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C. Rochais · SciRah

Researcher profile · Semantic Scholar

C. Rochais

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C. Rochais — researcher profile on SciRah

h-index: 23
Works: 112
Citations: 2,262

Most-cited papers

Drug repositioning: a brief overview
J. Jourdan, R. Bureau, C. Rochais, P. Dallemagne
2020The Journal of pharmacy and pharmacology379 citations Open access
Semantic Scholar
hERG toxicity assessment: Useful guidelines for drug design.
Amanda Garrido, Alban Lepailleur, S. Mignani, P. Dallemagne +1 more
2020European journal of medicinal chemistry297 citations Open access
Semantic Scholar
Design of donecopride, a dual serotonin subtype 4 receptor agonist/acetylcholinesterase inhibitor with potential interest for Alzheimer's disease treatment
Cédric Lecoutey, Damien Hédou, T. Freret, P. Giannoni +12 more
2014Proceedings of the National Academy of Sciences of the United States of America118 citations Open access
Semantic Scholar
Novel multitarget-directed ligands (MTDLs) with acetylcholinesterase (AChE) inhibitory and serotonergic subtype 4 receptor (5-HT4R) agonist activities as potential agents against Alzheimer's disease: the design of donecopride.
C. Rochais, Cédric Lecoutey, Florence Gaven, P. Giannoni +16 more
2015Journal of Medicinal Chemistry116 citations Open access
Semantic Scholar
Therapeutic Potential of 5-HT6 Receptor Agonists.
D. Karila, T. Freret, V. Bouet, M. Boulouard +2 more
2015Journal of Medicinal Chemistry79 citations Open access
Semantic Scholar
Matrix Metalloproteinases as New Targets in Alzheimer's Disease: Opportunities and Challenges.
P. Zipfel, C. Rochais, K. Baranger, S. Rivera +1 more
2020Journal of Medicinal Chemistry72 citations Open access
Semantic Scholar
Pharmacotechnical Development of a Nasal Drug Delivery Composite Nanosystem Intended for Alzheimer’s Disease Treatment
Thomas Adnet, A. Groo, C. Picard, Audrey Davis +7 more
2020Pharmaceutics68 citations Open access
Semantic Scholar
Modulating 5-HT4 and 5-HT6 receptors in Alzheimer's disease treatment.
Julien Lalut, D. Karila, P. Dallemagne, C. Rochais
2017Future Medicinal Chemistry48 citations
Semantic Scholar
Synergistic effect of acetylcholinesterase inhibition (donepezil) and 5-HT(4) receptor activation (RS67333) on object recognition in mice.
T. Freret, V. Bouet, A. Quiedeville, G. Née +3 more
2012Behavioural Brain Research48 citations
Semantic Scholar
Chronic activation of 5-HT4 receptors or blockade of 5-HT6 receptors improve memory performances.
A. Quiedeville, M. Boulouard, Katia Hamidouche, Virginie Da Silva Costa-Aze +6 more
2015Behavioural Brain Research46 citations
Semantic Scholar
Novel multitarget-directed ligands targeting acetylcholinesterase and σ1 receptors as lead compounds for treatment of Alzheimer's disease: Synthesis, evaluation, and structural characterization of their complexes with acetylcholinesterase.
Julien Lalut, G. Santoni, D. Karila, Cédric Lecoutey +8 more
2019European journal of medicinal chemistry44 citations Open access
Semantic Scholar
3-(Dipropylamino)-5-hydroxybenzofuro[2,3-f]quinazolin-1(2H)-one (DPA-HBFQ-1) plays an inhibitory role on breast cancer cell growth and progression.
P. Rizza, M. Pellegrino, A. Caruso, D. Iacopetta +11 more
2016European journal of medicinal chemistry41 citations Open access
Semantic Scholar
Design, synthesis, and pharmacological evaluation of multitarget-directed ligands with both serotonergic subtype 4 receptor (5-HT4R) partial agonist and 5-HT6R antagonist activities, as potential treatment of Alzheimer's disease.
S. Yahiaoui, Katia Hamidouche, Céline Ballandonne, Audrey Davis +5 more
2016European journal of medicinal chemistry33 citations Open access
Semantic Scholar
Pleiotropic prodrugs: Design of a dual butyrylcholinesterase inhibitor and 5-HT6 receptor antagonist with therapeutic interest in Alzheimer's disease.
François-Xavier Toublet, Julien Lalut, Bérénice Hatat, Cédric Lecoutey +9 more
2020European journal of medicinal chemistry31 citations Open access
Semantic Scholar
Donecopride, a Swiss army knife with potential against Alzheimer's disease
C. Rochais, Cédric Lecoutey, Katia Hamidouche, P. Giannoni +10 more
2019British Journal of Pharmacology31 citations Open access
Semantic Scholar
Rational design of novel benzisoxazole derivatives with acetylcholinesterase inhibitory and serotoninergic 5-HT4 receptors activities for the treatment of Alzheimer’s disease
Julien Lalut, Hugo Payan, Audrey Davis, Cédric Lecoutey +5 more
2020Scientific Reports28 citations Open access
Semantic Scholar
Design, synthesis and biological evaluation of novel indano- and thiaindano-pyrazoles with potential interest for Alzheimer's disease
D. Genest, C. Rochais, Cédric Lecoutey, J. S. O. Santos +5 more
201328 citations
Semantic Scholar
Inhibiting Acetylcholinesterase to Activate Pleiotropic Prodrugs with Therapeutic Interest in Alzheimer’s Disease
François-Xavier Toublet, Cédric Lecoutey, Julien Lalut, Bérénice Hatat +9 more
2019Molecules25 citations Open access
Semantic Scholar
Virtual Screening Discovery of New Acetylcholinesterase Inhibitors Issued from CERMN Chemical Library
J. S. O. Santos, Aurélien Lesnard, J. Agondanou, N. Dupont +7 more
2010Journal of Chemical Information and Modeling24 citations
Semantic Scholar
A Novel in vivo Anti-amnesic Agent, Specially Designed to Express Both Acetylcholinesterase (AChE) Inhibitory, Serotonergic Subtype 4 Receptor (5-HT4R) Agonist and Serotonergic Subtype 6 Receptor (5-HT6R) Inverse Agonist Activities, With a Potential Interest Against Alzheimer’s Disease
Bérénice Hatat, S. Yahiaoui, Cédric Lecoutey, Audrey Davis +5 more
2019Frontiers in Aging Neuroscience23 citations Open access
Semantic Scholar
Recent Advances in Phenanthroindolizidine and Phenanthroquinolizidine Derivatives with Anticancer Activities.
Maria de Fátima Pereira, C. Rochais, P. Dallemagne
2015Anti-Cancer Agents in Medicinal Chemistry23 citations
Semantic Scholar
Disproportionality analysis in VigiBase as a drug repositioning method for the discovery of potentially useful drugs in Alzheimer's disease
B. Chrétien, J. Jourdan, Audrey Davis, S. Fédrizzi +7 more
2020British Journal of Clinical Pharmacology22 citations Open access
Semantic Scholar
First Synthesis of Racemic Trans Propargylamino-Donepezil, a Pleiotrope Agent Able to Both Inhibit AChE and MAO-B, with Potential Interest against Alzheimer’s Disease
Benjamin Guieu, Cédric Lecoutey, Rémi Legay, Audrey Davis +5 more
2020Molecules22 citations Open access
Semantic Scholar
Synthesis of new dipyrrolo- and furopyrrolopyrazinones related to tripentones and their biological evaluation as potential kinases (CDKs1-5, GSK-3) inhibitors.
C. Rochais, N. V. Duc, Elodie Lescot, Jana Sopková-de Oliveira Santos +4 more
2009European journal of medicinal chemistry22 citations Open access
Semantic Scholar
Indenopyrazole oxime ethers: synthesis and β1-adrenergic blocking activity.
T. Angelone, A. Caruso, C. Rochais, A. Caputo +9 more
2015European journal of medicinal chemistry20 citations Open access
Semantic Scholar
Hydrogenative desulphurization of thienopyrrolizinones: an easy and selective access to (Z)-phenethylidenepyrrolizinones with in vitro cytotoxic activity.
Vittoria Perri, C. Rochais, Jana Sopková-de Oliveira Santos, Rémi Legay +3 more
2010European journal of medicinal chemistry19 citations
Semantic Scholar
Dynamic microfluidic single-cell screening identifies pheno-tuning compounds to potentiate tuberculosis therapy
M. Mistretta, M. Cimino, Pascal Campagne, Stevenn Volant +18 more
2024Nature Communications16 citations Open access
Semantic Scholar
Desirable drug-drug interactions or when a matter of concern becomes a renewed therapeutic strategy.
Benjamin Guieu, J. Jourdan, Aurore Dreneau, N. Willand +2 more
2020Drug Discovery Today16 citations Open access
Semantic Scholar
Therapeutic modulators of the serotonin 5-HT4 receptor: a patent review (2014-present)
Caroline Lanthier, P. Dallemagne, Cédric Lecoutey, S. Claeysen +1 more
2020Expert Opinion on Therapeutic Patents16 citations Open access
Semantic Scholar
MR22388, a novel anti-cancer agent with a strong FLT-3 ITD kinase affinity.
C. Rochais, T. Cresteil, Vittoria Perri, M. Jouanne +3 more
2013Cancer Letters16 citations
Semantic Scholar
Tripentones: a promising series of potent anti-cancer agents.
C. Rochais, P. Dallemagne, S. Rault
2009Anti-Cancer Agents in Medicinal Chemistry16 citations
Semantic Scholar
Analysis of skeletal diversity of multi-target directed ligands (MTDLs) targeting Alzheimer's disease.
Uzma Azam, Muhammad Moazzam Naseer, C. Rochais
2025European journal of medicinal chemistry15 citations Open access
Semantic Scholar
Conceptual Framework of the Design of Pleiotropic Drugs against Alzheimer’s Disease
Thomas Guiselin, Cédric Lecoutey, C. Rochais, P. Dallemagne
2023Pharmaceutics15 citations Open access
Semantic Scholar
Phenanthrolinic analogs of quinolones show antibacterial activity against M. tuberculosis.
S. Coulibaly, M. Cimino, M. Ouattara, Cédric Lecoutey +7 more
2020European journal of medicinal chemistry15 citations Open access
Semantic Scholar
Structure-activity relationships of serotonin 5-HT7 receptors ligands: A review.
S. Thirumaran, Alban Lepailleur, C. Rochais
2019European journal of medicinal chemistry15 citations Open access
Semantic Scholar
Synthesis of dual AChE/5-HT4 receptor multi-target directed ligands
Cédric Lecoutey, C. Rochais, D. Genest, Sabrina Butt-Gueulle +6 more
201215 citations
Semantic Scholar
C3-Symmetric Ligands in Drug Design: When the Target Controls the Aesthetics of the Drug
M. Antonijevic, C. Rochais, P. Dallemagne
2023Molecules14 citations Open access
Semantic Scholar
Novel benzylidenephenylpyrrolizinones with pleiotropic activities potentially useful in Alzheimer's disease treatment.
J. Jourdan, M. Since, L. El Kihel, Cédric Lecoutey +7 more
2016European journal of medicinal chemistry14 citations
Semantic Scholar
Novel multi target-directed ligands targeting 5-HT4 receptors with in cellulo antioxidant properties as promising leads in Alzheimer's disease.
Caroline Lanthier, Hugo Payan, Irene Liparulo, Bérénice Hatat +8 more
2019European journal of medicinal chemistry12 citations Open access
Semantic Scholar
Inducing neuronal regeneration and differentiation via the BDNF/TrkB signaling pathway: a key target against neurodegenerative diseases?
M. Antonijevic, P. Dallemagne, C. Rochais
2023Neural Regeneration Research11 citations Open access
Semantic Scholar
Biginelli Reaction Synthesis of Novel Multitarget-Directed Ligands with Ca2+ Channel Blocking Ability, Cholinesterase Inhibition, Antioxidant Capacity, and Nrf2 Activation
Rim Malek, Alexey Simakov, Audrey Davis, M. Maj +9 more
2022Molecules11 citations Open access
Semantic Scholar
Benzylphenylpyrrolizinones with Anti‐amyloid and Radical Scavenging Effects, Potentially Useful in Alzheimer's Disease Treatment
J. Jourdan, M. Since, L. El Kihel, Cédric Lecoutey +7 more
2017ChemMedChem11 citations Open access
Semantic Scholar
One-pot synthesis of novel poly-substituted phenanthrenes
R. Yougnia, C. Rochais, J. S. O. Santos, P. Dallemagne +1 more
201011 citations
Semantic Scholar
Indirect influence on the BDNF/TrkB receptor signaling pathway via GPCRs, an emerging strategy in the treatment of neurodegenerative disorders
M. Antonijevic, P. Dallemagne, C. Rochais
2024Medicinal research reviews (Print)10 citations
Semantic Scholar
One-pot synthesis of new aza- and diaza-aminophenanthrenes
C. Rochais, R. Yougnia, T. Cailly, J. S. O. Santos +2 more
201110 citations
Semantic Scholar
Design, synthesis and biological characterization of novel activators of the TrkB neurotrophin receptor.
M. Antonijevic, Despoina Charou, I. Ramos, M. Valcárcel +7 more
2023European journal of medicinal chemistry9 citations Open access
Semantic Scholar
Synthesis and evaluation of novel serotonin 4 receptor radiotracers for single photon emission computed tomography.
Julien Lalut, B. Tournier, T. Cailly, Cédric Lecoutey +8 more
2016European journal of medicinal chemistry9 citations Open access
Semantic Scholar
First and mild synthesis of fluorene-9-malonic acid and some substituted derivatives via the intramolecular hydroarylation of 2-phenylbenzylidenemalonic acids
E. Chosson, C. Rochais, Rémi Legay, J. S. O. Santos +2 more
20119 citations
Semantic Scholar
Synthesis, reactivity and biological evaluation of novel halogenated tripentones.
Vittoria Perri, C. Rochais, T. Cresteil, P. Dallemagne +1 more
2009Bioorganic & Medicinal Chemistry9 citations
Semantic Scholar
Development of Pleiotropic TrkB and 5-HT4 Receptor Ligands as Neuroprotective Agents
M. Antonijevic, Despoina Charou, Audrey Davis, Thomas Curel +8 more
2024Molecules8 citations Open access
Semantic Scholar

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