTHY VOLUNTEERS AFTER A SINGLE ORAL DOSE AND SUPPLEMENTARY INVESTIGATIONS IN VITRO
M. Zollinger, F. Waldmeier, S. Hartmann, G. Zenke +7 more
2006Drug Metabolism And Disposition15 citations
Semantic Scholar
A locally active antiinflammatory macrolide (MLD987) for inhalation therapy of asthma.
R. Hersperger, K. Buchheit, S. Cammisuli, A. Enz +11 more
2004Journal of Medicinal Chemistry15 citations Open access
Semantic Scholar
Cymbimicin A and B, two novel cyclophilin-binding structures isolated from actinomycetes.
T. Fehr, V. Quesniaux, Jean-Jacques Sanglier, Lukas Oberer +7 more
1997Journal of antibiotics (Tokyo. 1968)15 citations Open access
Semantic Scholar
Synthesis of derivatives of the novel cyclophilin-binding immunosuppressant sanglifehrin A with reduced numbers of polar functions.
R. Bänteli, J. Wagner, G. Zenke
2001Bioorganic & Medicinal Chemistry Letters14 citations Open access
Semantic Scholar
Structural and functional analysis of an rRNA operon and its flanking tRNA genes from Zea mays chloroplasts.
H. Kössel, K. Edwards, W. Koch, Peter Langridge +4 more
1982Nucleic Acids Symposium Series14 citations
Semantic Scholar
Strongly reduced alloreactivity and long‐term survival times of cardiac allografts in Vav1‐ and Vav1/Vav2‐knockout mice
G. Weckbecker, C. Bruns, K. Fischer, C. Heusser +7 more
2007Transplant International13 citations Open access
Semantic Scholar
Indolyl-naphthyl-maleimides as potent and selective inhibitors of protein kinase C-α/β.
M. V. van Eis, J. Evenou, W. Schuler, G. Zenke +3 more
2017Bioorganic & Medicinal Chemistry Letters10 citations Open access
Semantic Scholar
Human immune response to group A streptococcal carbohydrate (A-CHO). II. Antigen-independent stimulation of IgM anti-A-CHO production in purified B cells by a monoclonal anti-idiotopic antibody.
A. Bloem, G. Zenke, K. Eichmann, F. Emmrich
1988Journal of Immunology10 citations
Semantic Scholar
Idiotope mapping on the variable region of an antibody clonotype produced by normal (nonmalignant) human B cells.
G. Zenke, K. Eichmann, F. Emmrich
1985Journal of Immunology10 citations
Semantic Scholar
A discrete affinity-driven elevation of ZAP-70 kinase activity initiates negative selection
M. Mallaun, G. Zenke, E. Palmer
2010Journal of Receptor and Signal Transduction Research9 citations Open access
Semantic Scholar
Isotype restriction of idiotopes associated with human anti‐streptococcal A carbohydrate antibodies
F. Emmrich, G. Zenke, K. Eichmann
1986European Journal of Immunology9 citations
Semantic Scholar
Characterization of a major human antibody clonotype (1A) by monoclonal antibodies to combining siteassociated idiotopes
G. Zenke, K. Eichmann, F. Emmrich
1984European Journal of Immunology9 citations
Semantic Scholar
Synthesis and in vitro cytotoxicity of diastereoisomerically modified dolastatin 15 analogues
F. Roux, Nathalie Galéotti, J. Poncet, P. Jouin +2 more
19946 citations
Semantic Scholar
The continuing search for new immunomodulators.
M. Schreier, G. Zenke, J. Borel, G. Baumann
1992Transplantation Proceedings6 citations
Semantic Scholar
Two Human IgM Myeloma Proteins with Unusual Specificities for Streptococcal Carbohydrate‐Associated Epitopes
F. Emmrich, D. Bundle, J. Zee, T. Out +2 more
1985Scandinavian Journal of Immunology6 citations
Semantic Scholar
Anti-LFA-1 monotherapy prevents neointimal formation in a murine model of transplant intimal hyperplasia.
B. Soleimani, G. Wieczorek, A. Katopodis, G. Zenke +3 more
2007The Journal of Heart and Lung Transplantation5 citations
Semantic Scholar
Secretion of Colony-Stimulating Factor for Macrophages (M-CSF) and Granulocyte/Macrophages (GM-CSF) is Developmentally Regulated in Human Macrophages
C. Scheibenbogen, G. Zenke, B. Faggs, K. Motoyoshi +4 more
19905 citations
Semantic Scholar
Fingerprints of CD8+ T cells on human pre-plasma and memory B cells
Ulrike Strittmatter-Keller, C. Walter, Celine Rauld, N. Egli +5 more
2018PLoS ONE4 citations Open access
Semantic Scholar
Preparation and immunosuppressive activity of 32-(O)-acylated and 32-(O)-thioacylated analogues of ascomycin.
Rene Hersperger, W. Schuler, G. Zenke
1999Bioorganic & Medicinal Chemistry Letters4 citations
Semantic Scholar
New Derivatives of Ascomycin with Modifications in the Amino Acid Region – Synthesis and Biological Activities, and X‐Ray Crystal Structure of 5,6‐Dehydroascomycin
M. Bulusu, Peter Waldstätten, Thomas Tricotet, C. Rochais +8 more
20093 citations
Semantic Scholar
Note Synthetic modifications of ascomycin : Part IIIl - A concise transformation of iso ascomycin to 19, 20-seeo-derivatives
R. Zimmer, M. Grassberger, K. Baumann, G. Zenke +1 more
19993 citations
Semantic Scholar
Modification of the immunosuppressant ascomycin (21-ethyl-FK506) at the C19-C20 double bond
K. Baumann, A. Edmunds, M. Grassberger, G. Schulz +2 more
19933 citations
Semantic Scholar
Evidence for shared receptor proteins for human interleukin-3 and granulocyte-macrophage colony-stimulating factor in the human M-07 cell line.
G. Woerly, G. Zenke, U. Strittmatter, B. Ryffel
1993Journal of Receptor Research2 citations
Semantic Scholar
The rRNA operon from maize chloroplasts: analysis of in vivo transcription products in relation to its structure.
G. Zenke, K. Edwards, P. Langridge, H. Kössel
1982Progress in clinical and biological research2 citations
Semantic Scholar
Derivatives of 2,4-di (hetero) arylamino-pyrimidine as inhibitors zap-70 and / or syk.
Rolf Baenteli, Marie Claude Bernhard, P. Buehlmayer, N. Cooke +7 more
20041 citations
Semantic Scholar

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S. Cottens×5
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V. Quesniaux×4

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G. Baumann — researcher profile on SciRah

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