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K. Beebe · SciRah

Researcher profile · Semantic Scholar

K. Beebe

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K. Beebe — researcher profile on SciRah

h-index: 33
Works: 58
Citations: 3,896

Most-cited papers

An acetylation site in the middle domain of Hsp90 regulates chaperone function.
B. Scroggins, Kenneth Robzyk, Dongxia Wang, M. Marcu +8 more
2007Molecules and Cells436 citations Open access
Semantic Scholar
Regulation and function of the human HSP90AA1 gene
A. Zuehlke, K. Beebe, L. Neckers, T. Prince
2015Gene313 citations Open access
Semantic Scholar
Affinity-based proteomics reveal cancer-specific networks coordinated by Hsp90
Kamalika Moulick, J. H. Ahn, Hong-Liang Zong, Anna Rodina +24 more
2011Nature Chemical Biology277 citations Open access
Semantic Scholar
Molecular chaperone TRAP1 regulates a metabolic switch between mitochondrial respiration and aerobic glycolysis
S. Yoshida, Shinji Tsutsumi, Guillaume Muhlebach, C. Sourbier +17 more
2013Proceedings of the National Academy of Sciences of the United States of America262 citations Open access
Semantic Scholar
Combinatorial drug design targeting multiple cancer signaling networks controlled by mitochondrial Hsp90.
B. Kang, J. Plescia, Ho-Young Song, M. Meli +5 more
2009Journal of Clinical Investigation224 citations Open access
Semantic Scholar
Swe1Wee1-dependent tyrosine phosphorylation of Hsp90 regulates distinct facets of chaperone function
M. Mollapour, Shinji Tsutsumi, Alison C. Donnelly, K. Beebe +15 more
2010Molecules and Cells196 citations Open access
Semantic Scholar
Threonine 22 phosphorylation attenuates Hsp90 interaction with co-chaperones and affects its chaperone activity
M. Mollapour, Shinji Tsutsumi, A. Truman, Wan-Ping Xu +10 more
2011Molecules and Cells174 citations Open access
Semantic Scholar
DYNAMIC TYROSINE PHOSPHORYLATION MODULATES CYCLING OF THE HSP90-P50CDC37-AHA1 CHAPERONE MACHINE
Wan-Ping Xu, M. Mollapour, C. Prodromou, Sui-Quan Wang +10 more
2012Molecules and Cells132 citations Open access
Semantic Scholar
Asymmetric Hsp90 N-domain SUMOylation recruits Aha1 and ATP-competitive inhibitors
M. Mollapour, D. Bourboulia, K. Beebe, Mark R. Woodford +19 more
2014Molecules and Cells129 citations Open access
Semantic Scholar
Integration of Gene Dosage and Gene Expression in Non-Small Cell Lung Cancer, Identification of HSP90 as Potential Target
M. G. Gallegos Ruiz, K. Floor, P. Roepman, J. Rodriguez +11 more
2008PLoS ONE126 citations Open access
Semantic Scholar
Dynamic Imaging of LDH Inhibition in Tumors Reveals Rapid In Vivo Metabolic Rewiring and Vulnerability to Combination Therapy
Nobu Oshima, R. Ishida, S. Kishimoto, K. Beebe +37 more
2020Cell Reports111 citations Open access
Semantic Scholar
Targeting the Hsp40/Hsp70 chaperone axis as a novel strategy to treat castration-resistant prostate cancer
M. Moses, Y. Kim, Génesis M. Rivera-Márquez, Nobu Oshima +13 more
2018Cancer Research109 citations Open access
Semantic Scholar
Selective inhibition of HER2-positive breast cancer cells by the HIV protease inhibitor nelfinavir.
J. Shim, R. Rao, K. Beebe, L. Neckers +3 more
2012Journal of the National Cancer Institute83 citations Open access
Semantic Scholar
Impact of heat-shock protein 90 on cancer metastasis
Shinji Tsutsumi, K. Beebe, L. Neckers
2009Future Oncology80 citations Open access
Semantic Scholar
Mps1 Mediated Phosphorylation of Hsp90 Confers Renal Cell Carcinoma Sensitivity and Selectivity to Hsp90 Inhibitors
Mark R. Woodford, A. Truman, Diana M. Dunn, S. Jensen +20 more
2016Cell Reports74 citations Open access
Semantic Scholar
Loss of Hsp90 Association Up-Regulates Src-Dependent ErbB2 Activity
Wan-Ping Xu, Xitong Yuan, K. Beebe, Zhexin Xiang +1 more
2006Molecular and Cellular Biology73 citations Open access
Semantic Scholar
The mitochondrial HSP90 paralog TRAP1 forms an OXPHOS-regulated tetramer and is involved in mitochondrial metabolic homeostasis
Abhinav Joshi, Li Dai, Yan-Xin Liu, Jungsoon Lee +10 more
2020BMC Biology69 citations Open access
Semantic Scholar
HSP90 inhibitors disrupt a transient HSP90-HSF1 interaction and identify a noncanonical model of HSP90-mediated HSF1 regulation
T. Kijima, T. Prince, Megan L. Tigue, Kendrick H. Yim +9 more
2017Scientific Reports62 citations Open access
Semantic Scholar
Activation of Hsp90 enzymatic activity and conformational dynamics through rationally designed allosteric ligands
S. Sattin, J. Tao, G. Vettoretti, E. Moroni +15 more
2015Chemistry62 citations Open access
Semantic Scholar
The HSP90 Inhibitor Ganetespib Synergizes with the MET Kinase Inhibitor Crizotinib in both Crizotinib-Sensitive and -Resistant MET-Driven Tumor Models
N. Miyajima, Shinji Tsutsumi, C. Sourbier, K. Beebe +9 more
2013Cancer Research60 citations Open access
Semantic Scholar
Abstract 446: HSP90 inhibitors disrupt a transient HSP90-HSF1 interaction and identify a noncanonical model of HSP90-mediated HSF1 regulation
Megan L. Tigue, T. Kijima, T. Prince, Kendrick H. Yim +9 more
2018Molecular and Cellular Biology / Genetics59 citations
Semantic Scholar
Client Proteins and Small Molecule Inhibitors Display Distinct Binding Preferences for Constitutive and Stress-Induced HSP90 Isoforms and Their Conformationally Restricted Mutants
T. Prince, T. Kijima, M. Tatokoro, Sunmin Lee +10 more
2015PLoS ONE59 citations Open access
Semantic Scholar
Post-translational modification and conformational state of Heat Shock Protein 90 differentially affect binding of chemically diverse small molecule inhibitors
K. Beebe, M. Mollapour, B. Scroggins, C. Prodromou +11 more
2013OncoTarget59 citations Open access
Semantic Scholar
The Development of Hsp90β-selective Inhibitors to Overcome Detriments Associated with pan-Hsp90 Inhibition
Sanket Mishra, Wei-Ya Liu, K. Beebe, M. Banerjee +7 more
2021Journal of Medicinal Chemistry56 citations Open access
Semantic Scholar
Hsp90 middle domain phosphorylation initiates a complex conformational program to recruit the ATPase-stimulating cochaperone Aha1
Wan-Ping Xu, K. Beebe, Juan D. Chavez, M. Boysen +9 more
2019Nature Communications54 citations Open access
Semantic Scholar
Divergent synthesis of a pochonin library targeting HSP90 and in vivo efficacy of an identified inhibitor.
S. Barluenga, Cuihua Wang, J. Fontaine, Kaïss Aouadi +4 more
2008Angewandte Chemie51 citations Open access
Semantic Scholar
Phosphorylation induced cochaperone unfolding promotes kinase recruitment and client class-specific Hsp90 phosphorylation
Ashleigh B. Bachman, D. Keramisanou, Wan-Ping Xu, K. Beebe +7 more
2018Nature Communications46 citations Open access
Semantic Scholar
Identification of endogenously S-nitrosylated proteins in Arabidopsis plantlets : Effect of cold stress on cysteine nitrosylation level
M. Mollapour, D. Bourboulia, K. Beebe, Mark R. Woodford +17 more
201445 citations
Semantic Scholar
Inhibition of HSP90 with Pochoximes: SAR and Structure-Based Insights
S. Barluenga, J. Fontaine, Cuihua Wang, Kaïss Aouadi +4 more
2009ChemBioChem44 citations Open access
Semantic Scholar
Sensitivity of epidermal growth factor receptor and ErbB2 exon 20 insertion mutants to Hsp90 inhibition
W. Xu, S. Soga, K. Beebe, M.-J. Lee +3 more
2007British Journal of Cancer44 citations Open access
Semantic Scholar
An Hsp90 co-chaperone protein in yeast is functionally replaced by site-specific posttranslational modification in humans
A. Zuehlke, Michael Reidy, Coney Lin, P. LaPointe +11 more
2017Nature Communications39 citations Open access
Semantic Scholar
Azaspirene, a fungal product, inhibits angiogenesis by blocking Raf-1 activation
Yukihiro Asami, H. Kakeya, Yusuke Komi, S. Kojima +4 more
2008Cancer Science37 citations Open access
Semantic Scholar
Concise Modular Asymmetric Synthesis of Deguelin, Tephrosin and Investigation into Their Mode of Action
Josefina Garcia, S. Barluenga, K. Beebe, L. Neckers +1 more
2010Chemistry33 citations Open access
Semantic Scholar
The Ras Effector RASSF2 Controls the PAR-4 Tumor Suppressor
H. Donninger, L. Hesson, M. Vos, K. Beebe +8 more
2010Molecular and Cellular Biology32 citations Open access
Semantic Scholar
Calcium-dependent inhibition of Polo-like kinase 3 activity by CIB1 in breast cancer cells
Meghna U. Naik, N. T. Pham, K. Beebe, W. Dai +1 more
2011International Journal of Cancer31 citations Open access
Semantic Scholar
Computational Polypharmacology Analysis of the Heat Shock Protein 90 Interactome
A. Anighoro, Dagmar Stumpfe, Kathrin Heikamp, K. Beebe +3 more
2015Journal of Chemical Information and Modeling25 citations Open access
Semantic Scholar
Combined HSP90 and kinase inhibitor therapy: Insights from The Cancer Genome Atlas
Harvey Schwartz, B. Scroggins, A. Zuehlke, T. Kijima +4 more
2015Cell stress & chaperones (Print)22 citations Open access
Semantic Scholar
Phase 1 study of the HSP90 inhibitor onalespib in combination with AT7519, a pan-CDK inhibitor, in patients with advanced solid tumors
K. Do, Geraldine O'Sullivan Coyne, J. Hays, J. Supko +15 more
2020Cancer Chemotherapy and Pharmacology19 citations Open access
Semantic Scholar
Targeting Hsp90 in Non-Cancerous Maladies.
Mark R. Woodford, Diana M. Dunn, Joseph G Ciciarelli, K. Beebe +2 more
2016Current Topics in Medicinal Chemistry16 citations
Semantic Scholar
Emetine Promotes von Hippel-Lindau-Independent Degradation of Hypoxia-Inducible Factor-2α in Clear Cell Renal Carcinoma
Hyesik Kong, Sunmin Lee, K. Beebe, B. Scroggins +5 more
2010Molecular Pharmacology16 citations Open access
Semantic Scholar
Synthesis and structure-activity relationship studies of novel dihydropyridones as androgen receptor modulators.
Antonella Pepe, M. Pamment, Y. Kim, Sunmin Lee +6 more
2013Journal of Medicinal Chemistry14 citations Open access
Semantic Scholar
Pharmacologic dissection of the overlapping impact of heat shock protein family members on platelet function
Joseph W. Jackson, Génesis M. Rivera-Márquez, K. Beebe, Andy D. Tran +5 more
2020Journal of Thrombosis and Haemostasis10 citations Open access
Semantic Scholar
Abstract 3029: Biochemical evidence towards the existence of an oncogenic Hsp90 complex
Anna Rodina, Kamalika Moulick, J. H. Ahn, Hong-Liang Zong +24 more
201210 citations
Semantic Scholar
Synthesis and evaluation of 8,9-amido analogs of geldanamycin
M. Andrus, Yong Wong, Jing Liu, K. Beebe +1 more
20098 citations
Semantic Scholar
Low-penetrant RB allele in small-cell cancer shows geldanamycin instability and discordant expression with mutant ras
Yoonsoo Park, A. Kubo, T. Komiya, A. Coxon +4 more
2008Cell Cycle8 citations Open access
Semantic Scholar
Phase I trial of the combination of the heat shock protein-90 inhibitor onalespib (AT13387) and the cyclin-dependent kinase inhibitor AT7519M in patients with advanced solid tumors.
K. Do, J. Hays, Stephen V. Liu, Alice P. Chen +15 more
2019Journal of Clinical Oncology3 citations
Semantic Scholar
The mitochondrial HSP90 paralog TRAP1 forms an OXPHOS-regulated tetramer and is involved in maintaining mitochondrial metabolic homeostasis
Abhinav Joshi, J. Dai, Jungsoon Lee, N. Ghahhari +5 more
2019bioRxiv2 citations Open access
Semantic Scholar
The HSP90 inhibitor ganetespib synergizes with the MET kinase inhibitor crizotinib in both crizotinib-sensitive and crizotinib-resistant MET-driven tumor models
N. Miyajima, Shinji Tsutsumi, C. Sourbier, K. Beebe +11 more
20131 citations
Semantic Scholar
Antimetastatic activity of ganetespib: Preclinical studies and assessment of progressions due to new lesions in the GALAXY-1 NSCLC trial.
D. Proia, Masazumi Nagai, J. Jimenez, Chao-Hua Zhang +12 more
20131 citations
Semantic Scholar
Integrating Telemedicine and Embodied Virtual Reality: A Novel Functional Training Intervention for Chronic Shoulder Pain
K. Beebe, Anthony Alvarez, Lincoln Nguyen, James Petros +2 more
2025Journal of medical extended reality0 citations Open access
Semantic Scholar

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L. Neckers — researcher profile on SciRah
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Wan-Ping Xu — researcher profile on SciRah

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