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Selene Roberts · SciRah

Researcher profile · Semantic Scholar

Selene Roberts

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Selene Roberts — researcher profile on SciRah

h-index: 15
Works: 40
Citations: 887

Most-cited papers

EGFR oligomerization organizes kinase-active dimers into competent signalling platforms
S. R. Needham, Selene Roberts, A. Arkhipov, V. Mysore +17 more
2016Nature Communications189 citations Open access
Semantic Scholar
Single-molecule imaging and fluorescence lifetime imaging microscopy show different structures for high- and low-affinity epidermal growth factor receptors in A431 cells.
S. Webb, Selene Roberts, S. R. Needham, Christopher J. Tynan +5 more
2008Biophysical Journal88 citations Open access
Semantic Scholar
The architecture of EGFR’s basal complexes reveals autoinhibition mechanisms in dimers and oligomers
Laura C. Zanetti-Domingues, Dimitrios Korovesis, S. R. Needham, Christopher J. Tynan +17 more
2018Nature Communications85 citations Open access
Semantic Scholar
Structure and Dynamics of the EGF Receptor as Revealed by Experiments and Simulations and Its Relevance to Non-Small Cell Lung Cancer
M. Martin-Fernandez, D. Clarke, Selene Roberts, Laura C. Zanetti-Domingues +1 more
2019Cells74 citations Open access
Semantic Scholar
Inhibitor-induced HER2-HER3 heterodimerisation promotes proliferation through a novel dimer interface
J. Claus, G. Patel, Flavia Autore, A. Colomba +16 more
2018eLife62 citations Open access
Semantic Scholar
Ectodomain orientation, conformational plasticity and oligomerization of ErbB1 receptors investigated by molecular dynamics.
J. Kästner, Hannes H. Loeffler, Selene Roberts, M. Martin-Fernandez +1 more
2009Journal of Structural Biology54 citations
Semantic Scholar
Drug-resistant EGFR mutations promote lung cancer by stabilizing interfaces in ligand-free kinase-active EGFR oligomers
R. Iyer, S. R. Needham, Ioannis Galdadas, Benjamin M. Davis +9 more
2024Nature Communications53 citations Open access
Semantic Scholar
Human Epidermal Growth Factor Receptor (EGFR) Aligned on the Plasma Membrane Adopts Key Features of Drosophila EGFR Asymmetry
Christopher J. Tynan, Selene Roberts, Daniel J. Rolfe, D. Clarke +5 more
2011Molecular and Cellular Biology43 citations Open access
Semantic Scholar
Multidimensional single-molecule imaging in live cells using total-internal-reflection fluorescence microscopy.
S. Webb, S. R. Needham, Selene Roberts, M. L. Martin-Fernandez
2006Optics Letters43 citations
Semantic Scholar
Incandescent porous carbon microspheres to light up cells: solution phenomena and cellular uptake
P. Duffy, Luís M. Magno, Rahul B. Yadav, Selene Roberts +4 more
201231 citations Open access
Semantic Scholar
Structure-function relationships and supramolecular organization of the EGFR (epidermal growth factor receptor) on the cell surface.
S. R. Needham, Laura C. Zanetti-Domingues, Michael Hirsch, Daniel J. Rolfe +4 more
2014Biochemical Society Transactions19 citations
Semantic Scholar
The Rho family GEF FARP2 is activated by aPKCι to control tight junction formation and polarity
A. Elbediwy, Yixiao Zhang, Mathias Cobbaut, P. Riou +9 more
2019Journal of Cell Science17 citations Open access
Semantic Scholar
Targeting mutant EGFR in non-small cell lung cancer in the context of cell adaptation and resistance.
Selene Roberts, Ioannis Galgadas, David T. Clarke, Laura C. Zanetti-Domingues +2 more
2025Drug Discovery Today16 citations Open access
Semantic Scholar
Simultaneous widefield single molecule orientation and FRET microscopy in cells.
S. Webb, Daniel J. Rolfe, S. R. Needham, Selene Roberts +4 more
2008Optics Express16 citations Open access
Semantic Scholar
A tale of the epidermal growth factor receptor: The quest for structural resolution on cells.
Christopher J. Tynan, Valentina Lo Schiavo, Laura C. Zanetti-Domingues, S. R. Needham +6 more
2016Methods15 citations
Semantic Scholar
Optics clustered to output unique solutions: a multi-laser facility for combined single molecule and ensemble microscopy.
D. Clarke, S. Botchway, Benjamin C. Coles, S. R. Needham +8 more
2011Review of Scientific Instruments13 citations Open access
Semantic Scholar
Nanometric molecular separation measurements by single molecule photobleaching.
S. Webb, Michael Hirsch, S. R. Needham, Benjamin C. Coles +6 more
2015Methods12 citations
Semantic Scholar
Cluster Analysis of Endogenous HER2 and HER3 Receptors in SKBR3 Cells.
Selene Roberts, Michael Hirsch, A. McStea, Laura C. Zanetti-Domingues +5 more
2018Bio-protocol11 citations Open access
Semantic Scholar
A small molecule inhibitor of HER3: a proof-of-concept study
A. Colomba, M. Fitzek, R. George, G. Weitsman +13 more
2020Biochemical Journal10 citations Open access
Semantic Scholar
Investigating extracellular in situ EGFR structure and conformational changes using FRET microscopy.
Selene Roberts, Christopher J. Tynan, M. Winn, M. Martin-Fernandez
2012Biochemical Society Transactions10 citations
Semantic Scholar
Single-Molecule Imaging and Fluorescence Lifetime Imaging Microscopy Show Different Structures for High-and Low-Affinity Epidermal Growth Factor Receptors in A 431 Cells
S. Webb, Selene Roberts, S. R. Needham, Christopher J. Tynan +5 more
20089 citations
Semantic Scholar
Determining the geometry of oligomers of the human epidermal growth factor family on cells with <10 nm resolution.
S. R. Needham, Laura C. Zanetti-Domingues, K. Scherer, Michael Hirsch +5 more
2015Biochemical Society Transactions7 citations
Semantic Scholar
Human-EGFR aligned on the plasma membrane adopts key features of Drosophila -EGFR asymmetry
Christopher J. Tynan, Selene Roberts, Daniel J. Rolfe, D. Clarke +5 more
20115 citations
Semantic Scholar
Piecing together the structure of epidermal growth factor receptor complexes: a journey from crystals to cells and its impact on cancer therapy.
Selene Roberts, David T. Clarke, Ioannis Galdadas, Marisa L. Martin-Fernandez
2026Philosophical transactions of the Royal Society of London. Series B, Biological sciences1 citations Open access
Semantic Scholar
Drug-resistant EGFR lung cancer mutations promote tumor growth by stabilizing interfaces in ligand-free signaling-competent EGFR oligomers
S. R. Needham, Sumanth Iyer, Benjamin M. Davis, Ioannis Galdadas +6 more
2024Biophysical Journal1 citations Open access
Semantic Scholar
The T766M-EGFR lung cancer mutation promotes tumor growth by exploiting newfound mechanisms assembling ligand-free EGFR oligomer structures
R. Iyer, S. R. Needham, I. Galdadas, Benjamin M. Davis +9 more
2023bioRxiv1 citations Open access
Semantic Scholar
Oligomerization of the Epidermal Growth Factor Receptor Organizes Kinase-Active Dimers into Competent Signaling Platforms
S. R. Needham, Laura C. Zanetti-Domigues, A. Arkhipov, V. Mysore +11 more
20171 citations Open access
Semantic Scholar
Signalling via vascular endothelial growth factor receptor complexes
Selene Roberts
20051 citations
Semantic Scholar
Disrupting aberrant EGFR catalytic trimers reverses T790M gefitinib resistance
Selene Roberts, Ioannis Galdadas, Nicola Piasentin, S. R. Needham +9 more
2026bioRxiv0 citations Open access
Semantic Scholar
Corrigendum to "Targeting mutant EGFR in non-small cell lung cancer in the context of cell adaptation and resistance" [Drug Discov. Today 30(7) (2025) 104407].
Selene Roberts, Ioannis Galgadas, David T. Clarke, Laura C. Zanetti-Domingues +2 more
2025Drug Discovery Today0 citations Open access
Semantic Scholar
FLImP-assisted MINFLUX overcomes molecular localization errors to reveal the structure of heterogeneous membrane protein systems
Benjamin M. Davis, S. R. Needham, Christopher J. Tynan, Selene Roberts +3 more
2024Biophysical Journal0 citations Open access
Semantic Scholar
Towards cloud-enabled fully automated end-to-end single molecule imaging.
Benjamin M. Davis, S. R. Needham, Sumanth Iyer, Selene Roberts +3 more
2023Biophysical Journal0 citations Open access
Semantic Scholar
Investigating the Structure of Epidermal Growth Factor Receptor (EGFR) Dimers and Oligomers in Cells
S. R. Needham, S. Iyer, Benjamin M. Davis, Laura C. Zanetti-Domingues +3 more
20210 citations Open access
Semantic Scholar
Fluorescence Localisation Imaging with Photobleaching at 5 nm Resolution Reveals the Architecture of Basal EGFR Complexes and Mechanisms of Autoinhibition and Activation
M. Martin-Fernandez, Laura C. Zanetti-Domingues, Dimitrios Korovesis, S. R. Needham +5 more
20180 citations Open access
Semantic Scholar
Author response: Inhibitor-induced HER2-HER3 heterodimerisation promotes proliferation through a novel dimer interface
J. Claus, G. Patel, Flavia Autore, A. Colomba +16 more
20180 citations Open access
Semantic Scholar
99PSIMULTANEOUS, MULTICOLOUR SINGLE MOLECULE IMAGING OF THE ENTIRE HUMAN EPIDERMAL GROWTH FACTOR RECEPTOR (HER) FAMILY IN LIVE BREAST CANCER CELLS
Laura C. Zanetti-Domingues, S. Webb, Christopher J. Tynan, Daniel J. Rolfe +6 more
20130 citations Open access
Semantic Scholar
Investigating the Conformation of HER Membrane Proteins in Cells via Single Molecule and FLIM Microscopy
M. Martin-Fernandez, D. Clarke, Michael Hirsch, S. R. Needham +6 more
20120 citations Open access
Semantic Scholar
Epidermal growth factor signaling studied using multidimensional single molecule fluorescence microscopy
S. Webb, Selene Roberts, S. R. Needham, Daniel J. Rolfe +2 more
2007SPIE BiOS0 citations
Semantic Scholar
Single molecule imaging and FLIM show different structures for high and low-affinity EGFRs in A 431 cells
S. Webb, Selene Roberts, S. R. Needham, Christopher J. Tynan +5 more
20070 citations
Semantic Scholar
Title Incandescent Porous Carbon Microspheres to Light up Cells : Solution Phenomena and Cellular Uptake
P. Duffy, Luís M. Magno, Rahul B. Yadav, Selene Roberts +5 more
0 citations
Semantic Scholar

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